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The map label for this gene is thsA [H]

Identifier: 15921055

GI number: 15921055

Start: 799968

End: 801605

Strand: Reverse

Name: thsA [H]

Synonym: ST0820

Alternate gene names: 15921055

Gene position: 801605-799968 (Counterclockwise)

Preceding gene: 15921056

Following gene: 15921051

Centisome position: 29.75

GC content: 34.62

Gene sequence:

>1638_bases
ATGTATAGTTTATTTAGGCAAGGTACACAAAAAGAAAGCGGAGAAGATGTATTAAGATCTAATATATTAGCTGTAAGAAC
CCTATCAGAAATGCTAAAAAGTAGCTTGGGTCCTAGAGGATTAGATAAGATGCTTATAAGCTCAACAAACGATGTAACAG
TAACAAATGATGGAGTTACAATAGTTAAAGAAATGGATGTACAGCACCCAGCAGCAAAATTGGTTGTTGAAGCAGCAAAA
GCTCAAGATACTCAAGTAGGAGACGGAACAACATCTGCTGTAGTATTAACTGGTTTCTTACTTGAACAAGCTGAGAAACT
TTTAGATCAAAAAGTCCATCCAACAATTATTATTGAAGGATATAAAAGAGCTTCAGATATAATTCTTAGTCATAGCAAAG
AAGTTGCAATAAAAATAAACACTTCAGATAAAGATTATTTAAGAAAAGTTACTTATACTTCATTATCAAGTAAATTCTTC
TCTGGTGAATCTACACTTAACAAAATCATAGACATTTCAATAGATGCTGTAGTTTCTATAGCTAAAAAACAAGACTCGTC
TTATAACATAGATCTTTCTGATATAAAATTTGTAAAGAAGAGAGGAGAAAGCGTAGATGAAACAGAACTTATTAGAGGAT
TTGTCCTAGATAAAGAAGTTGCTCATGAAAATATGCCAAGAAGAATAGAAAAGGCTAAGATAGCTATAATTGATTTTCCA
CTAGAAGTTGAAAAACCAGAAATCTCTGCAAAAATGAGTTTCACATCACCAGACCAGATAAGAGAGGCATTAGAAGAACA
ATCTAAATATGTTAAGTCCTTAGTAGATGCTTTAGCAAATGTTGGGGCAAACGTTATTGTTTCTCAAAAGGGTATGGATG
ATATAGCCTCTTACTTTATGGCTAAGAAGAAAATTATAGGAGTAAAGAATGTGAGTAGAAGTGATTTAGAGAAATTAGCA
AAATCTGTTGGGGCAAAAATAATTACAACAATAAAAGATGTTTCACCCGACGATTTAGGATATGCTGAGGTGGTTGAAGA
AAGAAAAATAGGAAATTCAAAGGCAGTATTCTTTGAAGGTGCAAAGCAGGGAGATGCTGTAACAATATTAATTAGAGGGT
CTAGTGATATTGTTATGGATGAATTAGAGAGAAGTTTTCAAGATTCATTGAATACTGTAAAGAATGTTCTACAGTATCCT
TACGTGGTGGCCGGTGGAGGAGCGTTTGAAATGGAGATGGCATTAAAGTTGAGAGAAGAGGCAAGAAAAATTGGAGGTAA
AGAACAATTAGCTGTTGAAGCCTATGCTGATGCATTAGAGGAATTTGCTATAACATTAGCTGAAACAGCTGGTTTGGATA
GTGTAGATGCTTTAGTTCAATTAAGGAACTTACATAGTAAAGGATTAAGAAATGCTGGGATTAATGTAGAGAGTGGTAAA
GTTGAGGAGGATATGGCTAAAATTGGTGTTCTTGATCCATTAATAGTAAAAGAACAAGTTATAAAGAGTTCAACTGAAGC
AGCAACAGCAATTTTAAAAATTGATGATTATATTGCAGCTGCTCCAGCAAAACCACAACCACAGCAAGGGCAAGGCGGAG
AAGGAGGCGGCGGAATGATGCCCGGAATGATGGGTTAA

Upstream 100 bases:

>100_bases
ACAAGCAGAATTCGATTAATCAGCCCCTGGTTCGTCATCAATATTCAGCCCCGCAGAGTTTCCTCATTATTTAAATATAA
CCGATTCTACTTTTAAATTC

Downstream 100 bases:

>100_bases
AAGATAGGATTTCTTTTCCATCCTTTATGAGAAAATCCTTCGCCTTTAAATCTCTCTTCTTCCCAAACATTTCCTCTCTC
GTGATAACCTCTTTCTTCCC

Product: hypothetical protein

Products: NA

Alternate protein names: Chaperonin subunit alpha; Ring complex subunit alpha; Thermophilic factor 55 alpha; TF55-alpha; Thermophilic factor 56; Thermosome subunit 1 [H]

Number of amino acids: Translated: 545; Mature: 545

Protein sequence:

>545_residues
MYSLFRQGTQKESGEDVLRSNILAVRTLSEMLKSSLGPRGLDKMLISSTNDVTVTNDGVTIVKEMDVQHPAAKLVVEAAK
AQDTQVGDGTTSAVVLTGFLLEQAEKLLDQKVHPTIIIEGYKRASDIILSHSKEVAIKINTSDKDYLRKVTYTSLSSKFF
SGESTLNKIIDISIDAVVSIAKKQDSSYNIDLSDIKFVKKRGESVDETELIRGFVLDKEVAHENMPRRIEKAKIAIIDFP
LEVEKPEISAKMSFTSPDQIREALEEQSKYVKSLVDALANVGANVIVSQKGMDDIASYFMAKKKIIGVKNVSRSDLEKLA
KSVGAKIITTIKDVSPDDLGYAEVVEERKIGNSKAVFFEGAKQGDAVTILIRGSSDIVMDELERSFQDSLNTVKNVLQYP
YVVAGGGAFEMEMALKLREEARKIGGKEQLAVEAYADALEEFAITLAETAGLDSVDALVQLRNLHSKGLRNAGINVESGK
VEEDMAKIGVLDPLIVKEQVIKSSTEAATAILKIDDYIAAAPAKPQPQQGQGGEGGGGMMPGMMG

Sequences:

>Translated_545_residues
MYSLFRQGTQKESGEDVLRSNILAVRTLSEMLKSSLGPRGLDKMLISSTNDVTVTNDGVTIVKEMDVQHPAAKLVVEAAK
AQDTQVGDGTTSAVVLTGFLLEQAEKLLDQKVHPTIIIEGYKRASDIILSHSKEVAIKINTSDKDYLRKVTYTSLSSKFF
SGESTLNKIIDISIDAVVSIAKKQDSSYNIDLSDIKFVKKRGESVDETELIRGFVLDKEVAHENMPRRIEKAKIAIIDFP
LEVEKPEISAKMSFTSPDQIREALEEQSKYVKSLVDALANVGANVIVSQKGMDDIASYFMAKKKIIGVKNVSRSDLEKLA
KSVGAKIITTIKDVSPDDLGYAEVVEERKIGNSKAVFFEGAKQGDAVTILIRGSSDIVMDELERSFQDSLNTVKNVLQYP
YVVAGGGAFEMEMALKLREEARKIGGKEQLAVEAYADALEEFAITLAETAGLDSVDALVQLRNLHSKGLRNAGINVESGK
VEEDMAKIGVLDPLIVKEQVIKSSTEAATAILKIDDYIAAAPAKPQPQQGQGGEGGGGMMPGMMG
>Mature_545_residues
MYSLFRQGTQKESGEDVLRSNILAVRTLSEMLKSSLGPRGLDKMLISSTNDVTVTNDGVTIVKEMDVQHPAAKLVVEAAK
AQDTQVGDGTTSAVVLTGFLLEQAEKLLDQKVHPTIIIEGYKRASDIILSHSKEVAIKINTSDKDYLRKVTYTSLSSKFF
SGESTLNKIIDISIDAVVSIAKKQDSSYNIDLSDIKFVKKRGESVDETELIRGFVLDKEVAHENMPRRIEKAKIAIIDFP
LEVEKPEISAKMSFTSPDQIREALEEQSKYVKSLVDALANVGANVIVSQKGMDDIASYFMAKKKIIGVKNVSRSDLEKLA
KSVGAKIITTIKDVSPDDLGYAEVVEERKIGNSKAVFFEGAKQGDAVTILIRGSSDIVMDELERSFQDSLNTVKNVLQYP
YVVAGGGAFEMEMALKLREEARKIGGKEQLAVEAYADALEEFAITLAETAGLDSVDALVQLRNLHSKGLRNAGINVESGK
VEEDMAKIGVLDPLIVKEQVIKSSTEAATAILKIDDYIAAAPAKPQPQQGQGGEGGGGMMPGMMG

Specific function: Molecular chaperone; binds unfolded polypeptides in vitro, stimulates protein folding and has ATPase activity [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TCP-1 chaperonin family [H]

Homologues:

Organism=Homo sapiens, GI38455427, Length=506, Percent_Identity=38.3399209486166, Blast_Score=349, Evalue=4e-96,
Organism=Homo sapiens, GI63162572, Length=538, Percent_Identity=33.271375464684, Blast_Score=339, Evalue=4e-93,
Organism=Homo sapiens, GI24307939, Length=508, Percent_Identity=35.2362204724409, Blast_Score=320, Evalue=2e-87,
Organism=Homo sapiens, GI57863257, Length=538, Percent_Identity=35.1301115241636, Blast_Score=320, Evalue=2e-87,
Organism=Homo sapiens, GI58761484, Length=478, Percent_Identity=32.8451882845188, Blast_Score=291, Evalue=7e-79,
Organism=Homo sapiens, GI5453607, Length=522, Percent_Identity=31.0344827586207, Blast_Score=285, Evalue=6e-77,
Organism=Homo sapiens, GI5453603, Length=538, Percent_Identity=32.7137546468402, Blast_Score=276, Evalue=3e-74,
Organism=Homo sapiens, GI4502643, Length=514, Percent_Identity=33.6575875486381, Blast_Score=275, Evalue=1e-73,
Organism=Homo sapiens, GI58331173, Length=511, Percent_Identity=31.8982387475538, Blast_Score=257, Evalue=3e-68,
Organism=Homo sapiens, GI261399877, Length=485, Percent_Identity=30.3092783505155, Blast_Score=254, Evalue=1e-67,
Organism=Homo sapiens, GI48762932, Length=535, Percent_Identity=31.9626168224299, Blast_Score=238, Evalue=1e-62,
Organism=Homo sapiens, GI302058290, Length=503, Percent_Identity=30.4174950298211, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI58331171, Length=514, Percent_Identity=29.5719844357977, Blast_Score=213, Evalue=5e-55,
Organism=Homo sapiens, GI261399875, Length=440, Percent_Identity=28.6363636363636, Blast_Score=209, Evalue=4e-54,
Organism=Homo sapiens, GI57863259, Length=353, Percent_Identity=32.8611898016997, Blast_Score=198, Evalue=1e-50,
Organism=Homo sapiens, GI302058292, Length=511, Percent_Identity=27.7886497064579, Blast_Score=194, Evalue=2e-49,
Organism=Homo sapiens, GI58331185, Length=315, Percent_Identity=28.2539682539683, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI7657253, Length=504, Percent_Identity=25.5952380952381, Blast_Score=155, Evalue=8e-38,
Organism=Homo sapiens, GI25914754, Length=458, Percent_Identity=20.7423580786026, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI9055272, Length=458, Percent_Identity=20.7423580786026, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17532603, Length=522, Percent_Identity=38.1226053639847, Blast_Score=347, Evalue=1e-95,
Organism=Caenorhabditis elegans, GI25144674, Length=515, Percent_Identity=36.3106796116505, Blast_Score=318, Evalue=4e-87,
Organism=Caenorhabditis elegans, GI17532601, Length=540, Percent_Identity=33.7037037037037, Blast_Score=313, Evalue=1e-85,
Organism=Caenorhabditis elegans, GI25148561, Length=543, Percent_Identity=31.4917127071823, Blast_Score=304, Evalue=8e-83,
Organism=Caenorhabditis elegans, GI25147750, Length=524, Percent_Identity=34.5419847328244, Blast_Score=301, Evalue=8e-82,
Organism=Caenorhabditis elegans, GI17564182, Length=547, Percent_Identity=31.2614259597806, Blast_Score=292, Evalue=3e-79,
Organism=Caenorhabditis elegans, GI25144678, Length=534, Percent_Identity=30.7116104868914, Blast_Score=252, Evalue=4e-67,
Organism=Caenorhabditis elegans, GI32566944, Length=442, Percent_Identity=30.9954751131222, Blast_Score=241, Evalue=6e-64,
Organism=Caenorhabditis elegans, GI71998178, Length=570, Percent_Identity=29.1228070175439, Blast_Score=219, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI25144680, Length=398, Percent_Identity=31.4070351758794, Blast_Score=207, Evalue=8e-54,
Organism=Caenorhabditis elegans, GI71981457, Length=326, Percent_Identity=32.2085889570552, Blast_Score=172, Evalue=4e-43,
Organism=Saccharomyces cerevisiae, GI6320058, Length=520, Percent_Identity=36.3461538461538, Blast_Score=323, Evalue=6e-89,
Organism=Saccharomyces cerevisiae, GI6322524, Length=526, Percent_Identity=34.7908745247148, Blast_Score=313, Evalue=4e-86,
Organism=Saccharomyces cerevisiae, GI6320418, Length=542, Percent_Identity=33.7638376383764, Blast_Score=309, Evalue=6e-85,
Organism=Saccharomyces cerevisiae, GI6322350, Length=551, Percent_Identity=32.486388384755, Blast_Score=300, Evalue=4e-82,
Organism=Saccharomyces cerevisiae, GI6322446, Length=526, Percent_Identity=30.2281368821293, Blast_Score=291, Evalue=2e-79,
Organism=Saccharomyces cerevisiae, GI6322049, Length=533, Percent_Identity=32.8330206378987, Blast_Score=274, Evalue=3e-74,
Organism=Saccharomyces cerevisiae, GI6322452, Length=551, Percent_Identity=28.1306715063521, Blast_Score=226, Evalue=6e-60,
Organism=Saccharomyces cerevisiae, GI6320393, Length=534, Percent_Identity=30.5243445692884, Blast_Score=224, Evalue=3e-59,
Organism=Drosophila melanogaster, GI24583944, Length=514, Percent_Identity=37.9377431906615, Blast_Score=342, Evalue=3e-94,
Organism=Drosophila melanogaster, GI24649027, Length=530, Percent_Identity=34.7169811320755, Blast_Score=306, Evalue=3e-83,
Organism=Drosophila melanogaster, GI24649029, Length=530, Percent_Identity=34.7169811320755, Blast_Score=306, Evalue=3e-83,
Organism=Drosophila melanogaster, GI17647245, Length=511, Percent_Identity=34.0508806262231, Blast_Score=297, Evalue=1e-80,
Organism=Drosophila melanogaster, GI24647512, Length=543, Percent_Identity=32.0441988950276, Blast_Score=294, Evalue=8e-80,
Organism=Drosophila melanogaster, GI24647510, Length=543, Percent_Identity=32.0441988950276, Blast_Score=294, Evalue=8e-80,
Organism=Drosophila melanogaster, GI24652903, Length=504, Percent_Identity=34.1269841269841, Blast_Score=292, Evalue=5e-79,
Organism=Drosophila melanogaster, GI24645179, Length=527, Percent_Identity=31.4990512333966, Blast_Score=287, Evalue=1e-77,
Organism=Drosophila melanogaster, GI28571140, Length=535, Percent_Identity=31.9626168224299, Blast_Score=284, Evalue=9e-77,
Organism=Drosophila melanogaster, GI18858175, Length=535, Percent_Identity=31.9626168224299, Blast_Score=284, Evalue=9e-77,
Organism=Drosophila melanogaster, GI18859933, Length=528, Percent_Identity=31.4393939393939, Blast_Score=246, Evalue=2e-65,
Organism=Drosophila melanogaster, GI19921848, Length=543, Percent_Identity=32.0441988950276, Blast_Score=236, Evalue=3e-62,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017998
- InterPro:   IPR002194
- InterPro:   IPR002423
- InterPro:   IPR012714 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 59169; Mature: 59169

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS00750 TCP1_1 ; PS00751 TCP1_2 ; PS00995 TCP1_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYSLFRQGTQKESGEDVLRSNILAVRTLSEMLKSSLGPRGLDKMLISSTNDVTVTNDGVT
CCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCEEEECCCEE
IVKEMDVQHPAAKLVVEAAKAQDTQVGDGTTSAVVLTGFLLEQAEKLLDQKVHPTIIIEG
EEEECCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEC
YKRASDIILSHSKEVAIKINTSDKDYLRKVTYTSLSSKFFSGESTLNKIIDISIDAVVSI
CHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
AKKQDSSYNIDLSDIKFVKKRGESVDETELIRGFVLDKEVAHENMPRRIEKAKIAIIDFP
HHHCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHCEEEEEECC
LEVEKPEISAKMSFTSPDQIREALEEQSKYVKSLVDALANVGANVIVSQKGMDDIASYFM
CCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHH
AKKKIIGVKNVSRSDLEKLAKSVGAKIITTIKDVSPDDLGYAEVVEERKIGNSKAVFFEG
HHHHHHCCCCCCHHHHHHHHHHHCHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCEEEEEC
AKQGDAVTILIRGSSDIVMDELERSFQDSLNTVKNVLQYPYVVAGGGAFEMEMALKLREE
CCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHH
ARKIGGKEQLAVEAYADALEEFAITLAETAGLDSVDALVQLRNLHSKGLRNAGINVESGK
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCC
VEEDMAKIGVLDPLIVKEQVIKSSTEAATAILKIDDYIAAAPAKPQPQQGQGGEGGGGMM
CHHHHHHHCCCCHHHHHHHHHHCCHHHHHEEEEEHHHHCCCCCCCCCCCCCCCCCCCCCC
PGMMG
CCCCC
>Mature Secondary Structure
MYSLFRQGTQKESGEDVLRSNILAVRTLSEMLKSSLGPRGLDKMLISSTNDVTVTNDGVT
CCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCEEEECCCEE
IVKEMDVQHPAAKLVVEAAKAQDTQVGDGTTSAVVLTGFLLEQAEKLLDQKVHPTIIIEG
EEEECCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEC
YKRASDIILSHSKEVAIKINTSDKDYLRKVTYTSLSSKFFSGESTLNKIIDISIDAVVSI
CHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
AKKQDSSYNIDLSDIKFVKKRGESVDETELIRGFVLDKEVAHENMPRRIEKAKIAIIDFP
HHHCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHCEEEEEECC
LEVEKPEISAKMSFTSPDQIREALEEQSKYVKSLVDALANVGANVIVSQKGMDDIASYFM
CCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHH
AKKKIIGVKNVSRSDLEKLAKSVGAKIITTIKDVSPDDLGYAEVVEERKIGNSKAVFFEG
HHHHHHCCCCCCHHHHHHHHHHHCHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCEEEEEC
AKQGDAVTILIRGSSDIVMDELERSFQDSLNTVKNVLQYPYVVAGGGAFEMEMALKLREE
CCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHH
ARKIGGKEQLAVEAYADALEEFAITLAETAGLDSVDALVQLRNLHSKGLRNAGINVESGK
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCC
VEEDMAKIGVLDPLIVKEQVIKSSTEAATAILKIDDYIAAAPAKPQPQQGQGGEGGGGMM
CHHHHHHHCCCCHHHHHHHHHHCCHHHHHEEEEEHHHHCCCCCCCCCCCCCCCCCCCCCC
PGMMG
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7473746 [H]