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The map label for this gene is 15922113

Identifier: 15922113

GI number: 15922113

Start: 1816221

End: 1817396

Strand: Reverse

Name: 15922113

Synonym: ST1799

Alternate gene names: NA

Gene position: 1817396-1816221 (Counterclockwise)

Preceding gene: 15922114

Following gene: 15922112

Centisome position: 67.44

GC content: 39.29

Gene sequence:

>1176_bases
ATGAAGACGAATTTATATTTTAGAAGGGTAGCTGTAATAGGTGCCGGATTAACGTTATTTAGAAGGAGAATGTTAGAGAC
TCCACAAGAATTGGCGTGGGAAGCGGCTAGGAAAGCTTTGGATGAGGCTGGTTTGGAGCTAAAAGATATTGATTGTGTTG
TAATTGGTAGTGCACCAGATGCTTTTGATGGAGTACATATGAAAGGAGAATATTTAGCTCATGGTTCTGGTGGAGTTAGG
AAAATGGTAAGTAGAGTCTTTGTTGGTGGTGCTACTGGAGTTATGGTTCCTAATACAGCCTGGTATCATGTTGCTAGTGG
TTTATGTGAGAAAGTTTTAGCTATTGCAGAGGAGAAGATGAGCCCTGCAAGGCCTCACCCGCAATCAGTATTTAGGTATA
TATGGGATCCGATTACTGAGAAGCCGTTAAATCCTAATCTAATCTGGATCTTTGCAATGGAGATGCATAGATATATGCAT
GTTAATAAAGTTACAAAAGAAGATATAGCTTTAGTATCTGTTAAAAACAAAAAGAATGCACTTAATAATCCTTATGCCCA
AGCTGCTGCTAATATTACAGTCAATGATGTTTTAAAGAGTGAGGTTTTAGTTTGGCCAGTCCAACTTTTAGATACTAGCC
CAGTTAGTGATGGTGCTGCTGCTATGGTTATTGTAAATGAGGATGTTGCACGTAGATATACTGATACTCCAGTATGGATT
GAAGGTGTTGGTTGGACACTAGATAATACAGAATGGACCGGAAGAGAATTAGCTTATCCTAGATATTTAGAACACGCAGC
TAGGATGGCTTATAAAATGGCTGGGATTGAAAGACCTAATAAGGAAATTGATGTGATTGAACCTTACGACCCCTTTGATT
ATAAAGAGTTACATCATATAGAGGGATTAATGATTGCTAGGAGAGGAGAAGCACCTAAGCTTCTTAAGGAAGGCATGTTT
GATATAGATGGAGATATTCCAAGCTCTCCATCAGGTGGGTTACTCGGCGTTGGTAATCCTATTGCGGCTGCTGGTCTGAT
GAAGACTATCAGTATATATTGGCAATTGAAAGGAACTGCTGGAAGAATGCAAGTAAAGAAACCAGTACATACTGGAGTAG
CCCAAGCTTGGGGCGATTTAATGCAAGCCTCAACTGTTATAGTTATGAGAAATTAA

Upstream 100 bases:

>100_bases
CTGTTGAATATTTGAGGCAAGGAGTTGTTGATAAAGCTGTAGTAGCAAGTTGGAGAGGAATTCCTACTTTTACAGGTGTT
GTTGGGGTGGTGAGTAGATA

Downstream 100 bases:

>100_bases
GGGGTGAGAAAATGGATGGGACTCCCTTAAAAGAAGAAGATTTAAAGAAAGTAAATACAATTGTATATAAACCAAATGCT
AAGTATGCCTATAGTGCTGG

Product: acetyl-CoA acetyltransferase

Products: CoA; 3-oxoacyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MKTNLYFRRVAVIGAGLTLFRRRMLETPQELAWEAARKALDEAGLELKDIDCVVIGSAPDAFDGVHMKGEYLAHGSGGVR
KMVSRVFVGGATGVMVPNTAWYHVASGLCEKVLAIAEEKMSPARPHPQSVFRYIWDPITEKPLNPNLIWIFAMEMHRYMH
VNKVTKEDIALVSVKNKKNALNNPYAQAAANITVNDVLKSEVLVWPVQLLDTSPVSDGAAAMVIVNEDVARRYTDTPVWI
EGVGWTLDNTEWTGRELAYPRYLEHAARMAYKMAGIERPNKEIDVIEPYDPFDYKELHHIEGLMIARRGEAPKLLKEGMF
DIDGDIPSSPSGGLLGVGNPIAAAGLMKTISIYWQLKGTAGRMQVKKPVHTGVAQAWGDLMQASTVIVMRN

Sequences:

>Translated_391_residues
MKTNLYFRRVAVIGAGLTLFRRRMLETPQELAWEAARKALDEAGLELKDIDCVVIGSAPDAFDGVHMKGEYLAHGSGGVR
KMVSRVFVGGATGVMVPNTAWYHVASGLCEKVLAIAEEKMSPARPHPQSVFRYIWDPITEKPLNPNLIWIFAMEMHRYMH
VNKVTKEDIALVSVKNKKNALNNPYAQAAANITVNDVLKSEVLVWPVQLLDTSPVSDGAAAMVIVNEDVARRYTDTPVWI
EGVGWTLDNTEWTGRELAYPRYLEHAARMAYKMAGIERPNKEIDVIEPYDPFDYKELHHIEGLMIARRGEAPKLLKEGMF
DIDGDIPSSPSGGLLGVGNPIAAAGLMKTISIYWQLKGTAGRMQVKKPVHTGVAQAWGDLMQASTVIVMRN
>Mature_391_residues
MKTNLYFRRVAVIGAGLTLFRRRMLETPQELAWEAARKALDEAGLELKDIDCVVIGSAPDAFDGVHMKGEYLAHGSGGVR
KMVSRVFVGGATGVMVPNTAWYHVASGLCEKVLAIAEEKMSPARPHPQSVFRYIWDPITEKPLNPNLIWIFAMEMHRYMH
VNKVTKEDIALVSVKNKKNALNNPYAQAAANITVNDVLKSEVLVWPVQLLDTSPVSDGAAAMVIVNEDVARRYTDTPVWI
EGVGWTLDNTEWTGRELAYPRYLEHAARMAYKMAGIERPNKEIDVIEPYDPFDYKELHHIEGLMIARRGEAPKLLKEGMF
DIDGDIPSSPSGGLLGVGNPIAAAGLMKTISIYWQLKGTAGRMQVKKPVHTGVAQAWGDLMQASTVIVMRN

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI19923233, Length=388, Percent_Identity=28.6082474226804, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI302344762, Length=390, Percent_Identity=26.6666666666667, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI302344760, Length=385, Percent_Identity=27.7922077922078, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI302344767, Length=301, Percent_Identity=29.2358803986711, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI55956775, Length=370, Percent_Identity=25.6756756756757, Blast_Score=79, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17537653, Length=395, Percent_Identity=23.2911392405063, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI19921506, Length=384, Percent_Identity=27.8645833333333, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24585051, Length=386, Percent_Identity=27.2020725388601, Blast_Score=107, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020617
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: 2.3.1.16

Molecular weight: Translated: 43352; Mature: 43352

Theoretical pI: Translated: 7.36; Mature: 7.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTNLYFRRVAVIGAGLTLFRRRMLETPQELAWEAARKALDEAGLELKDIDCVVIGSAPD
CCCCHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCEEECCCEEEECCCCC
AFDGVHMKGEYLAHGSGGVRKMVSRVFVGGATGVMVPNTAWYHVASGLCEKVLAIAEEKM
CCCCCEECCCEEECCCCHHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHC
SPARPHPQSVFRYIWDPITEKPLNPNLIWIFAMEMHRYMHVNKVTKEDIALVSVKNKKNA
CCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEEHHHHHHHHHHCCCCCEEEEEECCCCCC
LNNPYAQAAANITVNDVLKSEVLVWPVQLLDTSPVSDGAAAMVIVNEDVARRYTDTPVWI
CCCCHHHHHCCCCHHHHHHHHHHEEEHHHHCCCCCCCCCEEEEEECCHHHHHHCCCCEEE
EGVGWTLDNTEWTGRELAYPRYLEHAARMAYKMAGIERPNKEIDVIEPYDPFDYKELHHI
EEECEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCHHHHHHH
EGLMIARRGEAPKLLKEGMFDIDGDIPSSPSGGLLGVGNPIAAAGLMKTISIYWQLKGTA
CCEEEEECCCCHHHHHCCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHEEEEEEEEECCC
GRMQVKKPVHTGVAQAWGDLMQASTVIVMRN
CCEEECCHHHHHHHHHHHHHHHCCEEEEEEC
>Mature Secondary Structure
MKTNLYFRRVAVIGAGLTLFRRRMLETPQELAWEAARKALDEAGLELKDIDCVVIGSAPD
CCCCHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCEEECCCEEEECCCCC
AFDGVHMKGEYLAHGSGGVRKMVSRVFVGGATGVMVPNTAWYHVASGLCEKVLAIAEEKM
CCCCCEECCCEEECCCCHHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHC
SPARPHPQSVFRYIWDPITEKPLNPNLIWIFAMEMHRYMHVNKVTKEDIALVSVKNKKNA
CCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEEHHHHHHHHHHCCCCCEEEEEECCCCCC
LNNPYAQAAANITVNDVLKSEVLVWPVQLLDTSPVSDGAAAMVIVNEDVARRYTDTPVWI
CCCCHHHHHCCCCHHHHHHHHHHEEEHHHHCCCCCCCCCEEEEEECCHHHHHHCCCCEEE
EGVGWTLDNTEWTGRELAYPRYLEHAARMAYKMAGIERPNKEIDVIEPYDPFDYKELHHI
EEECEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCHHHHHHH
EGLMIARRGEAPKLLKEGMFDIDGDIPSSPSGGLLGVGNPIAAAGLMKTISIYWQLKGTA
CCEEEEECCCCHHHHHCCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHEEEEEEEEECCC
GRMQVKKPVHTGVAQAWGDLMQASTVIVMRN
CCEEECCHHHHHHHHHHHHHHHCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acetyl-CoA

Specific reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]