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The map label for this gene is ttuE [H]

Identifier: 15921917

GI number: 15921917

Start: 1615201

End: 1616517

Strand: Reverse

Name: ttuE [H]

Synonym: ST1617

Alternate gene names: 15921917

Gene position: 1616517-1615201 (Counterclockwise)

Preceding gene: 15921918

Following gene: 15921913

Centisome position: 59.99

GC content: 34.7

Gene sequence:

>1317_bases
ATGTTTAGAAAGACCAAAATTATCGCGACTTTGGGACCTAGTAGTGAAAATCACATTGATGAATTAGTAAAGTATGTAGA
CGTAATAAGGTTAAATTTCGCGCATGGAGATAAAGAACAGCATGAAAAGTACTTTAATCTAGTAAAAAATAGAGTTCCTA
TTCTAGTAGATTTGCCAGGGCCAAAGCTTAGGATCGGTGATTTAGGGAAAAATATGATATTACTTAAACCTGGAGATACC
ATAGAATTTGGAACTCAAATCCCCGTAGATGATATTTTATTCTTTAAACTTATCAGAAAAGGTTCAGAGGTACTAATATC
TGATGGAAGAATTAGAGTAAAAATAATAGAGGCTGGAAACAATTACGCTAAGGGATTAGTAGAAGAAGGAGGTATTTTAA
CATCCAGAAAGGGTATAAACATCCCAGATTCCGAAATACCAGTAGGATTGACTGATAGGGATTTAGAGTTATTAAAATAT
GCTTTAGAAATGGGAGCAACATTTATTGGACTCTCATTTGTAACTTCACCAGAGGAGATTAGAAAAGCTAAAGAAATTGT
TAAAGACCAAGCCTGGATAATAGCTAAAATAGAGAAAAAATCTGCGTTAAAGAAGTTGAAAGAGATAATAAGGGAAGCCG
ATGGTGTAATGGTTGCTAGAGGCGATTTGGGAGTAGAAGTAGGTTTAGCTAATTTACCACAAACTCAGAGAAGAATTGTT
AGACTGACTAGATTATATGGTAAGCCCGTAATTTTGGCCACACAAGTGCTTGAGTCAATGGTTACTTCTCCAATTCCAAC
TAGAGCTGAAGTGATTGATGTTGCAAATTCAATAATTCAAGGTGTTGATGCGATAATGCTTAGTGATGAAACTGCCATGG
GCCAATATCCTATAGATGCTGTAAGGACTTTGCATGAGCTAATATTAAGTGTTGAGAGATCTTTTAAACCCAGACCTCCA
CCACCACTAAAAAATATAGATGATGCAATAGCATATTCAGCTGTATCTGCTTCAAATCTGGCTTCTTCATCTGGTATAGT
AGTTTATACTAGGACTGGTGCTTCAGCACTAAGGATATCTAGGTTAAGACCAGTAGTTCCAATAATAGTATTAACTCAAA
ATCAAAGGGTCTACGAGAGACTAAAACTTTGTTATGGAATCTACTCTTTTATTTCAGAAGAATTAAATAGTCTAGATAAT
ATTGTTGAAAAGAGCAAAAACATAGCTAGACAAGTAGGTTTAAAGAACACTATAATAATAATTGCTGGTGGAATAGAAGA
AGGGTCAACTAGATTTTTAAAAGTTGAGGAGATCTAA

Upstream 100 bases:

>100_bases
TTAGACGCTTATTATACCGTGAGAAATGCTGGAATATTTGTCATTAATAGAATAAATAGAAAATTCGGAAATACAGCATC
TAGGAGAGGTACATCGTCAT

Downstream 100 bases:

>100_bases
TTCTGTCTTCAGTTAATTTAAAACTAAATAATAGAATTTATATTTCCAGAAATATATACTGTAAACTAGCTTAGTTAAAG
TGCTACATTACTAAATCTTC

Product: pyruvate kinase

Products: NA

Alternate protein names: PK [H]

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MFRKTKIIATLGPSSENHIDELVKYVDVIRLNFAHGDKEQHEKYFNLVKNRVPILVDLPGPKLRIGDLGKNMILLKPGDT
IEFGTQIPVDDILFFKLIRKGSEVLISDGRIRVKIIEAGNNYAKGLVEEGGILTSRKGINIPDSEIPVGLTDRDLELLKY
ALEMGATFIGLSFVTSPEEIRKAKEIVKDQAWIIAKIEKKSALKKLKEIIREADGVMVARGDLGVEVGLANLPQTQRRIV
RLTRLYGKPVILATQVLESMVTSPIPTRAEVIDVANSIIQGVDAIMLSDETAMGQYPIDAVRTLHELILSVERSFKPRPP
PPLKNIDDAIAYSAVSASNLASSSGIVVYTRTGASALRISRLRPVVPIIVLTQNQRVYERLKLCYGIYSFISEELNSLDN
IVEKSKNIARQVGLKNTIIIIAGGIEEGSTRFLKVEEI

Sequences:

>Translated_438_residues
MFRKTKIIATLGPSSENHIDELVKYVDVIRLNFAHGDKEQHEKYFNLVKNRVPILVDLPGPKLRIGDLGKNMILLKPGDT
IEFGTQIPVDDILFFKLIRKGSEVLISDGRIRVKIIEAGNNYAKGLVEEGGILTSRKGINIPDSEIPVGLTDRDLELLKY
ALEMGATFIGLSFVTSPEEIRKAKEIVKDQAWIIAKIEKKSALKKLKEIIREADGVMVARGDLGVEVGLANLPQTQRRIV
RLTRLYGKPVILATQVLESMVTSPIPTRAEVIDVANSIIQGVDAIMLSDETAMGQYPIDAVRTLHELILSVERSFKPRPP
PPLKNIDDAIAYSAVSASNLASSSGIVVYTRTGASALRISRLRPVVPIIVLTQNQRVYERLKLCYGIYSFISEELNSLDN
IVEKSKNIARQVGLKNTIIIIAGGIEEGSTRFLKVEEI
>Mature_438_residues
MFRKTKIIATLGPSSENHIDELVKYVDVIRLNFAHGDKEQHEKYFNLVKNRVPILVDLPGPKLRIGDLGKNMILLKPGDT
IEFGTQIPVDDILFFKLIRKGSEVLISDGRIRVKIIEAGNNYAKGLVEEGGILTSRKGINIPDSEIPVGLTDRDLELLKY
ALEMGATFIGLSFVTSPEEIRKAKEIVKDQAWIIAKIEKKSALKKLKEIIREADGVMVARGDLGVEVGLANLPQTQRRIV
RLTRLYGKPVILATQVLESMVTSPIPTRAEVIDVANSIIQGVDAIMLSDETAMGQYPIDAVRTLHELILSVERSFKPRPP
PPLKNIDDAIAYSAVSASNLASSSGIVVYTRTGASALRISRLRPVVPIIVLTQNQRVYERLKLCYGIYSFISEELNSLDN
IVEKSKNIARQVGLKNTIIIIAGGIEEGSTRFLKVEEI

Specific function: Glycolysis; final step. [C]

COG id: COG0469

COG function: function code G; Pyruvate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyruvate kinase family [H]

Homologues:

Organism=Homo sapiens, GI33286418, Length=477, Percent_Identity=31.6561844863732, Blast_Score=226, Evalue=2e-59,
Organism=Homo sapiens, GI33286422, Length=477, Percent_Identity=31.0272536687631, Blast_Score=221, Evalue=8e-58,
Organism=Homo sapiens, GI33286420, Length=477, Percent_Identity=31.0272536687631, Blast_Score=221, Evalue=8e-58,
Organism=Homo sapiens, GI32967597, Length=434, Percent_Identity=32.0276497695853, Blast_Score=219, Evalue=4e-57,
Organism=Homo sapiens, GI10835121, Length=434, Percent_Identity=32.0276497695853, Blast_Score=219, Evalue=5e-57,
Organism=Homo sapiens, GI310128732, Length=287, Percent_Identity=29.2682926829268, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI310128730, Length=287, Percent_Identity=29.2682926829268, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI310128736, Length=237, Percent_Identity=26.5822784810127, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI310128734, Length=237, Percent_Identity=26.5822784810127, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI310128738, Length=210, Percent_Identity=25.2380952380952, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1788160, Length=476, Percent_Identity=31.9327731092437, Blast_Score=221, Evalue=8e-59,
Organism=Escherichia coli, GI1787965, Length=455, Percent_Identity=32.7472527472527, Blast_Score=214, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI17544584, Length=426, Percent_Identity=34.037558685446, Blast_Score=235, Evalue=4e-62,
Organism=Caenorhabditis elegans, GI71984413, Length=477, Percent_Identity=32.4947589098532, Blast_Score=199, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17506829, Length=477, Percent_Identity=32.4947589098532, Blast_Score=199, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI71984406, Length=477, Percent_Identity=32.2851153039832, Blast_Score=199, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17506831, Length=477, Percent_Identity=32.2851153039832, Blast_Score=198, Evalue=4e-51,
Organism=Saccharomyces cerevisiae, GI6319279, Length=435, Percent_Identity=30.1149425287356, Blast_Score=197, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6324923, Length=434, Percent_Identity=32.7188940092166, Blast_Score=187, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24648966, Length=411, Percent_Identity=33.0900243309002, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI24648964, Length=485, Percent_Identity=31.9587628865979, Blast_Score=201, Evalue=7e-52,
Organism=Drosophila melanogaster, GI28571814, Length=485, Percent_Identity=31.9587628865979, Blast_Score=201, Evalue=8e-52,
Organism=Drosophila melanogaster, GI24581235, Length=424, Percent_Identity=30.4245283018868, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24646914, Length=284, Percent_Identity=34.5070422535211, Blast_Score=144, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001697
- InterPro:   IPR015813
- InterPro:   IPR011037
- InterPro:   IPR015794
- InterPro:   IPR018209
- InterPro:   IPR015793
- InterPro:   IPR015795
- InterPro:   IPR015806 [H]

Pfam domain/function: PF00224 PK; PF02887 PK_C [H]

EC number: =2.7.1.40 [H]

Molecular weight: Translated: 48480; Mature: 48480

Theoretical pI: Translated: 9.55; Mature: 9.55

Prosite motif: PS00110 PYRUVATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFRKTKIIATLGPSSENHIDELVKYVDVIRLNFAHGDKEQHEKYFNLVKNRVPILVDLPG
CCCCEEEEEEECCCCHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHCCCCEEEECCC
PKLRIGDLGKNMILLKPGDTIEFGTQIPVDDILFFKLIRKGSEVLISDGRIRVKIIEAGN
CCEEEECCCCCEEEECCCCCEECCCCCCHHHHHHHHHHHCCCEEEEECCEEEEEEEECCC
NYAKGLVEEGGILTSRKGINIPDSEIPVGLTDRDLELLKYALEMGATFIGLSFVTSPEEI
CHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEHEECCCHHHH
RKAKEIVKDQAWIIAKIEKKSALKKLKEIIREADGVMVARGDLGVEVGLANLPQTQRRIV
HHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHCCCEEEEECCCCEEECCCCCCHHHHHHH
RLTRLYGKPVILATQVLESMVTSPIPTRAEVIDVANSIIQGVDAIMLSDETAMGQYPIDA
HHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHEEECCCCCCCCCCHHH
VRTLHELILSVERSFKPRPPPPLKNIDDAIAYSAVSASNLASSSGIVVYTRTGASALRIS
HHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHH
RLRPVVPIIVLTQNQRVYERLKLCYGIYSFISEELNSLDNIVEKSKNIARQVGLKNTIII
HCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
IAGGIEEGSTRFLKVEEI
EECCCCCCCCEEEEEECC
>Mature Secondary Structure
MFRKTKIIATLGPSSENHIDELVKYVDVIRLNFAHGDKEQHEKYFNLVKNRVPILVDLPG
CCCCEEEEEEECCCCHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHCCCCEEEECCC
PKLRIGDLGKNMILLKPGDTIEFGTQIPVDDILFFKLIRKGSEVLISDGRIRVKIIEAGN
CCEEEECCCCCEEEECCCCCEECCCCCCHHHHHHHHHHHCCCEEEEECCEEEEEEEECCC
NYAKGLVEEGGILTSRKGINIPDSEIPVGLTDRDLELLKYALEMGATFIGLSFVTSPEEI
CHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEHEECCCHHHH
RKAKEIVKDQAWIIAKIEKKSALKKLKEIIREADGVMVARGDLGVEVGLANLPQTQRRIV
HHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHCCCEEEEECCCCEEECCCCCCHHHHHHH
RLTRLYGKPVILATQVLESMVTSPIPTRAEVIDVANSIIQGVDAIMLSDETAMGQYPIDA
HHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHEEECCCCCCCCCCHHH
VRTLHELILSVERSFKPRPPPPLKNIDDAIAYSAVSASNLASSSGIVVYTRTGASALRIS
HHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHH
RLRPVVPIIVLTQNQRVYERLKLCYGIYSFISEELNSLDNIVEKSKNIARQVGLKNTIII
HCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
IAGGIEEGSTRFLKVEEI
EECCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7592429 [H]