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The map label for this gene is gcvT [H]

Identifier: 15921469

GI number: 15921469

Start: 1207871

End: 1208911

Strand: Reverse

Name: gcvT [H]

Synonym: ST1206

Alternate gene names: 15921469

Gene position: 1208911-1207871 (Counterclockwise)

Preceding gene: 15921472

Following gene: 15921468

Centisome position: 44.86

GC content: 31.32

Gene sequence:

>1041_bases
ATGTTTAGTACGCCTCTTTTGGATATTGAATTAAAACTTAATGCTGATATAGGCGAATTTGCAGGTTGGAAAATGCCAAT
GAAATATACTTCTTATCAAGAAGAACATTTAGCTGTACGCTCTTCTGCTGCATTTTTTGACTTATCACACATGGGGAGAC
TAAAAATAACTGGAAAAATTGATGAGTTCGATCTTTTGATAGCGAAAGATATTAAAAAAGCTTCCTATAATACTATGATA
GGACCAACAGCATTTCTTAATGATAAAGGCGGTTTTATAGACGATGTAATGACATATAAGTTAAGTGATACCGAATTCTT
AATTGTTACAAATGCAATAAATAGAGAAAAAGTAATAAATTGGATAAAATCTAATTCGTCATTAGAAGTAGAAGATCTAA
CATTTAAATATGCTATGATTGCTATACAAGGAAGAAATGTGTGGAATTACATAGAAAAGACTGATCTACAACCATTAGAA
TTTAAAATTAATACTAAATTTCTTGGGGAAGAAGTCTTTCTTATTAGCAGATCAGGGTGGACTGGAGAAGATGGAGTAGA
AGTTTGGGGAAGCCCAGAAGTAATCTCAAAAATTATTCAAAGACTTATTTCGGTAGGAGTTAAACCATCTGGTTTAATTT
GTAGAGATAGTATAAGACAAGAAATGGGATTTGTATTGTATGGAGAAGATATAGATGAGAACATAACTCCCGTAGAAGCA
AGATATTGGGTTTTCTCTCTTGATAAACAATTTATTGGCAGAGAGAAAATAGTAGAACAGTTAAAGAATGGTGTCGAAAA
AATAAGAGTTGGATTAAAATTAAAGAAAGGAGAAAGAAGTATTCCTAGAAAAGATAATAAGATAAAAATACTAGATAACG
AAATTGGATATGTAACAAGTTCAACGTTTTCACCCTATCTTAATAGAGTCATAGGAATGGGGTATATTAACTCAAAATAC
GCTCTATTCGGCTACTCTGCCAATATAGAGATAAGAAATAGGCAAGTTGAAGCTAAATTACAAGACTTTCCATTTATTTA
G

Upstream 100 bases:

>100_bases
CCTATACTTTTCAACATCTCCTCTATATACTTTATATTTGGTAGCCATGGATGCATGTCCATATAAATATGCCTACTAGT
ATTCAATATGTGAATTAAAA

Downstream 100 bases:

>100_bases
TGATAGTAATGTCAGAAATTATAGTCGGTGGAAAATACAAAGTATTAAAAGATAGATATTATTCAGAAACAGATGAGTGG
ATATTGGTTAAAGAAAACAT

Product: glycine cleavage system aminomethyltransferase T

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MFSTPLLDIELKLNADIGEFAGWKMPMKYTSYQEEHLAVRSSAAFFDLSHMGRLKITGKIDEFDLLIAKDIKKASYNTMI
GPTAFLNDKGGFIDDVMTYKLSDTEFLIVTNAINREKVINWIKSNSSLEVEDLTFKYAMIAIQGRNVWNYIEKTDLQPLE
FKINTKFLGEEVFLISRSGWTGEDGVEVWGSPEVISKIIQRLISVGVKPSGLICRDSIRQEMGFVLYGEDIDENITPVEA
RYWVFSLDKQFIGREKIVEQLKNGVEKIRVGLKLKKGERSIPRKDNKIKILDNEIGYVTSSTFSPYLNRVIGMGYINSKY
ALFGYSANIEIRNRQVEAKLQDFPFI

Sequences:

>Translated_346_residues
MFSTPLLDIELKLNADIGEFAGWKMPMKYTSYQEEHLAVRSSAAFFDLSHMGRLKITGKIDEFDLLIAKDIKKASYNTMI
GPTAFLNDKGGFIDDVMTYKLSDTEFLIVTNAINREKVINWIKSNSSLEVEDLTFKYAMIAIQGRNVWNYIEKTDLQPLE
FKINTKFLGEEVFLISRSGWTGEDGVEVWGSPEVISKIIQRLISVGVKPSGLICRDSIRQEMGFVLYGEDIDENITPVEA
RYWVFSLDKQFIGREKIVEQLKNGVEKIRVGLKLKKGERSIPRKDNKIKILDNEIGYVTSSTFSPYLNRVIGMGYINSKY
ALFGYSANIEIRNRQVEAKLQDFPFI
>Mature_346_residues
MFSTPLLDIELKLNADIGEFAGWKMPMKYTSYQEEHLAVRSSAAFFDLSHMGRLKITGKIDEFDLLIAKDIKKASYNTMI
GPTAFLNDKGGFIDDVMTYKLSDTEFLIVTNAINREKVINWIKSNSSLEVEDLTFKYAMIAIQGRNVWNYIEKTDLQPLE
FKINTKFLGEEVFLISRSGWTGEDGVEVWGSPEVISKIIQRLISVGVKPSGLICRDSIRQEMGFVLYGEDIDENITPVEA
RYWVFSLDKQFIGREKIVEQLKNGVEKIRVGLKLKKGERSIPRKDNKIKILDNEIGYVTSSTFSPYLNRVIGMGYINSKY
ALFGYSANIEIRNRQVEAKLQDFPFI

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=369, Percent_Identity=32.2493224932249, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI257796258, Length=354, Percent_Identity=32.2033898305085, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI257796254, Length=361, Percent_Identity=31.0249307479224, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI257796256, Length=283, Percent_Identity=32.1554770318021, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI194306651, Length=306, Percent_Identity=22.8758169934641, Blast_Score=72, Evalue=5e-13,
Organism=Escherichia coli, GI1789272, Length=359, Percent_Identity=32.8690807799443, Blast_Score=174, Evalue=7e-45,
Organism=Caenorhabditis elegans, GI17560118, Length=375, Percent_Identity=32, Blast_Score=156, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6320222, Length=382, Percent_Identity=32.9842931937173, Blast_Score=157, Evalue=3e-39,
Organism=Drosophila melanogaster, GI20129441, Length=369, Percent_Identity=31.4363143631436, Blast_Score=161, Evalue=5e-40,
Organism=Drosophila melanogaster, GI28571104, Length=283, Percent_Identity=24.7349823321555, Blast_Score=72, Evalue=6e-13,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 39571; Mature: 39571

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSTPLLDIELKLNADIGEFAGWKMPMKYTSYQEEHLAVRSSAAFFDLSHMGRLKITGKI
CCCCCEEEEEEEECCCCHHHCCCCCCCCCCCCCHHHHHHCCCCCEEECCCCCEEEEEECC
DEFDLLIAKDIKKASYNTMIGPTAFLNDKGGFIDDVMTYKLSDTEFLIVTNAINREKVIN
CCCEEEEHHHHHHCCCCCCCCCEEEECCCCCCCCCEEEEEECCCEEEEEECCCCHHHHHH
WIKSNSSLEVEDLTFKYAMIAIQGRNVWNYIEKTDLQPLEFKINTKFLGEEVFLISRSGW
HHHCCCCEEEEHEEEEEEEEEEECCCHHHHHHHCCCCCEEEEEEEEECCCEEEEEECCCC
TGEDGVEVWGSPEVISKIIQRLISVGVKPSGLICRDSIRQEMGFVLYGEDIDENITPVEA
CCCCCCEECCCHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHCCEEEECCCCCCCCCCEEE
RYWVFSLDKQFIGREKIVEQLKNGVEKIRVGLKLKKGERSIPRKDNKIKILDNEIGYVTS
EEEEEECCHHHCCHHHHHHHHHHHHHHEEECEEEECCCCCCCCCCCEEEEEECCCCEEEC
STFSPYLNRVIGMGYINSKYALFGYSANIEIRNRQVEAKLQDFPFI
CCHHHHHHHHHCCCEECCEEEEEEEEECEEEECCEEEEHHHCCCCC
>Mature Secondary Structure
MFSTPLLDIELKLNADIGEFAGWKMPMKYTSYQEEHLAVRSSAAFFDLSHMGRLKITGKI
CCCCCEEEEEEEECCCCHHHCCCCCCCCCCCCCHHHHHHCCCCCEEECCCCCEEEEEECC
DEFDLLIAKDIKKASYNTMIGPTAFLNDKGGFIDDVMTYKLSDTEFLIVTNAINREKVIN
CCCEEEEHHHHHHCCCCCCCCCEEEECCCCCCCCCEEEEEECCCEEEEEECCCCHHHHHH
WIKSNSSLEVEDLTFKYAMIAIQGRNVWNYIEKTDLQPLEFKINTKFLGEEVFLISRSGW
HHHCCCCEEEEHEEEEEEEEEEECCCHHHHHHHCCCCCEEEEEEEEECCCEEEEEECCCC
TGEDGVEVWGSPEVISKIIQRLISVGVKPSGLICRDSIRQEMGFVLYGEDIDENITPVEA
CCCCCCEECCCHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHCCEEEECCCCCCCCCCEEE
RYWVFSLDKQFIGREKIVEQLKNGVEKIRVGLKLKKGERSIPRKDNKIKILDNEIGYVTS
EEEEEECCHHHCCHHHHHHHHHHHHHHEEECEEEECCCCCCCCCCCEEEEEECCCCEEEC
STFSPYLNRVIGMGYINSKYALFGYSANIEIRNRQVEAKLQDFPFI
CCHHHHHHHHHCCCEECCEEEEEEEEECEEEECCEEEEHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10382966 [H]