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The map label for this gene is purM

Identifier: 15921793

GI number: 15921793

Start: 1495486

End: 1496445

Strand: Direct

Name: purM

Synonym: ST1499

Alternate gene names: 15921793

Gene position: 1495486-1496445 (Clockwise)

Preceding gene: 15921792

Following gene: 15921794

Centisome position: 55.5

GC content: 32.5

Gene sequence:

>960_bases
ATGGTGAGTGAATATAAAAAGGCTGGAGTTGATTTAAACAAATTAAAGGAGTATCATACTCTAGCTTTAAACACTTTTCA
AAATTCTGGAGTATTAAAGATTGGACATTACGCTAATGCAATAAAACTTGATGATAAGTATTTAGCAATGCATGTTGATG
GTGTAGGTACAAAGACAATTTTAGCCTTAAAGACTGGAATAATTGAACCTACTGGAATTGATTGTATTGCTATGAATGTT
AATGATTTAGTATGTATTGGTGCAAGGCCTTTAGCTGGTGTTGATTATCTAGCTTTAGAAAAGCCAATGGATGATGTTGT
TGAGAAAGTAATGAAAGGTTTGAAGCAAGGTGCTGATGAAGCAAACATAGAAATTATTGGCGGCGAGACTGCAATAATGC
CCGGAGTAATAACTGGATATGATTTATCTTGCTCAGTAATAGGTATTTCAGATAGGTTGAAGACCGGCGAAGATGTTGCA
CCTGGCGATGTGATTTTAGGTTTAAAAAGTAATGGTGTTCATTCTAACGGTTATTCTCTGATTAGAAAACTCATAGATGA
AGGTAAATTGTCTCTTAATGACTGGGGAGAAGAATTAATGAGACCTACTAGAATATATTCTTCTTCTATAATACCAATTT
TAGATAAAATAAAAGCTTTGGCCCATATTACTGGTGGAGCCTTTTCTAAATTAAAGAGAATAACGAACTATAGGATTAAT
CTAAAAATGCCAGATCCTCCGGAGGTGTTTAAAGCAATTGAAAATGCTGGAGTACCTCATTTTGAAATGTATAAAATTTT
CAATATGGGTATAGGTATGATTATATTTGTTTCAAAGGATCTTAAAGATGATATAATTGAATTTTTGAGTAAAAAAGAAA
CAGTTTATGAATTAGGTTATGTAGAAAAAGGGGAAGGGATAAAAATTACGACCTATAAGAACGAAATTCTCTACATATAG

Upstream 100 bases:

>100_bases
ATCAAGTTGAAAAAGCTGAGATAGTAAGATACACGTATAAGTCAAGAGAGAAAAAAGGCCTTTTTGGAGTATCAGCAGAT
TGGTCTCCAAATGGTGGTTT

Downstream 100 bases:

>100_bases
CATTTAATGAAGTCCTTTTAAACTCTGGTGATAATATAGCCTTCTAGTGATTAAATATGAAACAAATGGATACAAAATCT
TTGGTAAATTATATAGCATT

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase

Number of amino acids: Translated: 319; Mature: 319

Protein sequence:

>319_residues
MVSEYKKAGVDLNKLKEYHTLALNTFQNSGVLKIGHYANAIKLDDKYLAMHVDGVGTKTILALKTGIIEPTGIDCIAMNV
NDLVCIGARPLAGVDYLALEKPMDDVVEKVMKGLKQGADEANIEIIGGETAIMPGVITGYDLSCSVIGISDRLKTGEDVA
PGDVILGLKSNGVHSNGYSLIRKLIDEGKLSLNDWGEELMRPTRIYSSSIIPILDKIKALAHITGGAFSKLKRITNYRIN
LKMPDPPEVFKAIENAGVPHFEMYKIFNMGIGMIIFVSKDLKDDIIEFLSKKETVYELGYVEKGEGIKITTYKNEILYI

Sequences:

>Translated_319_residues
MVSEYKKAGVDLNKLKEYHTLALNTFQNSGVLKIGHYANAIKLDDKYLAMHVDGVGTKTILALKTGIIEPTGIDCIAMNV
NDLVCIGARPLAGVDYLALEKPMDDVVEKVMKGLKQGADEANIEIIGGETAIMPGVITGYDLSCSVIGISDRLKTGEDVA
PGDVILGLKSNGVHSNGYSLIRKLIDEGKLSLNDWGEELMRPTRIYSSSIIPILDKIKALAHITGGAFSKLKRITNYRIN
LKMPDPPEVFKAIENAGVPHFEMYKIFNMGIGMIIFVSKDLKDDIIEFLSKKETVYELGYVEKGEGIKITTYKNEILYI
>Mature_319_residues
MVSEYKKAGVDLNKLKEYHTLALNTFQNSGVLKIGHYANAIKLDDKYLAMHVDGVGTKTILALKTGIIEPTGIDCIAMNV
NDLVCIGARPLAGVDYLALEKPMDDVVEKVMKGLKQGADEANIEIIGGETAIMPGVITGYDLSCSVIGISDRLKTGEDVA
PGDVILGLKSNGVHSNGYSLIRKLIDEGKLSLNDWGEELMRPTRIYSSSIIPILDKIKALAHITGGAFSKLKRITNYRIN
LKMPDPPEVFKAIENAGVPHFEMYKIFNMGIGMIIFVSKDLKDDIIEFLSKKETVYELGYVEKGEGIKITTYKNEILYI

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family

Homologues:

Organism=Homo sapiens, GI4503915, Length=346, Percent_Identity=32.6589595375723, Blast_Score=152, Evalue=5e-37,
Organism=Homo sapiens, GI209869995, Length=346, Percent_Identity=32.6589595375723, Blast_Score=152, Evalue=5e-37,
Organism=Homo sapiens, GI209869993, Length=346, Percent_Identity=32.6589595375723, Blast_Score=152, Evalue=5e-37,
Organism=Escherichia coli, GI1788845, Length=329, Percent_Identity=34.0425531914894, Blast_Score=157, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI17567511, Length=343, Percent_Identity=33.2361516034985, Blast_Score=153, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6321203, Length=283, Percent_Identity=36.7491166077738, Blast_Score=163, Evalue=4e-41,
Organism=Drosophila melanogaster, GI24582400, Length=280, Percent_Identity=33.5714285714286, Blast_Score=145, Evalue=3e-35,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PUR5_SULTO (Q970V2)

Other databases:

- EMBL:   BA000023
- RefSeq:   NP_377462.1
- ProteinModelPortal:   Q970V2
- SMR:   Q970V2
- GeneID:   1459535
- GenomeReviews:   BA000023_GR
- KEGG:   sto:ST1499
- NMPDR:   fig|273063.1.peg.1630
- HOGENOM:   HBG531222
- OMA:   GIDMIAM
- ProtClustDB:   PRK05385
- BioCyc:   STOK273063:ST1499-MONOMER
- BRENDA:   6.3.3.1
- GO:   GO:0005737
- HAMAP:   MF_00741_A
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188
- TIGRFAMs:   TIGR00878

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.3.1

Molecular weight: Translated: 35044; Mature: 35044

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSEYKKAGVDLNKLKEYHTLALNTFQNSGVLKIGHYANAIKLDDKYLAMHVDGVGTKTI
CCCCHHHHCCCHHHHHHHHHHEEEEECCCCCEEECCCCCEEEECCEEEEEEECCCCCCEE
LALKTGIIEPTGIDCIAMNVNDLVCIGARPLAGVDYLALEKPMDDVVEKVMKGLKQGADE
EEEHHCCCCCCCCCEEEECCCCEEEECCCCCCCCCHHHHCCCHHHHHHHHHHHHHCCCCC
ANIEIIGGETAIMPGVITGYDLSCSVIGISDRLKTGEDVAPGDVILGLKSNGVHSNGYSL
CCEEEECCCEEECCCEEECCCCEEEEEECCCCCCCCCCCCCCCEEEEEECCCCCCHHHHH
IRKLIDEGKLSLNDWGEELMRPTRIYSSSIIPILDKIKALAHITGGAFSKLKRITNYRIN
HHHHHHCCCCCHHHHHHHHHCHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCEEEE
LKMPDPPEVFKAIENAGVPHFEMYKIFNMGIGMIIFVSKDLKDDIIEFLSKKETVYELGY
EECCCCHHHHHHHHHCCCCCHHHHHHHHCCCEEEEEEECCHHHHHHHHHHCCCCEEEECC
VEKGEGIKITTYKNEILYI
EECCCCEEEEEECCEEEEC
>Mature Secondary Structure
MVSEYKKAGVDLNKLKEYHTLALNTFQNSGVLKIGHYANAIKLDDKYLAMHVDGVGTKTI
CCCCHHHHCCCHHHHHHHHHHEEEEECCCCCEEECCCCCEEEECCEEEEEEECCCCCCEE
LALKTGIIEPTGIDCIAMNVNDLVCIGARPLAGVDYLALEKPMDDVVEKVMKGLKQGADE
EEEHHCCCCCCCCCEEEECCCCEEEECCCCCCCCCHHHHCCCHHHHHHHHHHHHHCCCCC
ANIEIIGGETAIMPGVITGYDLSCSVIGISDRLKTGEDVAPGDVILGLKSNGVHSNGYSL
CCEEEECCCEEECCCEEECCCCEEEEEECCCCCCCCCCCCCCCEEEEEECCCCCCHHHHH
IRKLIDEGKLSLNDWGEELMRPTRIYSSSIIPILDKIKALAHITGGAFSKLKRITNYRIN
HHHHHHCCCCCHHHHHHHHHCHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCEEEE
LKMPDPPEVFKAIENAGVPHFEMYKIFNMGIGMIIFVSKDLKDDIIEFLSKKETVYELGY
EECCCCHHHHHHHHHCCCCCHHHHHHHHCCCEEEEEEECCHHHHHHHHHHCCCCEEEECC
VEKGEGIKITTYKNEILYI
EECCCCEEEEEECCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479