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The map label for this gene is 15922055

Identifier: 15922055

GI number: 15922055

Start: 1752873

End: 1754570

Strand: Direct

Name: 15922055

Synonym: ST1745

Alternate gene names: NA

Gene position: 1752873-1754570 (Clockwise)

Preceding gene: 15922052

Following gene: 15922060

Centisome position: 65.05

GC content: 34.86

Gene sequence:

>1698_bases
ATGGAATACTCAGAGATAGTAAAAACTCTTGAAGAATTAGTGAGCCTTCCTATTTATGCTGTAATTGGAAAACTGAAAGA
TACACCAGTATTGTTGACAACTACTGAAGGAAAAGTAAATATTTCAATTTTAGAAGGAGATAAACTAAGAGTGTTGACTA
AGGAGCCTATAGCTGGGTCTCCTTATCCTAAACCTCAGTTAGACTTTATCCCCTTTATTAGAGATGTGGTGAAGGGGAAA
GAGTTACACTCAATTTATATTACCAACCTAAAAGGAGAAGAGTACGAAGTAGCTTCACCCAAGATAAGAATATTTTCGTT
AGCATATGACGATAAGAACATAGCATTCATAGGTGCTTCTCAGAACGAATCCTCACTTTATGTTATTGAAGGAGGGAAAA
TTAGGAAATTAGTTAACGTTCCTCCTTTCTCATTCGTGACAGATATTAGCGGAGATTACATACTCGGTTTTGGGATTTTA
AAAGGAAATCCAAGATCTCAAGAGTTCTTTGTAGCCGATTTGAGTGGTAACATGAGAATTTTTACTCCAAAAGACGGGAG
CATGAATATTGCATACTATATAAAAGATAATAAAATATATCTGGTTAGCGACTATGAGAATCTAGGAGAGTCTTACTGGA
TTTACACTTTTGATTTTCAGAAATATGAGAGAGTAGAATTCCCAGAAAAAGACATATATAGTTATAAGGCTGTGGAAATA
TCTTATAACCCAGACGATTCTCTAATTATAGCTAAAAGAGACGGTGAATCTAAATTATTCCTTAATGGTAAATTACTAAA
TAACCCTTCTGGTATAATTGCCGGTGCAACTAAAATAGGGGATAATGTGTACTTTGCAGCTTCTTCCCTTAATACTCCAT
ATAAGGTATATAAATATGATTTAAAGGAAAATAAGGTTGATGTCGTAATAAATAATAAAGACGTTAACATAGGAGAGGTA
GAATATGTCAAAATAAAAAATGAGAATGTTGAAGTCCCTACATGGATTATAAAGTCTAGGAAACCTAATAAGGTAGGAAT
AGTTTACGTTCATGGAGGTCCATGGTCTGAAGTAGATAATAGTTGGGATTTACTGATATCACCGCTAGTCTTACTAGGGT
ATAATGTTATTGCACCTAATTTTAGAGGTTCTACGGGTTATGGGAGTAAATTTAACTTGATGGATATTGGAGATCCGGGT
GGTGGAGATTTAAGTGATGTAATAGCTGCTAGAGATTACGCAATTGAAAAGGGAATTGTTGAGAAAATAGGAATTATGGG
GTATAGTTATGGAGGGTATATGACTCTATTAGCTGTGGGTAAGGTACCGGATAAATGGGACTTTGGTATTGCCGGTGCCT
CAGTAGCTGATTGGGTAGAAATGTATGATTTATCTGATTCCTTCTTTAAGGGCTTTATGGAGACCTTATTTATGGGAAAG
AATTTAGAACTCATGGAAGATAGATCACCCATTACCTATGTTAATAATGTAAAATGTCCCCTATGTATAATACACTCTCA
GAACGATACAAGAACACCCTTAACGCCCGTGTTAAAATACGTTCAGAAACTCCAAGAGAATAATAAAACCTTCTACTTAC
ATGTAATTCCTAATTTGGGACATGCAATATATAAGATAGACGATGATGTAGACTTACTGTTACCTGCTCTAATCTTCTTG
GAGAAGATGTTTGGATAA

Upstream 100 bases:

>100_bases
CTCTGTATATCACAGTCCATTATAGAATCAGCTAAACTGGGTCATCTTTATACTTAATTTTTATCAATAATCTTTTATAT
TGTTATTTTTACTAAACATT

Downstream 100 bases:

>100_bases
TTAAAGTTGAATGTCTATTTATTCTATAGGTTCTTCTATCAAGTATCTGAAATTCTTAATGCATACTTAATCTTTCTTTA
ATAAAATCTATGTTTGATTA

Product: acylamino acid-releasing enzyme

Products: NA

Alternate protein names: AARE; Acyl-peptide hydrolase; APH; Acylaminoacyl-peptidase [H]

Number of amino acids: Translated: 565; Mature: 565

Protein sequence:

>565_residues
MEYSEIVKTLEELVSLPIYAVIGKLKDTPVLLTTTEGKVNISILEGDKLRVLTKEPIAGSPYPKPQLDFIPFIRDVVKGK
ELHSIYITNLKGEEYEVASPKIRIFSLAYDDKNIAFIGASQNESSLYVIEGGKIRKLVNVPPFSFVTDISGDYILGFGIL
KGNPRSQEFFVADLSGNMRIFTPKDGSMNIAYYIKDNKIYLVSDYENLGESYWIYTFDFQKYERVEFPEKDIYSYKAVEI
SYNPDDSLIIAKRDGESKLFLNGKLLNNPSGIIAGATKIGDNVYFAASSLNTPYKVYKYDLKENKVDVVINNKDVNIGEV
EYVKIKNENVEVPTWIIKSRKPNKVGIVYVHGGPWSEVDNSWDLLISPLVLLGYNVIAPNFRGSTGYGSKFNLMDIGDPG
GGDLSDVIAARDYAIEKGIVEKIGIMGYSYGGYMTLLAVGKVPDKWDFGIAGASVADWVEMYDLSDSFFKGFMETLFMGK
NLELMEDRSPITYVNNVKCPLCIIHSQNDTRTPLTPVLKYVQKLQENNKTFYLHVIPNLGHAIYKIDDDVDLLLPALIFL
EKMFG

Sequences:

>Translated_565_residues
MEYSEIVKTLEELVSLPIYAVIGKLKDTPVLLTTTEGKVNISILEGDKLRVLTKEPIAGSPYPKPQLDFIPFIRDVVKGK
ELHSIYITNLKGEEYEVASPKIRIFSLAYDDKNIAFIGASQNESSLYVIEGGKIRKLVNVPPFSFVTDISGDYILGFGIL
KGNPRSQEFFVADLSGNMRIFTPKDGSMNIAYYIKDNKIYLVSDYENLGESYWIYTFDFQKYERVEFPEKDIYSYKAVEI
SYNPDDSLIIAKRDGESKLFLNGKLLNNPSGIIAGATKIGDNVYFAASSLNTPYKVYKYDLKENKVDVVINNKDVNIGEV
EYVKIKNENVEVPTWIIKSRKPNKVGIVYVHGGPWSEVDNSWDLLISPLVLLGYNVIAPNFRGSTGYGSKFNLMDIGDPG
GGDLSDVIAARDYAIEKGIVEKIGIMGYSYGGYMTLLAVGKVPDKWDFGIAGASVADWVEMYDLSDSFFKGFMETLFMGK
NLELMEDRSPITYVNNVKCPLCIIHSQNDTRTPLTPVLKYVQKLQENNKTFYLHVIPNLGHAIYKIDDDVDLLLPALIFL
EKMFG
>Mature_565_residues
MEYSEIVKTLEELVSLPIYAVIGKLKDTPVLLTTTEGKVNISILEGDKLRVLTKEPIAGSPYPKPQLDFIPFIRDVVKGK
ELHSIYITNLKGEEYEVASPKIRIFSLAYDDKNIAFIGASQNESSLYVIEGGKIRKLVNVPPFSFVTDISGDYILGFGIL
KGNPRSQEFFVADLSGNMRIFTPKDGSMNIAYYIKDNKIYLVSDYENLGESYWIYTFDFQKYERVEFPEKDIYSYKAVEI
SYNPDDSLIIAKRDGESKLFLNGKLLNNPSGIIAGATKIGDNVYFAASSLNTPYKVYKYDLKENKVDVVINNKDVNIGEV
EYVKIKNENVEVPTWIIKSRKPNKVGIVYVHGGPWSEVDNSWDLLISPLVLLGYNVIAPNFRGSTGYGSKFNLMDIGDPG
GGDLSDVIAARDYAIEKGIVEKIGIMGYSYGGYMTLLAVGKVPDKWDFGIAGASVADWVEMYDLSDSFFKGFMETLFMGK
NLELMEDRSPITYVNNVKCPLCIIHSQNDTRTPLTPVLKYVQKLQENNKTFYLHVIPNLGHAIYKIDDDVDLLLPALIFL
EKMFG

Specific function: This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N- acetylated amino acid and a peptide with a free N-terminus [H]

COG id: COG1506

COG function: function code E; Dipeptidyl aminopeptidases/acylaminoacyl-peptidases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9C family [H]

Homologues:

Organism=Homo sapiens, GI23510451, Length=233, Percent_Identity=28.3261802575107, Blast_Score=97, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI25144537, Length=234, Percent_Identity=27.3504273504274, Blast_Score=97, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI25144540, Length=234, Percent_Identity=27.3504273504274, Blast_Score=97, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17552908, Length=277, Percent_Identity=24.5487364620939, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI25144543, Length=137, Percent_Identity=32.1167883211679, Blast_Score=72, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI25149159, Length=230, Percent_Identity=25.2173913043478, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45550825, Length=230, Percent_Identity=27.8260869565217, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI45553511, Length=230, Percent_Identity=27.8260869565217, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI45551969, Length=230, Percent_Identity=27.8260869565217, Blast_Score=72, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011042
- InterPro:   IPR001375
- InterPro:   IPR004106 [H]

Pfam domain/function: PF00326 Peptidase_S9 [H]

EC number: =3.4.19.1 [H]

Molecular weight: Translated: 63493; Mature: 63493

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEYSEIVKTLEELVSLPIYAVIGKLKDTPVLLTTTEGKVNISILEGDKLRVLTKEPIAGS
CCHHHHHHHHHHHHCCCHHHHHHCCCCCCEEEEECCCEEEEEEEECCEEEEEEECCCCCC
PYPKPQLDFIPFIRDVVKGKELHSIYITNLKGEEYEVASPKIRIFSLAYDDKNIAFIGAS
CCCCCCCCHHHHHHHHHCCCEEEEEEEEECCCCEEEECCCEEEEEEEEECCCCEEEEECC
QNESSLYVIEGGKIRKLVNVPPFSFVTDISGDYILGFGILKGNPRSQEFFVADLSGNMRI
CCCCEEEEEECCCEEEEECCCCCCEEECCCCCEEEEEEEECCCCCCCEEEEEECCCCEEE
FTPKDGSMNIAYYIKDNKIYLVSDYENLGESYWIYTFDFQKYERVEFPEKDIYSYKAVEI
EECCCCCEEEEEEEECCEEEEEECHHHCCCEEEEEEEECCCHHCCCCCCCCCCEEEEEEE
SYNPDDSLIIAKRDGESKLFLNGKLLNNPSGIIAGATKIGDNVYFAASSLNTPYKVYKYD
EECCCCCEEEEEECCCCEEEEEEEEECCCCCEEEEEEECCCEEEEEECCCCCCEEEEEEE
LKENKVDVVINNKDVNIGEVEYVKIKNENVEVPTWIIKSRKPNKVGIVYVHGGPWSEVDN
CCCCEEEEEECCCCCCCCCEEEEEEECCCEECCEEEEECCCCCEEEEEEECCCCCCCCCC
SWDLLISPLVLLGYNVIAPNFRGSTGYGSKFNLMDIGDPGGGDLSDVIAARDYAIEKGIV
CHHHHHHHHHHHCCEEECCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHH
EKIGIMGYSYGGYMTLLAVGKVPDKWDFGIAGASVADWVEMYDLSDSFFKGFMETLFMGK
HHHHHEEECCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCC
NLELMEDRSPITYVNNVKCPLCIIHSQNDTRTPLTPVLKYVQKLQENNKTFYLHVIPNLG
CCEEECCCCCEEEECCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCC
HAIYKIDDDVDLLLPALIFLEKMFG
CEEEEECCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEYSEIVKTLEELVSLPIYAVIGKLKDTPVLLTTTEGKVNISILEGDKLRVLTKEPIAGS
CCHHHHHHHHHHHHCCCHHHHHHCCCCCCEEEEECCCEEEEEEEECCEEEEEEECCCCCC
PYPKPQLDFIPFIRDVVKGKELHSIYITNLKGEEYEVASPKIRIFSLAYDDKNIAFIGAS
CCCCCCCCHHHHHHHHHCCCEEEEEEEEECCCCEEEECCCEEEEEEEEECCCCEEEEECC
QNESSLYVIEGGKIRKLVNVPPFSFVTDISGDYILGFGILKGNPRSQEFFVADLSGNMRI
CCCCEEEEEECCCEEEEECCCCCCEEECCCCCEEEEEEEECCCCCCCEEEEEECCCCEEE
FTPKDGSMNIAYYIKDNKIYLVSDYENLGESYWIYTFDFQKYERVEFPEKDIYSYKAVEI
EECCCCCEEEEEEEECCEEEEEECHHHCCCEEEEEEEECCCHHCCCCCCCCCCEEEEEEE
SYNPDDSLIIAKRDGESKLFLNGKLLNNPSGIIAGATKIGDNVYFAASSLNTPYKVYKYD
EECCCCCEEEEEECCCCEEEEEEEEECCCCCEEEEEEECCCEEEEEECCCCCCEEEEEEE
LKENKVDVVINNKDVNIGEVEYVKIKNENVEVPTWIIKSRKPNKVGIVYVHGGPWSEVDN
CCCCEEEEEECCCCCCCCCEEEEEEECCCEECCEEEEECCCCCEEEEEEECCCCCCCCCC
SWDLLISPLVLLGYNVIAPNFRGSTGYGSKFNLMDIGDPGGGDLSDVIAARDYAIEKGIV
CHHHHHHHHHHHCCEEECCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHH
EKIGIMGYSYGGYMTLLAVGKVPDKWDFGIAGASVADWVEMYDLSDSFFKGFMETLFMGK
HHHHHEEECCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCC
NLELMEDRSPITYVNNVKCPLCIIHSQNDTRTPLTPVLKYVQKLQENNKTFYLHVIPNLG
CCEEECCCCCEEEECCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCC
HAIYKIDDDVDLLLPALIFLEKMFG
CEEEEECCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10382966; 12037315 [H]