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The map label for this gene is phr [H]

Identifier: 15921125

GI number: 15921125

Start: 866984

End: 868282

Strand: Reverse

Name: phr [H]

Synonym: ST0889

Alternate gene names: 15921125

Gene position: 868282-866984 (Counterclockwise)

Preceding gene: 15921126

Following gene: 15921124

Centisome position: 32.22

GC content: 35.95

Gene sequence:

>1299_bases
GTGGATTGTATATTCATATTTCGCAGGGATTTAAGGCTTGAAGATAATACGGGGCTTAATTATGCTTTAAGTGAGTGTGA
TAGGGTAATCCCAGTTTTTATAGCAGATCCTAGGCAATTAATTAATAATCCCTACAAGTCCGAGTTTGCTGTTTCTTTTA
TGATAAACTCTTTACTTGAACTTGATGATGAGTTAAGGAAAAAGGGAAGTAGGCTTAACGTATTTTTTGGAGAGGCAGAA
AAGGTTGTGAGTAGATTCTTCAACAAGGTAGACGCTATTTACGTTAATGAAGATTATACCCCTTTTAGTATTTCCAGAGA
TGAAAAAATAAGGAAAGTATGCGAGGAAAACGGTATTGAGTTCAAAGCCTATGAGGACTATTTATTGACTCCTAAGTCCT
TATTTCATCATAGGAACTTCACTTCTTTCTATAATGAGGTTAGTAAAGTAAAGGTTAGGGAACCAGAGACTATGGAGGGT
AGTTTTGATGTTACGGATTCTTCCATGAATGTGGATTTTCTCCTTACTTTTAAGAAAATTGAGTCTCCTTTGTTTCGTGG
TGGTAGAAGAGAAGGACTTTATCTATTACATAGGAATGTGGATTTTAGAAGAAGGGATTATCCAGCTGAGAACAATAACT
ATAGGCTATCCCCACACCTTAAATTCGGAACAATATCGATGAGGGAGGCTTATTATACTCAAAAGGGTAAAGAGGAATTT
GTAAGAGAGTTGTATTGGAGAGACTTCTTTACGCTTTTAGCTTATTATAACCCTCATGTGTTTGGACATTGTTATAGGAG
AGAATATGATAATATTTCGTGGGAAAATAATGAAAGTTACTTTGAAGCATGGAAAGAGGGAAGGACGGGTTATCCGATAA
TCGATGCAGGAATGAGGATGCTTAATTCAACTGGCTATATAAATGGAAGAGTTAGGATGTTGGTGGCCTTTTTCTTAGTC
AAAGTTTTATTTGTGGACTGGAGATGGGGAGAGAGATATTTTGCTACTAAATTAGTTGACTATGACCCCGCTATTAATAA
TGGTAATTGGCAGTGGATTGCTTCTACTGGCGTTGATTACATGTTTAGAGTTTTTAATCCGTGGAAACAGCAAGAGAAAT
TTGATCCAGAGGCTAAGTTTATTAAAGAGTGGGTTGAAGAATTAAAAGACGTCCCCCCGTCAATCATTCATTCCATCTAT
AAGACAAAAGTCCCTGGTTATCCTTCACCAATAGTTAACTGGTTAGAAAGGGTTAATTATGTTAAAAGTGAATATAAGAA
TGTTAAGGCAGTTTTATAA

Upstream 100 bases:

>100_bases
GGGGATCTGCCATACTTTGCTAAAGGACTGTTAAAGGCTTTAAAAAGTGTGAGAGAAAAAAGCTAACACGATTTTTTTAT
TTTTTATTCTTTAATTGCAT

Downstream 100 bases:

>100_bases
TAAATAGAAAGTTCATGCATTTATCCATAAAATGTTAGGTGAATATCGCCAGGTAAAGGCCATACAAAGCCTTATGTTAA
TGTATATCAAATATAGGACG

Product: deoxyribodipyrimidine photolyase

Products: NA

Alternate protein names: DNA photolyase; Photoreactivating enzyme [H]

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MDCIFIFRRDLRLEDNTGLNYALSECDRVIPVFIADPRQLINNPYKSEFAVSFMINSLLELDDELRKKGSRLNVFFGEAE
KVVSRFFNKVDAIYVNEDYTPFSISRDEKIRKVCEENGIEFKAYEDYLLTPKSLFHHRNFTSFYNEVSKVKVREPETMEG
SFDVTDSSMNVDFLLTFKKIESPLFRGGRREGLYLLHRNVDFRRRDYPAENNNYRLSPHLKFGTISMREAYYTQKGKEEF
VRELYWRDFFTLLAYYNPHVFGHCYRREYDNISWENNESYFEAWKEGRTGYPIIDAGMRMLNSTGYINGRVRMLVAFFLV
KVLFVDWRWGERYFATKLVDYDPAINNGNWQWIASTGVDYMFRVFNPWKQQEKFDPEAKFIKEWVEELKDVPPSIIHSIY
KTKVPGYPSPIVNWLERVNYVKSEYKNVKAVL

Sequences:

>Translated_432_residues
MDCIFIFRRDLRLEDNTGLNYALSECDRVIPVFIADPRQLINNPYKSEFAVSFMINSLLELDDELRKKGSRLNVFFGEAE
KVVSRFFNKVDAIYVNEDYTPFSISRDEKIRKVCEENGIEFKAYEDYLLTPKSLFHHRNFTSFYNEVSKVKVREPETMEG
SFDVTDSSMNVDFLLTFKKIESPLFRGGRREGLYLLHRNVDFRRRDYPAENNNYRLSPHLKFGTISMREAYYTQKGKEEF
VRELYWRDFFTLLAYYNPHVFGHCYRREYDNISWENNESYFEAWKEGRTGYPIIDAGMRMLNSTGYINGRVRMLVAFFLV
KVLFVDWRWGERYFATKLVDYDPAINNGNWQWIASTGVDYMFRVFNPWKQQEKFDPEAKFIKEWVEELKDVPPSIIHSIY
KTKVPGYPSPIVNWLERVNYVKSEYKNVKAVL
>Mature_432_residues
MDCIFIFRRDLRLEDNTGLNYALSECDRVIPVFIADPRQLINNPYKSEFAVSFMINSLLELDDELRKKGSRLNVFFGEAE
KVVSRFFNKVDAIYVNEDYTPFSISRDEKIRKVCEENGIEFKAYEDYLLTPKSLFHHRNFTSFYNEVSKVKVREPETMEG
SFDVTDSSMNVDFLLTFKKIESPLFRGGRREGLYLLHRNVDFRRRDYPAENNNYRLSPHLKFGTISMREAYYTQKGKEEF
VRELYWRDFFTLLAYYNPHVFGHCYRREYDNISWENNESYFEAWKEGRTGYPIIDAGMRMLNSTGYINGRVRMLVAFFLV
KVLFVDWRWGERYFATKLVDYDPAINNGNWQWIASTGVDYMFRVFNPWKQQEKFDPEAKFIKEWVEELKDVPPSIIHSIY
KTKVPGYPSPIVNWLERVNYVKSEYKNVKAVL

Specific function: Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ul

COG id: COG0415

COG function: function code L; Deoxyribodipyrimidine photolyase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DNA photolyase domain [H]

Homologues:

Organism=Homo sapiens, GI4758072, Length=483, Percent_Identity=26.7080745341615, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI188536100, Length=473, Percent_Identity=28.1183932346723, Blast_Score=135, Evalue=7e-32,
Organism=Homo sapiens, GI188536103, Length=422, Percent_Identity=27.9620853080569, Blast_Score=124, Evalue=1e-28,
Organism=Escherichia coli, GI1786926, Length=464, Percent_Identity=33.6206896551724, Blast_Score=223, Evalue=1e-59,
Organism=Saccharomyces cerevisiae, GI6324962, Length=190, Percent_Identity=43.1578947368421, Blast_Score=150, Evalue=5e-37,
Organism=Drosophila melanogaster, GI17137248, Length=463, Percent_Identity=28.2937365010799, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24585455, Length=463, Percent_Identity=28.2937365010799, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24648152, Length=478, Percent_Identity=26.1506276150628, Blast_Score=149, Evalue=4e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002081
- InterPro:   IPR018394
- InterPro:   IPR006050
- InterPro:   IPR005101
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00875 DNA_photolyase; PF03441 FAD_binding_7 [H]

EC number: =4.1.99.3 [H]

Molecular weight: Translated: 51555; Mature: 51555

Theoretical pI: Translated: 7.56; Mature: 7.56

Prosite motif: PS00394 DNA_PHOTOLYASES_1_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDCIFIFRRDLRLEDNTGLNYALSECDRVIPVFIADPRQLINNPYKSEFAVSFMINSLLE
CCEEEEEEECCCCCCCCCCHHHHHHCCCEEEEEECCCHHHHCCCCHHHHHHHHHHHHHHH
LDDELRKKGSRLNVFFGEAEKVVSRFFNKVDAIYVNEDYTPFSISRDEKIRKVCEENGIE
HHHHHHHCCCEEEEEECCHHHHHHHHHHHHCEEEECCCCCCCCCCCHHHHHHHHHHCCCE
FKAYEDYLLTPKSLFHHRNFTSFYNEVSKVKVREPETMEGSFDVTDSSMNVDFLLTFKKI
EEEECCHHCCHHHHHHCCCHHHHHHHHHHEEECCCCCCCCCEEECCCCCCEEEEEEHHHH
ESPLFRGGRREGLYLLHRNVDFRRRDYPAENNNYRLSPHLKFGTISMREAYYTQKGKEEF
CCHHHCCCCCCCEEEEECCCCCHHCCCCCCCCCEEECCCEEECCEEHHHHHHHCCCHHHH
VRELYWRDFFTLLAYYNPHVFGHCYRREYDNISWENNESYFEAWKEGRTGYPIIDAGMRM
HHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHH
LNSTGYINGRVRMLVAFFLVKVLFVDWRWGERYFATKLVDYDPAINNGNWQWIASTGVDY
HHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHEECCCCCCCCCEEEEECCCHHH
MFRVFNPWKQQEKFDPEAKFIKEWVEELKDVPPSIIHSIYKTKVPGYPSPIVNWLERVNY
HHHHCCCHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHH
VKSEYKNVKAVL
HHHHHHHHHHCC
>Mature Secondary Structure
MDCIFIFRRDLRLEDNTGLNYALSECDRVIPVFIADPRQLINNPYKSEFAVSFMINSLLE
CCEEEEEEECCCCCCCCCCHHHHHHCCCEEEEEECCCHHHHCCCCHHHHHHHHHHHHHHH
LDDELRKKGSRLNVFFGEAEKVVSRFFNKVDAIYVNEDYTPFSISRDEKIRKVCEENGIE
HHHHHHHCCCEEEEEECCHHHHHHHHHHHHCEEEECCCCCCCCCCCHHHHHHHHHHCCCE
FKAYEDYLLTPKSLFHHRNFTSFYNEVSKVKVREPETMEGSFDVTDSSMNVDFLLTFKKI
EEEECCHHCCHHHHHHCCCHHHHHHHHHHEEECCCCCCCCCEEECCCCCCEEEEEEHHHH
ESPLFRGGRREGLYLLHRNVDFRRRDYPAENNNYRLSPHLKFGTISMREAYYTQKGKEEF
CCHHHCCCCCCCEEEEECCCCCHHCCCCCCCCCEEECCCEEECCEEHHHHHHHCCCHHHH
VRELYWRDFFTLLAYYNPHVFGHCYRREYDNISWENNESYFEAWKEGRTGYPIIDAGMRM
HHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHH
LNSTGYINGRVRMLVAFFLVKVLFVDWRWGERYFATKLVDYDPAINNGNWQWIASTGVDY
HHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHEECCCCCCCCCEEEEECCCHHH
MFRVFNPWKQQEKFDPEAKFIKEWVEELKDVPPSIIHSIYKTKVPGYPSPIVNWLERVNY
HHHHCCCHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHH
VKSEYKNVKAVL
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2681164; 11016950 [H]