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The map label for this gene is caiD [H]

Identifier: 15920830

GI number: 15920830

Start: 595285

End: 596043

Strand: Reverse

Name: caiD [H]

Synonym: ST0610

Alternate gene names: 15920830

Gene position: 596043-595285 (Counterclockwise)

Preceding gene: 15920833

Following gene: 15920827

Centisome position: 22.12

GC content: 31.75

Gene sequence:

>759_bases
ATGACTAAAGTAATTGTTCAAAAAGAGTCGGATATAGGTAAAATACTAATAAGTAATGAAGAAGGAAAATACAATCTAGT
GGATATAAAGTTTATGCATAATCTTATAGATTCCTTAAGAATGTTAGATTCAAATAAAGAAGTTAGATTTGTGATTATAA
GGGGAATAAATAATTTTGGTGCAGGAGCAGACATAGGCGAACTAAGAAGAGCTTCAGAAAATAGAGAATATGCCACAAAT
TTCTTTTCAACAATGTTCGAAATGTTTCGAACTTTGCTTAATTTATCCAAAATTACAATAGCAAATGTCGAAGGTATAGC
TTATGGTGCGTCAATGGAAATCCTATTGGCAACTGATTTTGTTGTTGCATCAAAAAATTCAAAATTCGCAGTTCCTGGTG
GAAAAATAGGAGTATTCCCTCCAGTAATGCTTACACTAGGAAAATATAGACTTGGATGGAACAATGTGTTAAAAATGGCA
TTTTTAGGGAGAGAATTAAATGCTGAAGAAGCCAAACAAATAGGCTTAGTTTATGAAATAACTGATAATTTTGAAGAGAC
AAATACTAACTTAATTAGAGAGCTTAAGCAAATAGCACCTTCGTCTTTATCCATGATGAGGAAAATTTTATTCACAGAAC
ATGAAAAAGAGTTAGAAAAAGCTTTCCAAGAACTAATTGACCAAGTATTAACAGAAGACGCTAGGACAGGAGTAATATCG
TTTCTAACTAAAACTAAGCCTAAATGGGCTATTCTCTAA

Upstream 100 bases:

>100_bases
GCATTTAAACGAAATATTTAATTTTGTTTATTTTTTAGTTCCTTATTTTCCAATAAAAAGCAAGAAAAGATTATAAGAGA
CCTTTGCAATCAACTAATAA

Downstream 100 bases:

>100_bases
GTTTTAACAGCCTACTCCCTATTCCTATAAATACTGCGGTTAAAAGGATAATAATAAAGAAGATTGTGGGACTTGGCAAT
TTATCATAAATAAGAATATC

Product: cyclohex-1-ene-1-carboxyl-CoA hydratase

Products: L-Carnitine.; L-carnitinyl-CoA [C]

Alternate protein names: Crotonobetainyl-CoA hydratase [H]

Number of amino acids: Translated: 252; Mature: 251

Protein sequence:

>252_residues
MTKVIVQKESDIGKILISNEEGKYNLVDIKFMHNLIDSLRMLDSNKEVRFVIIRGINNFGAGADIGELRRASENREYATN
FFSTMFEMFRTLLNLSKITIANVEGIAYGASMEILLATDFVVASKNSKFAVPGGKIGVFPPVMLTLGKYRLGWNNVLKMA
FLGRELNAEEAKQIGLVYEITDNFEETNTNLIRELKQIAPSSLSMMRKILFTEHEKELEKAFQELIDQVLTEDARTGVIS
FLTKTKPKWAIL

Sequences:

>Translated_252_residues
MTKVIVQKESDIGKILISNEEGKYNLVDIKFMHNLIDSLRMLDSNKEVRFVIIRGINNFGAGADIGELRRASENREYATN
FFSTMFEMFRTLLNLSKITIANVEGIAYGASMEILLATDFVVASKNSKFAVPGGKIGVFPPVMLTLGKYRLGWNNVLKMA
FLGRELNAEEAKQIGLVYEITDNFEETNTNLIRELKQIAPSSLSMMRKILFTEHEKELEKAFQELIDQVLTEDARTGVIS
FLTKTKPKWAIL
>Mature_251_residues
TKVIVQKESDIGKILISNEEGKYNLVDIKFMHNLIDSLRMLDSNKEVRFVIIRGINNFGAGADIGELRRASENREYATNF
FSTMFEMFRTLLNLSKITIANVEGIAYGASMEILLATDFVVASKNSKFAVPGGKIGVFPPVMLTLGKYRLGWNNVLKMAF
LGRELNAEEAKQIGLVYEITDNFEETNTNLIRELKQIAPSSLSMMRKILFTEHEKELEKAFQELIDQVLTEDARTGVISF
LTKTKPKWAIL

Specific function: Catalyzes the reversible dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA [H]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI31542718, Length=250, Percent_Identity=28, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI194097323, Length=257, Percent_Identity=26.4591439688716, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI221142681, Length=252, Percent_Identity=30.5555555555556, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1787659, Length=260, Percent_Identity=26.1538461538462, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1787660, Length=233, Percent_Identity=25.7510729613734, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI87082183, Length=243, Percent_Identity=24.2798353909465, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1790281, Length=165, Percent_Identity=27.8787878787879, Blast_Score=61, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17554946, Length=239, Percent_Identity=27.1966527196653, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17540306, Length=232, Percent_Identity=25.4310344827586, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI25145438, Length=245, Percent_Identity=26.9387755102041, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17560910, Length=169, Percent_Identity=30.1775147928994, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022852
- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: 4.2.1.- [C]

Molecular weight: Translated: 28512; Mature: 28380

Theoretical pI: Translated: 7.66; Mature: 7.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKVIVQKESDIGKILISNEEGKYNLVDIKFMHNLIDSLRMLDSNKEVRFVIIRGINNFG
CCEEEEECCCCCCEEEEECCCCCEEEEHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCC
AGADIGELRRASENREYATNFFSTMFEMFRTLLNLSKITIANVEGIAYGASMEILLATDF
CCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCEEECCCEEEEEEEEE
VVASKNSKFAVPGGKIGVFPPVMLTLGKYRLGWNNVLKMAFLGRELNAEEAKQIGLVYEI
EEECCCCEEECCCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHCCEEEEE
TDNFEETNTNLIRELKQIAPSSLSMMRKILFTEHEKELEKAFQELIDQVLTEDARTGVIS
CCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLTKTKPKWAIL
HHHCCCCCCCCC
>Mature Secondary Structure 
TKVIVQKESDIGKILISNEEGKYNLVDIKFMHNLIDSLRMLDSNKEVRFVIIRGINNFG
CEEEEECCCCCCEEEEECCCCCEEEEHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCC
AGADIGELRRASENREYATNFFSTMFEMFRTLLNLSKITIANVEGIAYGASMEILLATDF
CCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCEEECCCEEEEEEEEE
VVASKNSKFAVPGGKIGVFPPVMLTLGKYRLGWNNVLKMAFLGRELNAEEAKQIGLVYEI
EEECCCCEEECCCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHCCEEEEE
TDNFEETNTNLIRELKQIAPSSLSMMRKILFTEHEKELEKAFQELIDQVLTEDARTGVIS
CCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLTKTKPKWAIL
HHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-Carnitine; D-carnitinyl-CoA [C]

Specific reaction: D-Carnitine = L-Carnitine. D-carnitinyl-CoA = L-carnitinyl-CoA [C]

General reaction: Isomerases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA