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The map label for this gene is gabT [C]

Identifier: 15921369

GI number: 15921369

Start: 1103152

End: 1104477

Strand: Reverse

Name: gabT [C]

Synonym: ST1114

Alternate gene names: 15921369

Gene position: 1104477-1103152 (Counterclockwise)

Preceding gene: 15921371

Following gene: 15921368

Centisome position: 40.99

GC content: 35.52

Gene sequence:

>1326_bases
ATGGATGATGATAAGAAAATTATAAGAGAGCATACCTTCAAGACATGGAGTAAGCAAAGTAGTTGGGAACCAATTATTGT
AACGAGTAGTAGGGGTGTCTATTTTTACGACAGCAATGGTAAAAAATATCTCGATTTTTCGTCACAATTTGTAAATGTTA
ATCTTGGTTACGGAAATGAAAGAGTAATAAATGCAATAAAAGAGCAACTTGACACTTTACAATACATTAATCCTTCTTTC
GGTGCAGTAGTTAGAGCTAAGGCTACAAAAGCACTTCTCGAAGTAATGCCAAAAAATCTTACAAAATTCTTCTTTTCAAC
ATCAGGTACAGAGGCTAATGAAGCTGCGGTAAAGGTAAGTAGGTTATATAAAAAACCATCATATAAGATATTAGCTAGGT
ATAGATCATATCATGGCTCTACAGAGGCATCAATATCGTTAACTGGTGATTACAGAAGATGGTTTGTTGAACCAAATACA
ATGCCGGGTGTAGTGAGATTTCCAGAGCCTTATTGTTTCAGATGCCCTTTAAAGCTAAAATATCCTGAGTGTAATTTAGC
ATGTGCAAATTACGTTGATTATATAATAAAGCAAGAGAAAAATGTGGCTGCAATTATAGTAGAACCAATAACTGGAACTA
ATGGCGTTATAGTTCCCCCTAAAGAGTATATGCCATTACTTTGGAAGATAGCCAAAGAGAACGACGTATTGTTTATAGCT
GATGAAGTGATGACTGGTTGGGGAAGGGTAGGGGAGTGGTTTGCGGTTAACTTATGGAACATACAGCCAGATATTTTAAC
TACTGCTAAAGGAGCCTCAGCCTCCTATGTCCCAATAGGAATTACTGCATTTAATAAGGAGATTGGTGAGTTTTTTGAAG
ACCATATATTTGCCCACGGCCATACGTTTGAAGCACATCCTGTATCATTAGCTGCAATACCGGCAGTAATTGAAGAATAC
AAGAGGTTAAACCTATTATCACATGTTAAAGTTATGGGAGAATACCTGGGGAAAAGATTACTTGAGCTTAAGGAAAGACA
TAAGAGTATTGGTGATATTAGGGGAATTGGACTATTTTGGGCTGTAGAATTAGTTAAAGATAAGAATAATACACCTTTTG
GTGATTATGAAGATAAATATGAGGGAAAACCCACAGTTGTAGATATTATATCTAAAAAAGCATTAGAGAAGGGTGTTTAT
GTATATAATGGACCCTCATGGCTCATAATCTCTCCACCCCTTATCATAAATAAAGAAGAGATAGATCAAGGTATAGAAAC
ACTAGATGAGGTAATAAAAGAAGCAGATAGTGCATTTAAAGATTAA

Upstream 100 bases:

>100_bases
TAATATTTTAAGATAGTACCGCTATTTTACTATAAGGTTGAATATTATACAAGAATAAAATAGGTCAGATTTATAAGTAG
TACTAAAATAACAATATTTT

Downstream 100 bases:

>100_bases
CATTAATAATGTTTTTATGAACTTCTTCATAATGTTGTCGTTGAGGATTTATATTTCTATAAATTTTCAGCATATAGTAA
TATGTTAATTTAATATTTAT

Product: aminotransferase

Products: L-Glutamate; Succinic semialdehyde [C]

Alternate protein names: ORF B [H]

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
MDDDKKIIREHTFKTWSKQSSWEPIIVTSSRGVYFYDSNGKKYLDFSSQFVNVNLGYGNERVINAIKEQLDTLQYINPSF
GAVVRAKATKALLEVMPKNLTKFFFSTSGTEANEAAVKVSRLYKKPSYKILARYRSYHGSTEASISLTGDYRRWFVEPNT
MPGVVRFPEPYCFRCPLKLKYPECNLACANYVDYIIKQEKNVAAIIVEPITGTNGVIVPPKEYMPLLWKIAKENDVLFIA
DEVMTGWGRVGEWFAVNLWNIQPDILTTAKGASASYVPIGITAFNKEIGEFFEDHIFAHGHTFEAHPVSLAAIPAVIEEY
KRLNLLSHVKVMGEYLGKRLLELKERHKSIGDIRGIGLFWAVELVKDKNNTPFGDYEDKYEGKPTVVDIISKKALEKGVY
VYNGPSWLIISPPLIINKEEIDQGIETLDEVIKEADSAFKD

Sequences:

>Translated_441_residues
MDDDKKIIREHTFKTWSKQSSWEPIIVTSSRGVYFYDSNGKKYLDFSSQFVNVNLGYGNERVINAIKEQLDTLQYINPSF
GAVVRAKATKALLEVMPKNLTKFFFSTSGTEANEAAVKVSRLYKKPSYKILARYRSYHGSTEASISLTGDYRRWFVEPNT
MPGVVRFPEPYCFRCPLKLKYPECNLACANYVDYIIKQEKNVAAIIVEPITGTNGVIVPPKEYMPLLWKIAKENDVLFIA
DEVMTGWGRVGEWFAVNLWNIQPDILTTAKGASASYVPIGITAFNKEIGEFFEDHIFAHGHTFEAHPVSLAAIPAVIEEY
KRLNLLSHVKVMGEYLGKRLLELKERHKSIGDIRGIGLFWAVELVKDKNNTPFGDYEDKYEGKPTVVDIISKKALEKGVY
VYNGPSWLIISPPLIINKEEIDQGIETLDEVIKEADSAFKD
>Mature_441_residues
MDDDKKIIREHTFKTWSKQSSWEPIIVTSSRGVYFYDSNGKKYLDFSSQFVNVNLGYGNERVINAIKEQLDTLQYINPSF
GAVVRAKATKALLEVMPKNLTKFFFSTSGTEANEAAVKVSRLYKKPSYKILARYRSYHGSTEASISLTGDYRRWFVEPNT
MPGVVRFPEPYCFRCPLKLKYPECNLACANYVDYIIKQEKNVAAIIVEPITGTNGVIVPPKEYMPLLWKIAKENDVLFIA
DEVMTGWGRVGEWFAVNLWNIQPDILTTAKGASASYVPIGITAFNKEIGEFFEDHIFAHGHTFEAHPVSLAAIPAVIEEY
KRLNLLSHVKVMGEYLGKRLLELKERHKSIGDIRGIGLFWAVELVKDKNNTPFGDYEDKYEGKPTVVDIISKKALEKGVY
VYNGPSWLIISPPLIINKEEIDQGIETLDEVIKEADSAFKD

Specific function: 4-aminobutyrate (GABA) degradation. [C]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI13994255, Length=436, Percent_Identity=27.0642201834862, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI37574042, Length=432, Percent_Identity=28.0092592592593, Blast_Score=155, Evalue=5e-38,
Organism=Homo sapiens, GI226442705, Length=432, Percent_Identity=28.2407407407407, Blast_Score=152, Evalue=7e-37,
Organism=Homo sapiens, GI24119277, Length=431, Percent_Identity=26.6821345707657, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI4557809, Length=436, Percent_Identity=26.605504587156, Blast_Score=142, Evalue=6e-34,
Organism=Homo sapiens, GI226442709, Length=398, Percent_Identity=27.8894472361809, Blast_Score=139, Evalue=7e-33,
Organism=Homo sapiens, GI284507298, Length=336, Percent_Identity=26.7857142857143, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI188536080, Length=385, Percent_Identity=25.4545454545455, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI38679950, Length=385, Percent_Identity=25.4545454545455, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI38679946, Length=385, Percent_Identity=25.4545454545455, Blast_Score=98, Evalue=2e-20,
Organism=Escherichia coli, GI1789016, Length=444, Percent_Identity=28.3783783783784, Blast_Score=169, Evalue=5e-43,
Organism=Escherichia coli, GI145693181, Length=412, Percent_Identity=29.8543689320388, Blast_Score=162, Evalue=6e-41,
Organism=Escherichia coli, GI1789759, Length=415, Percent_Identity=26.7469879518072, Blast_Score=145, Evalue=6e-36,
Organism=Escherichia coli, GI1788044, Length=411, Percent_Identity=26.7639902676399, Blast_Score=135, Evalue=6e-33,
Organism=Escherichia coli, GI1787560, Length=422, Percent_Identity=26.7772511848341, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1786991, Length=445, Percent_Identity=23.1460674157303, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI1786349, Length=326, Percent_Identity=25.7668711656442, Blast_Score=96, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI71992977, Length=433, Percent_Identity=29.5612009237875, Blast_Score=167, Evalue=9e-42,
Organism=Caenorhabditis elegans, GI32564660, Length=437, Percent_Identity=26.7734553775744, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI25144271, Length=419, Percent_Identity=26.2529832935561, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI25144274, Length=238, Percent_Identity=28.9915966386555, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17541228, Length=456, Percent_Identity=24.3421052631579, Blast_Score=100, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6323470, Length=434, Percent_Identity=29.0322580645161, Blast_Score=149, Evalue=9e-37,
Organism=Saccharomyces cerevisiae, GI6324432, Length=441, Percent_Identity=27.437641723356, Blast_Score=132, Evalue=8e-32,
Organism=Saccharomyces cerevisiae, GI6321456, Length=383, Percent_Identity=24.2819843342037, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6324386, Length=442, Percent_Identity=23.0769230769231, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI161085790, Length=440, Percent_Identity=29.0909090909091, Blast_Score=164, Evalue=8e-41,
Organism=Drosophila melanogaster, GI28574759, Length=441, Percent_Identity=28.5714285714286, Blast_Score=155, Evalue=4e-38,
Organism=Drosophila melanogaster, GI21356575, Length=451, Percent_Identity=26.3858093126386, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI21357415, Length=420, Percent_Identity=25.4761904761905, Blast_Score=122, Evalue=7e-28,
Organism=Drosophila melanogaster, GI281366494, Length=385, Percent_Identity=26.2337662337662, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24667139, Length=385, Percent_Identity=26.2337662337662, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24667143, Length=385, Percent_Identity=26.2337662337662, Blast_Score=87, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: 2.6.1.19 [C]

Molecular weight: Translated: 50042; Mature: 50042

Theoretical pI: Translated: 7.23; Mature: 7.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDDDKKIIREHTFKTWSKQSSWEPIIVTSSRGVYFYDSNGKKYLDFSSQFVNVNLGYGNE
CCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCEEEEECCCCEEEEECCEEEEEEECCCCH
RVINAIKEQLDTLQYINPSFGAVVRAKATKALLEVMPKNLTKFFFSTSGTEANEAAVKVS
HHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
RLYKKPSYKILARYRSYHGSTEASISLTGDYRRWFVEPNTMPGVVRFPEPYCFRCPLKLK
HHHCCCCHHHHHHHHHHCCCCCEEEEEECCCEEEEECCCCCCCEEECCCCCEEECCEEEE
YPECNLACANYVDYIIKQEKNVAAIIVEPITGTNGVIVPPKEYMPLLWKIAKENDVLFIA
CCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCEEECCHHHHHHHHHEECCCCEEEEE
DEVMTGWGRVGEWFAVNLWNIQPDILTTAKGASASYVPIGITAFNKEIGEFFEDHIFAHG
HHHHHCCCCCCCEEEEEEEECCCCCEEECCCCCCCEEEEEEEHHHHHHHHHHHHHEEECC
HTFEAHPVSLAAIPAVIEEYKRLNLLSHVKVMGEYLGKRLLELKERHKSIGDIRGIGLFW
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
AVELVKDKNNTPFGDYEDKYEGKPTVVDIISKKALEKGVYVYNGPSWLIISPPLIINKEE
HEEHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCEEEEECCEEEEECCCEEEEHHH
IDQGIETLDEVIKEADSAFKD
HHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDDDKKIIREHTFKTWSKQSSWEPIIVTSSRGVYFYDSNGKKYLDFSSQFVNVNLGYGNE
CCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCEEEEECCCCEEEEECCEEEEEEECCCCH
RVINAIKEQLDTLQYINPSFGAVVRAKATKALLEVMPKNLTKFFFSTSGTEANEAAVKVS
HHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
RLYKKPSYKILARYRSYHGSTEASISLTGDYRRWFVEPNTMPGVVRFPEPYCFRCPLKLK
HHHCCCCHHHHHHHHHHCCCCCEEEEEECCCEEEEECCCCCCCEEECCCCCEEECCEEEE
YPECNLACANYVDYIIKQEKNVAAIIVEPITGTNGVIVPPKEYMPLLWKIAKENDVLFIA
CCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCEEECCHHHHHHHHHEECCCCEEEEE
DEVMTGWGRVGEWFAVNLWNIQPDILTTAKGASASYVPIGITAFNKEIGEFFEDHIFAHG
HHHHHCCCCCCCEEEEEEEECCCCCEEECCCCCCCEEEEEEEHHHHHHHHHHHHHEEECC
HTFEAHPVSLAAIPAVIEEYKRLNLLSHVKVMGEYLGKRLLELKERHKSIGDIRGIGLFW
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
AVELVKDKNNTPFGDYEDKYEGKPTVVDIISKKALEKGVYVYNGPSWLIISPPLIINKEE
HEEHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCEEEEECCEEEEECCCEEEEHHH
IDQGIETLDEVIKEADSAFKD
HHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Pyridoxal 5'-phosphate lysine-residue [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 3.3 {4-aminobutanoate}} 1.1 {4-aminobutanoate}} 1.3 {2-oxoglutarate}} 0.7 {2-oxoglutarate}} [C]

Substrates: 4-Aminobutanoate; 2-Oxoglutarate [C]

Specific reaction: 4-Aminobutanoate + 2-Oxoglutarate --> L-Glutamate + Succinic semialdehyde [C]

General reaction: Amino group transfer [C]

Inhibitor: 2-Oxoglutarate; Lysyl reagents; SH-group reagents [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA