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The map label for this gene is moeA [C]

Identifier: 15922363

GI number: 15922363

Start: 2054827

End: 2055993

Strand: Direct

Name: moeA [C]

Synonym: ST2045

Alternate gene names: 15922363

Gene position: 2054827-2055993 (Clockwise)

Preceding gene: 15922359

Following gene: 15922364

Centisome position: 76.25

GC content: 33.08

Gene sequence:

>1167_bases
GTGCTAATAAGCTTAGAAGAAGCTAGAAAAATAATTGATATTAACATTTCTTCAAAGCATAATTATTATAGATATGAAAG
CATTTATAATTCAGTAGGGAAAATTATCCTAGAAGATATTTACGCAATAAAAAGTATTCCAGAGGTCAATTTGTCCGCTA
TGGACGGGTTTGCGTTCAAGGTGTCCGACTATAAAAAATATGGAAAACTAAAAATAGTCGGAAAACTGTTCCCCTCGTCT
AAGGAAATCCCAGAACTTAAGGAAGGCGAGGCATATTATGTAGCCACAGGTGCACCAGTACCAAAGGGCGCTGATGCAGT
AGTTAGAATAGAAGCTTCAAAAGTTATAAATAATGAATTAATTGTAGGAGAAGAGGTTTTTGAAGGAAAGGATATAAAAT
ATGCGGGTGAGGATATAAAAGAAGGAGAGTTAATAATTAGGAAAGGAGATGTATTAACTCCTTATCATCTTGGAATATTA
ACTTACCAAGGTATAAGGGAAGTAAAAATAGGGAATATAAAGAGTTGTGTTATAGCATCTGGAGATGAAATAACACCATT
CAATAATCCTTCACCAGAGCTTATACCAGATTCAATATCACCAATTATTCTATCAATACTCGAAAAAATTGGAAAAGCAA
CATATTATGGTGTAGTTAGAGATGAAAAAGAAAGTATAAAAGAGAAATTAATTAAAATGGAAGAAACTTGCGATGTTATT
TTCTTTATAGGGGGTTCTTCAGTAGGAGAAAAAGATTATGTTAAAAAACTTGTTGTCGAGTTAGGAAAACTTTTGTTTGA
AGGAGTAAGTGTGAATATTATAAAAAGAGGCGGTGTGGGATTGCTAGGAGAAACACCAATTGTAAGCTTACCCGGTCAAG
TTGTCTCAGCAGTAACTGTTTTTTATGAACATGGACTTCATGTTATATCTAGAATGTTAGATAGTGAGATAAGAAAATTT
GTAAAGGTTAAGTTAGGCAAAGATATGTATGTAGAGCATAAAATGGACTCGACTTATTTGTTTAGAATTGAAAATGGGGA
AGCTTTTCCTTTAAGATGGGGTACAGGGTTATACAGTGAACTAATTAAAGCTGATGGTTTTGGTTATCTTTCAAGGGGAA
AGACCCATAAAAGAGGAGAAGAAATTGAAATTCAAAAATTCCTTTGA

Upstream 100 bases:

>100_bases
GCTCTTTCAATTGCTGAAGTCTTTCCTGTATCCTTTTTGCCTACTACTTGTATAATGCAACCCATATGCTAATTTATACC
AGTTAGTAATATTTTATAAT

Downstream 100 bases:

>100_bases
CGTAATTATTTTAGCCGGGGGAGAATCAAAAAGATTTGGATCTGATAAATGCTCATATGAACTTGACGGGAAAACATTTC
TAGAAAGAATAGCAGATAAT

Product: molybdopterin biosynthesis MoeA protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MLISLEEARKIIDINISSKHNYYRYESIYNSVGKIILEDIYAIKSIPEVNLSAMDGFAFKVSDYKKYGKLKIVGKLFPSS
KEIPELKEGEAYYVATGAPVPKGADAVVRIEASKVINNELIVGEEVFEGKDIKYAGEDIKEGELIIRKGDVLTPYHLGIL
TYQGIREVKIGNIKSCVIASGDEITPFNNPSPELIPDSISPIILSILEKIGKATYYGVVRDEKESIKEKLIKMEETCDVI
FFIGGSSVGEKDYVKKLVVELGKLLFEGVSVNIIKRGGVGLLGETPIVSLPGQVVSAVTVFYEHGLHVISRMLDSEIRKF
VKVKLGKDMYVEHKMDSTYLFRIENGEAFPLRWGTGLYSELIKADGFGYLSRGKTHKRGEEIEIQKFL

Sequences:

>Translated_388_residues
MLISLEEARKIIDINISSKHNYYRYESIYNSVGKIILEDIYAIKSIPEVNLSAMDGFAFKVSDYKKYGKLKIVGKLFPSS
KEIPELKEGEAYYVATGAPVPKGADAVVRIEASKVINNELIVGEEVFEGKDIKYAGEDIKEGELIIRKGDVLTPYHLGIL
TYQGIREVKIGNIKSCVIASGDEITPFNNPSPELIPDSISPIILSILEKIGKATYYGVVRDEKESIKEKLIKMEETCDVI
FFIGGSSVGEKDYVKKLVVELGKLLFEGVSVNIIKRGGVGLLGETPIVSLPGQVVSAVTVFYEHGLHVISRMLDSEIRKF
VKVKLGKDMYVEHKMDSTYLFRIENGEAFPLRWGTGLYSELIKADGFGYLSRGKTHKRGEEIEIQKFL
>Mature_388_residues
MLISLEEARKIIDINISSKHNYYRYESIYNSVGKIILEDIYAIKSIPEVNLSAMDGFAFKVSDYKKYGKLKIVGKLFPSS
KEIPELKEGEAYYVATGAPVPKGADAVVRIEASKVINNELIVGEEVFEGKDIKYAGEDIKEGELIIRKGDVLTPYHLGIL
TYQGIREVKIGNIKSCVIASGDEITPFNNPSPELIPDSISPIILSILEKIGKATYYGVVRDEKESIKEKLIKMEETCDVI
FFIGGSSVGEKDYVKKLVVELGKLLFEGVSVNIIKRGGVGLLGETPIVSLPGQVVSAVTVFYEHGLHVISRMLDSEIRKF
VKVKLGKDMYVEHKMDSTYLFRIENGEAFPLRWGTGLYSELIKADGFGYLSRGKTHKRGEEIEIQKFL

Specific function: Involved In The Biosynthesis Of A Demolybdo-Cofactor (Molybdopterin), Necessary For Molybdo-Enzymes. Seems To Be Involved In A Step Of Activation Of Molybdenum In The Form Of Thiomolybdenum. [C]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=355, Percent_Identity=27.0422535211268, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI66932975, Length=355, Percent_Identity=27.0422535211268, Blast_Score=116, Evalue=3e-26,
Organism=Escherichia coli, GI1787049, Length=279, Percent_Identity=30.8243727598566, Blast_Score=137, Evalue=9e-34,
Organism=Caenorhabditis elegans, GI25147659, Length=330, Percent_Identity=26.6666666666667, Blast_Score=98, Evalue=6e-21,
Organism=Drosophila melanogaster, GI17136978, Length=299, Percent_Identity=27.4247491638796, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24638841, Length=299, Percent_Identity=27.4247491638796, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 43277; Mature: 43277

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLISLEEARKIIDINISSKHNYYRYESIYNSVGKIILEDIYAIKSIPEVNLSAMDGFAFK
CEEEHHHCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEE
VSDYKKYGKLKIVGKLFPSSKEIPELKEGEAYYVATGAPVPKGADAVVRIEASKVINNEL
ECCHHHCCCEEEEEEECCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEEHHHHCCCCE
IVGEEVFEGKDIKYAGEDIKEGELIIRKGDVLTPYHLGILTYQGIREVKIGNIKSCVIAS
EECHHHHCCCCCEECCCCCCCCCEEEEECCCCCCHHHHEEEECCCCEEECCCCCEEEEEC
GDEITPFNNPSPELIPDSISPIILSILEKIGKATYYGVVRDEKESIKEKLIKMEETCDVI
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHCCCCEE
FFIGGSSVGEKDYVKKLVVELGKLLFEGVSVNIIKRGGVGLLGETPIVSLPGQVVSAVTV
EEECCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCEEECCHHHHHHHHH
FYEHGLHVISRMLDSEIRKFVKVKLGKDMYVEHKMDSTYLFRIENGEAFPLRWGTGLYSE
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEEEEECCCEEEEECCCHHHHH
LIKADGFGYLSRGKTHKRGEEIEIQKFL
HHHCCCCCCCCCCCCCCCCCEEEEEECC
>Mature Secondary Structure
MLISLEEARKIIDINISSKHNYYRYESIYNSVGKIILEDIYAIKSIPEVNLSAMDGFAFK
CEEEHHHCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEE
VSDYKKYGKLKIVGKLFPSSKEIPELKEGEAYYVATGAPVPKGADAVVRIEASKVINNEL
ECCHHHCCCEEEEEEECCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEEHHHHCCCCE
IVGEEVFEGKDIKYAGEDIKEGELIIRKGDVLTPYHLGILTYQGIREVKIGNIKSCVIAS
EECHHHHCCCCCEECCCCCCCCCEEEEECCCCCCHHHHEEEECCCCEEECCCCCEEEEEC
GDEITPFNNPSPELIPDSISPIILSILEKIGKATYYGVVRDEKESIKEKLIKMEETCDVI
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHCCCCEE
FFIGGSSVGEKDYVKKLVVELGKLLFEGVSVNIIKRGGVGLLGETPIVSLPGQVVSAVTV
EEECCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCEEECCHHHHHHHHH
FYEHGLHVISRMLDSEIRKFVKVKLGKDMYVEHKMDSTYLFRIENGEAFPLRWGTGLYSE
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEEEEECCCEEEEECCCHHHHH
LIKADGFGYLSRGKTHKRGEEIEIQKFL
HHHCCCCCCCCCCCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]