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The map label for this gene is 15922047

Identifier: 15922047

GI number: 15922047

Start: 1741593

End: 1743203

Strand: Reverse

Name: 15922047

Synonym: ST1737

Alternate gene names: NA

Gene position: 1743203-1741593 (Counterclockwise)

Preceding gene: 15922049

Following gene: 15922043

Centisome position: 64.69

GC content: 35.2

Gene sequence:

>1611_bases
ATGAAATATGAAGATTTATTCAAGATAAAACCTGTACTAAATTATGACGTATATAACGGAAAAATTGCGACAATTATAAG
AGATGAAAAACCGGTCCTTTACGTTAATGGGGAAAAGGTCCAACTTGAGGGTTACGTTGAGGATGTTGACTGGATAAATA
GAAATAAAATGTTTATCACCGTAGACCCAAATGGCAGTGAAATAAGAAAGGTCTATCTTTATGATGACGGGAAGATAGAG
AAAATTATTGACAATGAGTTTGATAATGTTTCTCCCCATGAGACAAAAGAAGGGATATTAGTAATATCAAATTATGACAA
AAGGACATTACATCTTTACCTTTACAATGAAGGAAAATACATAAAGCTAAGTAAGGGTGAAGGACCCGTAAACAATTACT
GTTTTAACGGTAAATACATAGTCTATTCCACGGGAATTTATGATAACAATATTCACGTAACAGATCTCAGCGGTAATGAA
ATTCATGTAATTAACATTCCAAATTCAGAGCAGGAGCTTGCAAATGAGAACTGTTTTACTTCTCCTTCGTCATTCATCTT
CCTCTCGAATCACGAGGATTTGTTTAAAGTTTATGAATTTGACATTCTAAAAGGGGAAATCAGAAAAATAAAGGAAAGCA
ACTATGAAATATTTGAAGCTATTCCATATAAGGGTTCTATTGCTTATGTTGAAGATATGCACGGTGACTTTGTTCTAGTT
CATGAGAAGGAGATTGTAAATGAAGGATTTACACGCACCTTGACGGTTGATGGTGATTATCTTTATTTTATAAACTCTAA
ACATGATAGATCAGCAGATTTATACAGATATGGAAAAGAAGTAGAGAGGCTAACTGACTCAATGAGTAACGTTAAAGGTG
ATTTCATAAAGCCTAAGGTCGTTTCTTATGATTCTAATGGAGTTAGGATTTATGCTTTACTCTATGAAAAGGGTGATGAG
GATAAGGGTGTAGTCTATATTCACGGTGGTCCAGATTGGGAATGCATGAATAATTTTAACCCAGAAATTCAGTTCCTTTT
GGAGAAAGGGTTTAAAGTAATCTGTCCCAACTATAGGGGATCTACCGGTTACGGGAGAAAGTTTAATCACTTAAACGACA
GAGACCCAGGGGGAGGAGAGCTGTTGGACGTTATAAATTCAGTAAAAGTCTTAGGAGTTAAAAAGGTTGCAATAATTGGC
GCAAGTTACGGAGGTTATTTAACTATGATGGCCATTACTAAGTTTCCAGACCTCTGGTGTTCTGCTGTAGCTGTAGTACC
TTTTGTAAATTGGTTTACTGAGAAGAAATTTGAGAGAGAGGTACTTCAACAATACGACGAAATAAAGGTTGGTAATGATG
AAAACTTATTGAAAGATAGATCGCCTATATTCTTTATAGATAGGATTAAAGCCCCATTGCTTCTCTTAGCTGGTGAAAAT
GACCCTAGATGCCCAGCTGAGGAAACTTTACAAGTGGTTGAAGAACTTAAAAAGCTAGGTAGGAAAGTTAAGTATAAGAT
ATATAAGGATGAGGGACACGGATTTGCAAAAATGGAGAATTATGTAGACTCTATAAGAGAAACTGTAGAGTTCATTAGTA
CACATTGCTAA

Upstream 100 bases:

>100_bases
ATTTATATCATGTTTTGATGATGAACCTGACCGGGAGTGATAGGTGATATAAGGCCAGCTTTCTGAATAACTTTTTATTT
TTACTCTCTTTCTATTATTT

Downstream 100 bases:

>100_bases
TCATCTTATAGGCGATTCGGAAGGAAGAGATTTTCCAATAACCACTACTTTGCATAAAATAGATATCCTTAGAGAGATTT
AAAGTATTTCTTGAAAGATT

Product: acylamino acid-releasing enzyme

Products: NA

Alternate protein names: AARE; Acyl-peptide hydrolase; APH; Acylaminoacyl-peptidase [H]

Number of amino acids: Translated: 536; Mature: 536

Protein sequence:

>536_residues
MKYEDLFKIKPVLNYDVYNGKIATIIRDEKPVLYVNGEKVQLEGYVEDVDWINRNKMFITVDPNGSEIRKVYLYDDGKIE
KIIDNEFDNVSPHETKEGILVISNYDKRTLHLYLYNEGKYIKLSKGEGPVNNYCFNGKYIVYSTGIYDNNIHVTDLSGNE
IHVINIPNSEQELANENCFTSPSSFIFLSNHEDLFKVYEFDILKGEIRKIKESNYEIFEAIPYKGSIAYVEDMHGDFVLV
HEKEIVNEGFTRTLTVDGDYLYFINSKHDRSADLYRYGKEVERLTDSMSNVKGDFIKPKVVSYDSNGVRIYALLYEKGDE
DKGVVYIHGGPDWECMNNFNPEIQFLLEKGFKVICPNYRGSTGYGRKFNHLNDRDPGGGELLDVINSVKVLGVKKVAIIG
ASYGGYLTMMAITKFPDLWCSAVAVVPFVNWFTEKKFEREVLQQYDEIKVGNDENLLKDRSPIFFIDRIKAPLLLLAGEN
DPRCPAEETLQVVEELKKLGRKVKYKIYKDEGHGFAKMENYVDSIRETVEFISTHC

Sequences:

>Translated_536_residues
MKYEDLFKIKPVLNYDVYNGKIATIIRDEKPVLYVNGEKVQLEGYVEDVDWINRNKMFITVDPNGSEIRKVYLYDDGKIE
KIIDNEFDNVSPHETKEGILVISNYDKRTLHLYLYNEGKYIKLSKGEGPVNNYCFNGKYIVYSTGIYDNNIHVTDLSGNE
IHVINIPNSEQELANENCFTSPSSFIFLSNHEDLFKVYEFDILKGEIRKIKESNYEIFEAIPYKGSIAYVEDMHGDFVLV
HEKEIVNEGFTRTLTVDGDYLYFINSKHDRSADLYRYGKEVERLTDSMSNVKGDFIKPKVVSYDSNGVRIYALLYEKGDE
DKGVVYIHGGPDWECMNNFNPEIQFLLEKGFKVICPNYRGSTGYGRKFNHLNDRDPGGGELLDVINSVKVLGVKKVAIIG
ASYGGYLTMMAITKFPDLWCSAVAVVPFVNWFTEKKFEREVLQQYDEIKVGNDENLLKDRSPIFFIDRIKAPLLLLAGEN
DPRCPAEETLQVVEELKKLGRKVKYKIYKDEGHGFAKMENYVDSIRETVEFISTHC
>Mature_536_residues
MKYEDLFKIKPVLNYDVYNGKIATIIRDEKPVLYVNGEKVQLEGYVEDVDWINRNKMFITVDPNGSEIRKVYLYDDGKIE
KIIDNEFDNVSPHETKEGILVISNYDKRTLHLYLYNEGKYIKLSKGEGPVNNYCFNGKYIVYSTGIYDNNIHVTDLSGNE
IHVINIPNSEQELANENCFTSPSSFIFLSNHEDLFKVYEFDILKGEIRKIKESNYEIFEAIPYKGSIAYVEDMHGDFVLV
HEKEIVNEGFTRTLTVDGDYLYFINSKHDRSADLYRYGKEVERLTDSMSNVKGDFIKPKVVSYDSNGVRIYALLYEKGDE
DKGVVYIHGGPDWECMNNFNPEIQFLLEKGFKVICPNYRGSTGYGRKFNHLNDRDPGGGELLDVINSVKVLGVKKVAIIG
ASYGGYLTMMAITKFPDLWCSAVAVVPFVNWFTEKKFEREVLQQYDEIKVGNDENLLKDRSPIFFIDRIKAPLLLLAGEN
DPRCPAEETLQVVEELKKLGRKVKYKIYKDEGHGFAKMENYVDSIRETVEFISTHC

Specific function: This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N- acetylated amino acid and a peptide with a free N-terminus [H]

COG id: COG1506

COG function: function code E; Dipeptidyl aminopeptidases/acylaminoacyl-peptidases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9C family [H]

Homologues:

Organism=Homo sapiens, GI23510451, Length=299, Percent_Identity=26.0869565217391, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI18450280, Length=240, Percent_Identity=26.25, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI37577089, Length=240, Percent_Identity=26.25, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI194394146, Length=254, Percent_Identity=23.6220472440945, Blast_Score=68, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI25144537, Length=218, Percent_Identity=30.7339449541284, Blast_Score=118, Evalue=7e-27,
Organism=Caenorhabditis elegans, GI25144540, Length=218, Percent_Identity=30.7339449541284, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17552908, Length=310, Percent_Identity=25.8064516129032, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI25144543, Length=111, Percent_Identity=31.5315315315315, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI25149159, Length=208, Percent_Identity=29.3269230769231, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45550825, Length=232, Percent_Identity=25.4310344827586, Blast_Score=77, Evalue=4e-14,
Organism=Drosophila melanogaster, GI45553511, Length=232, Percent_Identity=25.4310344827586, Blast_Score=77, Evalue=4e-14,
Organism=Drosophila melanogaster, GI45551969, Length=232, Percent_Identity=25.4310344827586, Blast_Score=76, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011042
- InterPro:   IPR001375
- InterPro:   IPR004106 [H]

