Definition Sulfolobus tokodaii str. 7 chromosome, complete genome.
Accession NC_003106
Length 2,694,756

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The map label for this gene is yvrD [H]

Identifier: 15922570

GI number: 15922570

Start: 2246488

End: 2247276

Strand: Direct

Name: yvrD [H]

Synonym: ST2239

Alternate gene names: 15922570

Gene position: 2246488-2247276 (Clockwise)

Preceding gene: 15922569

Following gene: 15922571

Centisome position: 83.37

GC content: 35.49

Gene sequence:

>789_bases
GTGGTAAGAATAGATCTTGGGATAAAAGGGAAAAAAGTGATAGTAACAGCGGCAAGTAAAGGTATAGGTTTTGCAACAGC
GAAAAGGTTTTTAGAGGAAGGTGCAAAAGTTATTATATCTTCTCATGACGAAAATAATCTAAGGAAAGCTTATGAAAGAC
TAAAGAATCTCGGTGAAGTAAATTATATCATAGCAGATTTAACAAAACCATCTGATGTAGAGAACCTAATAAAGTCTGGT
TATAGTACTTTAGGCGGGCTAGATGTATTAGTGTATGTTACTGGAAGTCCGAAGCCAGGAAATTTGTTTGAGTTAACAAA
TGAAGATTGGATTAATGCTTTTTATCTTCTTTTAATGAGTGCTGTTATTGCAGTAAGGGAAGCTGGGAAATTAATGAAAA
GTGGTGGTCGGATTATTCTATCTACATCAATGACATTAAAAGAACCTTTGCCTAATTTGGACTTGTCTAACGTAGTAAGG
TTATCTTTAGCTGGATTAATTAAAGTTGCAGCTAGAGAATTAGGAGAAAAAGGAATATTAGTTAACGGTGTAATGCCAGG
CTGGACATTAACTGATAGGGTAGATCAACTAGTTAAGGATAGAGCAAAAAGGGAAGGTAGAAGTGAAGAGGAAATAATAA
GGGATATCACGAGGGATGTCCCATTAAAGAGAATTGGAAAACCTGAAGAGGTAGCCAATGTTATCCTATTCTTAGCTTCT
GAGCTTTCAACATATGTAAACGGTGTATTAATTCCAGTAGATGGAGGACTTATTAAGGCAACCCTTTAA

Upstream 100 bases:

>100_bases
CTTTATAATCCTAATCTTAGGAAAATTCTTGAGGAAGATTTTAAGAAGATAAGAGAGTTAGCGATAACCCCAAAAAGGTA
TACAATTGATTATTTTCTTG

Downstream 100 bases:

>100_bases
AACTATTAGCACTAATAATACTTCCTTTTTTTCTCTCATTATAGAACGACATAAAATAGTTGGTTAACGATTATATTATA
GGAAGGAGAAATATGCGTAG

Product: reductase

Products: 3-oxoacyl-[acyl-carrier protein]; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 262; Mature: 262

Protein sequence:

>262_residues
MVRIDLGIKGKKVIVTAASKGIGFATAKRFLEEGAKVIISSHDENNLRKAYERLKNLGEVNYIIADLTKPSDVENLIKSG
YSTLGGLDVLVYVTGSPKPGNLFELTNEDWINAFYLLLMSAVIAVREAGKLMKSGGRIILSTSMTLKEPLPNLDLSNVVR
LSLAGLIKVAARELGEKGILVNGVMPGWTLTDRVDQLVKDRAKREGRSEEEIIRDITRDVPLKRIGKPEEVANVILFLAS
ELSTYVNGVLIPVDGGLIKATL

Sequences:

>Translated_262_residues
MVRIDLGIKGKKVIVTAASKGIGFATAKRFLEEGAKVIISSHDENNLRKAYERLKNLGEVNYIIADLTKPSDVENLIKSG
YSTLGGLDVLVYVTGSPKPGNLFELTNEDWINAFYLLLMSAVIAVREAGKLMKSGGRIILSTSMTLKEPLPNLDLSNVVR
LSLAGLIKVAARELGEKGILVNGVMPGWTLTDRVDQLVKDRAKREGRSEEEIIRDITRDVPLKRIGKPEEVANVILFLAS
ELSTYVNGVLIPVDGGLIKATL
>Mature_262_residues
MVRIDLGIKGKKVIVTAASKGIGFATAKRFLEEGAKVIISSHDENNLRKAYERLKNLGEVNYIIADLTKPSDVENLIKSG
YSTLGGLDVLVYVTGSPKPGNLFELTNEDWINAFYLLLMSAVIAVREAGKLMKSGGRIILSTSMTLKEPLPNLDLSNVVR
LSLAGLIKVAARELGEKGILVNGVMPGWTLTDRVDQLVKDRAKREGRSEEEIIRDITRDVPLKRIGKPEEVANVILFLAS
ELSTYVNGVLIPVDGGLIKATL

Specific function: 7-Alpha-Dehydroxylation Of Cholic Acid, Yielding Deoxycholic Acid And Lithocholic Acid, Respectively. Highest Affinity With Taurochenodeoxycholic Acid. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI32483357, Length=263, Percent_Identity=32.6996197718631, Blast_Score=118, Evalue=5e-27,
Organism=Homo sapiens, GI5031737, Length=245, Percent_Identity=30.6122448979592, Blast_Score=107, Evalue=8e-24,
Organism=Homo sapiens, GI126723750, Length=267, Percent_Identity=30.7116104868914, Blast_Score=98, Evalue=7e-21,
Organism=Homo sapiens, GI33667109, Length=182, Percent_Identity=32.4175824175824, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI19923817, Length=256, Percent_Identity=27.734375, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI15277342, Length=262, Percent_Identity=28.6259541984733, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI126723191, Length=211, Percent_Identity=30.8056872037915, Blast_Score=78, Evalue=9e-15,
Organism=Homo sapiens, GI40254992, Length=250, Percent_Identity=26.8, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI66933014, Length=252, Percent_Identity=28.1746031746032, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI7705925, Length=258, Percent_Identity=27.906976744186, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI1787905, Length=264, Percent_Identity=29.1666666666667, Blast_Score=108, Evalue=2e-25,
Organism=Escherichia coli, GI1787335, Length=257, Percent_Identity=30.7392996108949, Blast_Score=98, Evalue=5e-22,
Organism=Escherichia coli, GI1789378, Length=260, Percent_Identity=28.4615384615385, Blast_Score=97, Evalue=9e-22,
Organism=Escherichia coli, GI1786812, Length=258, Percent_Identity=30.6201550387597, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI87082160, Length=256, Percent_Identity=28.90625, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI87082100, Length=254, Percent_Identity=25.5905511811024, Blast_Score=88, Evalue=5e-19,
Organism=Escherichia coli, GI1788459, Length=252, Percent_Identity=28.1746031746032, Blast_Score=87, Evalue=9e-19,
Organism=Escherichia coli, GI2367365, Length=252, Percent_Identity=26.984126984127, Blast_Score=84, Evalue=7e-18,
Organism=Escherichia coli, GI1790717, Length=260, Percent_Identity=25.7692307692308, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1789208, Length=262, Percent_Identity=27.4809160305344, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1789057, Length=198, Percent_Identity=28.7878787878788, Blast_Score=61, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17561402, Length=258, Percent_Identity=31.3953488372093, Blast_Score=115, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17560676, Length=249, Percent_Identity=28.9156626506024, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17555706, Length=257, Percent_Identity=29.1828793774319, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17560150, Length=267, Percent_Identity=29.9625468164794, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17562904, Length=262, Percent_Identity=30.5343511450382, Blast_Score=91, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI25147288, Length=262, Percent_Identity=25.9541984732824, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17562990, Length=268, Percent_Identity=27.2388059701493, Blast_Score=84, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI72000259, Length=267, Percent_Identity=28.8389513108614, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17559104, Length=258, Percent_Identity=26.3565891472868, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17562910, Length=258, Percent_Identity=29.4573643410853, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17531453, Length=260, Percent_Identity=29.2307692307692, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17544670, Length=267, Percent_Identity=26.5917602996255, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17562906, Length=265, Percent_Identity=27.1698113207547, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI193204405, Length=265, Percent_Identity=28.3018867924528, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17560332, Length=262, Percent_Identity=28.6259541984733, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17538486, Length=257, Percent_Identity=27.2373540856031, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17560220, Length=265, Percent_Identity=28.6792452830189, Blast_Score=70, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17563726, Length=265, Percent_Identity=27.9245283018868, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17562908, Length=262, Percent_Identity=25.9541984732824, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17551412, Length=263, Percent_Identity=29.277566539924, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17538480, Length=260, Percent_Identity=28.4615384615385, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI115534694, Length=254, Percent_Identity=25.9842519685039, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17565030, Length=254, Percent_Identity=27.9527559055118, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17508651, Length=250, Percent_Identity=28.8, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21355319, Length=254, Percent_Identity=30.7086614173228, Blast_Score=111, Evalue=6e-25,
Organism=Drosophila melanogaster, GI24644339, Length=260, Percent_Identity=28.0769230769231, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24639444, Length=263, Percent_Identity=31.1787072243346, Blast_Score=95, Evalue=5e-20,
Organism=Drosophila melanogaster, GI23397609, Length=256, Percent_Identity=29.296875, Blast_Score=91, Evalue=6e-19,
Organism=Drosophila melanogaster, GI28571526, Length=261, Percent_Identity=28.3524904214559, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24644337, Length=262, Percent_Identity=31.2977099236641, Blast_Score=85, Evalue=6e-17,
Organism=Drosophila melanogaster, GI21357041, Length=259, Percent_Identity=26.6409266409266, Blast_Score=78, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100

Molecular weight: Translated: 28554; Mature: 28554

Theoretical pI: Translated: 9.67; Mature: 9.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MVRIDLGIKGKKVIVTAASKGIGFATAKRFLEEGAKVIISSHDENNLRKAYERLKNLGEV
CEEEECCCCCCEEEEEECCCCCCHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHCCCHH
NYIIADLTKPSDVENLIKSGYSTLGGLDVLVYVTGSPKPGNLFELTNEDWINAFYLLLMS
EEEEEECCCCHHHHHHHHHCHHHCCCCEEEEEEECCCCCCCEEEECCHHHHHHHHHHHHH
AVIAVREAGKLMKSGGRIILSTSMTLKEPLPNLDLSNVVRLSLAGLIKVAARELGEKGIL
HHHHHHHHHHHHHCCCEEEEEECCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEE
VNGVMPGWTLTDRVDQLVKDRAKREGRSEEEIIRDITRDVPLKRIGKPEEVANVILFLAS
EECCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHH
ELSTYVNGVLIPVDGGLIKATL
HHHHHHCEEEEEECCCEEEECC
>Mature Secondary Structure
MVRIDLGIKGKKVIVTAASKGIGFATAKRFLEEGAKVIISSHDENNLRKAYERLKNLGEV
CEEEECCCCCCEEEEEECCCCCCHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHCCCHH
NYIIADLTKPSDVENLIKSGYSTLGGLDVLVYVTGSPKPGNLFELTNEDWINAFYLLLMS
EEEEEECCCCHHHHHHHHHCHHHCCCCEEEEEEECCCCCCCEEEECCHHHHHHHHHHHHH
AVIAVREAGKLMKSGGRIILSTSMTLKEPLPNLDLSNVVRLSLAGLIKVAARELGEKGIL
HHHHHHHHHHHHHCCCEEEEEECCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEE
VNGVMPGWTLTDRVDQLVKDRAKREGRSEEEIIRDITRDVPLKRIGKPEEVANVILFLAS
EECCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHH
ELSTYVNGVLIPVDGGLIKATL
HHHHHHCEEEEEECCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (3R)-3-hydroxyacyl-[acyl-carrier protein]; NADP+

Specific reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377 [H]