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The map label for this gene is coxL [H]

Identifier: 15920967

GI number: 15920967

Start: 720397

End: 722445

Strand: Direct

Name: coxL [H]

Synonym: ST0739

Alternate gene names: 15920967

Gene position: 720397-722445 (Clockwise)

Preceding gene: 15920966

Following gene: 15920968

Centisome position: 26.73

GC content: 36.85

Gene sequence:

>2049_bases
ATGAAACTAAGAGAACATTACTCAATCATAACCGGTAAATCAGTATATACTGATGATATAAACTTTCCAGACATGTTATA
TTTAGGTGTAGTTAGATCAACATATGCAAGGGCAATTGTAAAATCTTATACAGAACCTTCTGGAGTTGAATTATTCCTAG
ATTGGAATAAAGTTAAAACTTACATGCCAGTAAGACCGGATCCTAGGGCAAAAAACATTGTAAAAATGCCTGTAGTATCA
GATGGAAGGGTAAATTTTGTAGGTCAACCGATTGTAGCCTTTGTAGTTAAAGATAGGTACGAAATTGAGGATAAGATTGA
TGAAGTGGCTGTAGATTACGACCCATTATCACCAGTACTCACTATAGATGAATCTTTAAAGAATGAGGAAAAAATACACA
CCAACGGAAATATAGCTATCGACCTCGATCTATCTGGAGGAGAAGTTGAGAAAAGACTTACTGCTGAAGTTACTGTTGAG
AGAGAAATACTACAAGATAGAATTGTCGTGAATCCCATGGAGCCCAAGGGAGTAATTGCAAACTTTGATGGTGATAAGTT
ATACATAATCGGTAGTTTTCAGTCCTCATTTAGAATAAGGTCAGATCTACAAGAAGCCTTAGGTTTACCTCCAGAAAAAA
TAATAGTAAAATCAGCCCCAAACGTTGGAGGAGGTTTCGGAAATAAAGTCCCTGCACATCCAGAATATGTTTTAGCAGCA
ATTGCTTCTATGATCTTAAGAAAACCAGTTAAATGGATTGAAACTAGGAGAGAGCACTTAACAAATCCAACTCAAGGTAG
AGGAGTAAAATCAAAAGTTAAACTTTATGGAAAGAGAGATGGTACAATATTAGGTTTAGAAGGTGAAGTTATTGTTGATC
TGGGAGCTTACGCTTATACAATTAATACAACAACACCCGCATTCATAGCAGGCTTACTAAATGGCCCATATAAGATGAGA
TTTATGAAAATAAGAGCTTTAGGAGTTTACACAAATAAACCACCAACTGGTCCATATAGAGGTGCTGGAAGACCGGAAGC
TGCACTAATTACAGAGACGCTTGTTGAAGATTTCGCAGAGGCAATAGGCATGGATTCTGTAGAAGTAAGGAAGAAAAACT
TCCTTGATGGGGAGTTTATTACACCATTAGGTATTAAAATTGATAAGGCTGATTATACTGGATTGATAGAAAGAGGAGAA
AAAATTTATAGATCATTAAAGGAAAAATATAAAGATAAAGGTATAGCCTTAATTGCGTTTACAGAAGTTGTTAGAGCATC
GCCAGGTGAAGGTGCAAAAATAAGAGTTGGAAAAGGAAAAGTTGAATTGTTTGTCGGTACTGGACCTCATGGGCAGGCTC
ATCAATCTACTTTTGCCTTATTAGCATCAGAGGTACTTGGATTACCTCCAGAGAAGATTAACGTGACTTTGAATGATACT
GAGAATGTAAAAGAAGGAATTGGAAGTTTTGGTAGCAGATCTGCTGCAGCTGGCGGTAGTGCTGTGATTGAGGTTTGTAA
AGGACTACTTGAAGTTTTGAAGAAGAAGGGTAAAACTTTAGAAGAAGCAATAAACTCTGATGAGTATACGGAAGTTGAAA
CATTTTATAAAACCTCTGACATTTATACGCCAGGAGTTCATATTGCTGTAGTAGATATTGACGAAACATATAAGCCTAGA
GTAGTTGAATACTACGCTATTGATGATGTAGGTAGAGCTATAATAAAGGATGAAGTTGAGGGGCAAATAGTTGGCGGTAT
TTTACAAGGAATATCTCAAGTTTATCTTGAATGGGCACCATATGATGAGAATGGCAATCCAATTTATGCTAGTATTGCTG
AAGCTGGTGTTCCTACCTCTTTAGAGAGTGACTATAAACTAACTCTCGAATTTGTAGAAACACCAGCTAATCTGCCTAGT
GGTGCTAGAGGTGTTGGTGAGGCTGGAACTACTGGGGCCTTGCCAGCAACATTTATTGCTCTTGAAAAATTGCTAAAAAG
GAAATTTAACAAAACACCAATATTACCCTCAGAATTGATAACTCCTTAG

Upstream 100 bases:

>100_bases
AAGTTCGGTGATTGGAGAAGTTGGAAAACTGGGCATTAAGTAACTTCTTATAACTTGTTTGAGGAAAGCTTTATATTTAA
TAAACAAGTACTCGTCTAAC

Downstream 100 bases:

>100_bases
GCTCTTAGGGATTAGTTGATAGGCATCGTACACAGGCCCCTAACTGATTAAAGTTTAAGGACTGTAGGAAGAAAAGCAAT
AAACTGAATAATTTTCGTTT

Product: carbon-monoxide dehydrogenase large subunit

Products: NA

Alternate protein names: CO dehydrogenase subunit L; CO-DH L [H]

Number of amino acids: Translated: 682; Mature: 682

Protein sequence:

>682_residues
MKLREHYSIITGKSVYTDDINFPDMLYLGVVRSTYARAIVKSYTEPSGVELFLDWNKVKTYMPVRPDPRAKNIVKMPVVS
DGRVNFVGQPIVAFVVKDRYEIEDKIDEVAVDYDPLSPVLTIDESLKNEEKIHTNGNIAIDLDLSGGEVEKRLTAEVTVE
REILQDRIVVNPMEPKGVIANFDGDKLYIIGSFQSSFRIRSDLQEALGLPPEKIIVKSAPNVGGGFGNKVPAHPEYVLAA
IASMILRKPVKWIETRREHLTNPTQGRGVKSKVKLYGKRDGTILGLEGEVIVDLGAYAYTINTTTPAFIAGLLNGPYKMR
FMKIRALGVYTNKPPTGPYRGAGRPEAALITETLVEDFAEAIGMDSVEVRKKNFLDGEFITPLGIKIDKADYTGLIERGE
KIYRSLKEKYKDKGIALIAFTEVVRASPGEGAKIRVGKGKVELFVGTGPHGQAHQSTFALLASEVLGLPPEKINVTLNDT
ENVKEGIGSFGSRSAAAGGSAVIEVCKGLLEVLKKKGKTLEEAINSDEYTEVETFYKTSDIYTPGVHIAVVDIDETYKPR
VVEYYAIDDVGRAIIKDEVEGQIVGGILQGISQVYLEWAPYDENGNPIYASIAEAGVPTSLESDYKLTLEFVETPANLPS
GARGVGEAGTTGALPATFIALEKLLKRKFNKTPILPSELITP

Sequences:

>Translated_682_residues
MKLREHYSIITGKSVYTDDINFPDMLYLGVVRSTYARAIVKSYTEPSGVELFLDWNKVKTYMPVRPDPRAKNIVKMPVVS
DGRVNFVGQPIVAFVVKDRYEIEDKIDEVAVDYDPLSPVLTIDESLKNEEKIHTNGNIAIDLDLSGGEVEKRLTAEVTVE
REILQDRIVVNPMEPKGVIANFDGDKLYIIGSFQSSFRIRSDLQEALGLPPEKIIVKSAPNVGGGFGNKVPAHPEYVLAA
IASMILRKPVKWIETRREHLTNPTQGRGVKSKVKLYGKRDGTILGLEGEVIVDLGAYAYTINTTTPAFIAGLLNGPYKMR
FMKIRALGVYTNKPPTGPYRGAGRPEAALITETLVEDFAEAIGMDSVEVRKKNFLDGEFITPLGIKIDKADYTGLIERGE
KIYRSLKEKYKDKGIALIAFTEVVRASPGEGAKIRVGKGKVELFVGTGPHGQAHQSTFALLASEVLGLPPEKINVTLNDT
ENVKEGIGSFGSRSAAAGGSAVIEVCKGLLEVLKKKGKTLEEAINSDEYTEVETFYKTSDIYTPGVHIAVVDIDETYKPR
VVEYYAIDDVGRAIIKDEVEGQIVGGILQGISQVYLEWAPYDENGNPIYASIAEAGVPTSLESDYKLTLEFVETPANLPS
GARGVGEAGTTGALPATFIALEKLLKRKFNKTPILPSELITP
>Mature_682_residues
MKLREHYSIITGKSVYTDDINFPDMLYLGVVRSTYARAIVKSYTEPSGVELFLDWNKVKTYMPVRPDPRAKNIVKMPVVS
DGRVNFVGQPIVAFVVKDRYEIEDKIDEVAVDYDPLSPVLTIDESLKNEEKIHTNGNIAIDLDLSGGEVEKRLTAEVTVE
REILQDRIVVNPMEPKGVIANFDGDKLYIIGSFQSSFRIRSDLQEALGLPPEKIIVKSAPNVGGGFGNKVPAHPEYVLAA
IASMILRKPVKWIETRREHLTNPTQGRGVKSKVKLYGKRDGTILGLEGEVIVDLGAYAYTINTTTPAFIAGLLNGPYKMR
FMKIRALGVYTNKPPTGPYRGAGRPEAALITETLVEDFAEAIGMDSVEVRKKNFLDGEFITPLGIKIDKADYTGLIERGE
KIYRSLKEKYKDKGIALIAFTEVVRASPGEGAKIRVGKGKVELFVGTGPHGQAHQSTFALLASEVLGLPPEKINVTLNDT
ENVKEGIGSFGSRSAAAGGSAVIEVCKGLLEVLKKKGKTLEEAINSDEYTEVETFYKTSDIYTPGVHIAVVDIDETYKPR
VVEYYAIDDVGRAIIKDEVEGQIVGGILQGISQVYLEWAPYDENGNPIYASIAEAGVPTSLESDYKLTLEFVETPANLPS
GARGVGEAGTTGALPATFIALEKLLKRKFNKTPILPSELITP

Specific function: Catalyzes the oxidation of carbon monoxide to carbon dioxide [H]

COG id: COG1529

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI91823271, Length=654, Percent_Identity=24.7706422018349, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI71773480, Length=706, Percent_Identity=24.0793201133144, Blast_Score=82, Evalue=2e-15,
Organism=Escherichia coli, GI1789230, Length=530, Percent_Identity=25.2830188679245, Blast_Score=122, Evalue=1e-28,
Organism=Escherichia coli, GI1789246, Length=782, Percent_Identity=22.1227621483376, Blast_Score=121, Evalue=2e-28,
Organism=Escherichia coli, GI1786478, Length=561, Percent_Identity=23.3511586452763, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17540638, Length=541, Percent_Identity=24.9537892791128, Blast_Score=111, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17539860, Length=674, Percent_Identity=21.513353115727, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17737937, Length=652, Percent_Identity=24.3865030674847, Blast_Score=103, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000674
- InterPro:   IPR008274
- InterPro:   IPR012780 [H]

Pfam domain/function: PF01315 Ald_Xan_dh_C; PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.2.99.2 [H]

Molecular weight: Translated: 74692; Mature: 74692

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLREHYSIITGKSVYTDDINFPDMLYLGVVRSTYARAIVKSYTEPSGVELFLDWNKVKT
CCCHHHCEEEECCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCEEE
YMPVRPDPRAKNIVKMPVVSDGRVNFVGQPIVAFVVKDRYEIEDKIDEVAVDYDPLSPVL
ECCCCCCCCCCCEEECCEECCCCEEECCCCEEEEEECCCHHHHHHHHHHEECCCCCCCEE
TIDESLKNEEKIHTNGNIAIDLDLSGGEVEKRLTAEVTVEREILQDRIVVNPMEPKGVIA
EECHHHCCCCCEECCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHCCEEECCCCCCCEEE
NFDGDKLYIIGSFQSSFRIRSDLQEALGLPPEKIIVKSAPNVGGGFGNKVPAHPEYVLAA
ECCCCEEEEEECCCCHHHHHHHHHHHHCCCHHHEEEECCCCCCCCCCCCCCCCHHHHHHH
IASMILRKPVKWIETRREHLTNPTQGRGVKSKVKLYGKRDGTILGLEGEVIVDLGAYAYT
HHHHHHHCCHHHHHHHHHHCCCCCCCCCCCHHHEEEECCCCEEEECCCCEEEEECCEEEE
INTTTPAFIAGLLNGPYKMRFMKIRALGVYTNKPPTGPYRGAGRPEAALITETLVEDFAE
ECCCCHHHHHHHHCCCEEEEEEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
AIGMDSVEVRKKNFLDGEFITPLGIKIDKADYTGLIERGEKIYRSLKEKYKDKGIALIAF
HHCCCCHHHHHHCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEE
TEVVRASPGEGAKIRVGKGKVELFVGTGPHGQAHQSTFALLASEVLGLPPEKINVTLNDT
HHHHHCCCCCCCEEEECCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCC
ENVKEGIGSFGSRSAAAGGSAVIEVCKGLLEVLKKKGKTLEEAINSDEYTEVETFYKTSD
HHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCHHHHHHEECCC
IYTPGVHIAVVDIDETYKPRVVEYYAIDDVGRAIIKDEVEGQIVGGILQGISQVYLEWAP
EECCCEEEEEEECCCCCCCCEEEEEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHEEEECC
YDENGNPIYASIAEAGVPTSLESDYKLTLEFVETPANLPSGARGVGEAGTTGALPATFIA
CCCCCCEEEEEHHHCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHH
LEKLLKRKFNKTPILPSELITP
HHHHHHHHCCCCCCCCHHHCCC
>Mature Secondary Structure
MKLREHYSIITGKSVYTDDINFPDMLYLGVVRSTYARAIVKSYTEPSGVELFLDWNKVKT
CCCHHHCEEEECCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCEEE
YMPVRPDPRAKNIVKMPVVSDGRVNFVGQPIVAFVVKDRYEIEDKIDEVAVDYDPLSPVL
ECCCCCCCCCCCEEECCEECCCCEEECCCCEEEEEECCCHHHHHHHHHHEECCCCCCCEE
TIDESLKNEEKIHTNGNIAIDLDLSGGEVEKRLTAEVTVEREILQDRIVVNPMEPKGVIA
EECHHHCCCCCEECCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHCCEEECCCCCCCEEE
NFDGDKLYIIGSFQSSFRIRSDLQEALGLPPEKIIVKSAPNVGGGFGNKVPAHPEYVLAA
ECCCCEEEEEECCCCHHHHHHHHHHHHCCCHHHEEEECCCCCCCCCCCCCCCCHHHHHHH
IASMILRKPVKWIETRREHLTNPTQGRGVKSKVKLYGKRDGTILGLEGEVIVDLGAYAYT
HHHHHHHCCHHHHHHHHHHCCCCCCCCCCCHHHEEEECCCCEEEECCCCEEEEECCEEEE
INTTTPAFIAGLLNGPYKMRFMKIRALGVYTNKPPTGPYRGAGRPEAALITETLVEDFAE
ECCCCHHHHHHHHCCCEEEEEEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
AIGMDSVEVRKKNFLDGEFITPLGIKIDKADYTGLIERGEKIYRSLKEKYKDKGIALIAF
HHCCCCHHHHHHCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEE
TEVVRASPGEGAKIRVGKGKVELFVGTGPHGQAHQSTFALLASEVLGLPPEKINVTLNDT
HHHHHCCCCCCCEEEECCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCC
ENVKEGIGSFGSRSAAAGGSAVIEVCKGLLEVLKKKGKTLEEAINSDEYTEVETFYKTSD
HHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCHHHHHHEECCC
IYTPGVHIAVVDIDETYKPRVVEYYAIDDVGRAIIKDEVEGQIVGGILQGISQVYLEWAP
EECCCEEEEEEECCCCCCCCEEEEEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHEEEECC
YDENGNPIYASIAEAGVPTSLESDYKLTLEFVETPANLPSGARGVGEAGTTGALPATFIA
CCCCCCEEEEEHHHCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHH
LEKLLKRKFNKTPILPSELITP
HHHHHHHHCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7721710; 2818128; 12515558; 10430865; 12475995 [H]