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The map label for this gene is trxA [H]

Identifier: 15922449

GI number: 15922449

Start: 2129761

End: 2130183

Strand: Direct

Name: trxA [H]

Synonym: ST2123

Alternate gene names: 15922449

Gene position: 2129761-2130183 (Clockwise)

Preceding gene: 15922446

Following gene: 15922450

Centisome position: 79.03

GC content: 35.46

Gene sequence:

>423_bases
ATGACGAGTAAAGATAAAATTAGTATGACAACTGAGAAAGACCCTGAATTAGGAAAATTGCTAGAGAAGAAAGCCAAAGA
ACTTATGAGCCAAAAGCCTAAAGGAGAAGTAATTCATTTAGATAGTAAAAACTTTGACTCTTTCTTAGCTTCGCACAAAA
TCGCAGTAGTTGATTTTTGGGCAGAGTGGTGTGCACCATGTTTAATCCTTGCACCCATAATTGAGGAATTAGCAGAAGAT
TATCCACAAGTTGGATTTGGAAAGTTAAACAGCGACGAAAATCCAGATATTGCCGCAAGATATGGTGTCATGAGTCTACC
TACAGTTATCTTCTTTAAAGATGGTGAACCAGTAGATGAAATTATAGGTGCTGTTCCAAGAGAAGAAATAGAGATAAGAA
TTAAGAATTTATTAGGTGAATAA

Upstream 100 bases:

>100_bases
TAAAAAGCTTTGATATAAGTAGTCCCGTGATTCCAGAACCTATTATAGTTAAATCAGCCATAAATTATTTATAAAAGATA
AGATAAAATAAACTTTTTAA

Downstream 100 bases:

>100_bases
AATTGAAACCAATTCTTCTTGGTATTCCAGGACTAAGTTATTCTAGTTTTATGAAATGTAATCCTAGATTTTTAATGATG
CTCTTTAGTAGTACATTTAG

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 140; Mature: 139

Protein sequence:

>140_residues
MTSKDKISMTTEKDPELGKLLEKKAKELMSQKPKGEVIHLDSKNFDSFLASHKIAVVDFWAEWCAPCLILAPIIEELAED
YPQVGFGKLNSDENPDIAARYGVMSLPTVIFFKDGEPVDEIIGAVPREEIEIRIKNLLGE

Sequences:

>Translated_140_residues
MTSKDKISMTTEKDPELGKLLEKKAKELMSQKPKGEVIHLDSKNFDSFLASHKIAVVDFWAEWCAPCLILAPIIEELAED
YPQVGFGKLNSDENPDIAARYGVMSLPTVIFFKDGEPVDEIIGAVPREEIEIRIKNLLGE
>Mature_139_residues
TSKDKISMTTEKDPELGKLLEKKAKELMSQKPKGEVIHLDSKNFDSFLASHKIAVVDFWAEWCAPCLILAPIIEELAEDY
PQVGFGKLNSDENPDIAARYGVMSLPTVIFFKDGEPVDEIIGAVPREEIEIRIKNLLGE

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=101, Percent_Identity=36.6336633663366, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI50592994, Length=89, Percent_Identity=39.3258426966292, Blast_Score=70, Evalue=6e-13,
Organism=Homo sapiens, GI95113651, Length=76, Percent_Identity=36.8421052631579, Blast_Score=68, Evalue=3e-12,
Organism=Homo sapiens, GI52487191, Length=87, Percent_Identity=36.7816091954023, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI87082331, Length=98, Percent_Identity=39.7959183673469, Blast_Score=90, Evalue=5e-20,
Organism=Escherichia coli, GI1788936, Length=94, Percent_Identity=40.4255319148936, Blast_Score=84, Evalue=3e-18,
Organism=Escherichia coli, GI87081747, Length=105, Percent_Identity=34.2857142857143, Blast_Score=66, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71980565, Length=99, Percent_Identity=37.3737373737374, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71980562, Length=106, Percent_Identity=36.7924528301887, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17507705, Length=74, Percent_Identity=37.8378378378378, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71998175, Length=89, Percent_Identity=42.6966292134831, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI25144092, Length=91, Percent_Identity=32.967032967033, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI212646193, Length=84, Percent_Identity=36.9047619047619, Blast_Score=63, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=85, Percent_Identity=45.8823529411765, Blast_Score=91, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6321648, Length=92, Percent_Identity=47.8260869565217, Blast_Score=88, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6319925, Length=93, Percent_Identity=39.7849462365591, Blast_Score=76, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24639826, Length=78, Percent_Identity=44.8717948717949, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24658597, Length=86, Percent_Identity=39.5348837209302, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI17648013, Length=76, Percent_Identity=42.1052631578947, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24583090, Length=76, Percent_Identity=42.1052631578947, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24664269, Length=98, Percent_Identity=36.734693877551, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 15675; Mature: 15544

Theoretical pI: Translated: 4.47; Mature: 4.47

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSKDKISMTTEKDPELGKLLEKKAKELMSQKPKGEVIHLDSKNFDSFLASHKIAVVDFW
CCCCCCEEECCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHCCHHHHHHH
AEWCAPCLILAPIIEELAEDYPQVGFGKLNSDENPDIAARYGVMSLPTVIFFKDGEPVDE
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHCHHHCCEEEEEECCCCHHH
IIGAVPREEIEIRIKNLLGE
HHCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
TSKDKISMTTEKDPELGKLLEKKAKELMSQKPKGEVIHLDSKNFDSFLASHKIAVVDFW
CCCCCEEECCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHCCHHHHHHH
AEWCAPCLILAPIIEELAEDYPQVGFGKLNSDENPDIAARYGVMSLPTVIFFKDGEPVDE
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHCHHHCCEEEEEECCCCHHH
IIGAVPREEIEIRIKNLLGE
HHCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9359865; 10632710 [H]