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The map label for this gene is copA [H]

Identifier: 15922019

GI number: 15922019

Start: 1716201

End: 1718423

Strand: Reverse

Name: copA [H]

Synonym: ST1715

Alternate gene names: 15922019

Gene position: 1718423-1716201 (Counterclockwise)

Preceding gene: 15922020

Following gene: 15922012

Centisome position: 63.77

GC content: 36.93

Gene sequence:

>2223_bases
ATGAGCGAGGTGAGAAATGAGAAGAAGGACCTTAGGATTAAGAGAGAAGAAGAGTTAAAAATCGTAGGAATGCATTGTGC
AACATGTGTTTCAACAGTATCTAAAGCTATTTCTTCTGTTCAAGGGGTAAAAGATGTAAATGTCAACTTAGCCTCTGGTA
ATGCTAGGGTTGTAATCGAAAATGCTAGATTGAAAGATATTGTAAGGGCTGTTAGAAAAGCCGGTTATGACGTTGTAACG
CAAAAAGTGACTTTGAAAGTAAGTCTTAGTGAAGAAGAAGCCGGTAAGATAGTTTCCGTTCTAGATAATATCCCGGGAAT
TATTGATGTTAAGATCAATCCTTCTTCGGGTATCGTTATCCTGGAAATTAATCCGGTAACTGTAACTGGAGATGAAATCG
TAGAAGAGTTAAAGAAAAGAGGTTATAAAGCTGAAATTACTACTGAGAGTTTTAAAGGAAAGAGTGACTTTCACGATTTG
CTTATAAGGTTAATAATTGCCTCAGTTTTCTCTTCTCTTATCTTTATCTTTCCAGCTTATCAACTTTTCTTATCAATTCC
AGTCCAATTCTATTCGGGCTTAAGATTTCATCTAGGTTTTCTTAGAGCTTTAAGAAATAAGACCAGTAATATGGATACGT
TAGTCTCTCTCTCGTCTAACATAGCCTGGTTTTACAGTCTTTACTCTTACCTAATACATTCTCCTAATTACTTCTTTGAA
GCTTCTTCCCTCCTAATTACTTTCATTCTTATAGGAAAGACTTTAGAAGCTTACATTAAGGAGAAGACTTCAGATGACGT
TATTAGACTTCAAACCGTTAAGGCTAGGCTTACTGATGGCACGTTAGTGGATTCCTCTAAATTGAGGGTTGGTGATGTAG
TCATAGTTAAGTCTGGTGAGATTATTCCAGCTGACGGTATTGTTGATGAAGGAGAGGGATATGTTAATGAGGCAATTTAT
ACTGGTGAGACTATACCGGTGAGAAAGAAGAAGGGAGATGCTGTTATTGGCGGTTCAATATTAACTTCTGGTTTTCTTAA
AGTTTATGTTACTAGGGCTGGGAATAGGACTTATATTTCGCAAGTTATCGAGGCTATAAGAGAGGCTGAGACTACTAGGT
TGCCTATACAGTCACTTGTTGATAAGGTTTCATCAGTCTTTGTTCCAGCAGTTATTGGAGTTTCTGTTTTAGCCTTTGCA
TTATGGTATGTAGTCTCTCATTCGCTTACTTTCTCTATTTTAATTTCTGTTGCAGTCTTAGCCTCAGCATGTCCGTGTCC
TTTTGGTTTGGCAACACCTATGGCTGTTATGGTCGGAATAAGGAAATTGGTTAAAAAGGGAATTAAGGTAAGGAATGCTG
AGAGTTTAGAGAGGCTTAGAGAGGCAAAATACATAGTTTTTGATAAAACAGGGACTATAACTACTGGAGAGTTTATAGTA
AAACCGATAGGTGACGAAAACGCAATAAAGTTAGCATGTGCTGTAGAAAAGCTTAGTTCTCACCCCGTAGGTGAGGCTAT
TGCGTCTTTATATGATGTAAAAGATGAAGTTAAGGACTTTAATGAGTTTCAAGGGGAAGGAGTTTACGGGAAAGTTAATG
ATCACGATGTAATAGTGGGTAAAAGGGAGTTTGTTCTTAAGAACTGTGAAGGAGATTTAGATGCTGATGTTTTAGTTTGT
GTTGATTCAAAAGTTGTTGCAGGGTTTTTGTTGGAAGATAAAATAAGGGACGGAGTTGTTGAGCTGGTTAATGAGCTTAA
GAAATATTATGAAGTTATTATTGCTACTGGTGATTCAAGTAATTTTGCCGATAAGGTAGGAGAAGTTCTGGGAGTAAAAG
TGTATAAGGGTCTTTCGCCAGATGATAAAGTAGAATTAGTTAGAAAGCTTGGTAAGGCAATTTTTGTAGGTGATGGTGTT
AATGATGCTCAAGCTTTGAAAGAGGCTTTAGTTGGTATTGCTGTTTCTACCGGTACTGATATTGCTAAGTACGCTGGAGA
TATTATTGTACCTTCTGTTCTCTCAATCAAATATGTTATCGAACAGTCTAAGAGGACTGTGAGGAAAATAAAGGAGAATT
TAGCTTGGGCTTTTACTTATAATTCTGTTTTGATACCAATTTCAGCTGGTATACTTTATCCTTTCTATTTGCCTCCAGAA
TACGCTGCCTTAGCTATGTCTATGGATAGTGTTCTAGTTTCCTTATGGAGTTTTGTTCAGTAA

