Click here to switch to the map view.

The map label for this gene is cbiHC [H]

Identifier: 15922137

GI number: 15922137

Start: 1837271

End: 1837939

Strand: Reverse

Name: cbiHC [H]

Synonym: ST1825

Alternate gene names: 15922137

Gene position: 1837939-1837271 (Counterclockwise)

Preceding gene: 161751091

Following gene: 15922136

Centisome position: 68.2

GC content: 32.29

Gene sequence:

>669_bases
ATGACACTTTATGTAATTGGCGTTGGGCCTGGTGACCCAAGTTTAATTACAGTTAAGGGGTTAGAAGTTTTGAGAGATAG
TAAAGTAGTTACTGGCTGGGGAAGCGTAATAGAGCGTTTTTCTTCTTATATTCAGGGTAAGCAAGTAATCAGATTAAATT
ATAAAGAAGAGGAGAAACAACTTAACGAGATTATGAAATTAGCCAAGAACGAGAATGTGGCTTTCCTTAATCACGGTGAT
CCTGCTGTTTCTGATTTTCAGTTGTTAAATAAGTTGAAGAAATTATGTATGGATAACAGAGTAGAGTTAGTTATTATACC
CGGTGTTTCTTCAATAATTAGGGCATTACATATTATAGGAAAAGACCTTTCAGAAATAGTCTTTCTTACTTTTCATGTTA
GGGGAGAAATTAATTATGATGAAATTAAGAAGTTTCTAAATACCGGTAGAGGAATTTTAATTAACCCAGAGCCTTATCCA
GATGGCGTTAAAAGGATTGCATTAAAGTTGAAAGAATATGGCTGTAATTTTATTACTTTGACTATAATGGAAAAGTTAAC
ATATCAAGATGAAAAAGTGTATAATTTTAATGTTGACGAGATTATAACGCGTGATCTAAAATTTAGTGATCTTACTATAG
TTTATATTCCTCCTTGTTCCTTTTCTTAG

Upstream 100 bases:

>100_bases
CAGAAGTTTCAGCATTAATAGCTGGTGGCAAGGAGGCTAAATTACTTTTAAGAAAAATTACTTATAATAATGAAGTAACT
ATAGCTATAGCGGGATTTGA

Downstream 100 bases:

>100_bases
AAATATTTTTATATTTGGATAAGCTATCCAATACCGTGAGCAATTCAGCTATTATAATAATCACACATGGTTCTAGAAGA
AATACCTTTGTAGAGGACAT

Product: cobalt-precorrin-6Y C(5)-methyltransferase

Products: S-adenosyl-L-homocysteine; Precorrin 8X; CO2

Alternate protein names: Cobalt-precorrin-3B C(17)-methyltransferase; Cobalt-precorrin-3 methylase; Cobalt-precorrin-3 methyltransferase; Cobalt-precorrin-8X methylmutase; Cobalt-precorrin isomerase [H]

Number of amino acids: Translated: 222; Mature: 221

Protein sequence:

>222_residues
MTLYVIGVGPGDPSLITVKGLEVLRDSKVVTGWGSVIERFSSYIQGKQVIRLNYKEEEKQLNEIMKLAKNENVAFLNHGD
PAVSDFQLLNKLKKLCMDNRVELVIIPGVSSIIRALHIIGKDLSEIVFLTFHVRGEINYDEIKKFLNTGRGILINPEPYP
DGVKRIALKLKEYGCNFITLTIMEKLTYQDEKVYNFNVDEIITRDLKFSDLTIVYIPPCSFS

Sequences:

>Translated_222_residues
MTLYVIGVGPGDPSLITVKGLEVLRDSKVVTGWGSVIERFSSYIQGKQVIRLNYKEEEKQLNEIMKLAKNENVAFLNHGD
PAVSDFQLLNKLKKLCMDNRVELVIIPGVSSIIRALHIIGKDLSEIVFLTFHVRGEINYDEIKKFLNTGRGILINPEPYP
DGVKRIALKLKEYGCNFITLTIMEKLTYQDEKVYNFNVDEIITRDLKFSDLTIVYIPPCSFS
>Mature_221_residues
TLYVIGVGPGDPSLITVKGLEVLRDSKVVTGWGSVIERFSSYIQGKQVIRLNYKEEEKQLNEIMKLAKNENVAFLNHGDP
AVSDFQLLNKLKKLCMDNRVELVIIPGVSSIIRALHIIGKDLSEIVFLTFHVRGEINYDEIKKFLNTGRGILINPEPYPD
GVKRIALKLKEYGCNFITLTIMEKLTYQDEKVYNFNVDEIITRDLKFSDLTIVYIPPCSFS

Specific function: Bifunctional enzyme with a methyltransferase domain that catalyzes the methylation of C-17 in cobalt-precorrin-3B to form cobalt-precorrin-4 and an isomerase domain that catalyzes the conversion of cobalt-precorrin-8X to cobyrinic acid; a methyl migration

COG id: COG2241

COG function: function code H; Precorrin-6B methylase 1

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the CobH family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014422
- InterPro:   IPR003722
- InterPro:   IPR006363 [H]

Pfam domain/function: PF02570 CbiC; PF00590 TP_methylase [H]

EC number: 2.1.1.132

Molecular weight: Translated: 25259; Mature: 25128

Theoretical pI: Translated: 7.43; Mature: 7.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLYVIGVGPGDPSLITVKGLEVLRDSKVVTGWGSVIERFSSYIQGKQVIRLNYKEEEKQ
CEEEEEEECCCCCCEEEEECHHHHHCCCEEECHHHHHHHHHHHHCCCEEEEECCHHHHHH
LNEIMKLAKNENVAFLNHGDPAVSDFQLLNKLKKLCMDNRVELVIIPGVSSIIRALHIIG
HHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHC
KDLSEIVFLTFHVRGEINYDEIKKFLNTGRGILINPEPYPDGVKRIALKLKEYGCNFITL
CCHHHEEEEEEEEECCCCHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHCCCCEEEE
TIMEKLTYQDEKVYNFNVDEIITRDLKFSDLTIVYIPPCSFS
EEHHHHCCCCCEEEECCHHHHHHCCCCCCCEEEEEECCCCCC
>Mature Secondary Structure 
TLYVIGVGPGDPSLITVKGLEVLRDSKVVTGWGSVIERFSSYIQGKQVIRLNYKEEEKQ
EEEEEEECCCCCCEEEEECHHHHHCCCEEECHHHHHHHHHHHHCCCEEEEECCHHHHHH
LNEIMKLAKNENVAFLNHGDPAVSDFQLLNKLKKLCMDNRVELVIIPGVSSIIRALHIIG
HHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHC
KDLSEIVFLTFHVRGEINYDEIKKFLNTGRGILINPEPYPDGVKRIALKLKEYGCNFITL
CCHHHEEEEEEEEECCCCHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHCCCCEEEE
TIMEKLTYQDEKVYNFNVDEIITRDLKFSDLTIVYIPPCSFS
EEHHHHCCCCCEEEECCHHHHHHCCCCCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: S-adenosyl-L-methionine; Precorrin 6Y

Specific reaction: 2 S-adenosyl-L-methionine + precorrin-6Y = 2 S-adenosyl-L-homocysteine + precorrin-8X + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]