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The map label for this gene is birA [H]

Identifier: 15921818

GI number: 15921818

Start: 1518276

End: 1518977

Strand: Reverse

Name: birA [H]

Synonym: ST1525

Alternate gene names: 15921818

Gene position: 1518977-1518276 (Counterclockwise)

Preceding gene: 15921819

Following gene: 15921814

Centisome position: 56.37

GC content: 29.49

Gene sequence:

>702_bases
GTGATGTGTATAAGTATGTTAATATTTAAGTTTCCTAGTGTAACTTCAACTCAAGATTTAGCTGAAGCAATATATCAAAT
AATAAACGCAGATGAGTTTGTAATTGTTGCTGAAGAGCAAACTAGGGCAAGAGGTAGATATAAAAGAGAATGGTATTCTC
CTAAAGGTGGTTTATGGTTTACTTATGTGATAAAGAACTATAATGCAGAAAAAATTCCCTTTCTTACTTTTAGATCTTCA
TTAGCTGTTAGAAAAGTGTTATCAACTTTTCTTAATGTAAAGATAAGGTGGCCAAATGATATTGTCTACGGAAAAAGAAA
GATTTCTGGTATTCTTATTGAGGGAATTAGTGAAGGAGCAAATAGTACAGTTTTCATAGGTATAGGAATTGATACGAACG
TAAAGAGCTTACCAGAAGAATTAAGTGCTACTTCTCTTTATCTAGAATTAAATAGGGAAGTAGATAATGATAAGATGCTA
AATGAAATTATTAATGAAATAAAAAATTATGAAAAAATTAGTGATAAGGAAATCATAGATGAAATTAATGAACATCTGTC
TATAAAGGATAAGAAGGTAAAACTAATAAGTAAGAGTGAAGAGAGAAATTGCCTAGCATTATTTGTTGACTATTATGGAA
GACTTGTAACAGAATGTGGAATATTCGAAGTAGAAGACATTTTAAGAGTAATAGAGGAATAA

Upstream 100 bases:

>100_bases
GACTTAGGCATTATGATAGGTTTTCCAGAAAGAGGAATAGGATTTGCTATCATGAATAGGGCAAGAAAAGCATCAGGCTT
TTCAATTATCAAAGCTATTA

Downstream 100 bases:

>100_bases
AAAGAAAGAAGAATTTTTACTTTACGACTAATACGGGTATTTTAGCCTCTTGAACTAGTTTTGTGGATACGCTCCCTAGA
ATTATTCTCTTAAATGTTGA

Product: hypothetical protein

Products: NA

Alternate protein names: Biotin operon repressor; Biotin--[acetyl-CoA-carboxylase] synthetase; Biotin--protein ligase [H]

Number of amino acids: Translated: 233; Mature: 233

Protein sequence:

>233_residues
MMCISMLIFKFPSVTSTQDLAEAIYQIINADEFVIVAEEQTRARGRYKREWYSPKGGLWFTYVIKNYNAEKIPFLTFRSS
LAVRKVLSTFLNVKIRWPNDIVYGKRKISGILIEGISEGANSTVFIGIGIDTNVKSLPEELSATSLYLELNREVDNDKML
NEIINEIKNYEKISDKEIIDEINEHLSIKDKKVKLISKSEERNCLALFVDYYGRLVTECGIFEVEDILRVIEE

Sequences:

>Translated_233_residues
MMCISMLIFKFPSVTSTQDLAEAIYQIINADEFVIVAEEQTRARGRYKREWYSPKGGLWFTYVIKNYNAEKIPFLTFRSS
LAVRKVLSTFLNVKIRWPNDIVYGKRKISGILIEGISEGANSTVFIGIGIDTNVKSLPEELSATSLYLELNREVDNDKML
NEIINEIKNYEKISDKEIIDEINEHLSIKDKKVKLISKSEERNCLALFVDYYGRLVTECGIFEVEDILRVIEE
>Mature_233_residues
MMCISMLIFKFPSVTSTQDLAEAIYQIINADEFVIVAEEQTRARGRYKREWYSPKGGLWFTYVIKNYNAEKIPFLTFRSS
LAVRKVLSTFLNVKIRWPNDIVYGKRKISGILIEGISEGANSTVFIGIGIDTNVKSLPEELSATSLYLELNREVDNDKML
NEIINEIKNYEKISDKEIIDEINEHLSIKDKKVKLISKSEERNCLALFVDYYGRLVTECGIFEVEDILRVIEE

Specific function: BirA acts both as a biotin-operon repressor and as the enzyme that synthesizes the corepressor, acetyl-CoA:carbon-dioxide ligase. This protein also activates biotin to form biotinyl-5'- adenylate and transfers the biotin moiety to biotin-accepting protein

COG id: COG0340

COG function: function code H; Biotin-(acetyl-CoA carboxylase) ligase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the biotin--protein ligase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: =6.3.4.15 [H]

Molecular weight: Translated: 26883; Mature: 26883

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMCISMLIFKFPSVTSTQDLAEAIYQIINADEFVIVAEEQTRARGRYKREWYSPKGGLWF
CHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEECHHHHHCCCHHHHHCCCCCCEEE
TYVIKNYNAEKIPFLTFRSSLAVRKVLSTFLNVKIRWPNDIVYGKRKISGILIEGISEGA
EEEEECCCCCCCCEEHHHHHHHHHHHHHHHHCEEEECCCCEEECHHHHHHHEEECCCCCC
NSTVFIGIGIDTNVKSLPEELSATSLYLELNREVDNDKMLNEIINEIKNYEKISDKEIID
CCEEEEEECCCCCHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHHHHCCHHHHHH
EINEHLSIKDKKVKLISKSEERNCLALFVDYYGRLVTECGIFEVEDILRVIEE
HHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCC
>Mature Secondary Structure
MMCISMLIFKFPSVTSTQDLAEAIYQIINADEFVIVAEEQTRARGRYKREWYSPKGGLWF
CHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEECHHHHHCCCHHHHHCCCCCCEEE
TYVIKNYNAEKIPFLTFRSSLAVRKVLSTFLNVKIRWPNDIVYGKRKISGILIEGISEGA
EEEEECCCCCCCCEEHHHHHHHHHHHHHHHHCEEEECCCCEEECHHHHHHHEEECCCCCC
NSTVFIGIGIDTNVKSLPEELSATSLYLELNREVDNDKMLNEIINEIKNYEKISDKEIID
CCEEEEEECCCCCHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHHHHCCHHHHHH
EINEHLSIKDKKVKLISKSEERNCLALFVDYYGRLVTECGIFEVEDILRVIEE
HHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7730294 [H]