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The map label for this gene is dgoD [H]

Identifier: 15921363

GI number: 15921363

Start: 1095313

End: 1096434

Strand: Reverse

Name: dgoD [H]

Synonym: ST1108

Alternate gene names: 15921363

Gene position: 1096434-1095313 (Counterclockwise)

Preceding gene: 15921368

Following gene: 15921357

Centisome position: 40.69

GC content: 35.47

Gene sequence:

>1122_bases
ATGATAAAAGATATTAGAACCTACAAACTGTGTTATGAAGGAATAAATGAGGAAAGGGATGCATTAGCCGTTAAAGCCTT
AGCTGAACACCCTATGGAAATTGTAGTTACGGAAATAGAGACTTCCGATGGACAAGTAGGTTATGGCGAATCATTAGCTT
ATGGCTGTTCTGATGTAGTGAAAGTTACGATAGATAAAATTCTCAAACCACTTCTTCTTAATGAGGACGAGGAACTTATT
GAAAATTTATGGGATAAAATGTATAAAGCAACTTTAAGATTCGGAAGAAGAGGTATAGTGATTGCCGGTATTAGTGGTAT
TGATATAGCCCTTTGGGATATAATGGGTAAGAAGACAAAGAAACCGATATATAAATTATTAGGTGGAGCAAAAAAGAAAA
TTAGAGCTTATATTACTGGGGGATATTATTCAGAGAAAAAGGATTTGGAAAGGCTAAAGGATGAAGTAGCATATTACGTG
AAGATGGGCTTTAAAGGTGTTAAGATTAAAATTGGTGGAAAGTCTATGAATGAGGACTTGGAAAGACTTAAAGCTGTTAA
GGAGGTTGTAGGAGATGATGTAAGAATAGCTGTTGATGCTAATAACGTATATACCTTTGAAGAGGCATTAAAAATGGGTA
AAGAACTTGAGAAGTTAAACATATGGTTCTTTGAAGAACCGATACAGACAGATTTGTTAGATCTAAGTGCTGAGCTTGCG
AAGGCATTAGAAGTCCCAATAGCTGGATATGAGACAGCATATACTAGATGGGAGTTTTATGAGATTATGAGAAAGAAGTC
TGTAGACATAGTTCAAACTGATGCAATGTGGACTGGAGGAATATCGGAAATGATGAAAATAGGGAATATGGCTAAAGTAA
TGGGATATCCCCTTATTCCACATTACTCTGCTGGTGGAATATCACTCATAGCAAATCTTCATGTTGCAAGTGCATTAGGA
ACTGAATGGATTGAGATGCACTTAAGAAGAAACGACTTAAGGGATAAGATATTTAAGGAGCAAATTGAAATAGATGATGG
ACATTTAGTTACTCCAGATAGACCTGGATTAGGATATACTTTAAGAGAAGGTGTGCTAGAAGAGTATAAATGTAAAAGTT
AA

Upstream 100 bases:

>100_bases
GGTTATCTGTGTATGCACTATTCATTATATAAACTTCCACGAAGGGATCTTAATTTATTAAGGTTTCTTTTTATAAGTAA
GAAATGTTAATGATTATGTA

Downstream 100 bases:

>100_bases
GTTAGTTGAAGAATTTTTGTTTTAATCGGTCACTAAATGACCAATATCATATTTTCTAATTACATTATGATTTTTCGGTA
TTTTTCTAAGTCTATAGTGT

Product: mandelate racemase

Products: NA

Alternate protein names: GalD [H]

Number of amino acids: Translated: 373; Mature: 373

Protein sequence:

>373_residues
MIKDIRTYKLCYEGINEERDALAVKALAEHPMEIVVTEIETSDGQVGYGESLAYGCSDVVKVTIDKILKPLLLNEDEELI
ENLWDKMYKATLRFGRRGIVIAGISGIDIALWDIMGKKTKKPIYKLLGGAKKKIRAYITGGYYSEKKDLERLKDEVAYYV
KMGFKGVKIKIGGKSMNEDLERLKAVKEVVGDDVRIAVDANNVYTFEEALKMGKELEKLNIWFFEEPIQTDLLDLSAELA
KALEVPIAGYETAYTRWEFYEIMRKKSVDIVQTDAMWTGGISEMMKIGNMAKVMGYPLIPHYSAGGISLIANLHVASALG
TEWIEMHLRRNDLRDKIFKEQIEIDDGHLVTPDRPGLGYTLREGVLEEYKCKS

Sequences:

>Translated_373_residues
MIKDIRTYKLCYEGINEERDALAVKALAEHPMEIVVTEIETSDGQVGYGESLAYGCSDVVKVTIDKILKPLLLNEDEELI
ENLWDKMYKATLRFGRRGIVIAGISGIDIALWDIMGKKTKKPIYKLLGGAKKKIRAYITGGYYSEKKDLERLKDEVAYYV
KMGFKGVKIKIGGKSMNEDLERLKAVKEVVGDDVRIAVDANNVYTFEEALKMGKELEKLNIWFFEEPIQTDLLDLSAELA
KALEVPIAGYETAYTRWEFYEIMRKKSVDIVQTDAMWTGGISEMMKIGNMAKVMGYPLIPHYSAGGISLIANLHVASALG
TEWIEMHLRRNDLRDKIFKEQIEIDDGHLVTPDRPGLGYTLREGVLEEYKCKS
>Mature_373_residues
MIKDIRTYKLCYEGINEERDALAVKALAEHPMEIVVTEIETSDGQVGYGESLAYGCSDVVKVTIDKILKPLLLNEDEELI
ENLWDKMYKATLRFGRRGIVIAGISGIDIALWDIMGKKTKKPIYKLLGGAKKKIRAYITGGYYSEKKDLERLKDEVAYYV
KMGFKGVKIKIGGKSMNEDLERLKAVKEVVGDDVRIAVDANNVYTFEEALKMGKELEKLNIWFFEEPIQTDLLDLSAELA
KALEVPIAGYETAYTRWEFYEIMRKKSVDIVQTDAMWTGGISEMMKIGNMAKVMGYPLIPHYSAGGISLIANLHVASALG
TEWIEMHLRRNDLRDKIFKEQIEIDDGHLVTPDRPGLGYTLREGVLEEYKCKS

Specific function: Catalyzes the dehydration of D-galactonate to 2-keto-3- deoxy-D-galactonate [H]

COG id: COG4948

COG function: function code MR; L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mandelate racemase/muconate lactonizing enzyme family. GalD subfamily [H]

Homologues:

Organism=Homo sapiens, GI42544119, Length=399, Percent_Identity=23.0576441102757, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI186972148, Length=347, Percent_Identity=23.0547550432277, Blast_Score=85, Evalue=9e-17,
Organism=Homo sapiens, GI42544117, Length=395, Percent_Identity=21.5189873417722, Blast_Score=80, Evalue=4e-15,
Organism=Escherichia coli, GI48994953, Length=353, Percent_Identity=28.0453257790368, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI1787864, Length=376, Percent_Identity=23.1382978723404, Blast_Score=111, Evalue=8e-26,
Organism=Escherichia coli, GI226510960, Length=369, Percent_Identity=25.2032520325203, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1789150, Length=291, Percent_Identity=25.4295532646048, Blast_Score=65, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018110
- InterPro:   IPR013342
- InterPro:   IPR013341
- InterPro:   IPR001354 [H]

Pfam domain/function: PF01188 MR_MLE; PF02746 MR_MLE_N [H]

EC number: =4.2.1.6 [H]

Molecular weight: Translated: 42259; Mature: 42259

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKDIRTYKLCYEGINEERDALAVKALAEHPMEIVVTEIETSDGQVGYGESLAYGCSDVV
CCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCEEEEEEEEECCCCCCCCCCHHHHCHHHHH
KVTIDKILKPLLLNEDEELIENLWDKMYKATLRFGRRGIVIAGISGIDIALWDIMGKKTK
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHCCCCC
KPIYKLLGGAKKKIRAYITGGYYSEKKDLERLKDEVAYYVKMGFKGVKIKIGGKSMNEDL
HHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHH
ERLKAVKEVVGDDVRIAVDANNVYTFEEALKMGKELEKLNIWFFEEPIQTDLLDLSAELA
HHHHHHHHHHCCCEEEEEECCCEEEHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHH
KALEVPIAGYETAYTRWEFYEIMRKKSVDIVQTDAMWTGGISEMMKIGNMAKVMGYPLIP
HHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCEECCCHHHHHHHCCHHHHHCCCCCC
HYSAGGISLIANLHVASALGTEWIEMHLRRNDLRDKIFKEQIEIDDGHLVTPDRPGLGYT
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCHH
LREGVLEEYKCKS
HHHHHHHHHCCCC
>Mature Secondary Structure
MIKDIRTYKLCYEGINEERDALAVKALAEHPMEIVVTEIETSDGQVGYGESLAYGCSDVV
CCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCEEEEEEEEECCCCCCCCCCHHHHCHHHHH
KVTIDKILKPLLLNEDEELIENLWDKMYKATLRFGRRGIVIAGISGIDIALWDIMGKKTK
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHCCCCC
KPIYKLLGGAKKKIRAYITGGYYSEKKDLERLKDEVAYYVKMGFKGVKIKIGGKSMNEDL
HHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHH
ERLKAVKEVVGDDVRIAVDANNVYTFEEALKMGKELEKLNIWFFEEPIQTDLLDLSAELA
HHHHHHHHHHCCCEEEEEECCCEEEHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHH
KALEVPIAGYETAYTRWEFYEIMRKKSVDIVQTDAMWTGGISEMMKIGNMAKVMGYPLIP
HHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCEECCCHHHHHHHCCHHHHHCCCCCC
HYSAGGISLIANLHVASALGTEWIEMHLRRNDLRDKIFKEQIEIDDGHLVTPDRPGLGYT
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCHH
LREGVLEEYKCKS
HHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA