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The map label for this gene is ilvB [H]

Identifier: 15921738

GI number: 15921738

Start: 1451218

End: 1452936

Strand: Reverse

Name: ilvB [H]

Synonym: ST1447

Alternate gene names: 15921738

Gene position: 1452936-1451218 (Counterclockwise)

Preceding gene: 15921739

Following gene: 15921737

Centisome position: 53.92

GC content: 37.35

Gene sequence:

>1719_bases
ATGCCAACAGGGGCTAGAATAACAATAGATGCTCTAAAAAGAGAAGGAGTAAAAGTAATATTCGGAATACCTGGCCTATC
CAATATGCAACTTTATGACGCATTTATTGAAGACTTACAAAATGGAGAACTAAGACACGTATTAATGAGACATGAACAAG
CTGCCGCTCATGCAGCTGATGGGTATGCAAGAGCTTCAGGAATACCGGGAGTATGTACAGCAACATCCGGTCCTGGTGCA
ACAAACTTAGTTACTGGCCTAATAACAGCATACTGGGATTCCTCGCCAGTTATAGCAATAACTGGACAAGTACCTAGAAA
TTCCATTGGAAAAATGGCATTCCAGGAAGCCGATGCCATGGGTATATTTGAACATATTACAAAATACGTTGTAGAAGTAA
AGAAATTAGAAGAAATTCCAATTTGGATAAAGAATGCATTCTATATAGCAACAACAGGTAGACCAGGACCTGTAGTTGTT
GACATACCTAGAGATATTTTCTATGAAAAAGTTGAGGAAGTAAAATGGCCAGAAAAACCCATGGTAAAAGGTTACAAAGA
GTTTCCTACAATAATTGATAGACAGAAGTTAAAGAAAGCTGCAGAAATACTGGTAAATGCTGAGAGACCTATAATTTTAG
TAGGAACTGGTGTTGTATGGTCTAACGCAACACAAGAGGTTCTTGAACTTGCCGAGTATTTGCATATTCCAATAGTATCA
ACATTCCCTGGTAAGTCCGCTATACCACATGACCACCCACTATATTTCGGTGCCATGGGATACTATGGAAGAGCAGAAGC
TTCAATGGCTGCCTTAGAATCAGATGCTATGTTAGTTATTGGAGCTAGGTTTAGTGATAGAACCTTTACTTCATACGATG
AAATGATTGAGACAAGAAAGAAATTCATAATGATTAACATAGATCCCTCAGATGGAGAAAGAGCAATAAAAGTTGATGTA
AATCTTGTAGGTAATGCAAAAATTCTACTTAGGGAATTGATGAAAGCAATATACGAAGTAGGTAAAAAGAATGATCATAG
CGCCTGGATAAAAAGAGTAAAAGAATATAAGGAATATTACTCACAATTCTATTATTATGACGAACCAAATAAACTAAAAC
CATGGAAGATATTAAAGACAATAAGGAATACGATACCTAGAGATGCTATAGTAACTACTGGTGTGGGACAACATCAAATG
TGGGCAGAAGTATTCTGGGAAGTATTAGAACCTAGAACGTTTTTATCTTCGACTGGTATGGGAACAATGGGATTTGGTTT
ACCAGCTGCAATGGGAGCTAAATTAGCTAAACCAGATAAGGTTGTAGTGGATCTGGATGGTGATGGGTCTTTCTTAATGA
CTGGAAATAATCTCGCTACTGCTGTGGATGAGCATATTCCAATTATATCAGTAGTGTTTGATAATAGGACATTAGGTCTA
GTAAGGCAAGTTCAAGATTTGTTCTTTGGAAACAGAATTGTAGGAGTAGACTACGGACCCTCGCCAGATTTCGTAAAATT
AGCAGAGGCATTTGGAGCTCTAGGATTTAACGCTACTTCTTATGAAGAAATAGAAAAATCACTTAAAACAGCTATGAAAG
AAAATATTCCTGCAGTAATAAGAATTCCGGTCGATAAAGAAGAATTAGCATTACCCACATTACCTCCTGGAGGAAGATTA
AAGCAGGTGATTGTACGTGACCCAAGAAAAAGTAGTTAG

Upstream 100 bases:

>100_bases
CTGTACCCTCCAAGTCTAATTCTTTTCCTCAAGTCAAAGATAACTTTGAACAAGCACAAATTAACTATAAAAGAAATAAT
TCTAAAGAGGTGTTACTATA

Downstream 100 bases:

>100_bases
AGTAGTTGGATATTATAGAGATCCAGGGTTCTTTGAAAGAGTTGCTGGAGCTTTTAGAAAACTATTAATGGATATAAATT
GGATGCAAGCTAGGAGGATT

Product: acetolactate synthase catalytic subunit

Products: NA

Alternate protein names: AHAS; Acetohydroxy-acid synthase large subunit; ALS [H]

Number of amino acids: Translated: 572; Mature: 571

Protein sequence:

>572_residues
MPTGARITIDALKREGVKVIFGIPGLSNMQLYDAFIEDLQNGELRHVLMRHEQAAAHAADGYARASGIPGVCTATSGPGA
TNLVTGLITAYWDSSPVIAITGQVPRNSIGKMAFQEADAMGIFEHITKYVVEVKKLEEIPIWIKNAFYIATTGRPGPVVV
DIPRDIFYEKVEEVKWPEKPMVKGYKEFPTIIDRQKLKKAAEILVNAERPIILVGTGVVWSNATQEVLELAEYLHIPIVS
TFPGKSAIPHDHPLYFGAMGYYGRAEASMAALESDAMLVIGARFSDRTFTSYDEMIETRKKFIMINIDPSDGERAIKVDV
NLVGNAKILLRELMKAIYEVGKKNDHSAWIKRVKEYKEYYSQFYYYDEPNKLKPWKILKTIRNTIPRDAIVTTGVGQHQM
WAEVFWEVLEPRTFLSSTGMGTMGFGLPAAMGAKLAKPDKVVVDLDGDGSFLMTGNNLATAVDEHIPIISVVFDNRTLGL
VRQVQDLFFGNRIVGVDYGPSPDFVKLAEAFGALGFNATSYEEIEKSLKTAMKENIPAVIRIPVDKEELALPTLPPGGRL
KQVIVRDPRKSS

Sequences:

>Translated_572_residues
MPTGARITIDALKREGVKVIFGIPGLSNMQLYDAFIEDLQNGELRHVLMRHEQAAAHAADGYARASGIPGVCTATSGPGA
TNLVTGLITAYWDSSPVIAITGQVPRNSIGKMAFQEADAMGIFEHITKYVVEVKKLEEIPIWIKNAFYIATTGRPGPVVV
DIPRDIFYEKVEEVKWPEKPMVKGYKEFPTIIDRQKLKKAAEILVNAERPIILVGTGVVWSNATQEVLELAEYLHIPIVS
TFPGKSAIPHDHPLYFGAMGYYGRAEASMAALESDAMLVIGARFSDRTFTSYDEMIETRKKFIMINIDPSDGERAIKVDV
NLVGNAKILLRELMKAIYEVGKKNDHSAWIKRVKEYKEYYSQFYYYDEPNKLKPWKILKTIRNTIPRDAIVTTGVGQHQM
WAEVFWEVLEPRTFLSSTGMGTMGFGLPAAMGAKLAKPDKVVVDLDGDGSFLMTGNNLATAVDEHIPIISVVFDNRTLGL
VRQVQDLFFGNRIVGVDYGPSPDFVKLAEAFGALGFNATSYEEIEKSLKTAMKENIPAVIRIPVDKEELALPTLPPGGRL
KQVIVRDPRKSS
>Mature_571_residues
PTGARITIDALKREGVKVIFGIPGLSNMQLYDAFIEDLQNGELRHVLMRHEQAAAHAADGYARASGIPGVCTATSGPGAT
NLVTGLITAYWDSSPVIAITGQVPRNSIGKMAFQEADAMGIFEHITKYVVEVKKLEEIPIWIKNAFYIATTGRPGPVVVD
IPRDIFYEKVEEVKWPEKPMVKGYKEFPTIIDRQKLKKAAEILVNAERPIILVGTGVVWSNATQEVLELAEYLHIPIVST
FPGKSAIPHDHPLYFGAMGYYGRAEASMAALESDAMLVIGARFSDRTFTSYDEMIETRKKFIMINIDPSDGERAIKVDVN
LVGNAKILLRELMKAIYEVGKKNDHSAWIKRVKEYKEYYSQFYYYDEPNKLKPWKILKTIRNTIPRDAIVTTGVGQHQMW
AEVFWEVLEPRTFLSSTGMGTMGFGLPAAMGAKLAKPDKVVVDLDGDGSFLMTGNNLATAVDEHIPIISVVFDNRTLGLV
RQVQDLFFGNRIVGVDYGPSPDFVKLAEAFGALGFNATSYEEIEKSLKTAMKENIPAVIRIPVDKEELALPTLPPGGRLK
QVIVRDPRKSS

Specific function: Valine and isoleucine biosynthesis; first step. [C]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI93004078, Length=569, Percent_Identity=27.2407732864675, Blast_Score=185, Evalue=8e-47,
Organism=Homo sapiens, GI21361361, Length=585, Percent_Identity=25.2991452991453, Blast_Score=150, Evalue=3e-36,
Organism=Escherichia coli, GI87081685, Length=573, Percent_Identity=36.9982547993019, Blast_Score=382, Evalue=1e-107,
Organism=Escherichia coli, GI1790104, Length=556, Percent_Identity=35.6115107913669, Blast_Score=345, Evalue=4e-96,
Organism=Escherichia coli, GI1786717, Length=551, Percent_Identity=31.7604355716878, Blast_Score=275, Evalue=6e-75,
Organism=Escherichia coli, GI1787096, Length=547, Percent_Identity=28.8848263254113, Blast_Score=206, Evalue=2e-54,
Organism=Escherichia coli, GI1788716, Length=567, Percent_Identity=24.1622574955908, Blast_Score=146, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17531299, Length=563, Percent_Identity=26.8206039076377, Blast_Score=157, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17531301, Length=563, Percent_Identity=26.8206039076377, Blast_Score=156, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17542570, Length=553, Percent_Identity=24.4122965641953, Blast_Score=129, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6323755, Length=584, Percent_Identity=36.1301369863014, Blast_Score=375, Evalue=1e-105,
Organism=Saccharomyces cerevisiae, GI6320816, Length=543, Percent_Identity=23.0202578268877, Blast_Score=110, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6321524, Length=505, Percent_Identity=23.960396039604, Blast_Score=80, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6323163, Length=492, Percent_Identity=25, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI19922626, Length=575, Percent_Identity=24.8695652173913, Blast_Score=170, Evalue=3e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012846
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =2.2.1.6 [H]

Molecular weight: Translated: 63487; Mature: 63356

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: PS00187 TPP_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTGARITIDALKREGVKVIFGIPGLSNMQLYDAFIEDLQNGELRHVLMRHEQAAAHAAD
CCCCCEEEHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHC
GYARASGIPGVCTATSGPGATNLVTGLITAYWDSSPVIAITGQVPRNSIGKMAFQEADAM
CHHHHCCCCCEEECCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHH
GIFEHITKYVVEVKKLEEIPIWIKNAFYIATTGRPGPVVVDIPRDIFYEKVEEVKWPEKP
HHHHHHHHHHHHHHHHHCCCEEEECEEEEEECCCCCCEEEECCHHHHHHHHHHCCCCCCH
MVKGYKEFPTIIDRQKLKKAAEILVNAERPIILVGTGVVWSNATQEVLELAEYLHIPIVS
HHCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCEECCCHHHHHHHHHHHCCCEEE
TFPGKSAIPHDHPLYFGAMGYYGRAEASMAALESDAMLVIGARFSDRTFTSYDEMIETRK
ECCCCCCCCCCCCEEEECCCCCCCCHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHCC
KFIMINIDPSDGERAIKVDVNLVGNAKILLRELMKAIYEVGKKNDHSAWIKRVKEYKEYY
EEEEEEECCCCCCEEEEEEEEEECCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
SQFYYYDEPNKLKPWKILKTIRNTIPRDAIVTTGVGQHQMWAEVFWEVLEPRTFLSSTGM
HHEEEECCCCCCCHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHCCHHHHHCCCC
GTMGFGLPAAMGAKLAKPDKVVVDLDGDGSFLMTGNNLATAVDEHIPIISVVFDNRTLGL
CCCCCCCHHHHCCCCCCCCEEEEEECCCCCEEEECCCHHHHHHCCCCEEEEEECCCHHHH
VRQVQDLFFGNRIVGVDYGPSPDFVKLAEAFGALGFNATSYEEIEKSLKTAMKENIPAVI
HHHHHHHHHCCEEEEECCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEE
RIPVDKEELALPTLPPGGRLKQVIVRDPRKSS
EECCCHHHCCCCCCCCCCCCHHHEECCCCCCC
>Mature Secondary Structure 
PTGARITIDALKREGVKVIFGIPGLSNMQLYDAFIEDLQNGELRHVLMRHEQAAAHAAD
CCCCEEEHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHC
GYARASGIPGVCTATSGPGATNLVTGLITAYWDSSPVIAITGQVPRNSIGKMAFQEADAM
CHHHHCCCCCEEECCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHH
GIFEHITKYVVEVKKLEEIPIWIKNAFYIATTGRPGPVVVDIPRDIFYEKVEEVKWPEKP
HHHHHHHHHHHHHHHHHCCCEEEECEEEEEECCCCCCEEEECCHHHHHHHHHHCCCCCCH
MVKGYKEFPTIIDRQKLKKAAEILVNAERPIILVGTGVVWSNATQEVLELAEYLHIPIVS
HHCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCEECCCHHHHHHHHHHHCCCEEE
TFPGKSAIPHDHPLYFGAMGYYGRAEASMAALESDAMLVIGARFSDRTFTSYDEMIETRK
ECCCCCCCCCCCCEEEECCCCCCCCHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHCC
KFIMINIDPSDGERAIKVDVNLVGNAKILLRELMKAIYEVGKKNDHSAWIKRVKEYKEYY
EEEEEEECCCCCCEEEEEEEEEECCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
SQFYYYDEPNKLKPWKILKTIRNTIPRDAIVTTGVGQHQMWAEVFWEVLEPRTFLSSTGM
HHEEEECCCCCCCHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHCCHHHHHCCCC
GTMGFGLPAAMGAKLAKPDKVVVDLDGDGSFLMTGNNLATAVDEHIPIISVVFDNRTLGL
CCCCCCCHHHHCCCCCCCCEEEEEECCCCCEEEECCCHHHHHHCCCCEEEEEECCCHHHH
VRQVQDLFFGNRIVGVDYGPSPDFVKLAEAFGALGFNATSYEEIEKSLKTAMKENIPAVI
HHHHHHHHHCCEEEEECCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEE
RIPVDKEELALPTLPPGGRLKQVIVRDPRKSS
EECCCHHHCCCCCCCCCCCCHHHEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]