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The map label for this gene is pccB [H]

Identifier: 15920810

GI number: 15920810

Start: 578345

End: 579916

Strand: Reverse

Name: pccB [H]

Synonym: ST0591

Alternate gene names: 15920810

Gene position: 579916-578345 (Counterclockwise)

Preceding gene: 15920811

Following gene: 15920809

Centisome position: 21.52

GC content: 37.4

Gene sequence:

>1572_bases
ATGTCTATGTATGAAAAACCTCCAGTTGAAAAATTAATTGAAGAATTAAGACAATTAAAAGAAAAAGCGTATAAGGGAGG
AGGAGATGAAAGAATACAATTCCAGCACAGTAAAGGTAAGCTTACAGCTAGAGAGAGATTAGCACTTTTGTTTGATGATG
GTAAATTTAATGAAATTATGACTTTTGCAACTACCAGAGCTACGGAATTCGGTCTAGATAAGCAGAGATTCTATGGAGAT
GGTGTTGTTACTGGTTGGGGTAAAGTTGACGGTAGAACAGTTTTTGCGTATGCCCAAGATTTTACAGTATTAGGAGGAAG
CTTAGGAGAGACACATGCAAATAAGATTGTTAGAGCTTATGAATTAGCTCTAAAAGTAGGAGCACCAGTTGTGGGTATTA
ATGATTCTGGTGGTGCAAGAATACAAGAAGGTGCATTATCGTTAGAAGGATATGGTGCTGTATTCAAAATGAATGTAATG
GCTTCTGGTGTGATTCCACAAATAACTATTATGGCTGGACCAGCAGCAGGTGGTGCGGTTTATTCGCCAGCACTAACAGA
TTTCATAATTATGATTAAAGGAGACGCGTACTATATGTTTGTAACGGGGCCAGAAATTACTAAAGTAGTTTTAGGAGAAG
AAGTATCTTTCCAGGATTTGGGTGGAGCTGTCGTTCATGCAACAAAGTCCGGTGTAGTACATTTCATGGTTGATAGTGAA
CAAGAAGCAATTAATTTAACTAAAAGACTATTATCATATTTACCATCAAATAACATGGAAGAACCTCCTTATATTGATAC
TGGAGATCCAGCAGATAGAGATGCAACTGGAGTAGAACAAATAGTTCCTAATGATGCGGCAAAACCCTATAACATGAGGG
AAATAATTTACAAGATTGTAGATAATGGTGAATTCCTTGAGGTTCATAAACATTGGGCACAAAACATAATAGTAGGATTC
GCGAGAATTGCGGGTAATGTTGTTGGAATAGTAGCTAATAACCCAGAAGAATTTGGCGGTTCTATAGATATCGATGCTGC
TGATAAGGCAGCAAGATTTATTAGATTCTGTGATGCGTTCAACATACCCCTAATTAGCTTAGTAGATACTCCAGGTTACG
TGCCGGGGACTGATCAAGAGTATAAAGGCATAATAAGGCATGGTGCAAAAATGCTATATGCATTTGCTGAAGCGACTGTA
CCTAAAATTACAGTAATTGTTAGAAAATCTTATGGAGGAGCACATATAGCAATGAGCATAAAGAGTTTAGGAGCAGATTT
AGTATATGCTTGGCCAACAGCCGAAATTGCTGTAACGGGACCGGAAGGTGCAGTAAGAATTCTTTATAGAAAAGAAATTC
AACAAGCTTCAAATCCAGATGATGTATTAAAGCAAAGAATAGCAGAATATAGGAAGTTGTTTGCAAATCCGTACTGGGCT
GCTGAGAAGGGACTGGTTGATGATGTCATTGAGCCAAAAGATACTAGAAGAGTAATTGTAGCTGGATTAGAAATGCTAAA
GACTAAGAGAGAATATAGGTATCCTAAGAAACATGGTAATATACCATTATGA

Upstream 100 bases:

>100_bases
TTATGGTAAAACCTGGTCAGGGTGTAAAGAAAGGTGATTTATTACTTATTATTAAATGATATTTTTTCTTTCTTTATTAT
AAAAAGTATGGTGATAAAAT

Downstream 100 bases:

>100_bases
CACATTCTTCTCCTTTTTTCTCTTTCACTACTACATTTCTACCTAAGGCTAAAAATAATTTCCTTATTTTTTCAATGCTA
TCACATGGAATTGAGAATTC

Product: methylmalonyl-CoA decarboxylase subunit alpha

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 523; Mature: 522

Protein sequence:

>523_residues
MSMYEKPPVEKLIEELRQLKEKAYKGGGDERIQFQHSKGKLTARERLALLFDDGKFNEIMTFATTRATEFGLDKQRFYGD
GVVTGWGKVDGRTVFAYAQDFTVLGGSLGETHANKIVRAYELALKVGAPVVGINDSGGARIQEGALSLEGYGAVFKMNVM
ASGVIPQITIMAGPAAGGAVYSPALTDFIIMIKGDAYYMFVTGPEITKVVLGEEVSFQDLGGAVVHATKSGVVHFMVDSE
QEAINLTKRLLSYLPSNNMEEPPYIDTGDPADRDATGVEQIVPNDAAKPYNMREIIYKIVDNGEFLEVHKHWAQNIIVGF
ARIAGNVVGIVANNPEEFGGSIDIDAADKAARFIRFCDAFNIPLISLVDTPGYVPGTDQEYKGIIRHGAKMLYAFAEATV
PKITVIVRKSYGGAHIAMSIKSLGADLVYAWPTAEIAVTGPEGAVRILYRKEIQQASNPDDVLKQRIAEYRKLFANPYWA
AEKGLVDDVIEPKDTRRVIVAGLEMLKTKREYRYPKKHGNIPL

Sequences:

>Translated_523_residues
MSMYEKPPVEKLIEELRQLKEKAYKGGGDERIQFQHSKGKLTARERLALLFDDGKFNEIMTFATTRATEFGLDKQRFYGD
GVVTGWGKVDGRTVFAYAQDFTVLGGSLGETHANKIVRAYELALKVGAPVVGINDSGGARIQEGALSLEGYGAVFKMNVM
ASGVIPQITIMAGPAAGGAVYSPALTDFIIMIKGDAYYMFVTGPEITKVVLGEEVSFQDLGGAVVHATKSGVVHFMVDSE
QEAINLTKRLLSYLPSNNMEEPPYIDTGDPADRDATGVEQIVPNDAAKPYNMREIIYKIVDNGEFLEVHKHWAQNIIVGF
ARIAGNVVGIVANNPEEFGGSIDIDAADKAARFIRFCDAFNIPLISLVDTPGYVPGTDQEYKGIIRHGAKMLYAFAEATV
PKITVIVRKSYGGAHIAMSIKSLGADLVYAWPTAEIAVTGPEGAVRILYRKEIQQASNPDDVLKQRIAEYRKLFANPYWA
AEKGLVDDVIEPKDTRRVIVAGLEMLKTKREYRYPKKHGNIPL
>Mature_522_residues
SMYEKPPVEKLIEELRQLKEKAYKGGGDERIQFQHSKGKLTARERLALLFDDGKFNEIMTFATTRATEFGLDKQRFYGDG
VVTGWGKVDGRTVFAYAQDFTVLGGSLGETHANKIVRAYELALKVGAPVVGINDSGGARIQEGALSLEGYGAVFKMNVMA
SGVIPQITIMAGPAAGGAVYSPALTDFIIMIKGDAYYMFVTGPEITKVVLGEEVSFQDLGGAVVHATKSGVVHFMVDSEQ
EAINLTKRLLSYLPSNNMEEPPYIDTGDPADRDATGVEQIVPNDAAKPYNMREIIYKIVDNGEFLEVHKHWAQNIIVGFA
RIAGNVVGIVANNPEEFGGSIDIDAADKAARFIRFCDAFNIPLISLVDTPGYVPGTDQEYKGIIRHGAKMLYAFAEATVP
KITVIVRKSYGGAHIAMSIKSLGADLVYAWPTAEIAVTGPEGAVRILYRKEIQQASNPDDVLKQRIAEYRKLFANPYWAA
EKGLVDDVIEPKDTRRVIVAGLEMLKTKREYRYPKKHGNIPL

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=514, Percent_Identity=51.9455252918288, Blast_Score=536, Evalue=1e-152,
Organism=Homo sapiens, GI295821216, Length=532, Percent_Identity=50, Blast_Score=523, Evalue=1e-148,
Organism=Homo sapiens, GI11545863, Length=507, Percent_Identity=33.3333333333333, Blast_Score=231, Evalue=2e-60,
Organism=Homo sapiens, GI134142062, Length=477, Percent_Identity=23.2704402515723, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI38679971, Length=344, Percent_Identity=27.0348837209302, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI38679960, Length=344, Percent_Identity=27.0348837209302, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI38679977, Length=344, Percent_Identity=27.0348837209302, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI38679967, Length=344, Percent_Identity=27.0348837209302, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI38679974, Length=344, Percent_Identity=27.0348837209302, Blast_Score=86, Evalue=1e-16,
Organism=Escherichia coli, GI1788655, Length=243, Percent_Identity=27.5720164609054, Blast_Score=69, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI25147359, Length=513, Percent_Identity=51.6569200779727, Blast_Score=554, Evalue=1e-158,
Organism=Caenorhabditis elegans, GI25147362, Length=513, Percent_Identity=51.6569200779727, Blast_Score=554, Evalue=1e-158,
Organism=Caenorhabditis elegans, GI17552936, Length=508, Percent_Identity=32.8740157480315, Blast_Score=254, Evalue=1e-67,
Organism=Caenorhabditis elegans, GI71997163, Length=295, Percent_Identity=26.4406779661017, Blast_Score=87, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6323863, Length=350, Percent_Identity=25.1428571428571, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324343, Length=377, Percent_Identity=24.1379310344828, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24586065, Length=534, Percent_Identity=32.9588014981273, Blast_Score=250, Evalue=2e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 57368; Mature: 57237

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMYEKPPVEKLIEELRQLKEKAYKGGGDERIQFQHSKGKLTARERLALLFDDGKFNEIM
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEHHHEEEEEECCCCCCCEE
TFATTRATEFGLDKQRFYGDGVVTGWGKVDGRTVFAYAQDFTVLGGSLGETHANKIVRAY
EEHHHHHHHCCCCHHHEECCCEEECCCCCCCEEEEEEECCCEEECCCCCHHHHHHHHHHH
ELALKVGAPVVGINDSGGARIQEGALSLEGYGAVFKMNVMASGVIPQITIMAGPAAGGAV
HHHHHHCCCEEEECCCCCCEEECCCEEECCCCEEEEEEEHHCCCCCEEEEEECCCCCCCE
YSPALTDFIIMIKGDAYYMFVTGPEITKVVLGEEVSFQDLGGAVVHATKSGVVHFMVDSE
ECCCCEEEEEEEECCEEEEEEECCCEEEEEECCCCCHHHCCCEEEEEECCCEEEEEECCC
QEAINLTKRLLSYLPSNNMEEPPYIDTGDPADRDATGVEQIVPNDAAKPYNMREIIYKIV
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCHHHHHHHHH
DNGEFLEVHKHWAQNIIVGFARIAGNVVGIVANNPEEFGGSIDIDAADKAARFIRFCDAF
CCCCEEHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHCCEEEECCHHHHHHHHHHHHCC
NIPLISLVDTPGYVPGTDQEYKGIIRHGAKMLYAFAEATVPKITVIVRKSYGGAHIAMSI
CCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCEEEEEEH
KSLGADLVYAWPTAEIAVTGPEGAVRILYRKEIQQASNPDDVLKQRIAEYRKLFANPYWA
HHCCCCEEEECCCCEEEEECCCCCEEHEEHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCC
AEKGLVDDVIEPKDTRRVIVAGLEMLKTKREYRYPKKHGNIPL
CCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
SMYEKPPVEKLIEELRQLKEKAYKGGGDERIQFQHSKGKLTARERLALLFDDGKFNEIM
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEHHHEEEEEECCCCCCCEE
TFATTRATEFGLDKQRFYGDGVVTGWGKVDGRTVFAYAQDFTVLGGSLGETHANKIVRAY
EEHHHHHHHCCCCHHHEECCCEEECCCCCCCEEEEEEECCCEEECCCCCHHHHHHHHHHH
ELALKVGAPVVGINDSGGARIQEGALSLEGYGAVFKMNVMASGVIPQITIMAGPAAGGAV
HHHHHHCCCEEEECCCCCCEEECCCEEECCCCEEEEEEEHHCCCCCEEEEEECCCCCCCE
YSPALTDFIIMIKGDAYYMFVTGPEITKVVLGEEVSFQDLGGAVVHATKSGVVHFMVDSE
ECCCCEEEEEEEECCEEEEEEECCCEEEEEECCCCCHHHCCCEEEEEECCCEEEEEECCC
QEAINLTKRLLSYLPSNNMEEPPYIDTGDPADRDATGVEQIVPNDAAKPYNMREIIYKIV
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCHHHHHHHHH
DNGEFLEVHKHWAQNIIVGFARIAGNVVGIVANNPEEFGGSIDIDAADKAARFIRFCDAF
CCCCEEHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHCCEEEECCHHHHHHHHHHHHCC
NIPLISLVDTPGYVPGTDQEYKGIIRHGAKMLYAFAEATVPKITVIVRKSYGGAHIAMSI
CCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCEEEEEEH
KSLGADLVYAWPTAEIAVTGPEGAVRILYRKEIQQASNPDDVLKQRIAEYRKLFANPYWA
HHCCCCEEEECCCCEEEEECCCCCEEHEEHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCC
AEKGLVDDVIEPKDTRRVIVAGLEMLKTKREYRYPKKHGNIPL
CCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8830278 [H]