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The map label for this gene is lpd [H]

Identifier: 15921780

GI number: 15921780

Start: 1483407

End: 1484765

Strand: Reverse

Name: lpd [H]

Synonym: ST1487

Alternate gene names: 15921780

Gene position: 1484765-1483407 (Counterclockwise)

Preceding gene: 15921781

Following gene: 15921779

Centisome position: 55.1

GC content: 33.7

Gene sequence:

>1359_bases
ATGCATTACGACGTGATCATAATCGGCGGAGGAGTAGGAGGTTTAGCCGCAGCAATAAGAAGTGCCGAATTAGGTAAAAA
AGTAGCAATCATAGAGAAAAATGAGATAGGCGGTGAATGTATAAACAGAGCATGCATACCATCAAAAACATTAATAGATA
CTGCAAAGATAGTAAATAAGATATTAAAATCGCCATGGATAGCTACTTCAGCAAAGATAAATTATAATCTGATGAATAAA
TTCAAAGATGATATTATCGAGGGAATAAAAGATAACTTATACCAAGTTATCAATAAGCATAAAATAGATCTACTTTCTGG
AAAAGGAGAGGTAAAAAATGAGGGAGAAGTAATAGTAAATGGAAAAGTTTATACTTATGAGAATTTAGTTATTGCGACAG
GTTCAGAACCTCTATCGCTTGCGGATTTTCCGCTCAATGGAAAGAATGTAGTAGATCCTTGGACTGCAATGAATATGACC
AACTTGCCAGAAAATATAATAATAGTTGGTGGAGGAGTTGCTGGTGTTGAGCTAGCAACTCTATTTAGAGCACTAAACAA
AAATGTAACAATAATAGAGTTAATGCCTAGATTGCTTCCAGTACCTGGAATTGATATTGAAATAGCTAATGAAGTTAAAA
AAAGACTAGAAGAAAAGGGAGTGAGAATTTACGTAAATACTAAATCTAGGATTATAAAGAGCGATGATAAAGTAATATTT
CAAGCACAAACACCTTCTTCAAATGAAGAAATTTCTGGAGATTTAGCAGTAATTACAATCGGAAGAAAACCAGTTACTGA
CGGAATAGACTTAAAGGCAATAAAAGTTGAGACTGACCAAAGGGGTTATATTAAAGTCGACAATAGAGCTAGAACAAGTA
ACTCGAAAGTTTATGCTGTAGGAGATGTAGCCGGTGCGCCTTTATCAGCTACTAAAGCATGGAGGCAAGGTATAGTCGCT
GGCGATAATATTGGTAATAGAAATTCTCAAATGCCCAAATATATTCCAACCTCTATATTTGCTGACCTAGAAATAGGTGT
AGTTGGAAGTACACTAGAAGAGTTGAAGAAAAATGGAATAAACGGAAGGGAAGTAAAAGTTAATATGAAAGAAATACCAA
GAGCATGGACATTAAATGAAACAGAAGGATTTCTAAAAATAGTCATTGGAGAAGATAATAGGATTTTAGGAGCTAATATG
ATAGGAGAAAACGCTACTGAAGTAATTAACACAATTACATTAGCTATGGAATTATCATTAAAAATTGACGATTTATATAA
GGTTCAGTTCTCTCATCCTACAGTTTCTGAAATTATAACAGAGGTAGTACAAAGAGCTATAGTTGGAGAAATTTATTAA

Upstream 100 bases:

>100_bases
CCTTATGTGAAAGTGAAGAAAAAAATAATTTGCATAAGGATCTTATTTACGTTTTAAATAAGCTTAAATCTTATCTAATA
AGTAAAAACAAGAGATAATA

Downstream 100 bases:

>100_bases
GAGTGAAAAATAAACTTAAAACCCAGAGTGAATGAAAAGGAATTACGCCAGATAAAGAAACTTTTTAAATTTCTCTTTCT
TACCTCTAGAGGAGGAAATA

Product: dihydrolipoamide dehydrogenase

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase [H]

Number of amino acids: Translated: 452; Mature: 452

Protein sequence:

>452_residues
MHYDVIIIGGGVGGLAAAIRSAELGKKVAIIEKNEIGGECINRACIPSKTLIDTAKIVNKILKSPWIATSAKINYNLMNK
FKDDIIEGIKDNLYQVINKHKIDLLSGKGEVKNEGEVIVNGKVYTYENLVIATGSEPLSLADFPLNGKNVVDPWTAMNMT
NLPENIIIVGGGVAGVELATLFRALNKNVTIIELMPRLLPVPGIDIEIANEVKKRLEEKGVRIYVNTKSRIIKSDDKVIF
QAQTPSSNEEISGDLAVITIGRKPVTDGIDLKAIKVETDQRGYIKVDNRARTSNSKVYAVGDVAGAPLSATKAWRQGIVA
GDNIGNRNSQMPKYIPTSIFADLEIGVVGSTLEELKKNGINGREVKVNMKEIPRAWTLNETEGFLKIVIGEDNRILGANM
IGENATEVINTITLAMELSLKIDDLYKVQFSHPTVSEIITEVVQRAIVGEIY

Sequences:

>Translated_452_residues
MHYDVIIIGGGVGGLAAAIRSAELGKKVAIIEKNEIGGECINRACIPSKTLIDTAKIVNKILKSPWIATSAKINYNLMNK
FKDDIIEGIKDNLYQVINKHKIDLLSGKGEVKNEGEVIVNGKVYTYENLVIATGSEPLSLADFPLNGKNVVDPWTAMNMT
NLPENIIIVGGGVAGVELATLFRALNKNVTIIELMPRLLPVPGIDIEIANEVKKRLEEKGVRIYVNTKSRIIKSDDKVIF
QAQTPSSNEEISGDLAVITIGRKPVTDGIDLKAIKVETDQRGYIKVDNRARTSNSKVYAVGDVAGAPLSATKAWRQGIVA
GDNIGNRNSQMPKYIPTSIFADLEIGVVGSTLEELKKNGINGREVKVNMKEIPRAWTLNETEGFLKIVIGEDNRILGANM
IGENATEVINTITLAMELSLKIDDLYKVQFSHPTVSEIITEVVQRAIVGEIY
>Mature_452_residues
MHYDVIIIGGGVGGLAAAIRSAELGKKVAIIEKNEIGGECINRACIPSKTLIDTAKIVNKILKSPWIATSAKINYNLMNK
FKDDIIEGIKDNLYQVINKHKIDLLSGKGEVKNEGEVIVNGKVYTYENLVIATGSEPLSLADFPLNGKNVVDPWTAMNMT
NLPENIIIVGGGVAGVELATLFRALNKNVTIIELMPRLLPVPGIDIEIANEVKKRLEEKGVRIYVNTKSRIIKSDDKVIF
QAQTPSSNEEISGDLAVITIGRKPVTDGIDLKAIKVETDQRGYIKVDNRARTSNSKVYAVGDVAGAPLSATKAWRQGIVA
GDNIGNRNSQMPKYIPTSIFADLEIGVVGSTLEELKKNGINGREVKVNMKEIPRAWTLNETEGFLKIVIGEDNRILGANM
IGENATEVINTITLAMELSLKIDDLYKVQFSHPTVSEIITEVVQRAIVGEIY

Specific function: Has chromate reductase activity [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=465, Percent_Identity=31.8279569892473, Blast_Score=227, Evalue=1e-59,
Organism=Homo sapiens, GI50301238, Length=462, Percent_Identity=27.0562770562771, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI33519430, Length=488, Percent_Identity=26.2295081967213, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI33519428, Length=488, Percent_Identity=26.2295081967213, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI33519426, Length=488, Percent_Identity=26.2295081967213, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI148277065, Length=488, Percent_Identity=26.2295081967213, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI148277071, Length=488, Percent_Identity=26.2295081967213, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI22035672, Length=476, Percent_Identity=24.7899159663866, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI291045266, Length=485, Percent_Identity=26.1855670103093, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI291045268, Length=475, Percent_Identity=24.8421052631579, Blast_Score=83, Evalue=4e-16,
Organism=Escherichia coli, GI1786307, Length=450, Percent_Identity=28.6666666666667, Blast_Score=204, Evalue=1e-53,
Organism=Escherichia coli, GI87082354, Length=457, Percent_Identity=28.6652078774617, Blast_Score=177, Evalue=2e-45,
Organism=Escherichia coli, GI87081717, Length=455, Percent_Identity=28.3516483516484, Blast_Score=158, Evalue=7e-40,
Organism=Escherichia coli, GI1789915, Length=451, Percent_Identity=28.3813747228381, Blast_Score=139, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI32565766, Length=465, Percent_Identity=28.8172043010753, Blast_Score=216, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI17557007, Length=477, Percent_Identity=28.7211740041929, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI71983419, Length=437, Percent_Identity=24.9427917620137, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI71983429, Length=437, Percent_Identity=24.9427917620137, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI71982272, Length=482, Percent_Identity=26.5560165975104, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17559934, Length=196, Percent_Identity=30.1020408163265, Blast_Score=78, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6321091, Length=463, Percent_Identity=29.3736501079914, Blast_Score=204, Evalue=3e-53,
Organism=Saccharomyces cerevisiae, GI6325240, Length=474, Percent_Identity=25.3164556962025, Blast_Score=154, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6325166, Length=475, Percent_Identity=23.5789473684211, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI21358499, Length=463, Percent_Identity=30.4535637149028, Blast_Score=214, Evalue=7e-56,
Organism=Drosophila melanogaster, GI24640553, Length=477, Percent_Identity=26.4150943396226, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24640549, Length=477, Percent_Identity=26.4150943396226, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24640551, Length=477, Percent_Identity=26.4150943396226, Blast_Score=116, Evalue=4e-26,
Organism=Drosophila melanogaster, GI17737741, Length=476, Percent_Identity=24.1596638655462, Blast_Score=101, Evalue=8e-22,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 49299; Mature: 49299

Theoretical pI: Translated: 6.82; Mature: 6.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHYDVIIIGGGVGGLAAAIRSAELGKKVAIIEKNEIGGECINRACIPSKTLIDTAKIVNK
CCEEEEEEECCHHHHHHHHHHHHCCCEEEEEECCCCCHHHHCCCCCCCHHHHHHHHHHHH
ILKSPWIATSAKINYNLMNKFKDDIIEGIKDNLYQVINKHKIDLLSGKGEVKNEGEVIVN
HHCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCEEEEC
GKVYTYENLVIATGSEPLSLADFPLNGKNVVDPWTAMNMTNLPENIIIVGGGVAGVELAT
CEEEEEEEEEEEECCCCCEEECCCCCCCCCCCCHHHCCCCCCCCCEEEEECCHHHHHHHH
LFRALNKNVTIIELMPRLLPVPGIDIEIANEVKKRLEEKGVRIYVNTKSRIIKSDDKVIF
HHHHHCCCCEEEEEHHHHCCCCCCCEEHHHHHHHHHHHCCCEEEEECCCEEEECCCCEEE
QAQTPSSNEEISGDLAVITIGRKPVTDGIDLKAIKVETDQRGYIKVDNRARTSNSKVYAV
EEECCCCCCCCCCCEEEEEECCCCCCCCCCEEEEEEECCCCCEEEECCCCCCCCCEEEEE
GDVAGAPLSATKAWRQGIVAGDNIGNRNSQMPKYIPTSIFADLEIGVVGSTLEELKKNGI
ECCCCCCCHHHHHHHCCCEECCCCCCCCCCCCCCCCCHHEEEEEEEEEHHHHHHHHHCCC
NGREVKVNMKEIPRAWTLNETEGFLKIVIGEDNRILGANMIGENATEVINTITLAMELSL
CCCEEEEEHHHCCCEEECCCCCCEEEEEECCCCEEEECCCCCCCHHHHHHHEEEEEEEEE
KIDDLYKVQFSHPTVSEIITEVVQRAIVGEIY
EECEEEEEEECCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MHYDVIIIGGGVGGLAAAIRSAELGKKVAIIEKNEIGGECINRACIPSKTLIDTAKIVNK
CCEEEEEEECCHHHHHHHHHHHHCCCEEEEEECCCCCHHHHCCCCCCCHHHHHHHHHHHH
ILKSPWIATSAKINYNLMNKFKDDIIEGIKDNLYQVINKHKIDLLSGKGEVKNEGEVIVN
HHCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCEEEEC
GKVYTYENLVIATGSEPLSLADFPLNGKNVVDPWTAMNMTNLPENIIIVGGGVAGVELAT
CEEEEEEEEEEEECCCCCEEECCCCCCCCCCCCHHHCCCCCCCCCEEEEECCHHHHHHHH
LFRALNKNVTIIELMPRLLPVPGIDIEIANEVKKRLEEKGVRIYVNTKSRIIKSDDKVIF
HHHHHCCCCEEEEEHHHHCCCCCCCEEHHHHHHHHHHHCCCEEEEECCCEEEECCCCEEE
QAQTPSSNEEISGDLAVITIGRKPVTDGIDLKAIKVETDQRGYIKVDNRARTSNSKVYAV
EEECCCCCCCCCCCEEEEEECCCCCCCCCCEEEEEEECCCCCEEEECCCCCCCCCEEEEE
GDVAGAPLSATKAWRQGIVAGDNIGNRNSQMPKYIPTSIFADLEIGVVGSTLEELKKNGI
ECCCCCCCHHHHHHHCCCEECCCCCCCCCCCCCCCCCHHEEEEEEEEEHHHHHHHHHCCC
NGREVKVNMKEIPRAWTLNETEGFLKIVIGEDNRILGANMIGENATEVINTITLAMELSL
CCCEEEEEHHHCCCEEECCCCCCEEEEEECCCCEEEECCCCCCCHHHHHHHEEEEEEEEE
KIDDLYKVQFSHPTVSEIITEVVQRAIVGEIY
EECEEEEEEECCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA