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The map label for this gene is cobB [H]

Identifier: 15920853

GI number: 15920853

Start: 617329

End: 618183

Strand: Reverse

Name: cobB [H]

Synonym: ST0633

Alternate gene names: 15920853

Gene position: 618183-617329 (Counterclockwise)

Preceding gene: 15920854

Following gene: 15920850

Centisome position: 22.94

GC content: 34.04

Gene sequence:

>855_bases
ATGAAGATAATACAACAATTTGTTATATCAGATAATATTTTTCTTCATCTTTCCGTACTCGGCAAACTCATCATTTTTAT
TTTTTCCAAACATCTTATTTGTATGGAATGTGATAAAGTTGGTGATTTACTTTTAACATCAACTTATGCTATAGCCTTTA
CTGGAGCAGGAATAAGTACGGCATCTGGGATACCAGATTTTAGGGGACCAAATGGTTTATGGAAAAAATACTCACCAGAG
TTAGCTACAATAGAGTATTTTAAAAAAGATCCTAAAGGTTTTTGGGAATTCTACAGGTTAAGAATGAGAGGACTATTTAC
AGCTTTACCAAATAGAGCACACTACGCATTAGCTGAACTAGAGAAAATGGGATTAATAAGAGCTATAATAACACAGAATA
TTGACGGTTTACATCAATTAGCTGGTTCAAGAAATGTAATTGAACTTCACGGAAATATGAGAAAATGTTATTGTGTGAAC
TGTCTGAAAACTTATGATAGTGATACGGTATTAGATAAAATAGATAAAGAGGGACTACCACCTAAATGTGAGTGCGGAGG
AGTAATAAGACCAGATGTCGTTTTATTTGGTGAGCCAGTATATAATATTTCATCGGCTTTAGAGATAGCTAGAGAAGCTG
ATTTAGTTTTGGCAATTGGAAGCTCATTAACAGTATATCCAGCAAACATGATACCCCTAACTGTTAAAGAAATGGGTGGA
AAACTGATCATTTTAAATGCAGAAGAAACACCTCTTGATAACATAGCGGATATTGTAGTTAGAGAAAGAGTCGAAGAGTT
TTTGCCGTGTGTTGTAGATTATATTAAAAGTCAGACCCTACACCGCTCTTCATAA

Upstream 100 bases:

>100_bases
ATGTTAACTGCATATAGAGTTTTATATATAACGCCAGAATTAAGAAAAGAACTGAGCAGGCTAGTAGGGACAAGCAGAAT
AGAATGCGATAAAATAGAGA

Downstream 100 bases:

>100_bases
ATCCGATTATTTTTTATCATCACCTAATATTTTTTGATTATTCTGTTTAAAGCTTCTATGTCACCTAATGCAGATAATAA
AATCCCTTCTATTCCTTTAT

Product: NAD-dependent deacetylase

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog [H]

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MKIIQQFVISDNIFLHLSVLGKLIIFIFSKHLICMECDKVGDLLLTSTYAIAFTGAGISTASGIPDFRGPNGLWKKYSPE
LATIEYFKKDPKGFWEFYRLRMRGLFTALPNRAHYALAELEKMGLIRAIITQNIDGLHQLAGSRNVIELHGNMRKCYCVN
CLKTYDSDTVLDKIDKEGLPPKCECGGVIRPDVVLFGEPVYNISSALEIAREADLVLAIGSSLTVYPANMIPLTVKEMGG
KLIILNAEETPLDNIADIVVRERVEEFLPCVVDYIKSQTLHRSS

Sequences:

>Translated_284_residues
MKIIQQFVISDNIFLHLSVLGKLIIFIFSKHLICMECDKVGDLLLTSTYAIAFTGAGISTASGIPDFRGPNGLWKKYSPE
LATIEYFKKDPKGFWEFYRLRMRGLFTALPNRAHYALAELEKMGLIRAIITQNIDGLHQLAGSRNVIELHGNMRKCYCVN
CLKTYDSDTVLDKIDKEGLPPKCECGGVIRPDVVLFGEPVYNISSALEIAREADLVLAIGSSLTVYPANMIPLTVKEMGG
KLIILNAEETPLDNIADIVVRERVEEFLPCVVDYIKSQTLHRSS
>Mature_284_residues
MKIIQQFVISDNIFLHLSVLGKLIIFIFSKHLICMECDKVGDLLLTSTYAIAFTGAGISTASGIPDFRGPNGLWKKYSPE
LATIEYFKKDPKGFWEFYRLRMRGLFTALPNRAHYALAELEKMGLIRAIITQNIDGLHQLAGSRNVIELHGNMRKCYCVN
CLKTYDSDTVLDKIDKEGLPPKCECGGVIRPDVVLFGEPVYNISSALEIAREADLVLAIGSSLTVYPANMIPLTVKEMGG
KLIILNAEETPLDNIADIVVRERVEEFLPCVVDYIKSQTLHRSS

Specific function: Modulates the activity of chromatin proteins, thereby having an effect on transcription per subunit [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI6912664, Length=242, Percent_Identity=36.3636363636364, Blast_Score=142, Evalue=3e-34,
Organism=Homo sapiens, GI13787215, Length=242, Percent_Identity=36.3636363636364, Blast_Score=142, Evalue=3e-34,
Organism=Homo sapiens, GI300795542, Length=228, Percent_Identity=37.719298245614, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI300797577, Length=247, Percent_Identity=35.2226720647773, Blast_Score=135, Evalue=4e-32,
Organism=Homo sapiens, GI300797597, Length=235, Percent_Identity=33.6170212765957, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI6912662, Length=273, Percent_Identity=30.7692307692308, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI7657575, Length=228, Percent_Identity=33.7719298245614, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI13775602, Length=192, Percent_Identity=36.9791666666667, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI13775600, Length=192, Percent_Identity=36.9791666666667, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI63054862, Length=202, Percent_Identity=32.6732673267327, Blast_Score=101, Evalue=7e-22,
Organism=Homo sapiens, GI300797705, Length=188, Percent_Identity=36.7021276595745, Blast_Score=101, Evalue=8e-22,
Organism=Homo sapiens, GI7706712, Length=242, Percent_Identity=31.8181818181818, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI6912660, Length=206, Percent_Identity=32.0388349514563, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI215982798, Length=178, Percent_Identity=33.7078651685393, Blast_Score=86, Evalue=3e-17,
Organism=Escherichia coli, GI308199517, Length=233, Percent_Identity=37.7682403433476, Blast_Score=117, Evalue=7e-28,
Organism=Caenorhabditis elegans, GI17541892, Length=228, Percent_Identity=33.7719298245614, Blast_Score=126, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17567771, Length=266, Percent_Identity=32.3308270676692, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI71990482, Length=262, Percent_Identity=28.2442748091603, Blast_Score=97, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI71990487, Length=264, Percent_Identity=28.030303030303, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17505510, Length=229, Percent_Identity=28.3842794759825, Blast_Score=88, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6325242, Length=263, Percent_Identity=28.5171102661597, Blast_Score=100, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6324599, Length=288, Percent_Identity=26.0416666666667, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6324504, Length=235, Percent_Identity=25.9574468085106, Blast_Score=73, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24648389, Length=189, Percent_Identity=39.1534391534392, Blast_Score=118, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24645650, Length=257, Percent_Identity=29.9610894941634, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI28571445, Length=284, Percent_Identity=29.2253521126761, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI17137536, Length=242, Percent_Identity=30.9917355371901, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24650933, Length=255, Percent_Identity=27.843137254902, Blast_Score=91, Evalue=8e-19,
Organism=Drosophila melanogaster, GI28571443, Length=218, Percent_Identity=28.4403669724771, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI28571441, Length=218, Percent_Identity=28.4403669724771, Blast_Score=85, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 31717; Mature: 31717

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIIQQFVISDNIFLHLSVLGKLIIFIFSKHLICMECDKVGDLLLTSTYAIAFTGAGIST
CHHHHHHHHCCCCEEHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHEEEEEECCCCCC
ASGIPDFRGPNGLWKKYSPELATIEYFKKDPKGFWEFYRLRMRGLFTALPNRAHYALAEL
CCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
EKMGLIRAIITQNIDGLHQLAGSRNVIELHGNMRKCYCVNCLKTYDSDTVLDKIDKEGLP
HHHHHHHHHHHCCHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHCCCC
PKCECGGVIRPDVVLFGEPVYNISSALEIAREADLVLAIGSSLTVYPANMIPLTVKEMGG
CCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHCCEEEEECCCEEEEECCCCEEEHHHHCC
KLIILNAEETPLDNIADIVVRERVEEFLPCVVDYIKSQTLHRSS
EEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKIIQQFVISDNIFLHLSVLGKLIIFIFSKHLICMECDKVGDLLLTSTYAIAFTGAGIST
CHHHHHHHHCCCCEEHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHEEEEEECCCCCC
ASGIPDFRGPNGLWKKYSPELATIEYFKKDPKGFWEFYRLRMRGLFTALPNRAHYALAEL
CCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
EKMGLIRAIITQNIDGLHQLAGSRNVIELHGNMRKCYCVNCLKTYDSDTVLDKIDKEGLP
HHHHHHHHHHHCCHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHCCCC
PKCECGGVIRPDVVLFGEPVYNISSALEIAREADLVLAIGSSLTVYPANMIPLTVKEMGG
CCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHCCEEEEECCCEEEEECCCCEEEHHHHCC
KLIILNAEETPLDNIADIVVRERVEEFLPCVVDYIKSQTLHRSS
EEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479 [H]