Upstream 100 bases:

>100_bases
TAAAAAAGCGTTTGAAAAAGACCCTGAAAAATATTTGAGGGAAGGACCTAAAGGAATGCCTGGTGAGGAAGGTCATCATT
AATAGTTCGGTGAATTTCTA

Downstream 100 bases:

>100_bases
TCTTATTTTTTAAGAGAAAGAAACATTAAACTTATAAGTATTAAGTATAGCTAAAAACGAAATAGAGCAAAACTATTTAT
TCACATCGTTCTTTTTACTG

Product: cation-transporter ATPase

Products: ADP; Orthophosphate. [C]

Alternate protein names: NA

Number of amino acids: Translated: 740; Mature: 739

Protein sequence:

>740_residues
MSEVRNEKKDLRIKREEELKIVGMHCATCVSTVSKAISSVQGVKDVNVNLASGNARVVIENARLKDIVRAVRKAGYDVVT
QKVTLKVSLSEEEAGKIVSVLDNIPGIIDVKINPSSGIVILEINPVTVTGDEIVEELKKRGYKAEITTESFKGKSDFHDL
LIRLIIASVFSSLIFIFPAYQLFLSIPVQFYSGLRFHLGFLRALRNKTSNMDTLVSLSSNIAWFYSLYSYLIHSPNYFFE
ASSLLITFILIGKTLEAYIKEKTSDDVIRLQTVKARLTDGTLVDSSKLRVGDVVIVKSGEIIPADGIVDEGEGYVNEAIY
TGETIPVRKKKGDAVIGGSILTSGFLKVYVTRAGNRTYISQVIEAIREAETTRLPIQSLVDKVSSVFVPAVIGVSVLAFA
LWYVVSHSLTFSILISVAVLASACPCPFGLATPMAVMVGIRKLVKKGIKVRNAESLERLREAKYIVFDKTGTITTGEFIV
KPIGDENAIKLACAVEKLSSHPVGEAIASLYDVKDEVKDFNEFQGEGVYGKVNDHDVIVGKREFVLKNCEGDLDADVLVC
VDSKVVAGFLLEDKIRDGVVELVNELKKYYEVIIATGDSSNFADKVGEVLGVKVYKGLSPDDKVELVRKLGKAIFVGDGV
NDAQALKEALVGIAVSTGTDIAKYAGDIIVPSVLSIKYVIEQSKRTVRKIKENLAWAFTYNSVLIPISAGILYPFYLPPE
YAALAMSMDSVLVSLWSFVQ

Sequences:

