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The map label for this gene is purC

Identifier: 15921786

GI number: 15921786

Start: 1487782

End: 1488486

Strand: Direct

Name: purC

Synonym: ST1493

Alternate gene names: 15921786

Gene position: 1487782-1488486 (Clockwise)

Preceding gene: 15921782

Following gene: 15921787

Centisome position: 55.21

GC content: 33.19

Gene sequence:

>705_bases
ATGGAATTTCTAAAGCTTAGTGAAGGGAAAACGAAAGAAGTTTATGCATATGACGATTCCCATGTTCTTTTGAAATTCAA
AGATTCTATAACTGCGGGTGATGGTGCAAGGAAAGATATACTCGAAGGAAAAGGAATATTAAATGCACAAACTTCGGCGT
TTTTATTTAGACTATTAGAATCAAAAGGAATAGAGACACACTATATTGGAATGTTTGACGAAAGAACAATGATAGCTAAA
AAACTAAAAATGATACCGGTTGAAGTTGTTTTAAGGAATATTGCTACTGGCAGTATAGTAAAGAGATTACCCATAAAAGA
GGGTGAAGTTTTTGAGCCTCCAATTATAGAGTTTTTCCTTAAGGATGACGAAAGACATGATCCAATGCTAAATTACTATC
ACATGGAATACTTGAAATTAATGACAAGAAAAGAAGCAGAAAAAATAGAAGAGATTATGCTTAAGGTTAATGAGATTTTA
TATCCGTTTTTCAGAAGTAAAAAGCTTCTCCTCTATGATTTTAAACTTGAATTTGGTAGAGTGAATGACAAGTTAATCAT
AGGTGATGAACTCACATTAGACTCTATGAGGATTAGAGAGGAAGGTTCCGGTAGAATACTAGATAAAGATTTGTATAGGA
AAGGAGCTGATTTAGAAACCGTCAAGAAGGCTTACGAAGAGTTCTTCAAAAGGATAAGTGAGTAA

Upstream 100 bases:

>100_bases
AGTAAAATGAACTAGATAATGAGTATTCGTTTACTTAGCTAAGTAAAAATACTTAGGTTATTAACACAAGTTTTTTATAC
TGCTCATGTAAAGTTGTCAT

Downstream 100 bases:

>100_bases
AATGCTTTACCGTGTAGAACTGATAATAACTAATAAAGAAGGAGTAAGAGATCCAGAAGGAGAAACAATTCAGCGTTATG
TTGTTAGTAGATTTAGCGAT

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase

Number of amino acids: Translated: 234; Mature: 234

Protein sequence:

>234_residues
MEFLKLSEGKTKEVYAYDDSHVLLKFKDSITAGDGARKDILEGKGILNAQTSAFLFRLLESKGIETHYIGMFDERTMIAK
KLKMIPVEVVLRNIATGSIVKRLPIKEGEVFEPPIIEFFLKDDERHDPMLNYYHMEYLKLMTRKEAEKIEEIMLKVNEIL
YPFFRSKKLLLYDFKLEFGRVNDKLIIGDELTLDSMRIREEGSGRILDKDLYRKGADLETVKKAYEEFFKRISE

Sequences:

>Translated_234_residues
MEFLKLSEGKTKEVYAYDDSHVLLKFKDSITAGDGARKDILEGKGILNAQTSAFLFRLLESKGIETHYIGMFDERTMIAK
KLKMIPVEVVLRNIATGSIVKRLPIKEGEVFEPPIIEFFLKDDERHDPMLNYYHMEYLKLMTRKEAEKIEEIMLKVNEIL
YPFFRSKKLLLYDFKLEFGRVNDKLIIGDELTLDSMRIREEGSGRILDKDLYRKGADLETVKKAYEEFFKRISE
>Mature_234_residues
MEFLKLSEGKTKEVYAYDDSHVLLKFKDSITAGDGARKDILEGKGILNAQTSAFLFRLLESKGIETHYIGMFDERTMIAK
KLKMIPVEVVLRNIATGSIVKRLPIKEGEVFEPPIIEFFLKDDERHDPMLNYYHMEYLKLMTRKEAEKIEEIMLKVNEIL
YPFFRSKKLLLYDFKLEFGRVNDKLIIGDELTLDSMRIREEGSGRILDKDLYRKGADLETVKKAYEEFFKRISE

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family

Homologues:

Organism=Homo sapiens, GI119220557, Length=245, Percent_Identity=37.1428571428571, Blast_Score=137, Evalue=7e-33,
Organism=Homo sapiens, GI5453539, Length=245, Percent_Identity=37.1428571428571, Blast_Score=137, Evalue=7e-33,
Organism=Homo sapiens, GI119220559, Length=252, Percent_Identity=36.1111111111111, Blast_Score=129, Evalue=2e-30,
Organism=Escherichia coli, GI1788820, Length=230, Percent_Identity=36.0869565217391, Blast_Score=154, Evalue=6e-39,
Organism=Caenorhabditis elegans, GI17531275, Length=220, Percent_Identity=35, Blast_Score=110, Evalue=8e-25,
Organism=Saccharomyces cerevisiae, GI6319326, Length=239, Percent_Identity=24.2677824267782, Blast_Score=62, Evalue=7e-11,
Organism=Drosophila melanogaster, GI18860083, Length=234, Percent_Identity=37.1794871794872, Blast_Score=137, Evalue=8e-33,
Organism=Drosophila melanogaster, GI24583917, Length=247, Percent_Identity=34.412955465587, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI160714955, Length=95, Percent_Identity=43.1578947368421, Blast_Score=74, Evalue=6e-14,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): PUR7_SULTO (Q970V9)

Other databases:

- EMBL:   BA000023
- RefSeq:   NP_377455.1
- ProteinModelPortal:   Q970V9
- SMR:   Q970V9
- GeneID:   1459528
- GenomeReviews:   BA000023_GR
- KEGG:   sto:ST1493
- NMPDR:   fig|273063.1.peg.1623
- HOGENOM:   HBG306070
- OMA:   YKDDALG
- ProtClustDB:   PRK09362
- BioCyc:   STOK273063:ST1493-MONOMER
- BRENDA:   6.3.2.6
- HAMAP:   MF_00137
- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236
- Gene3D:   G3DSA:3.30.470.20
- PANTHER:   PTHR11609
- TIGRFAMs:   TIGR00081

Pfam domain/function: PF01259 SAICAR_synt

EC number: =6.3.2.6

Molecular weight: Translated: 27409; Mature: 27409

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: PS01057 SAICAR_SYNTHETASE_1; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFLKLSEGKTKEVYAYDDSHVLLKFKDSITAGDGARKDILEGKGILNAQTSAFLFRLLE
CCCEECCCCCCCEEEEECCCEEEEEEECCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHH
SKGIETHYIGMFDERTMIAKKLKMIPVEVVLRNIATGSIVKRLPIKEGEVFEPPIIEFFL
HCCCCEEEEECCCCHHHHHHHHHHCHHHHHHHHHCCCHHHHHCCCCCCCCCCCHHHEEEE
KDDERHDPMLNYYHMEYLKLMTRKEAEKIEEIMLKVNEILYPFFRSKKLLLYDFKLEFGR
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEECC
VNDKLIIGDELTLDSMRIREEGSGRILDKDLYRKGADLETVKKAYEEFFKRISE
CCCEEEECCCCCCCHHHCCCCCCCCEECHHHHHCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEFLKLSEGKTKEVYAYDDSHVLLKFKDSITAGDGARKDILEGKGILNAQTSAFLFRLLE
CCCEECCCCCCCEEEEECCCEEEEEEECCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHH
SKGIETHYIGMFDERTMIAKKLKMIPVEVVLRNIATGSIVKRLPIKEGEVFEPPIIEFFL
HCCCCEEEEECCCCHHHHHHHHHHCHHHHHHHHHCCCHHHHHCCCCCCCCCCCHHHEEEE
KDDERHDPMLNYYHMEYLKLMTRKEAEKIEEIMLKVNEILYPFFRSKKLLLYDFKLEFGR
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEECC
VNDKLIIGDELTLDSMRIREEGSGRILDKDLYRKGADLETVKKAYEEFFKRISE
CCCEEEECCCCCCCHHHCCCCCCCCEECHHHHHCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479