Click here to switch to the map view.

The map label for this gene is proC [H]

Identifier: 15920867

GI number: 15920867

Start: 631908

End: 632687

Strand: Direct

Name: proC [H]

Synonym: ST0646

Alternate gene names: 15920867

Gene position: 631908-632687 (Clockwise)

Preceding gene: 15920866

Following gene: 15920868

Centisome position: 23.45

GC content: 36.92

Gene sequence:

>780_bases
ATGAGAGTAAGTATAATAGGAGTAGGTAAGATAGGTTATGCTATTTTAAAAGGACTAAAAAGCCTTAATGTTGAAATCAT
AGGTACTGGAAGAAGTGAAGAGACCTTAGATAAAATTAAAAAAGAAGGCGTAGAGGCTACTAGAGACAATGAGTATGCTA
TAAAAAAGAGTGATATAATTATATTGGCTGTAAAACCTCAACATTTCCATTCCATCTTAGACAAGGTGAGTAAAACTGCA
TGGGAGGGTAAAAAAGTTGTTTCAGTTATGGCTGGTATAAGGATTTCTACGTTAACTAGGCTGACGAATGCTAAAGTATA
TAGGGCAATGCCTAACATAAATGCGGTCATTGGTAAGGCTACAACAGCATTAGCTGAAGAAAGAGATGAGGAAGTTGAAA
GAATTTTTAGGACTATTGGAAACGTTTACTGGATTCCAGAGGAATTGTTTGATGCATGGACAGCAATAATTGGTAGTGGT
CCAGCGTTTGTTGCAGAGATAATAGATGCTTTCGCACTAGGTGCTGTAGCATGTGGAATGTCAAGAGAACTTGCCTATCA
GGCAATATTAGATATGGTAGAAGGTACCGTATATACTTTAAGAAAGGATAAAACTCATCCGGTTCTATTGAGAGATCAGG
TAACTACTCCTGCCGGTACCACTATTAGGGGGTTAATGGTTATGGAAAGTGAGGGAATAAAATCAGCTATTATTAAGACT
ATTGAGGCTGCATATCAAAGGTCAATGGCAATAGGTAAGGAGATCGATAAAATGTATTAA

Upstream 100 bases:

>100_bases
AATTGGCTTCAGCACTAATACCATTTTTGCCTCAAGGACAGCAAGGGGGAATTAATTTACCATTTTAAAAGTTTTTAATT
CTTCTATGTTTTGATAGCTT

Downstream 100 bases:

>100_bases
GCTTATTAGTAATGAAATCGAGTATTACCTTATGATAGTAATATCATCACTTTTAGATAAAAGAATGAGTGATCATAATC
TTAATGCTAAAGATGTTATT

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 259; Mature: 259

Protein sequence:

>259_residues
MRVSIIGVGKIGYAILKGLKSLNVEIIGTGRSEETLDKIKKEGVEATRDNEYAIKKSDIIILAVKPQHFHSILDKVSKTA
WEGKKVVSVMAGIRISTLTRLTNAKVYRAMPNINAVIGKATTALAEERDEEVERIFRTIGNVYWIPEELFDAWTAIIGSG
PAFVAEIIDAFALGAVACGMSRELAYQAILDMVEGTVYTLRKDKTHPVLLRDQVTTPAGTTIRGLMVMESEGIKSAIIKT
IEAAYQRSMAIGKEIDKMY

Sequences:

>Translated_259_residues
MRVSIIGVGKIGYAILKGLKSLNVEIIGTGRSEETLDKIKKEGVEATRDNEYAIKKSDIIILAVKPQHFHSILDKVSKTA
WEGKKVVSVMAGIRISTLTRLTNAKVYRAMPNINAVIGKATTALAEERDEEVERIFRTIGNVYWIPEELFDAWTAIIGSG
PAFVAEIIDAFALGAVACGMSRELAYQAILDMVEGTVYTLRKDKTHPVLLRDQVTTPAGTTIRGLMVMESEGIKSAIIKT
IEAAYQRSMAIGKEIDKMY
>Mature_259_residues
MRVSIIGVGKIGYAILKGLKSLNVEIIGTGRSEETLDKIKKEGVEATRDNEYAIKKSDIIILAVKPQHFHSILDKVSKTA
WEGKKVVSVMAGIRISTLTRLTNAKVYRAMPNINAVIGKATTALAEERDEEVERIFRTIGNVYWIPEELFDAWTAIIGSG
PAFVAEIIDAFALGAVACGMSRELAYQAILDMVEGTVYTLRKDKTHPVLLRDQVTTPAGTTIRGLMVMESEGIKSAIIKT
IEAAYQRSMAIGKEIDKMY

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI21361454, Length=275, Percent_Identity=32.3636363636364, Blast_Score=135, Evalue=3e-32,
Organism=Homo sapiens, GI198041662, Length=268, Percent_Identity=30.9701492537313, Blast_Score=132, Evalue=4e-31,
Organism=Homo sapiens, GI24797095, Length=274, Percent_Identity=31.021897810219, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI24797097, Length=275, Percent_Identity=31.2727272727273, Blast_Score=130, Evalue=1e-30,
Organism=Escherichia coli, GI1786585, Length=265, Percent_Identity=29.4339622641509, Blast_Score=112, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17569021, Length=268, Percent_Identity=32.4626865671642, Blast_Score=144, Evalue=6e-35,
Organism=Caenorhabditis elegans, GI17540664, Length=287, Percent_Identity=28.9198606271777, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6320861, Length=229, Percent_Identity=32.3144104803493, Blast_Score=115, Evalue=9e-27,
Organism=Drosophila melanogaster, GI24648116, Length=276, Percent_Identity=31.5217391304348, Blast_Score=128, Evalue=3e-30,
Organism=Drosophila melanogaster, GI21358587, Length=264, Percent_Identity=31.4393939393939, Blast_Score=127, Evalue=9e-30,
Organism=Drosophila melanogaster, GI24647700, Length=168, Percent_Identity=35.1190476190476, Blast_Score=97, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 28477; Mature: 28477

Theoretical pI: Translated: 9.19; Mature: 9.19

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVSIIGVGKIGYAILKGLKSLNVEIIGTGRSEETLDKIKKEGVEATRDNEYAIKKSDII
CEEEEEEECHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHCCCCCCCCCCEEEEECCEE
ILAVKPQHFHSILDKVSKTAWEGKKVVSVMAGIRISTLTRLTNAKVYRAMPNINAVIGKA
EEEECCHHHHHHHHHHHHHHHCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHH
TTALAEERDEEVERIFRTIGNVYWIPEELFDAWTAIIGSGPAFVAEIIDAFALGAVACGM
HHHHHHHHHHHHHHHHHHHCCEEECHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCC
SRELAYQAILDMVEGTVYTLRKDKTHPVLLRDQVTTPAGTTIRGLMVMESEGIKSAIIKT
HHHHHHHHHHHHHCCCEEEEECCCCCCEEEECCCCCCCCCCEEEEEEEECCCHHHHHHHH
IEAAYQRSMAIGKEIDKMY
HHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRVSIIGVGKIGYAILKGLKSLNVEIIGTGRSEETLDKIKKEGVEATRDNEYAIKKSDII
CEEEEEEECHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHCCCCCCCCCCEEEEECCEE
ILAVKPQHFHSILDKVSKTAWEGKKVVSVMAGIRISTLTRLTNAKVYRAMPNINAVIGKA
EEEECCHHHHHHHHHHHHHHHCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHH
TTALAEERDEEVERIFRTIGNVYWIPEELFDAWTAIIGSGPAFVAEIIDAFALGAVACGM
HHHHHHHHHHHHHHHHHHHCCEEECHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCC
SRELAYQAILDMVEGTVYTLRKDKTHPVLLRDQVTTPAGTTIRGLMVMESEGIKSAIIKT
HHHHHHHHHHHHHCCCEEEEECCCCCCEEEECCCCCCCCCCEEEEEEEECCCHHHHHHHH
IEAAYQRSMAIGKEIDKMY
HHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]