Pfam domain/function: PF00326 Peptidase_S9 [H]

EC number: =3.4.19.1 [H]

Molecular weight: Translated: 61758; Mature: 61758

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYEDLFKIKPVLNYDVYNGKIATIIRDEKPVLYVNGEKVQLEGYVEDVDWINRNKMFIT
CCCCCCEEECEEEEEEEECCEEEEEEECCCCEEEECCCEEEEEEEEECCCCCCCCEEEEE
VDPNGSEIRKVYLYDDGKIEKIIDNEFDNVSPHETKEGILVISNYDKRTLHLYLYNEGKY
ECCCCCCEEEEEEECCCCCHHHHCCCCCCCCCCCCCCCEEEEECCCCEEEEEEEECCCCE
IKLSKGEGPVNNYCFNGKYIVYSTGIYDNNIHVTDLSGNEIHVINIPNSEQELANENCFT
EEEECCCCCCCCEEECCEEEEEECCEECCCEEEEECCCCEEEEEECCCCHHHHCCCCCCC
SPSSFIFLSNHEDLFKVYEFDILKGEIRKIKESNYEIFEAIPYKGSIAYVEDMHGDFVLV
CCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEECCCCEEEE
HEKEIVNEGFTRTLTVDGDYLYFINSKHDRSADLYRYGKEVERLTDSMSNVKGDFIKPKV
ECHHHHCCCCEEEEEECCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEE
VSYDSNGVRIYALLYEKGDEDKGVVYIHGGPDWECMNNFNPEIQFLLEKGFKVICPNYRG
EEECCCCEEEEEEEEECCCCCCCEEEEECCCCHHHHCCCCHHHHHHHHCCCEEEECCCCC
STGYGRKFNHLNDRDPGGGELLDVINSVKVLGVKKVAIIGASYGGYLTMMAITKFPDLWC
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHEEEEEEEEEECCCCCEEEEEEHHHCCHHHH
SAVAVVPFVNWFTEKKFEREVLQQYDEIKVGNDENLLKDRSPIFFIDRIKAPLLLLAGEN
HHHHHHHHHHHHHHHHHHHHHHHHHHCEECCCCCCHHHCCCCEEEEEECCCCEEEEECCC
DPRCPAEETLQVVEELKKLGRKVKYKIYKDEGHGFAKMENYVDSIRETVEFISTHC
CCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKYEDLFKIKPVLNYDVYNGKIATIIRDEKPVLYVNGEKVQLEGYVEDVDWINRNKMFIT
CCCCCCEEECEEEEEEEECCEEEEEEECCCCEEEECCCEEEEEEEEECCCCCCCCEEEEE
VDPNGSEIRKVYLYDDGKIEKIIDNEFDNVSPHETKEGILVISNYDKRTLHLYLYNEGKY
ECCCCCCEEEEEEECCCCCHHHHCCCCCCCCCCCCCCCEEEEECCCCEEEEEEEECCCCE
IKLSKGEGPVNNYCFNGKYIVYSTGIYDNNIHVTDLSGNEIHVINIPNSEQELANENCFT
EEEECCCCCCCCEEECCEEEEEECCEECCCEEEEECCCCEEEEEECCCCHHHHCCCCCCC
SPSSFIFLSNHEDLFKVYEFDILKGEIRKIKESNYEIFEAIPYKGSIAYVEDMHGDFVLV
CCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEECCCCEEEE
HEKEIVNEGFTRTLTVDGDYLYFINSKHDRSADLYRYGKEVERLTDSMSNVKGDFIKPKV
ECHHHHCCCCEEEEEECCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEE
VSYDSNGVRIYALLYEKGDEDKGVVYIHGGPDWECMNNFNPEIQFLLEKGFKVICPNYRG
EEECCCCEEEEEEEEECCCCCCCEEEEECCCCHHHHCCCCHHHHHHHHCCCEEEECCCCC
STGYGRKFNHLNDRDPGGGELLDVINSVKVLGVKKVAIIGASYGGYLTMMAITKFPDLWC
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHEEEEEEEEEECCCCCEEEEEEHHHCCHHHH
SAVAVVPFVNWFTEKKFEREVLQQYDEIKVGNDENLLKDRSPIFFIDRIKAPLLLLAGEN
HHHHHHHHHHHHHHHHHHHHHHHHHHCEECCCCCCHHHCCCCEEEEEECCCCEEEEECCC
DPRCPAEETLQVVEELKKLGRKVKYKIYKDEGHGFAKMENYVDSIRETVEFISTHC
CCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10382966; 12037315 [H]