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The map label for this gene is 15921219

Identifier: 15921219

GI number: 15921219

Start: 955335

End: 956108

Strand: Reverse

Name: 15921219

Synonym: ST0977

Alternate gene names: NA

Gene position: 956108-955335 (Counterclockwise)

Preceding gene: 15921220

Following gene: 15921215

Centisome position: 35.48

GC content: 33.46

Gene sequence:

>774_bases
GTGAAAGAATATAGTGGTAGAGTTTTAAATATATTTAGAAAGTTATATGGTAAAGAAATTTACGCTAAAGTGGAATCATG
GAGTAATTTTCCTAAATCTACTGGATTAGCTTCTTCAGCCGCAGGGATAGCTGCGTTAGTTTATGCTACTAATGAAGCTT
TAGAGTTAGGTTTATCACAGAAAGAATTATCAAAAATTGCAAGAATTGGTTCTGGTAGTGCTTGTAGAAGTACTGCTGGA
GGGTTTGTACTATGGGAGAAGGGAGAAAGAGATGATGGTGAAGATTCTTACTGCTACTCACTTTTCCCAGAAAACCACTG
GAAAGAACTGGTAGATATTATTGCAATTGTGAGTGAAAAGAGTAAGAAAATCTCTTCTAGAGAAGGAATGATAATTACTG
CTAAGACATCAAATTTAATGAAATGTAGGCTAAAATTTATAGAAGAAACATTACCTAAAGTAATTAAAAGTATAGAGGAA
AGGAACGAGAAAGAGTTCTACTATTGGTTAATGAGACATAGTAACAGTATGCATGCAGTTATCTTAGATTCATGGCCATC
CTTCTTTTACTTGAACGATACATCACTAAAAATTATGGAATGGATTCAAGAGTTTGGAAAAGCAGGATATACTTTTGATG
CTGGGCCAAATCCTCATATTTTTACTACTGAAAAATACAAGGACGAAGTGATAAGATTTCTCAATTCCATAGGTGTTAAT
AAGATAATTATCTCTAAAGTGGGAAGTGGACCAAAAGTTAACAAGCTTCTTTAA

Upstream 100 bases:

>100_bases
AACTTTATCTGGATTAGAGGTTAAGACTAAAATAACTTTCTCAAAAGAATTTACAAAAGACGAGGTTTATATTAATGGGG
AAAGGGCAAAAGATGAAGAA

Downstream 100 bases:

>100_bases
GTTTTTCATAATATTTTCTCATTTTATCCTCCATACTATGATGATATACTATTATCGCCTTCTTTAAGTCTCTTATTGCT
GTTATGAGATTAGAGAATTG

Product: diphosphomevalonate decarboxylase

Products: ADP; phosphate; isopentenyl diphosphate; CO2

Alternate protein names: Mevalonate Diphosphate Decarboxylase; Mevalonate Pyrophosphate Decarboxylase; Phosphomevalonate Kinase; GHMP Kinase

Number of amino acids: Translated: 257; Mature: 257

Protein sequence:

>257_residues
MKEYSGRVLNIFRKLYGKEIYAKVESWSNFPKSTGLASSAAGIAALVYATNEALELGLSQKELSKIARIGSGSACRSTAG
GFVLWEKGERDDGEDSYCYSLFPENHWKELVDIIAIVSEKSKKISSREGMIITAKTSNLMKCRLKFIEETLPKVIKSIEE
RNEKEFYYWLMRHSNSMHAVILDSWPSFFYLNDTSLKIMEWIQEFGKAGYTFDAGPNPHIFTTEKYKDEVIRFLNSIGVN
KIIISKVGSGPKVNKLL

Sequences:

>Translated_257_residues
MKEYSGRVLNIFRKLYGKEIYAKVESWSNFPKSTGLASSAAGIAALVYATNEALELGLSQKELSKIARIGSGSACRSTAG
GFVLWEKGERDDGEDSYCYSLFPENHWKELVDIIAIVSEKSKKISSREGMIITAKTSNLMKCRLKFIEETLPKVIKSIEE
RNEKEFYYWLMRHSNSMHAVILDSWPSFFYLNDTSLKIMEWIQEFGKAGYTFDAGPNPHIFTTEKYKDEVIRFLNSIGVN
KIIISKVGSGPKVNKLL
>Mature_257_residues
MKEYSGRVLNIFRKLYGKEIYAKVESWSNFPKSTGLASSAAGIAALVYATNEALELGLSQKELSKIARIGSGSACRSTAG
GFVLWEKGERDDGEDSYCYSLFPENHWKELVDIIAIVSEKSKKISSREGMIITAKTSNLMKCRLKFIEETLPKVIKSIEE
RNEKEFYYWLMRHSNSMHAVILDSWPSFFYLNDTSLKIMEWIQEFGKAGYTFDAGPNPHIFTTEKYKDEVIRFLNSIGVN
KIIISKVGSGPKVNKLL

Specific function: Unknown

COG id: COG3407

COG function: function code I; Mevalonate pyrophosphate decarboxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4505289, Length=276, Percent_Identity=35.1449275362319, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17537201, Length=222, Percent_Identity=41.4414414414414, Blast_Score=133, Evalue=9e-32,
Organism=Caenorhabditis elegans, GI17537203, Length=222, Percent_Identity=41.4414414414414, Blast_Score=133, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6324371, Length=219, Percent_Identity=41.5525114155251, Blast_Score=144, Evalue=1e-35,
Organism=Drosophila melanogaster, GI28571205, Length=273, Percent_Identity=34.7985347985348, Blast_Score=143, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 4.1.1.33

Molecular weight: Translated: 29127; Mature: 29127

Theoretical pI: Translated: 9.17; Mature: 9.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEYSGRVLNIFRKLYGKEIYAKVESWSNFPKSTGLASSAAGIAALVYATNEALELGLSQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHEEHEEECCHHHHHCCCH
KELSKIARIGSGSACRSTAGGFVLWEKGERDDGEDSYCYSLFPENHWKELVDIIAIVSEK
HHHHHHHHCCCCCCHHHCCCCEEEEECCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHH
SKKISSREGMIITAKTSNLMKCRLKFIEETLPKVIKSIEERNEKEFYYWLMRHSNSMHAV
HHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEEEECCCCEEEE
ILDSWPSFFYLNDTSLKIMEWIQEFGKAGYTFDAGPNPHIFTTEKYKDEVIRFLNSIGVN
EEECCCCEEEECCCCHHHHHHHHHHCCCCCEECCCCCCCEEECHHHHHHHHHHHHHCCCC
KIIISKVGSGPKVNKLL
EEEEEECCCCCCCCCCC
>Mature Secondary Structure
MKEYSGRVLNIFRKLYGKEIYAKVESWSNFPKSTGLASSAAGIAALVYATNEALELGLSQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHEEHEEECCHHHHHCCCH
KELSKIARIGSGSACRSTAGGFVLWEKGERDDGEDSYCYSLFPENHWKELVDIIAIVSEK
HHHHHHHHCCCCCCHHHCCCCEEEEECCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHH
SKKISSREGMIITAKTSNLMKCRLKFIEETLPKVIKSIEERNEKEFYYWLMRHSNSMHAV
HHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEEEECCCCEEEE
ILDSWPSFFYLNDTSLKIMEWIQEFGKAGYTFDAGPNPHIFTTEKYKDEVIRFLNSIGVN
EEECCCCEEEECCCCHHHHHHHHHHCCCCCEECCCCCCCEEECHHHHHHHHHHHHHCCCC
KIIISKVGSGPKVNKLL
EEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; (R)-5-diphosphomevalonate

Specific reaction: ATP + (R)-5-diphosphomevalonate = ADP + phosphate + isopentenyl diphosphate + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA