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The map label for this gene is argD [H]

Identifier: 15920964

GI number: 15920964

Start: 718651

End: 719910

Strand: Direct

Name: argD [H]

Synonym: ST0735

Alternate gene names: 15920964

Gene position: 718651-719910 (Clockwise)

Preceding gene: 15920963

Following gene: 15920966

Centisome position: 26.67

GC content: 36.11

Gene sequence:

>1260_bases
ATGTTAAGCAGAAAAATTATTGAGGAGAGCGATATTTACTTAGCAACATCAACTAGGGATCCAGAATTATTTCCTCTTGT
AATTGATCACGGTGAAGGAGTATGGATTTATGATGTTGATGGAAATAAGTATCTAGATTTTACATCTGGTATAGGTGTAA
ATAATTTAGGATGGCCTTCGCATCCAGAAGTTATAAAGATAGGTATTGAACAAATGCAAAAATTAGCTCATGCTGCAGCA
AATGATTTTTACAATATTCCCCAACTGGAATTAGCTAAAAAGCTTGTGACTTATTCACCAGGTAACTTCCAAAAGAAAGT
ATTCTTTTCTAACAGCGGTACCGAAGCTATTGAGGCATCAATTAAAGTTGTCAAAAACACTGGTAGAAAATACATAATAG
CTTTTTTAGGCGGTTTTCACGGAAGAACTTTTGGTTCAATTTCTTTAACAGCAAGCAAGGCTGTACAAAGATCTATAGTA
GGGCCTTTCATGCCTGGAGTAATTCATGTTCCATACCCCAATCCCTACAGAAATCCATGGCATATTAACGGATATGAAAA
CCCTAGCGAACTAGTAAATCGTGTTATTGAATTTATTGAGGATTATATCTTTGTAAACCTAGTTCCACCGGAAGAAGTGG
CTGGAATATTTTTCGAACCTATTCAGGGTGAAGGAGGGTATGTAATCCCTCCTAAGAATTTCTTTGCTGAACTCCAGAAA
TTAGCTAAGAAATATGGAATTTTACTGGTCGATGATGAAGTCCAAATGGGTTTAGGCAGAACTGGAAAGCTCTTTGCTAT
TGAAAACTTTAACACAGTTCCAGATGTAATTACTTTAGCTAAAGCATTAGGAGGAGGGATTATGCCTATTGGTGCAACTA
TATTTAGAAAAGATCTTGATTTTAAACCCGGAATGCATAGTAACACTTTCGGTGGTAATGCTTTAGCTTGTGCAATAGGT
TCAAAGGTGATCGACATTGTTAAGGATTTATTACCTCATGTAAATGAGATAGGGAAAATATTTGCTGAGGAATTACAAGG
CTTAGCTGATGACGTAAGAGGTATTGGTTTAGCTTGGGGTTTAGAATATAATGAGAAAAAAGTAAGGGATAGGATAATAG
GTGAGAGCTTTAAACGTGGTTTACTTTTATTACCTGCCGGTAGAAGTGCAATAAGAGTTATTCCGCCCCTAGTTATTTCT
GAGGAAGAGGCTAAACAAGGACTAGACATTTTAAAGAAAGTGATTAAGGTGGTAAAATGA

Upstream 100 bases:

>100_bases
AGGACAAGCTCCTTTCTCTATTAGATGAGAAAAATAAGAGAGTATATTTAGCTGGAAAAGAATCGATTACTTTTTTACGA
ATAAGATAGAGGTTATTTTT

Downstream 100 bases:

>100_bases
TAAAATGGGTTGGCATAAAAAGTTGGGATAAGTGTGGAATTTGTTGGGCATATTTTAAGCAAGGTATTCAGCATGAAAAT
TCTTTACACTGTTACAAACT

Product: 4-aminobutyrate aminotransferase

Products: NA

Alternate protein names: ACOAT [H]

Number of amino acids: Translated: 419; Mature: 419

Protein sequence:

>419_residues
MLSRKIIEESDIYLATSTRDPELFPLVIDHGEGVWIYDVDGNKYLDFTSGIGVNNLGWPSHPEVIKIGIEQMQKLAHAAA
NDFYNIPQLELAKKLVTYSPGNFQKKVFFSNSGTEAIEASIKVVKNTGRKYIIAFLGGFHGRTFGSISLTASKAVQRSIV
GPFMPGVIHVPYPNPYRNPWHINGYENPSELVNRVIEFIEDYIFVNLVPPEEVAGIFFEPIQGEGGYVIPPKNFFAELQK
LAKKYGILLVDDEVQMGLGRTGKLFAIENFNTVPDVITLAKALGGGIMPIGATIFRKDLDFKPGMHSNTFGGNALACAIG
SKVIDIVKDLLPHVNEIGKIFAEELQGLADDVRGIGLAWGLEYNEKKVRDRIIGESFKRGLLLLPAGRSAIRVIPPLVIS
EEEAKQGLDILKKVIKVVK

Sequences:

>Translated_419_residues
MLSRKIIEESDIYLATSTRDPELFPLVIDHGEGVWIYDVDGNKYLDFTSGIGVNNLGWPSHPEVIKIGIEQMQKLAHAAA
NDFYNIPQLELAKKLVTYSPGNFQKKVFFSNSGTEAIEASIKVVKNTGRKYIIAFLGGFHGRTFGSISLTASKAVQRSIV
GPFMPGVIHVPYPNPYRNPWHINGYENPSELVNRVIEFIEDYIFVNLVPPEEVAGIFFEPIQGEGGYVIPPKNFFAELQK
LAKKYGILLVDDEVQMGLGRTGKLFAIENFNTVPDVITLAKALGGGIMPIGATIFRKDLDFKPGMHSNTFGGNALACAIG
SKVIDIVKDLLPHVNEIGKIFAEELQGLADDVRGIGLAWGLEYNEKKVRDRIIGESFKRGLLLLPAGRSAIRVIPPLVIS
EEEAKQGLDILKKVIKVVK
>Mature_419_residues
MLSRKIIEESDIYLATSTRDPELFPLVIDHGEGVWIYDVDGNKYLDFTSGIGVNNLGWPSHPEVIKIGIEQMQKLAHAAA
NDFYNIPQLELAKKLVTYSPGNFQKKVFFSNSGTEAIEASIKVVKNTGRKYIIAFLGGFHGRTFGSISLTASKAVQRSIV
GPFMPGVIHVPYPNPYRNPWHINGYENPSELVNRVIEFIEDYIFVNLVPPEEVAGIFFEPIQGEGGYVIPPKNFFAELQK
LAKKYGILLVDDEVQMGLGRTGKLFAIENFNTVPDVITLAKALGGGIMPIGATIFRKDLDFKPGMHSNTFGGNALACAIG
SKVIDIVKDLLPHVNEIGKIFAEELQGLADDVRGIGLAWGLEYNEKKVRDRIIGESFKRGLLLLPAGRSAIRVIPPLVIS
EEEAKQGLDILKKVIKVVK

Specific function: 4-aminobutyrate (GABA) degradation. [C]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=413, Percent_Identity=30.9927360774818, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI13994255, Length=431, Percent_Identity=30.3944315545244, Blast_Score=172, Evalue=4e-43,
Organism=Homo sapiens, GI284507298, Length=324, Percent_Identity=31.7901234567901, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI37574042, Length=425, Percent_Identity=27.2941176470588, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI226442705, Length=423, Percent_Identity=26.9503546099291, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI226442709, Length=388, Percent_Identity=27.5773195876289, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI188536080, Length=445, Percent_Identity=28.5393258426966, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI38679950, Length=445, Percent_Identity=28.5393258426966, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI38679946, Length=445, Percent_Identity=28.5393258426966, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI24119277, Length=420, Percent_Identity=26.4285714285714, Blast_Score=129, Evalue=5e-30,
Organism=Escherichia coli, GI1789016, Length=418, Percent_Identity=33.2535885167464, Blast_Score=217, Evalue=1e-57,
Organism=Escherichia coli, GI145693181, Length=417, Percent_Identity=31.6546762589928, Blast_Score=206, Evalue=3e-54,
Organism=Escherichia coli, GI1787560, Length=406, Percent_Identity=33.2512315270936, Blast_Score=204, Evalue=9e-54,
Organism=Escherichia coli, GI1788044, Length=404, Percent_Identity=34.4059405940594, Blast_Score=202, Evalue=4e-53,
Organism=Escherichia coli, GI1789759, Length=409, Percent_Identity=33.0073349633252, Blast_Score=187, Evalue=8e-49,
Organism=Escherichia coli, GI1786991, Length=426, Percent_Identity=27.4647887323944, Blast_Score=134, Evalue=9e-33,
Organism=Escherichia coli, GI1786349, Length=335, Percent_Identity=29.5522388059701, Blast_Score=105, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI25144271, Length=411, Percent_Identity=30.9002433090024, Blast_Score=184, Evalue=7e-47,
Organism=Caenorhabditis elegans, GI32564660, Length=428, Percent_Identity=30.3738317757009, Blast_Score=164, Evalue=9e-41,
Organism=Caenorhabditis elegans, GI25144274, Length=400, Percent_Identity=28.5, Blast_Score=149, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI71992977, Length=431, Percent_Identity=29.0023201856148, Blast_Score=145, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI17541228, Length=458, Percent_Identity=25.1091703056769, Blast_Score=109, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6323470, Length=445, Percent_Identity=31.2359550561798, Blast_Score=201, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6324432, Length=437, Percent_Identity=33.4096109839817, Blast_Score=201, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6321456, Length=447, Percent_Identity=28.4116331096197, Blast_Score=112, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6324386, Length=408, Percent_Identity=24.0196078431373, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI21357415, Length=411, Percent_Identity=30.1703163017032, Blast_Score=179, Evalue=4e-45,
Organism=Drosophila melanogaster, GI28574759, Length=432, Percent_Identity=33.1018518518519, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI161085790, Length=433, Percent_Identity=32.5635103926097, Blast_Score=171, Evalue=1e-42,
Organism=Drosophila melanogaster, GI21356575, Length=422, Percent_Identity=26.5402843601896, Blast_Score=138, Evalue=9e-33,
Organism=Drosophila melanogaster, GI281366494, Length=433, Percent_Identity=30.2540415704388, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24667139, Length=433, Percent_Identity=30.2540415704388, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24667143, Length=433, Percent_Identity=30.2540415704388, Blast_Score=127, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004636
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.11 [H]

Molecular weight: Translated: 46218; Mature: 46218

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSRKIIEESDIYLATSTRDPELFPLVIDHGEGVWIYDVDGNKYLDFTSGIGVNNLGWPS
CCCCCCCCCCCEEEEECCCCCCEEEEEEECCCEEEEEECCCCEEEEECCCCCCCCCCCCC
HPEVIKIGIEQMQKLAHAAANDFYNIPQLELAKKLVTYSPGNFQKKVFFSNSGTEAIEAS
CCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHH
IKVVKNTGRKYIIAFLGGFHGRTFGSISLTASKAVQRSIVGPFMPGVIHVPYPNPYRNPW
HHHHHHCCCEEEEEEECCCCCCCCCEEEEHHHHHHHHHHCCCCCCCEEECCCCCCCCCCE
HINGYENPSELVNRVIEFIEDYIFVNLVPPEEVAGIFFEPIQGEGGYVIPPKNFFAELQK
EECCCCCHHHHHHHHHHHHHHHEEEEECCHHHHCCCEEEEECCCCCEEECCHHHHHHHHH
LAKKYGILLVDDEVQMGLGRTGKLFAIENFNTVPDVITLAKALGGGIMPIGATIFRKDLD
HHHHCCEEEEECHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCCCHHHHHHCCC
FKPGMHSNTFGGNALACAIGSKVIDIVKDLLPHVNEIGKIFAEELQGLADDVRGIGLAWG
CCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEC
LEYNEKKVRDRIIGESFKRGLLLLPAGRSAIRVIPPLVISEEEAKQGLDILKKVIKVVK
CCCCHHHHHHHHHHHHHCCCEEEEECCCCCEEECCCCEECHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLSRKIIEESDIYLATSTRDPELFPLVIDHGEGVWIYDVDGNKYLDFTSGIGVNNLGWPS
CCCCCCCCCCCEEEEECCCCCCEEEEEEECCCEEEEEECCCCEEEEECCCCCCCCCCCCC
HPEVIKIGIEQMQKLAHAAANDFYNIPQLELAKKLVTYSPGNFQKKVFFSNSGTEAIEAS
CCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHH
IKVVKNTGRKYIIAFLGGFHGRTFGSISLTASKAVQRSIVGPFMPGVIHVPYPNPYRNPW
HHHHHHCCCEEEEEEECCCCCCCCCEEEEHHHHHHHHHHCCCCCCCEEECCCCCCCCCCE
HINGYENPSELVNRVIEFIEDYIFVNLVPPEEVAGIFFEPIQGEGGYVIPPKNFFAELQK
EECCCCCHHHHHHHHHHHHHHHEEEEECCHHHHCCCEEEEECCCCCEEECCHHHHHHHHH
LAKKYGILLVDDEVQMGLGRTGKLFAIENFNTVPDVITLAKALGGGIMPIGATIFRKDLD
HHHHCCEEEEECHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCCCHHHHHHCCC
FKPGMHSNTFGGNALACAIGSKVIDIVKDLLPHVNEIGKIFAEELQGLADDVRGIGLAWG
CCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEC
LEYNEKKVRDRIIGESFKRGLLLLPAGRSAIRVIPPLVISEEEAKQGLDILKKVIKVVK
CCCCHHHHHHHHHHHHHCCCEEEEECCCCCEEECCCCEECHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]