>Translated_740_residues
MSEVRNEKKDLRIKREEELKIVGMHCATCVSTVSKAISSVQGVKDVNVNLASGNARVVIENARLKDIVRAVRKAGYDVVT
QKVTLKVSLSEEEAGKIVSVLDNIPGIIDVKINPSSGIVILEINPVTVTGDEIVEELKKRGYKAEITTESFKGKSDFHDL
LIRLIIASVFSSLIFIFPAYQLFLSIPVQFYSGLRFHLGFLRALRNKTSNMDTLVSLSSNIAWFYSLYSYLIHSPNYFFE
ASSLLITFILIGKTLEAYIKEKTSDDVIRLQTVKARLTDGTLVDSSKLRVGDVVIVKSGEIIPADGIVDEGEGYVNEAIY
TGETIPVRKKKGDAVIGGSILTSGFLKVYVTRAGNRTYISQVIEAIREAETTRLPIQSLVDKVSSVFVPAVIGVSVLAFA
LWYVVSHSLTFSILISVAVLASACPCPFGLATPMAVMVGIRKLVKKGIKVRNAESLERLREAKYIVFDKTGTITTGEFIV
KPIGDENAIKLACAVEKLSSHPVGEAIASLYDVKDEVKDFNEFQGEGVYGKVNDHDVIVGKREFVLKNCEGDLDADVLVC
VDSKVVAGFLLEDKIRDGVVELVNELKKYYEVIIATGDSSNFADKVGEVLGVKVYKGLSPDDKVELVRKLGKAIFVGDGV
NDAQALKEALVGIAVSTGTDIAKYAGDIIVPSVLSIKYVIEQSKRTVRKIKENLAWAFTYNSVLIPISAGILYPFYLPPE
YAALAMSMDSVLVSLWSFVQ
>Mature_739_residues
SEVRNEKKDLRIKREEELKIVGMHCATCVSTVSKAISSVQGVKDVNVNLASGNARVVIENARLKDIVRAVRKAGYDVVTQ
KVTLKVSLSEEEAGKIVSVLDNIPGIIDVKINPSSGIVILEINPVTVTGDEIVEELKKRGYKAEITTESFKGKSDFHDLL
IRLIIASVFSSLIFIFPAYQLFLSIPVQFYSGLRFHLGFLRALRNKTSNMDTLVSLSSNIAWFYSLYSYLIHSPNYFFEA
SSLLITFILIGKTLEAYIKEKTSDDVIRLQTVKARLTDGTLVDSSKLRVGDVVIVKSGEIIPADGIVDEGEGYVNEAIYT
GETIPVRKKKGDAVIGGSILTSGFLKVYVTRAGNRTYISQVIEAIREAETTRLPIQSLVDKVSSVFVPAVIGVSVLAFAL
WYVVSHSLTFSILISVAVLASACPCPFGLATPMAVMVGIRKLVKKGIKVRNAESLERLREAKYIVFDKTGTITTGEFIVK
PIGDENAIKLACAVEKLSSHPVGEAIASLYDVKDEVKDFNEFQGEGVYGKVNDHDVIVGKREFVLKNCEGDLDADVLVCV
DSKVVAGFLLEDKIRDGVVELVNELKKYYEVIIATGDSSNFADKVGEVLGVKVYKGLSPDDKVELVRKLGKAIFVGDGVN
DAQALKEALVGIAVSTGTDIAKYAGDIIVPSVLSIKYVIEQSKRTVRKIKENLAWAFTYNSVLIPISAGILYPFYLPPEY
AALAMSMDSVLVSLWSFVQ

Specific function: Involved in copper export [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 HMA domains [H]

Homologues:

Organism=Homo sapiens, GI115529486, Length=896, Percent_Identity=28.0133928571429, Blast_Score=295, Evalue=1e-79,
Organism=Homo sapiens, GI55743071, Length=866, Percent_Identity=27.8290993071594, Blast_Score=290, Evalue=4e-78,
Organism=Homo sapiens, GI55743073, Length=809, Percent_Identity=25.9579728059332, Blast_Score=210, Evalue=4e-54,
Organism=Homo sapiens, GI83700225, Length=267, Percent_Identity=26.5917602996255, Blast_Score=69, Evalue=2e-11,
Organism=Homo sapiens, GI297374799, Length=273, Percent_Identity=26.3736263736264, Blast_Score=67, Evalue=6e-11,
Organism=Escherichia coli, GI1786691, Length=825, Percent_Identity=27.3939393939394, Blast_Score=303, Evalue=2e-83,
Organism=Escherichia coli, GI1789879, Length=717, Percent_Identity=26.2203626220363, Blast_Score=186, Evalue=4e-48,
Organism=Escherichia coli, GI1786914, Length=435, Percent_Identity=26.8965517241379, Blast_Score=114, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17556548, Length=582, Percent_Identity=30.2405498281787, Blast_Score=223, Evalue=3e-58,
Organism=Saccharomyces cerevisiae, GI6320475, Length=862, Percent_Identity=29.6983758700696, Blast_Score=301, Evalue=3e-82,
Organism=Saccharomyces cerevisiae, GI6319772, Length=792, Percent_Identity=27.2727272727273, Blast_Score=242, Evalue=2e-64,
Organism=Saccharomyces cerevisiae, GI6325221, Length=513, Percent_Identity=23.0019493177388, Blast_Score=72, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6321430, Length=510, Percent_Identity=22.156862745098, Blast_Score=70, Evalue=8e-13,
Organism=Drosophila melanogaster, GI221329854, Length=578, Percent_Identity=28.719723183391, Blast_Score=206, Evalue=5e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR006403
- InterPro:   IPR000695
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: 3.6.3.4 [C]

Molecular weight: Translated: 80950; Mature: 80819

Theoretical pI: Translated: 7.14; Mature: 7.14

Prosite motif: PS00154 ATPASE_E1_E2 ; PS01047 HMA_1 ; PS50846 HMA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEVRNEKKDLRIKREEELKIVGMHCATCVSTVSKAISSVQGVKDVNVNLASGNARVVIE
CCCCCCCHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEEEE
NARLKDIVRAVRKAGYDVVTQKVTLKVSLSEEEAGKIVSVLDNIPGIIDVKINPSSGIVI
CCHHHHHHHHHHHCCCCEEEEEEEEEEEECHHHHHHHHHHHHCCCCEEEEEECCCCCEEE
LEINPVTVTGDEIVEELKKRGYKAEITTESFKGKSDFHDLLIRLIIASVFSSLIFIFPAY
EEECCEEECHHHHHHHHHHCCCEEEEEHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
QLFLSIPVQFYSGLRFHLGFLRALRNKTSNMDTLVSLSSNIAWFYSLYSYLIHSPNYFFE
HHHHHCCHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCCEEE
ASSLLITFILIGKTLEAYIKEKTSDDVIRLQTVKARLTDGTLVDSSKLRVGDVVIVKSGE
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHCCCCCCEECCCCEEECCEEEEECCC
IIPADGIVDEGEGYVNEAIYTGETIPVRKKKGDAVIGGSILTSGFLKVYVTRAGNRTYIS
EECCCCCCCCCCCHHHHHEECCCCCEEECCCCCEEECCHHHHCCEEEEEEEECCCHHHHH
QVIEAIREAETTRLPIQSLVDKVSSVFVPAVIGVSVLAFALWYVVSHSLTFSILISVAVL
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASACPCPFGLATPMAVMVGIRKLVKKGIKVRNAESLERLREAKYIVFDKTGTITTGEFIV
HHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCEEEEECCCCEEECCEEE
KPIGDENAIKLACAVEKLSSHPVGEAIASLYDVKDEVKDFNEFQGEGVYGKVNDHDVIVG
EECCCCCCEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCEEEEC
KREFVLKNCEGDLDADVLVCVDSKVVAGFLLEDKIRDGVVELVNELKKYYEVIIATGDSS
CHHHHHCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCC
NFADKVGEVLGVKVYKGLSPDDKVELVRKLGKAIFVGDGVNDAQALKEALVGIAVSTGTD
CHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHEEEECCCC
IAKYAGDIIVPSVLSIKYVIEQSKRTVRKIKENLAWAFTYNSVLIPISAGILYPFYLPPE
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCEEEEEECCEEEEEECCCH
YAALAMSMDSVLVSLWSFVQ
HHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SEVRNEKKDLRIKREEELKIVGMHCATCVSTVSKAISSVQGVKDVNVNLASGNARVVIE
CCCCCCHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEEEE
NARLKDIVRAVRKAGYDVVTQKVTLKVSLSEEEAGKIVSVLDNIPGIIDVKINPSSGIVI
CCHHHHHHHHHHHCCCCEEEEEEEEEEEECHHHHHHHHHHHHCCCCEEEEEECCCCCEEE
LEINPVTVTGDEIVEELKKRGYKAEITTESFKGKSDFHDLLIRLIIASVFSSLIFIFPAY
EEECCEEECHHHHHHHHHHCCCEEEEEHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
QLFLSIPVQFYSGLRFHLGFLRALRNKTSNMDTLVSLSSNIAWFYSLYSYLIHSPNYFFE
HHHHHCCHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCCEEE
ASSLLITFILIGKTLEAYIKEKTSDDVIRLQTVKARLTDGTLVDSSKLRVGDVVIVKSGE
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHCCCCCCEECCCCEEECCEEEEECCC
IIPADGIVDEGEGYVNEAIYTGETIPVRKKKGDAVIGGSILTSGFLKVYVTRAGNRTYIS
EECCCCCCCCCCCHHHHHEECCCCCEEECCCCCEEECCHHHHCCEEEEEEEECCCHHHHH
QVIEAIREAETTRLPIQSLVDKVSSVFVPAVIGVSVLAFALWYVVSHSLTFSILISVAVL
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASACPCPFGLATPMAVMVGIRKLVKKGIKVRNAESLERLREAKYIVFDKTGTITTGEFIV
HHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCEEEEECCCCEEECCEEE
KPIGDENAIKLACAVEKLSSHPVGEAIASLYDVKDEVKDFNEFQGEGVYGKVNDHDVIVG
EECCCCCCEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCEEEEC
KREFVLKNCEGDLDADVLVCVDSKVVAGFLLEDKIRDGVVELVNELKKYYEVIIATGDSS
CHHHHHCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCC
NFADKVGEVLGVKVYKGLSPDDKVELVRKLGKAIFVGDGVNDAQALKEALVGIAVSTGTD
CHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHEEEECCCC
IAKYAGDIIVPSVLSIKYVIEQSKRTVRKIKENLAWAFTYNSVLIPISAGILYPFYLPPE
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCEEEEEECCEEEEEECCCH
YAALAMSMDSVLVSLWSFVQ
HHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Cu [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O [C]

Specific reaction: ATP + H2O = ADP + Orthophosphate. [C]

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA