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The map label for this gene is coxA2 [H]

Identifier: 15920831

GI number: 15920831

Start: 596215

End: 597924

Strand: Direct

Name: coxA2 [H]

Synonym: ST0611

Alternate gene names: 15920831

Gene position: 596215-597924 (Clockwise)

Preceding gene: 15920829

Following gene: 15920832

Centisome position: 22.13

GC content: 34.04

Gene sequence:

>1710_bases
GTGAAAGTCATGAGTGCCTCTGATTTTATTAGAGGTTTAGGAAGAGCGATAGTTCTTGGATTATATTTTGGAACAAATTT
CGCATTAGCTAAAGTATCCAATTTTGTTAAGGATATTTTCCAGCTTGATAAGGACTGGGTTACGAGAATTACTATGGGTA
TGATAGTTTTAAGCCTTATATGGGGGATTTTAGGAATTGTTGACGCTTTAATGGTAAGGGTTCAGGAAGCGTCATGGGGA
TTAGCCCAAACATTACCTTTAACAGTTCAAGAATATGAAGCCTCAATAACGCTTCACGGCATGAGAGATCTGTTTGGATT
TGCACAACAGCTCATACTTGCTGTATTTATTTACTTTACATTCAAGATGCTTAATATTCAACCTAGATTAAAATGGATGT
TTAATTTGGGCTTTGTACTATTTAACATTTCTTTCATGCTTTTTGAAGGACCAATAGTTATAACTACGCAAACTGGTTTT
GACAATTATTTCTCTGCAACTGGTTGGTATTATTTAGCGCCAATAGGTGTTAACGGTTATTCATTATACGTAGTTTCTCC
ATTATGGTATATTGGCTGGATATTATTAGAAGTTGGAATATATTTAATGACTGGTTGGTATGTTTACCATTTCTATCTAG
CTTCAAGGAATTTGAAAGAGAAATTACCAATCTTCTTAGTTTTTGGTCTTGTAGTAGGTATACTTATATTAGAAAGTTAT
TCTGGCTCATTTATAACTGCTTTATGGGATTTATTGGCTTTCTACCATATAGTAGGATATAATATTATTGCTGATCAAAT
ATCCTTCGTGACTTTATGGCATGGGATTGTTTATATTGTTTGGTTCCCAGCTGTAGCCGCACTATACTTGCTAATACCAA
TGCTTTCAAATAGACCCCTTTATAGCGACAAATTAGCTAGAGTTTCAGCACTTTTATATTTAATATTTGCAACAGGTCCC
CTAGGAATTCATCACTTATATATGGTTGATTTACCAGTTCCAGTAAAGATAGTGACTGAAGTATTAACAGATGGTATTAT
TGTTCCATCCATGATGACATTCTTTAACTTATGGGCCACAGTAAAAGGTGCAAACATACAATGGAATATACTTGCTGCTC
TAACTACTATGTCTTTTGCTGGTTCTATATATGGAGGAGTTATGGGTATTTCTAACTCAGTAATAGCTTATGATGCTATA
GTTCATGAAGGAATGTATGTTGTAGCACACTTCCATGCATTCATATTATTCTCAATTGTTCCAGCTGGATTTGCTGCATT
ATACTTAATGATACCAATGATGACAAAAAGAATGTGGTACTCTGCAAAATTAGCATGGATTCACTTCTGGGGATATACGG
TCGGTGTTATTATGGTTGTTCTAGGCTTTTCCTATCTAGGAATTACCGGTTTAATAAGAAAAGAAATGATTTATCCTATT
TCATCAACATTTGTTACTGGGCAATTAATTACAACTGTTGGGGCAATTATTGCTGATCTTGCTACTGTTGGTTGGTTAAT
TAATTTAGTTCTAACAATAGTTAAGGGAAGAGTAGTTGAGAGGGAAGGCTTAAACTTAGGAGAGCTTACAACAAGTATTG
CTATGGCTCTGAACGGAAATAACGACATAGTCATTAATGGGATAACAAAAGGTATTGGATTAGTTAGAAGCGAAATTCAT
AATTTAATAGAAAAAAGACTTATGAAATAA

Upstream 100 bases:

>100_bases
AAACAAAATTAAATATTTCGTTTAAATGCTTTTATACATCTTTATTAACTTTATAAAAATACATTTAAGTCAGAAAAAGT
AAAAAGTGGTATCTGATTAG

Downstream 100 bases:

>100_bases
TAACTTTTTTTCCTATTTGTTTTAATATTTCTTCATGTTCTGGGAATCTTTTCTCTTGATATCTTGAAAAAATTAGTTCC
CCATTTAAATATACATCAAA

Product: cytochrome c oxidase polypeptide I

Products: NA

Alternate protein names: Cytochrome aa3 subunit 1; Cytochrome c oxidase polypeptide I [H]

Number of amino acids: Translated: 569; Mature: 569

Protein sequence:

>569_residues
MKVMSASDFIRGLGRAIVLGLYFGTNFALAKVSNFVKDIFQLDKDWVTRITMGMIVLSLIWGILGIVDALMVRVQEASWG
LAQTLPLTVQEYEASITLHGMRDLFGFAQQLILAVFIYFTFKMLNIQPRLKWMFNLGFVLFNISFMLFEGPIVITTQTGF
DNYFSATGWYYLAPIGVNGYSLYVVSPLWYIGWILLEVGIYLMTGWYVYHFYLASRNLKEKLPIFLVFGLVVGILILESY
SGSFITALWDLLAFYHIVGYNIIADQISFVTLWHGIVYIVWFPAVAALYLLIPMLSNRPLYSDKLARVSALLYLIFATGP
LGIHHLYMVDLPVPVKIVTEVLTDGIIVPSMMTFFNLWATVKGANIQWNILAALTTMSFAGSIYGGVMGISNSVIAYDAI
VHEGMYVVAHFHAFILFSIVPAGFAALYLMIPMMTKRMWYSAKLAWIHFWGYTVGVIMVVLGFSYLGITGLIRKEMIYPI
SSTFVTGQLITTVGAIIADLATVGWLINLVLTIVKGRVVEREGLNLGELTTSIAMALNGNNDIVINGITKGIGLVRSEIH
NLIEKRLMK

Sequences:

>Translated_569_residues
MKVMSASDFIRGLGRAIVLGLYFGTNFALAKVSNFVKDIFQLDKDWVTRITMGMIVLSLIWGILGIVDALMVRVQEASWG
LAQTLPLTVQEYEASITLHGMRDLFGFAQQLILAVFIYFTFKMLNIQPRLKWMFNLGFVLFNISFMLFEGPIVITTQTGF
DNYFSATGWYYLAPIGVNGYSLYVVSPLWYIGWILLEVGIYLMTGWYVYHFYLASRNLKEKLPIFLVFGLVVGILILESY
SGSFITALWDLLAFYHIVGYNIIADQISFVTLWHGIVYIVWFPAVAALYLLIPMLSNRPLYSDKLARVSALLYLIFATGP
LGIHHLYMVDLPVPVKIVTEVLTDGIIVPSMMTFFNLWATVKGANIQWNILAALTTMSFAGSIYGGVMGISNSVIAYDAI
VHEGMYVVAHFHAFILFSIVPAGFAALYLMIPMMTKRMWYSAKLAWIHFWGYTVGVIMVVLGFSYLGITGLIRKEMIYPI
SSTFVTGQLITTVGAIIADLATVGWLINLVLTIVKGRVVEREGLNLGELTTSIAMALNGNNDIVINGITKGIGLVRSEIH
NLIEKRLMK
>Mature_569_residues
MKVMSASDFIRGLGRAIVLGLYFGTNFALAKVSNFVKDIFQLDKDWVTRITMGMIVLSLIWGILGIVDALMVRVQEASWG
LAQTLPLTVQEYEASITLHGMRDLFGFAQQLILAVFIYFTFKMLNIQPRLKWMFNLGFVLFNISFMLFEGPIVITTQTGF
DNYFSATGWYYLAPIGVNGYSLYVVSPLWYIGWILLEVGIYLMTGWYVYHFYLASRNLKEKLPIFLVFGLVVGILILESY
SGSFITALWDLLAFYHIVGYNIIADQISFVTLWHGIVYIVWFPAVAALYLLIPMLSNRPLYSDKLARVSALLYLIFATGP
LGIHHLYMVDLPVPVKIVTEVLTDGIIVPSMMTFFNLWATVKGANIQWNILAALTTMSFAGSIYGGVMGISNSVIAYDAI
VHEGMYVVAHFHAFILFSIVPAGFAALYLMIPMMTKRMWYSAKLAWIHFWGYTVGVIMVVLGFSYLGITGLIRKEMIYPI
SSTFVTGQLITTVGAIIADLATVGWLINLVLTIVKGRVVEREGLNLGELTTSIAMALNGNNDIVINGITKGIGLVRSEIH
NLIEKRLMK

Specific function: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Escherichia coli, GI1786634, Length=507, Percent_Identity=23.6686390532544, Blast_Score=62, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6226519, Length=237, Percent_Identity=27.0042194092827, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014241 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: =1.9.3.1 [H]

Molecular weight: Translated: 63718; Mature: 63718

Theoretical pI: Translated: 8.98; Mature: 8.98

Prosite motif: PS50855 COX1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVMSASDFIRGLGRAIVLGLYFGTNFALAKVSNFVKDIFQLDKDWVTRITMGMIVLSLI
CCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
WGILGIVDALMVRVQEASWGLAQTLPLTVQEYEASITLHGMRDLFGFAQQLILAVFIYFT
HHHHHHHHHHHHHHHHCCCCCHHCCCCCHHHHHCEEEEHHHHHHHHHHHHHHHHHHHHHH
FKMLNIQPRLKWMFNLGFVLFNISFMLFEGPIVITTQTGFDNYFSATGWYYLAPIGVNGY
HHHHCCCHHHHHHHHHHHHHHHHHHHEEECCEEEEEECCCCCCCCCCCCEEEEEECCCCE
SLYVVSPLWYIGWILLEVGIYLMTGWYVYHFYLASRNLKEKLPIFLVFGLVVGILILESY
EEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCC
SGSFITALWDLLAFYHIVGYNIIADQISFVTLWHGIVYIVWFPAVAALYLLIPMLSNRPL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
YSDKLARVSALLYLIFATGPLGIHHLYMVDLPVPVKIVTEVLTDGIIVPSMMTFFNLWAT
CHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHH
VKGANIQWNILAALTTMSFAGSIYGGVMGISNSVIAYDAIVHEGMYVVAHFHAFILFSIV
EECCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHH
PAGFAALYLMIPMMTKRMWYSAKLAWIHFWGYTVGVIMVVLGFSYLGITGLIRKEMIYPI
HHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SSTFVTGQLITTVGAIIADLATVGWLINLVLTIVKGRVVEREGLNLGELTTSIAMALNGN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCCHHHHHHHHEEEEECC
NDIVINGITKGIGLVRSEIHNLIEKRLMK
CCEEEECHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKVMSASDFIRGLGRAIVLGLYFGTNFALAKVSNFVKDIFQLDKDWVTRITMGMIVLSLI
CCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
WGILGIVDALMVRVQEASWGLAQTLPLTVQEYEASITLHGMRDLFGFAQQLILAVFIYFT
HHHHHHHHHHHHHHHHCCCCCHHCCCCCHHHHHCEEEEHHHHHHHHHHHHHHHHHHHHHH
FKMLNIQPRLKWMFNLGFVLFNISFMLFEGPIVITTQTGFDNYFSATGWYYLAPIGVNGY
HHHHCCCHHHHHHHHHHHHHHHHHHHEEECCEEEEEECCCCCCCCCCCCEEEEEECCCCE
SLYVVSPLWYIGWILLEVGIYLMTGWYVYHFYLASRNLKEKLPIFLVFGLVVGILILESY
EEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCC
SGSFITALWDLLAFYHIVGYNIIADQISFVTLWHGIVYIVWFPAVAALYLLIPMLSNRPL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
YSDKLARVSALLYLIFATGPLGIHHLYMVDLPVPVKIVTEVLTDGIIVPSMMTFFNLWAT
CHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHH
VKGANIQWNILAALTTMSFAGSIYGGVMGISNSVIAYDAIVHEGMYVVAHFHAFILFSIV
EECCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHH
PAGFAALYLMIPMMTKRMWYSAKLAWIHFWGYTVGVIMVVLGFSYLGITGLIRKEMIYPI
HHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SSTFVTGQLITTVGAIIADLATVGWLINLVLTIVKGRVVEREGLNLGELTTSIAMALNGN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCCHHHHHHHHEEEEECC
NDIVINGITKGIGLVRSEIHNLIEKRLMK
CCEEEECHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1659810; 11016950 [H]