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The map label for this gene is ygeZ [C]

Identifier: 15921373

GI number: 15921373

Start: 1110494

End: 1111888

Strand: Reverse

Name: ygeZ [C]

Synonym: ST1118

Alternate gene names: 15921373

Gene position: 1111888-1110494 (Counterclockwise)

Preceding gene: 15921374

Following gene: 15921372

Centisome position: 41.26

GC content: 34.55

Gene sequence:

>1395_bases
ATGGTCTATGATTTAATTCTGAAAAATGTAAAAGCATTTACCGTATCAGGACCTTTCGAAGGAGATATTGCAATAAAAGA
TGGTAAAATAGCCAAAATAGGAGGAGATATACAAGAACAAGCAAATAAAGTAATAGACTTAACTGGAAAGTATGTTGTAC
CAGGTTTAATAGATGGTCATACTCACATGGAATTTCCCTTTATGAAAGAAGTTACCGCAGATGACTTCTATTATGGTACT
AGAGCTGCAGTTGCAGGAGGCGTAACTACTATTGTAGATTTCATAACTCCAGCTAAAGGTCAAGATTTATTAAGTGCATA
TGAGCAATGGAGGAGTAATGCTGATCCTAAAGTCATTTCAGATTATGGTCTTCATATGATTATACGAGAGAGTAATACTA
AAATTCTTGAACAAATCCCAGAAATAATAAATAAGGGGGTAGTGAGTTTTAAGTTATTTATGGCTTATAAAAACGAGTTT
ATGCTATCAGATGGGGAATTATATAAATTAATAAAAAGGATTAATGATTTTGGTGGTGTAATAGGTATACACGCAGAAAA
CGGAGAAATTATTAATGAATTGATACAACAATTCGTTTCAGAGGGCAAGATAGAGCCTATATATCATTATTATTCTAGGC
CCGACATAATGGAAATAGAGGCTACAAACAGAATAGCGTCTATCGCAAGTATGCTAGGTAAAGACGTTAAAATGTATATA
GTGCATACGTCTACTGGTGAAGCGGTAGATATTATGTCATCCTATAGAAAGCAAGGTTTCAAGTTTTATAATGAAACTGT
TCCTCACTATTTAACTTTAAACACTGATTTCTTAAAGAGGCCTGATGGTTACAGATATGTTATGAGTCCTCCTTTAAGAA
GTGATGAGCAGAGAACTAAATTATGGATGAGGTTAGCCTCTGGTGACATTTTTACTGTAGGTAGTGATCATTGTGTATAT
TCTGATGCTCAAAAGAAGAGGTATAGAGAGGAAGTGCCTCCTTTCCATGAGATTCCTAACGGAGTACCAGGTACTGAAAC
TATTCTACCTATCCTATTCTATTATGGTGTAAAGAAGGGAATAATAGGTATGGAAAGATTTATTGAAGTTACATCTTATA
ATCCTGCAAGGCTATTTGGTTTATATCCAAGAAAGGGAACTATAATGCCTGGCTCTGATGCTGACTTTGCAGTAATAGAT
CCTAATAGAAAAGTTAGGATATCTGCAGATGTTCTTCATAGTAATATTAACTACACGATATATGAAGGAATGGAAGTAGA
GGGATGGAATATTATGACTATAAGGAGAGGAGAAATAGTTTATGAAGAAGGTCAAGTAATAGGCAAAAAAGGAAGCGGTA
AATACATACCAGGCAAAACACCCGTTTTAGTGTGA

Upstream 100 bases:

>100_bases
TAGTTTCCAATTCAACAATTTTATTCCCTTTTTTGCTTAAAAAAATCCATTATTAATGACAGTATGATTTATAAAGCAAT
TAAAGCTATATGGTATTCTG

Downstream 100 bases:

>100_bases
TGGAAAATGACGGAAAAGGTTATAGATAGAGTGTCTATAACAAAATACTACCCAGAAACGGGTCAAGTAGAACTTACGGA
GACTTTTCCAAATGAAAAAT

Product: phenylhydantoinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 464; Mature: 464

Protein sequence:

>464_residues
MVYDLILKNVKAFTVSGPFEGDIAIKDGKIAKIGGDIQEQANKVIDLTGKYVVPGLIDGHTHMEFPFMKEVTADDFYYGT
RAAVAGGVTTIVDFITPAKGQDLLSAYEQWRSNADPKVISDYGLHMIIRESNTKILEQIPEIINKGVVSFKLFMAYKNEF
MLSDGELYKLIKRINDFGGVIGIHAENGEIINELIQQFVSEGKIEPIYHYYSRPDIMEIEATNRIASIASMLGKDVKMYI
VHTSTGEAVDIMSSYRKQGFKFYNETVPHYLTLNTDFLKRPDGYRYVMSPPLRSDEQRTKLWMRLASGDIFTVGSDHCVY
SDAQKKRYREEVPPFHEIPNGVPGTETILPILFYYGVKKGIIGMERFIEVTSYNPARLFGLYPRKGTIMPGSDADFAVID
PNRKVRISADVLHSNINYTIYEGMEVEGWNIMTIRRGEIVYEEGQVIGKKGSGKYIPGKTPVLV

Sequences:

>Translated_464_residues
MVYDLILKNVKAFTVSGPFEGDIAIKDGKIAKIGGDIQEQANKVIDLTGKYVVPGLIDGHTHMEFPFMKEVTADDFYYGT
RAAVAGGVTTIVDFITPAKGQDLLSAYEQWRSNADPKVISDYGLHMIIRESNTKILEQIPEIINKGVVSFKLFMAYKNEF
MLSDGELYKLIKRINDFGGVIGIHAENGEIINELIQQFVSEGKIEPIYHYYSRPDIMEIEATNRIASIASMLGKDVKMYI
VHTSTGEAVDIMSSYRKQGFKFYNETVPHYLTLNTDFLKRPDGYRYVMSPPLRSDEQRTKLWMRLASGDIFTVGSDHCVY
SDAQKKRYREEVPPFHEIPNGVPGTETILPILFYYGVKKGIIGMERFIEVTSYNPARLFGLYPRKGTIMPGSDADFAVID
PNRKVRISADVLHSNINYTIYEGMEVEGWNIMTIRRGEIVYEEGQVIGKKGSGKYIPGKTPVLV
>Mature_464_residues
MVYDLILKNVKAFTVSGPFEGDIAIKDGKIAKIGGDIQEQANKVIDLTGKYVVPGLIDGHTHMEFPFMKEVTADDFYYGT
RAAVAGGVTTIVDFITPAKGQDLLSAYEQWRSNADPKVISDYGLHMIIRESNTKILEQIPEIINKGVVSFKLFMAYKNEF
MLSDGELYKLIKRINDFGGVIGIHAENGEIINELIQQFVSEGKIEPIYHYYSRPDIMEIEATNRIASIASMLGKDVKMYI
VHTSTGEAVDIMSSYRKQGFKFYNETVPHYLTLNTDFLKRPDGYRYVMSPPLRSDEQRTKLWMRLASGDIFTVGSDHCVY
SDAQKKRYREEVPPFHEIPNGVPGTETILPILFYYGVKKGIIGMERFIEVTSYNPARLFGLYPRKGTIMPGSDADFAVID
PNRKVRISADVLHSNINYTIYEGMEVEGWNIMTIRRGEIVYEEGQVIGKKGSGKYIPGKTPVLV

Specific function: Catalyzes the stereospecific hydrolysis of the cyclic amide bond of D-hydantoin. Has no activity on dihydropyrimidines [H]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503375, Length=449, Percent_Identity=39.6436525612472, Blast_Score=331, Evalue=8e-91,
Organism=Homo sapiens, GI4503377, Length=463, Percent_Identity=37.3650107991361, Blast_Score=294, Evalue=9e-80,
Organism=Homo sapiens, GI19923821, Length=459, Percent_Identity=37.037037037037, Blast_Score=293, Evalue=2e-79,
Organism=Homo sapiens, GI4503379, Length=459, Percent_Identity=35.9477124183007, Blast_Score=283, Evalue=2e-76,
Organism=Homo sapiens, GI4503051, Length=462, Percent_Identity=35.9307359307359, Blast_Score=279, Evalue=4e-75,
Organism=Homo sapiens, GI62422571, Length=462, Percent_Identity=35.9307359307359, Blast_Score=278, Evalue=1e-74,
Organism=Homo sapiens, GI190194363, Length=450, Percent_Identity=34.8888888888889, Blast_Score=273, Evalue=3e-73,
Organism=Homo sapiens, GI18105007, Length=419, Percent_Identity=25.0596658711217, Blast_Score=105, Evalue=7e-23,
Organism=Escherichia coli, GI87082175, Length=464, Percent_Identity=36.8534482758621, Blast_Score=316, Evalue=2e-87,
Organism=Escherichia coli, GI1786722, Length=468, Percent_Identity=29.7008547008547, Blast_Score=190, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI17539558, Length=464, Percent_Identity=39.0086206896552, Blast_Score=325, Evalue=3e-89,
Organism=Caenorhabditis elegans, GI71989490, Length=465, Percent_Identity=39.1397849462366, Blast_Score=325, Evalue=4e-89,
Organism=Caenorhabditis elegans, GI86575075, Length=448, Percent_Identity=25, Blast_Score=142, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI193204318, Length=420, Percent_Identity=24.5238095238095, Blast_Score=103, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6322218, Length=459, Percent_Identity=27.2331154684096, Blast_Score=138, Evalue=1e-33,
Organism=Drosophila melanogaster, GI17137462, Length=461, Percent_Identity=37.0932754880694, Blast_Score=303, Evalue=2e-82,
Organism=Drosophila melanogaster, GI221377917, Length=466, Percent_Identity=37.7682403433476, Blast_Score=301, Evalue=7e-82,
Organism=Drosophila melanogaster, GI24644287, Length=309, Percent_Identity=37.5404530744337, Blast_Score=198, Evalue=6e-51,
Organism=Drosophila melanogaster, GI24644289, Length=230, Percent_Identity=41.7391304347826, Blast_Score=181, Evalue=1e-45,
Organism=Drosophila melanogaster, GI24642586, Length=419, Percent_Identity=25.0596658711217, Blast_Score=112, Evalue=8e-25,
Organism=Drosophila melanogaster, GI18859883, Length=435, Percent_Identity=26.4367816091954, Blast_Score=102, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011778
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: 3.-.-.- [C]

Molecular weight: Translated: 52351; Mature: 52351

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVYDLILKNVKAFTVSGPFEGDIAIKDGKIAKIGGDIQEQANKVIDLTGKYVVPGLIDGH
CHHHHHHCCCEEEEECCCCCCCEEEECCEEEEECCCHHHHCCCEEEECCCEEECCEECCC
THMEFPFMKEVTADDFYYGTRAAVAGGVTTIVDFITPAKGQDLLSAYEQWRSNADPKVIS
CCCCCCHHHHCCCCCCCCCCHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEE
DYGLHMIIRESNTKILEQIPEIINKGVVSFKLFMAYKNEFMLSDGELYKLIKRINDFGGV
CCCEEEEEECCCCHHHHHHHHHHHCCHHHEEEEEECCCCEEECCHHHHHHHHHHHHCCCE
IGIHAENGEIINELIQQFVSEGKIEPIYHYYSRPDIMEIEATNRIASIASMLGKDVKMYI
EEEECCCCHHHHHHHHHHHHCCCCCCHHHHCCCCCEEEEEHHHHHHHHHHHHCCCEEEEE
VHTSTGEAVDIMSSYRKQGFKFYNETVPHYLTLNTDFLKRPDGYRYVMSPPLRSDEQRTK
EECCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHCCCCCCEEEECCCCCCCHHHHH
LWMRLASGDIFTVGSDHCVYSDAQKKRYREEVPPFHEIPNGVPGTETILPILFYYGVKKG
HHHHEECCCEEEECCCCEEECCHHHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHHHHHHC
IIGMERFIEVTSYNPARLFGLYPRKGTIMPGSDADFAVIDPNRKVRISADVLHSNINYTI
CCCHHHHEEECCCCCCCEEEECCCCCCCCCCCCCCEEEECCCCEEEEEHHHHHCCCCEEE
YEGMEVEGWNIMTIRRGEIVYEEGQVIGKKGSGKYIPGKTPVLV
EECEEECCEEEEEEECCCEEEECCEEEECCCCCCCCCCCCCCCC
>Mature Secondary Structure
MVYDLILKNVKAFTVSGPFEGDIAIKDGKIAKIGGDIQEQANKVIDLTGKYVVPGLIDGH
CHHHHHHCCCEEEEECCCCCCCEEEECCEEEEECCCHHHHCCCEEEECCCEEECCEECCC
THMEFPFMKEVTADDFYYGTRAAVAGGVTTIVDFITPAKGQDLLSAYEQWRSNADPKVIS
CCCCCCHHHHCCCCCCCCCCHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEE
DYGLHMIIRESNTKILEQIPEIINKGVVSFKLFMAYKNEFMLSDGELYKLIKRINDFGGV
CCCEEEEEECCCCHHHHHHHHHHHCCHHHEEEEEECCCCEEECCHHHHHHHHHHHHCCCE
IGIHAENGEIINELIQQFVSEGKIEPIYHYYSRPDIMEIEATNRIASIASMLGKDVKMYI
EEEECCCCHHHHHHHHHHHHCCCCCCHHHHCCCCCEEEEEHHHHHHHHHHHHCCCEEEEE
VHTSTGEAVDIMSSYRKQGFKFYNETVPHYLTLNTDFLKRPDGYRYVMSPPLRSDEQRTK
EECCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHCCCCCCEEEECCCCCCCHHHHH
LWMRLASGDIFTVGSDHCVYSDAQKKRYREEVPPFHEIPNGVPGTETILPILFYYGVKKG
HHHHEECCCEEEECCCCEEECCHHHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHHHHHHC
IIGMERFIEVTSYNPARLFGLYPRKGTIMPGSDADFAVIDPNRKVRISADVLHSNINYTI
CCCHHHHEEECCCCCCCEEEECCCCCCCCCCCCCCEEEECCCCEEEEEHHHHHCCCCEEE
YEGMEVEGWNIMTIRRGEIVYEEGQVIGKKGSGKYIPGKTPVLV
EECEEECCEEEEEEECCCEEEECCEEEECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7765480 [H]