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The map label for this gene is hyuA [H]

Identifier: 15921266

GI number: 15921266

Start: 1004613

End: 1005854

Strand: Reverse

Name: hyuA [H]

Synonym: ST1020

Alternate gene names: 15921266

Gene position: 1005854-1004613 (Counterclockwise)

Preceding gene: 15921267

Following gene: 15921265

Centisome position: 37.33

GC content: 33.33

Gene sequence:

>1242_bases
ATGATTATAAAAAATGTGAGAATAATAACAAAGGAGGGAATTACAGAAGCTGAAGTCAAAATAGAAGAAGAAAGGATTGT
TAAAGTTAGTAAAGATATTCAGACTAATGAAAAAGTTTTAGATGGGGAGAGTAAACTCCTTTTACCTGGAGGAGTTGATA
ACCACGTCCATATTTATAAAAGGTACTTAAAAGTTCCAACATCTGATACTGTAGAAAAAAGCACATTAGCTGCAGCATTT
GGAGGAACAACAACTGTAATAGATTTTGCTTTTTCAGATATACAACCTAATGTTGAGGAAAGAATTAAGCAATTCTCTTC
CTCTTATGTTAATTACACTTTTCATATATTTGCTAATGATGTTACAGATAATTTGAAAAAAGCTTTTGATATAGGCTTTA
ATTCGGTTAAATTTATGATGATTGAGTATGCCGGCTTAAAAAGTACTTTAGCTGGGTTAAAGAGAATAAATGAGTTCATA
AATGAAAGACAAGGTTATGTAATGATTCACGCTGAAGATGAGGAATTAATTAGTGCATTGTCTAATAATTTAAGAGGTAG
TCCGAAACTTCATTTACTAACGAGGCCGGATGAAACTGAACTATCTGCAGCAATTAGGGCAATTCCTTTAATAGAAAACG
GATTAATAGCGCATGTAAGTAGCGGTAAAACTCTTGATTTGTTACCAGACAAAGTTAAGGCTGAGGTTGTCCTACATCAC
TTAATTTTAAGTAAGAAAGTATATGATAGAAGAGACTCATACCTTTTTGTGACCTCACCACCAGTTAGAGACCCAGAAGA
GATCTGGAAAAGAATTAATAAGGTGTCAATTATTGCTACTGATCATAATTGGTTTGACAAAGAAGTAAAGGAAAATCACA
AAGAATTTCCTGATTTAGTTCCAGGATTACCTGGTGTTGAGTTAAGGGTTCCAATTATTTTGACTGAATTCATAAAGAGA
AACCTACCACTTTATAAGGCAATAGAACTTCTCTCTGAGAACCCGGCTAAGATAAATAAATTAGATGTAGGTAAAATTGA
TATGGGCTATAGAGCTGATCTAGTAATCTATGACTCTGAAAAGAAATGGAGAGTTTCAGTAGAAAACACCCACATGGCGG
ACTGGACTCCTTATGAAGGTTACGAGATTATAGGAAAACCAGATACGATAATCATAAATGGAGAGGTTGTAATAGACAAA
GGAGAATTAGTTAGTTCACCAAAAGGAAAACTTTTAAAATAG

Upstream 100 bases:

>100_bases
ATTTATCAAAGGAAATTCATGTTAAAGCAGATAAACTATCAATATTTTACAGACATTATCTAAAAAGGAGAATTGGAAAG
TTTCCAGAGTTGGGTTTACT

Downstream 100 bases:

>100_bases
TTTTTAAAATATTTATTATATGGATTTTCTCTCTAAATATTTTAAAGAAGTAATAACTTCTATTGATATTCTTGAGAAAT
ATTCTACTGATTACTCGTAT

Product: D-hydantoinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 413; Mature: 413

Protein sequence:

>413_residues
MIIKNVRIITKEGITEAEVKIEEERIVKVSKDIQTNEKVLDGESKLLLPGGVDNHVHIYKRYLKVPTSDTVEKSTLAAAF
GGTTTVIDFAFSDIQPNVEERIKQFSSSYVNYTFHIFANDVTDNLKKAFDIGFNSVKFMMIEYAGLKSTLAGLKRINEFI
NERQGYVMIHAEDEELISALSNNLRGSPKLHLLTRPDETELSAAIRAIPLIENGLIAHVSSGKTLDLLPDKVKAEVVLHH
LILSKKVYDRRDSYLFVTSPPVRDPEEIWKRINKVSIIATDHNWFDKEVKENHKEFPDLVPGLPGVELRVPIILTEFIKR
NLPLYKAIELLSENPAKINKLDVGKIDMGYRADLVIYDSEKKWRVSVENTHMADWTPYEGYEIIGKPDTIIINGEVVIDK
GELVSSPKGKLLK

Sequences:

>Translated_413_residues
MIIKNVRIITKEGITEAEVKIEEERIVKVSKDIQTNEKVLDGESKLLLPGGVDNHVHIYKRYLKVPTSDTVEKSTLAAAF
GGTTTVIDFAFSDIQPNVEERIKQFSSSYVNYTFHIFANDVTDNLKKAFDIGFNSVKFMMIEYAGLKSTLAGLKRINEFI
NERQGYVMIHAEDEELISALSNNLRGSPKLHLLTRPDETELSAAIRAIPLIENGLIAHVSSGKTLDLLPDKVKAEVVLHH
LILSKKVYDRRDSYLFVTSPPVRDPEEIWKRINKVSIIATDHNWFDKEVKENHKEFPDLVPGLPGVELRVPIILTEFIKR
NLPLYKAIELLSENPAKINKLDVGKIDMGYRADLVIYDSEKKWRVSVENTHMADWTPYEGYEIIGKPDTIIINGEVVIDK
GELVSSPKGKLLK
>Mature_413_residues
MIIKNVRIITKEGITEAEVKIEEERIVKVSKDIQTNEKVLDGESKLLLPGGVDNHVHIYKRYLKVPTSDTVEKSTLAAAF
GGTTTVIDFAFSDIQPNVEERIKQFSSSYVNYTFHIFANDVTDNLKKAFDIGFNSVKFMMIEYAGLKSTLAGLKRINEFI
NERQGYVMIHAEDEELISALSNNLRGSPKLHLLTRPDETELSAAIRAIPLIENGLIAHVSSGKTLDLLPDKVKAEVVLHH
LILSKKVYDRRDSYLFVTSPPVRDPEEIWKRINKVSIIATDHNWFDKEVKENHKEFPDLVPGLPGVELRVPIILTEFIKR
NLPLYKAIELLSENPAKINKLDVGKIDMGYRADLVIYDSEKKWRVSVENTHMADWTPYEGYEIIGKPDTIIINGEVVIDK
GELVSSPKGKLLK

Specific function: Catalyzes the stereospecific hydrolysis of the cyclic amide bond of D-hydantoin derivatives [H]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503379, Length=454, Percent_Identity=25.3303964757709, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI4503375, Length=457, Percent_Identity=25.164113785558, Blast_Score=105, Evalue=9e-23,
Organism=Homo sapiens, GI190194363, Length=447, Percent_Identity=22.3713646532438, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI19923821, Length=454, Percent_Identity=25.5506607929515, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI4503051, Length=444, Percent_Identity=23.1981981981982, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI62422571, Length=444, Percent_Identity=23.1981981981982, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI4503377, Length=445, Percent_Identity=23.3707865168539, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI18105007, Length=401, Percent_Identity=22.6932668329177, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI87082175, Length=456, Percent_Identity=25.6578947368421, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI1786722, Length=456, Percent_Identity=22.1491228070175, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17539558, Length=451, Percent_Identity=26.1640798226164, Blast_Score=115, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI71989490, Length=459, Percent_Identity=25.4901960784314, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI193204318, Length=382, Percent_Identity=26.7015706806283, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI17137462, Length=446, Percent_Identity=25.7847533632287, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI221377917, Length=447, Percent_Identity=25.0559284116331, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24642586, Length=406, Percent_Identity=23.8916256157635, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24644289, Length=227, Percent_Identity=27.7533039647577, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24644287, Length=227, Percent_Identity=27.7533039647577, Blast_Score=72, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011778
- InterPro:   IPR011059
- InterPro:   IPR011612 [H]

Pfam domain/function: PF01979 Amidohydro_1; PF00449 Urease_alpha [H]

EC number: 3.-.-.- [C]

Molecular weight: Translated: 46760; Mature: 46760

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIKNVRIITKEGITEAEVKIEEERIVKVSKDIQTNEKVLDGESKLLLPGGVDNHVHIYK
CEEEEEEEEECCCCCHHHEEECHHHHHHHHCCCCCCCCEECCCCCEEECCCCCCHHHHHH
RYLKVPTSDTVEKSTLAAAFGGTTTVIDFAFSDIQPNVEERIKQFSSSYVNYTFHIFAND
HHHCCCCCCCHHHHHHHHHCCCCEEEEEEEHHCCCCCHHHHHHHHHCCCEEEEEEEEECC
VTDNLKKAFDIGFNSVKFMMIEYAGLKSTLAGLKRINEFINERQGYVMIHAEDEELISAL
HHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCCEEEEEECHHHHHHHH
SNNLRGSPKLHLLTRPDETELSAAIRAIPLIENGLIAHVSSGKTLDLLPDKVKAEVVLHH
HHCCCCCCCEEEEECCCHHHHHHHHHHHHEECCCEEEEECCCCEEECCCCHHHHHHHHHH
LILSKKVYDRRDSYLFVTSPPVRDPEEIWKRINKVSIIATDHNWFDKEVKENHKEFPDLV
HHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHCEEEEEEECCCCHHHHHHHHHHHHHHHC
PGLPGVELRVPIILTEFIKRNLPLYKAIELLSENPAKINKLDVGKIDMGYRADLVIYDSE
CCCCCCEEEEHHHHHHHHHCCCCHHHHHHHHCCCCCCCCEEECCEECCCCEEEEEEEECC
KKWRVSVENTHMADWTPYEGYEIIGKPDTIIINGEVVIDKGELVSSPKGKLLK
CCEEEEECCCCCCCCCCCCCEEEECCCCEEEECCEEEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MIIKNVRIITKEGITEAEVKIEEERIVKVSKDIQTNEKVLDGESKLLLPGGVDNHVHIYK
CEEEEEEEEECCCCCHHHEEECHHHHHHHHCCCCCCCCEECCCCCEEECCCCCCHHHHHH
RYLKVPTSDTVEKSTLAAAFGGTTTVIDFAFSDIQPNVEERIKQFSSSYVNYTFHIFAND
HHHCCCCCCCHHHHHHHHHCCCCEEEEEEEHHCCCCCHHHHHHHHHCCCEEEEEEEEECC
VTDNLKKAFDIGFNSVKFMMIEYAGLKSTLAGLKRINEFINERQGYVMIHAEDEELISAL
HHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCCEEEEEECHHHHHHHH
SNNLRGSPKLHLLTRPDETELSAAIRAIPLIENGLIAHVSSGKTLDLLPDKVKAEVVLHH
HHCCCCCCCEEEEECCCHHHHHHHHHHHHEECCCEEEEECCCCEEECCCCHHHHHHHHHH
LILSKKVYDRRDSYLFVTSPPVRDPEEIWKRINKVSIIATDHNWFDKEVKENHKEFPDLV
HHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHCEEEEEEECCCCHHHHHHHHHHHHHHHC
PGLPGVELRVPIILTEFIKRNLPLYKAIELLSENPAKINKLDVGKIDMGYRADLVIYDSE
CCCCCCEEEEHHHHHHHHHCCCCHHHHHHHHCCCCCCCCEEECCEECCCCEEEEEEEECC
KKWRVSVENTHMADWTPYEGYEIIGKPDTIIINGEVVIDKGELVSSPKGKLLK
CCEEEEECCCCCCCCCCCCCEEEECCCCEEEECCEEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA