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The map label for this gene is acdA [H]

Identifier: 15922104

GI number: 15922104

Start: 1809137

End: 1810351

Strand: Reverse

Name: acdA [H]

Synonym: ST1791

Alternate gene names: 15922104

Gene position: 1810351-1809137 (Counterclockwise)

Preceding gene: 15922105

Following gene: 15922103

Centisome position: 67.18

GC content: 35.8

Gene sequence:

>1215_bases
ATGCATTTATATGTGATGGTATTCCCTTTAAAGTCAATAGAGGATTTTACTATAGATTTAACTCAAGATCATGAATTATT
AAGGAATGCTGTAAGGGAGTTTGCTGAAAACGAAGTGAAAAAATACGTAGACAAGGGAGAGGTAGAAAGGGATTTTCCTA
AAGATCTTAAAGAAAGGGCTAAAGATTTAGGACTTTACGGACTTGATGTACCCACAGAATATAATGGACAAGGTGCTGAT
TATTTATCACTTTTGGTTACTGCTGAGGAATTAAGTAGAATTTGGACTTCTTTCTCAACTTTCTTTCTTATTCAGTGGAT
GTTCAACCAGGCTATTCTAAAGTGGGGTAACGAGAGTTTGAAAAAGAGATATTTAAGGGATACAGCTAAGGGTGAAAAAA
TAGCTGCTTTCTGCAATACTGAACCAGATGCAGGATCTGATGTAGCTGGAATTAAGTCCACTGCAAAAAAAGTTAACGAT
CACTATGTTCTAAATGCGAGAAAGATGTTTATCACAAATGGGGATGTTGCTGATTACTATTTAATAACTGCTAGAACTTC
TCCTCCAGATCCTAAGGCTAAATGGAAAGGTATAACAGTATTTATTGTTGAAAGAGAATGGGGAGTGAAGACTGTTAGCA
GAATAGAAACTACCGGGTTAAAAGCTTCACATACAGCTGAAATAATGCTTGAAGACGTAAAAGTTCCAGAAGAAAATGTA
CTTGGAGAAGTTGATATGGGCTTTAAATATGCTGTAGAATCTTTTGATTATGCACGTACAATCGTTTCATCACAAGCTAT
AGGTATAGCTCAACAAGCATTTGAGAAATTAGTCAACTATTCTCTTCAAAGAACAGCATTTGAGAAAAAACTTGCTGAAT
TTGAGTTAGTTCAACAAAAAGTTTCTGAGTCTCTAGACGATTTAGAGACTTCAAGGCTCTTAACGTATTGGGCTGGAACA
CTCTATAAAAGGGGAAGAATGCAAGAGTATATTATTGCAGCTTCTTTAGCAAAGTTCCATTCTACTGAAGCAGCTGAAAG
AATAGTAATGAGGGCAATGACTGTTCATGGAGGTTATGGGGTTTCAGTATCAACTGGATTAGAGAGGCTTTTGAGGGATT
TACAAATTTTGAAGACTTATGAAGGTACAAATGATATTCAGAGAATAAGTGCTGCTAGGCAATTCTACTATAGATTCATG
GGTGTTAAGGTATGA

Upstream 100 bases:

>100_bases
GTATCGTCGGGAACTATTTTAAAACAAGTTACTATATTCATCAAAAAATACAAGATTTTAACTCATTAATATTATTTGCT
TAACATTTTTTAGTTATTAG

Downstream 100 bases:

>100_bases
TAACTGAAGATGAGGTAAATAAACTTCTTAGTGAGAATGAAGCTCTCTTTAGGTTTATGGGTGCTAAGTTTGAAAAAATT
GAGAGAGGTGTGGCTAAACT

Product: acyl-CoA dehydrogenase

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 404; Mature: 404

Protein sequence:

>404_residues
MHLYVMVFPLKSIEDFTIDLTQDHELLRNAVREFAENEVKKYVDKGEVERDFPKDLKERAKDLGLYGLDVPTEYNGQGAD
YLSLLVTAEELSRIWTSFSTFFLIQWMFNQAILKWGNESLKKRYLRDTAKGEKIAAFCNTEPDAGSDVAGIKSTAKKVND
HYVLNARKMFITNGDVADYYLITARTSPPDPKAKWKGITVFIVEREWGVKTVSRIETTGLKASHTAEIMLEDVKVPEENV
LGEVDMGFKYAVESFDYARTIVSSQAIGIAQQAFEKLVNYSLQRTAFEKKLAEFELVQQKVSESLDDLETSRLLTYWAGT
LYKRGRMQEYIIAASLAKFHSTEAAERIVMRAMTVHGGYGVSVSTGLERLLRDLQILKTYEGTNDIQRISAARQFYYRFM
GVKV

Sequences:

>Translated_404_residues
MHLYVMVFPLKSIEDFTIDLTQDHELLRNAVREFAENEVKKYVDKGEVERDFPKDLKERAKDLGLYGLDVPTEYNGQGAD
YLSLLVTAEELSRIWTSFSTFFLIQWMFNQAILKWGNESLKKRYLRDTAKGEKIAAFCNTEPDAGSDVAGIKSTAKKVND
HYVLNARKMFITNGDVADYYLITARTSPPDPKAKWKGITVFIVEREWGVKTVSRIETTGLKASHTAEIMLEDVKVPEENV
LGEVDMGFKYAVESFDYARTIVSSQAIGIAQQAFEKLVNYSLQRTAFEKKLAEFELVQQKVSESLDDLETSRLLTYWAGT
LYKRGRMQEYIIAASLAKFHSTEAAERIVMRAMTVHGGYGVSVSTGLERLLRDLQILKTYEGTNDIQRISAARQFYYRFM
GVKV
>Mature_404_residues
MHLYVMVFPLKSIEDFTIDLTQDHELLRNAVREFAENEVKKYVDKGEVERDFPKDLKERAKDLGLYGLDVPTEYNGQGAD
YLSLLVTAEELSRIWTSFSTFFLIQWMFNQAILKWGNESLKKRYLRDTAKGEKIAAFCNTEPDAGSDVAGIKSTAKKVND
HYVLNARKMFITNGDVADYYLITARTSPPDPKAKWKGITVFIVEREWGVKTVSRIETTGLKASHTAEIMLEDVKVPEENV
LGEVDMGFKYAVESFDYARTIVSSQAIGIAQQAFEKLVNYSLQRTAFEKKLAEFELVQQKVSESLDDLETSRLLTYWAGT
LYKRGRMQEYIIAASLAKFHSTEAAERIVMRAMTVHGGYGVSVSTGLERLLRDLQILKTYEGTNDIQRISAARQFYYRFM
GVKV

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=375, Percent_Identity=34.4, Blast_Score=222, Evalue=6e-58,
Organism=Homo sapiens, GI4501859, Length=378, Percent_Identity=33.8624338624339, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI4557231, Length=381, Percent_Identity=35.4330708661417, Blast_Score=217, Evalue=1e-56,
Organism=Homo sapiens, GI187960098, Length=381, Percent_Identity=35.4330708661417, Blast_Score=217, Evalue=1e-56,
Organism=Homo sapiens, GI21361497, Length=390, Percent_Identity=34.6153846153846, Blast_Score=206, Evalue=4e-53,
Organism=Homo sapiens, GI76496475, Length=341, Percent_Identity=35.1906158357771, Blast_Score=192, Evalue=3e-49,
Organism=Homo sapiens, GI4557235, Length=341, Percent_Identity=35.1906158357771, Blast_Score=192, Evalue=3e-49,
Organism=Homo sapiens, GI226958412, Length=396, Percent_Identity=28.7878787878788, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI226958414, Length=341, Percent_Identity=30.4985337243402, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI4501857, Length=379, Percent_Identity=29.023746701847, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI7656849, Length=387, Percent_Identity=27.906976744186, Blast_Score=171, Evalue=9e-43,
Organism=Homo sapiens, GI4503943, Length=383, Percent_Identity=27.154046997389, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI7669494, Length=373, Percent_Identity=26.8096514745308, Blast_Score=118, Evalue=9e-27,
Organism=Homo sapiens, GI38505218, Length=366, Percent_Identity=26.775956284153, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI211971008, Length=357, Percent_Identity=23.8095238095238, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI48976061, Length=357, Percent_Identity=23.8095238095238, Blast_Score=97, Evalue=3e-20,
Organism=Escherichia coli, GI1786223, Length=382, Percent_Identity=27.7486910994764, Blast_Score=145, Evalue=6e-36,
Organism=Escherichia coli, GI87081958, Length=386, Percent_Identity=27.2020725388601, Blast_Score=144, Evalue=8e-36,
Organism=Caenorhabditis elegans, GI17570075, Length=381, Percent_Identity=34.6456692913386, Blast_Score=222, Evalue=3e-58,
Organism=Caenorhabditis elegans, GI17569725, Length=385, Percent_Identity=31.9480519480519, Blast_Score=205, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI17506239, Length=395, Percent_Identity=31.8987341772152, Blast_Score=202, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI17534899, Length=387, Percent_Identity=31.266149870801, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17508101, Length=376, Percent_Identity=29.7872340425532, Blast_Score=192, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17538396, Length=394, Percent_Identity=30.2030456852792, Blast_Score=192, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI71985184, Length=352, Percent_Identity=33.5227272727273, Blast_Score=191, Evalue=6e-49,
Organism=Caenorhabditis elegans, GI17533517, Length=379, Percent_Identity=29.287598944591, Blast_Score=171, Evalue=7e-43,
Organism=Caenorhabditis elegans, GI71982178, Length=292, Percent_Identity=33.2191780821918, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI71990804, Length=281, Percent_Identity=30.9608540925267, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI32563615, Length=233, Percent_Identity=34.7639484978541, Blast_Score=152, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI17551932, Length=368, Percent_Identity=25.2717391304348, Blast_Score=150, Evalue=9e-37,
Organism=Caenorhabditis elegans, GI71985192, Length=303, Percent_Identity=31.3531353135314, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17505929, Length=366, Percent_Identity=25.6830601092896, Blast_Score=144, Evalue=7e-35,
Organism=Caenorhabditis elegans, GI17534353, Length=379, Percent_Identity=28.4960422163588, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17531909, Length=244, Percent_Identity=27.0491803278689, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17562446, Length=331, Percent_Identity=25.3776435045317, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24660351, Length=379, Percent_Identity=36.4116094986807, Blast_Score=228, Evalue=6e-60,
Organism=Drosophila melanogaster, GI24666513, Length=376, Percent_Identity=33.5106382978723, Blast_Score=225, Evalue=3e-59,
Organism=Drosophila melanogaster, GI21356377, Length=372, Percent_Identity=33.3333333333333, Blast_Score=222, Evalue=4e-58,
Organism=Drosophila melanogaster, GI24646207, Length=371, Percent_Identity=33.9622641509434, Blast_Score=210, Evalue=1e-54,
Organism=Drosophila melanogaster, GI281363737, Length=338, Percent_Identity=34.0236686390533, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI21355753, Length=389, Percent_Identity=28.5347043701799, Blast_Score=172, Evalue=5e-43,
Organism=Drosophila melanogaster, GI19920834, Length=380, Percent_Identity=28.1578947368421, Blast_Score=135, Evalue=6e-32,
Organism=Drosophila melanogaster, GI24652780, Length=350, Percent_Identity=24, Blast_Score=79, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 46081; Mature: 46081

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHLYVMVFPLKSIEDFTIDLTQDHELLRNAVREFAENEVKKYVDKGEVERDFPKDLKERA
CEEEEEEEECCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
KDLGLYGLDVPTEYNGQGADYLSLLVTAEELSRIWTSFSTFFLIQWMFNQAILKWGNESL
HHCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
KKRYLRDTAKGEKIAAFCNTEPDAGSDVAGIKSTAKKVNDHYVLNARKMFITNGDVADYY
HHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCCEEEECEEEEEECCCCCEEE
LITARTSPPDPKAKWKGITVFIVEREWGVKTVSRIETTGLKASHTAEIMLEDVKVPEENV
EEEECCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHC
LGEVDMGFKYAVESFDYARTIVSSQAIGIAQQAFEKLVNYSLQRTAFEKKLAEFELVQQK
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSESLDDLETSRLLTYWAGTLYKRGRMQEYIIAASLAKFHSTEAAERIVMRAMTVHGGYG
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
VSVSTGLERLLRDLQILKTYEGTNDIQRISAARQFYYRFMGVKV
CCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MHLYVMVFPLKSIEDFTIDLTQDHELLRNAVREFAENEVKKYVDKGEVERDFPKDLKERA
CEEEEEEEECCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
KDLGLYGLDVPTEYNGQGADYLSLLVTAEELSRIWTSFSTFFLIQWMFNQAILKWGNESL
HHCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
KKRYLRDTAKGEKIAAFCNTEPDAGSDVAGIKSTAKKVNDHYVLNARKMFITNGDVADYY
HHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCCEEEECEEEEEECCCCCEEE
LITARTSPPDPKAKWKGITVFIVEREWGVKTVSRIETTGLKASHTAEIMLEDVKVPEENV
EEEECCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHC
LGEVDMGFKYAVESFDYARTIVSSQAIGIAQQAFEKLVNYSLQRTAFEKKLAEFELVQQK
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSESLDDLETSRLLTYWAGTLYKRGRMQEYIIAASLAKFHSTEAAERIVMRAMTVHGGYG
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
VSVSTGLERLLRDLQILKTYEGTNDIQRISAARQFYYRFMGVKV
CCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]