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The map label for this gene is dbh

Identifier: 15920791

GI number: 15920791

Start: 562410

End: 563471

Strand: Reverse

Name: dbh

Synonym: ST0573

Alternate gene names: 15920791

Gene position: 563471-562410 (Counterclockwise)

Preceding gene: 15920792

Following gene: 15920788

Centisome position: 20.91

GC content: 31.07

Gene sequence:

>1062_bases
ATGTATATGATAATATTGTTTGTGGATTTTGATTATTTCTTTGCTCAAGTAGAGGAAGTTTTAAATCCTCAATATAAAGG
AAAACCTCTTATAGTCTGTGTTTATTCTGGTAGAAATGAGAAAAGTGGAGCTGTAGCGACAGCTAATTATGAAGCTAGGA
AGTTAGGAGTAAAAGCTGGAATGCCTATATCAAGAGCAATGGAATTAGCACCAAATGCAATATTCGTTCCAATGCACAAA
GAAGTATATACTGAGGTTTCTAATAGAATAATGAGCATAATCAGTAGCTATTCGGATAAAATTGAAATAGCTAGCATAGA
CGAGGCCTACATCGATATAACTAGCAAGGTGAAAAATTTTGAAGAGGCGATAGAATTAGGAAAAAAATTAAAACGAGAAA
TAATGGAGAAGGAAAAGATTACAGTAACAGTTGGAATCGCACCAAATAAGGTTTTTGCAAAAATCATTGCAGATAGAGTA
AAACCAAATGGATTAGGAGTAGTAAAACCAGAAGAAATAGAGGAGTTCATCAAAAGTATTGATATAGATGAGGTTCCTGG
TGTAGGTAATGTTATTTCTGAAAGACTTCATTCATTAGGTGTAAATAAGTTGATAGATATTTTATCTGTTTCATTTGATA
AATTAAAAGAAGAGATAGGGGAAGCTAAGGCATTTTATCTTTATAGATTAGCCACAAACTCTTATTTTGAGCCGGTATTA
AATAAAGAAAGGGTACCGCATGGAAGATATTTGACATTACCTAAAAATACTAGAGATATAAAAGTGATAGAACTTTATCT
GAAAAAAGCTATAGATGAAGCATACAACAAAATAGAAGGTATACCTAAGAGAATGACTGTGGTAACTATCATGCAGGACT
TAGACATCGTAAGTAAAAGTAAAACTTTTAAAACTGGTATAAGTAAAGAGAGAGCTTATACAGAATCAATTGAATTATTA
AAACAAATTTTACAAAAAGATAGTAGATTAGTTAGAAGAGTTGGAGTAAGATTTGATAATATATACAAATCGAAGGGATT
AGACGTTTTCTTCAATAGTTAA

Upstream 100 bases:

>100_bases
TGACCGCATCTGCAATTAAGATACAAAGGCTTGGCGGAATAAGCTCACCAAATCTTAATGAAGTGCATGAAGCACTAAAA
ATCTATGAGCCTAAGGTAAA

Downstream 100 bases:

>100_bases
CTGAACAACATTTCTCACTTTAGTAACATCGATTCTTCCAAATTTAGCAACATAATTTATAAAACCTTTAACACCCCTCT
CATTAATATTAGCATCCTTT

Product: DNA polymerase IV

Products: NA

Alternate protein names: Pol IV

Number of amino acids: Translated: 353; Mature: 353

Protein sequence:

>353_residues
MYMIILFVDFDYFFAQVEEVLNPQYKGKPLIVCVYSGRNEKSGAVATANYEARKLGVKAGMPISRAMELAPNAIFVPMHK
EVYTEVSNRIMSIISSYSDKIEIASIDEAYIDITSKVKNFEEAIELGKKLKREIMEKEKITVTVGIAPNKVFAKIIADRV
KPNGLGVVKPEEIEEFIKSIDIDEVPGVGNVISERLHSLGVNKLIDILSVSFDKLKEEIGEAKAFYLYRLATNSYFEPVL
NKERVPHGRYLTLPKNTRDIKVIELYLKKAIDEAYNKIEGIPKRMTVVTIMQDLDIVSKSKTFKTGISKERAYTESIELL
KQILQKDSRLVRRVGVRFDNIYKSKGLDVFFNS

Sequences:

>Translated_353_residues
MYMIILFVDFDYFFAQVEEVLNPQYKGKPLIVCVYSGRNEKSGAVATANYEARKLGVKAGMPISRAMELAPNAIFVPMHK
EVYTEVSNRIMSIISSYSDKIEIASIDEAYIDITSKVKNFEEAIELGKKLKREIMEKEKITVTVGIAPNKVFAKIIADRV
KPNGLGVVKPEEIEEFIKSIDIDEVPGVGNVISERLHSLGVNKLIDILSVSFDKLKEEIGEAKAFYLYRLATNSYFEPVL
NKERVPHGRYLTLPKNTRDIKVIELYLKKAIDEAYNKIEGIPKRMTVVTIMQDLDIVSKSKTFKTGISKERAYTESIELL
KQILQKDSRLVRRVGVRFDNIYKSKGLDVFFNS
>Mature_353_residues
MYMIILFVDFDYFFAQVEEVLNPQYKGKPLIVCVYSGRNEKSGAVATANYEARKLGVKAGMPISRAMELAPNAIFVPMHK
EVYTEVSNRIMSIISSYSDKIEIASIDEAYIDITSKVKNFEEAIELGKKLKREIMEKEKITVTVGIAPNKVFAKIIADRV
KPNGLGVVKPEEIEEFIKSIDIDEVPGVGNVISERLHSLGVNKLIDILSVSFDKLKEEIGEAKAFYLYRLATNSYFEPVL
NKERVPHGRYLTLPKNTRDIKVIELYLKKAIDEAYNKIEGIPKRMTVVTIMQDLDIVSKSKTFKTGISKERAYTESIELL
KQILQKDSRLVRRVGVRFDNIYKSKGLDVFFNS

Specific function: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits

COG id: COG0389

COG function: function code L; Nucleotidyltransferase/DNA polymerase involved in DNA repair

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 umuC domain

Homologues:

Organism=Homo sapiens, GI7706681, Length=254, Percent_Identity=31.496062992126, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI84043967, Length=254, Percent_Identity=31.496062992126, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI154350220, Length=273, Percent_Identity=28.9377289377289, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI5729982, Length=306, Percent_Identity=24.1830065359477, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI7705344, Length=118, Percent_Identity=38.135593220339, Blast_Score=76, Evalue=4e-14,
Organism=Escherichia coli, GI1786425, Length=217, Percent_Identity=35.4838709677419, Blast_Score=157, Evalue=8e-40,
Organism=Escherichia coli, GI1787432, Length=212, Percent_Identity=30.6603773584906, Blast_Score=115, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17537959, Length=198, Percent_Identity=29.7979797979798, Blast_Score=95, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI115534089, Length=126, Percent_Identity=34.1269841269841, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI193205700, Length=113, Percent_Identity=35.3982300884956, Blast_Score=73, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6324921, Length=237, Percent_Identity=29.957805907173, Blast_Score=84, Evalue=4e-17,
Organism=Drosophila melanogaster, GI19923006, Length=271, Percent_Identity=23.2472324723247, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI21355641, Length=264, Percent_Identity=25.7575757575758, Blast_Score=88, Evalue=8e-18,
Organism=Drosophila melanogaster, GI24644984, Length=264, Percent_Identity=25.7575757575758, Blast_Score=88, Evalue=8e-18,
Organism=Drosophila melanogaster, GI24668444, Length=131, Percent_Identity=32.824427480916, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DPO4_SULTO (Q974T8)

Other databases:

- EMBL:   BA000023
- RefSeq:   NP_376460.1
- ProteinModelPortal:   Q974T8
- SMR:   Q974T8
- GeneID:   1458519
- GenomeReviews:   BA000023_GR
- KEGG:   sto:ST0573
- NMPDR:   fig|273063.1.peg.628
- HOGENOM:   HBG734504
- OMA:   DFDYFFA
- ProtClustDB:   PRK01216
- BioCyc:   STOK273063:ST0573-MONOMER
- BRENDA:   2.7.7.7
- HAMAP:   MF_01113
- InterPro:   IPR017962
- InterPro:   IPR017961
- InterPro:   IPR001126
- InterPro:   IPR017963
- InterPro:   IPR022880
- Gene3D:   G3DSA:3.30.1490.100
- PANTHER:   PTHR11076

Pfam domain/function: PF00817 IMS; SSF100879 DNA_pol_Y-fam_little_finger

EC number: =2.7.7.7

Molecular weight: Translated: 40126; Mature: 40126

Theoretical pI: Translated: 9.41; Mature: 9.41

Prosite motif: PS50173 UMUC

Important sites: ACT_SITE 108-108

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYMIILFVDFDYFFAQVEEVLNPQYKGKPLIVCVYSGRNEKSGAVATANYEARKLGVKAG
CEEEEEEECHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCEEECCCHHHHHCCCCC
MPISRAMELAPNAIFVPMHKEVYTEVSNRIMSIISSYSDKIEIASIDEAYIDITSKVKNF
CCHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHH
EEAIELGKKLKREIMEKEKITVTVGIAPNKVFAKIIADRVKPNGLGVVKPEEIEEFIKSI
HHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHC
DIDEVPGVGNVISERLHSLGVNKLIDILSVSFDKLKEEIGEAKAFYLYRLATNSYFEPVL
CCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHEEEEEECCCCHHHHHH
NKERVPHGRYLTLPKNTRDIKVIELYLKKAIDEAYNKIEGIPKRMTVVTIMQDLDIVSKS
CCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCC
KTFKTGISKERAYTESIELLKQILQKDSRLVRRVGVRFDNIYKSKGLDVFFNS
CHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCEEEECC
>Mature Secondary Structure
MYMIILFVDFDYFFAQVEEVLNPQYKGKPLIVCVYSGRNEKSGAVATANYEARKLGVKAG
CEEEEEEECHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCEEECCCHHHHHCCCCC
MPISRAMELAPNAIFVPMHKEVYTEVSNRIMSIISSYSDKIEIASIDEAYIDITSKVKNF
CCHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHH
EEAIELGKKLKREIMEKEKITVTVGIAPNKVFAKIIADRVKPNGLGVVKPEEIEEFIKSI
HHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHC
DIDEVPGVGNVISERLHSLGVNKLIDILSVSFDKLKEEIGEAKAFYLYRLATNSYFEPVL
CCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHEEEEEECCCCHHHHHH
NKERVPHGRYLTLPKNTRDIKVIELYLKKAIDEAYNKIEGIPKRMTVVTIMQDLDIVSKS
CCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCC
KTFKTGISKERAYTESIELLKQILQKDSRLVRRVGVRFDNIYKSKGLDVFFNS
CHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11572479