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The map label for this gene is thiD [H]

Identifier: 15920743

GI number: 15920743

Start: 522453

End: 523799

Strand: Reverse

Name: thiD [H]

Synonym: ST0526

Alternate gene names: 15920743

Gene position: 523799-522453 (Counterclockwise)

Preceding gene: 15920744

Following gene: 15920742

Centisome position: 19.44

GC content: 30.14

Gene sequence:

>1347_bases
ATGAAAAAGGTAGTAGCACTTAGTGTGGCAGGAATAGATACTGGTAATGGTGCAGGAGCAGAAACTGATATAAAAGTTTA
CGAAATATTAGGAGTACATGGTACGTTAGTAGTTTCTGCTATAACTGCTCAAAACACCAGAGGTATAAAAGATATACTTG
TCATTGAAAGAGATTTTTTTCAAAAACAACTAGAAACAGTTCTAGAGGATTTTGACATAAATAATGTTAAGATAGGAATG
ATTTACAATAAGGAACAATATGAAGTTGTAAAGGAATATTTAGAAGGAAAGACCATTGTAACAGATCCAGTAATATTTGC
TAAAGATGGAACTCAGCTAATTAAAGATCTTGAGGATTATAAAAAATATATCCTACCGATTACTACAGTTCTCACTCCTA
ATGCTGTTGAGGCCTCTTATTTTTCTGGTATTAACATTAAGACTCTTGAGGATATGAAGAAAAGTAGTAAGATAATTTCT
AATACATATAATATACCATACGTAATAGTTAAAGGTGGCCATATATCTACGAAGTACAGTTTTGACATTCTCTATGATGC
TAAAAAAGATTTCTTTTACCTAGTTGGTTATGAGAGAATTAATCAAAAAAATACACACGGAACTGGTAGCGTATTCTCAA
CAGTAATATCGGCCGAATTAGCAAAAGGAGAAAAAATATATAATGCGATAAGAATTGCTAGAGATATTCTTCAAACTTCT
ATTGAATATGGTCTTGAAATAGGAAAGGGAATAGGACCAGTGGATCCTCTTGTTTACATAGAAAAGAATGCTTATAAATA
TAAAGTTATAGAAGATATGTATAAATTTGCTAATTTTGTTGAATCTACTCCTTCATTTTATAAGTTAATACCAGAAGTTC
AATCAAACTTAGCCCACTCAATACCTTCATCATATGTTAAAGATCTTAATGATATTGCAACTTTTAAAAATAGGATAATA
AGAAATTGGGATAATAAAGTGAGTATAGGCTTTCCAGTAGTTTTCGGAAAACCTACACATACTGCCAGATTACTTCTAGC
AACAATAAGAAAAGGAGAAAGAGCTACGGTTCTTATTAATTTAAGATATGATGAAAATACAATAAAACTTCTACGCTTAT
ATGGATATGATGTTATAGAAATAGATAGGGAAAAAGAACCAGAGCATGAAATAGAGGGAAAAAGTATGCAATGGATAATA
GATTTTATATACGAAAATTACGGAAAGATTCCCAATGTAATATTTGATAAGGGAATGAAAGGAAAGGAAGCAATGATAAG
AATTTGGACAGAAGATATTGATACAATAATTGATACACTAAATTATATATGTAAAAATTTAAGCTGA

Upstream 100 bases:

>100_bases
ACCTTAGAATTAGTGAAACATACGACGGGTATTTGGAAATTAGAAATAAGAGATGATGGAGAATTTTGGGTAGTTGCTGG
AAATACTAGAGTGAGAAGAA

Downstream 100 bases:

>100_bases
AGCTTTGAAATTCTTTTCCCATGAGTTTAGAAAGAGTTATTATAGGATGTAAAAATTTAGTTAGAACTGGTTGGATGCAA
AGAGGAGTACCGCCATCAAT

Product: phosphomethylpyrimidine kinase

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MKKVVALSVAGIDTGNGAGAETDIKVYEILGVHGTLVVSAITAQNTRGIKDILVIERDFFQKQLETVLEDFDINNVKIGM
IYNKEQYEVVKEYLEGKTIVTDPVIFAKDGTQLIKDLEDYKKYILPITTVLTPNAVEASYFSGINIKTLEDMKKSSKIIS
NTYNIPYVIVKGGHISTKYSFDILYDAKKDFFYLVGYERINQKNTHGTGSVFSTVISAELAKGEKIYNAIRIARDILQTS
IEYGLEIGKGIGPVDPLVYIEKNAYKYKVIEDMYKFANFVESTPSFYKLIPEVQSNLAHSIPSSYVKDLNDIATFKNRII
RNWDNKVSIGFPVVFGKPTHTARLLLATIRKGERATVLINLRYDENTIKLLRLYGYDVIEIDREKEPEHEIEGKSMQWII
DFIYENYGKIPNVIFDKGMKGKEAMIRIWTEDIDTIIDTLNYICKNLS

Sequences:

>Translated_448_residues
MKKVVALSVAGIDTGNGAGAETDIKVYEILGVHGTLVVSAITAQNTRGIKDILVIERDFFQKQLETVLEDFDINNVKIGM
IYNKEQYEVVKEYLEGKTIVTDPVIFAKDGTQLIKDLEDYKKYILPITTVLTPNAVEASYFSGINIKTLEDMKKSSKIIS
NTYNIPYVIVKGGHISTKYSFDILYDAKKDFFYLVGYERINQKNTHGTGSVFSTVISAELAKGEKIYNAIRIARDILQTS
IEYGLEIGKGIGPVDPLVYIEKNAYKYKVIEDMYKFANFVESTPSFYKLIPEVQSNLAHSIPSSYVKDLNDIATFKNRII
RNWDNKVSIGFPVVFGKPTHTARLLLATIRKGERATVLINLRYDENTIKLLRLYGYDVIEIDREKEPEHEIEGKSMQWII
DFIYENYGKIPNVIFDKGMKGKEAMIRIWTEDIDTIIDTLNYICKNLS
>Mature_448_residues
MKKVVALSVAGIDTGNGAGAETDIKVYEILGVHGTLVVSAITAQNTRGIKDILVIERDFFQKQLETVLEDFDINNVKIGM
IYNKEQYEVVKEYLEGKTIVTDPVIFAKDGTQLIKDLEDYKKYILPITTVLTPNAVEASYFSGINIKTLEDMKKSSKIIS
NTYNIPYVIVKGGHISTKYSFDILYDAKKDFFYLVGYERINQKNTHGTGSVFSTVISAELAKGEKIYNAIRIARDILQTS
IEYGLEIGKGIGPVDPLVYIEKNAYKYKVIEDMYKFANFVESTPSFYKLIPEVQSNLAHSIPSSYVKDLNDIATFKNRII
RNWDNKVSIGFPVVFGKPTHTARLLLATIRKGERATVLINLRYDENTIKLLRLYGYDVIEIDREKEPEHEIEGKSMQWII
DFIYENYGKIPNVIFDKGMKGKEAMIRIWTEDIDTIIDTLNYICKNLS

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=262, Percent_Identity=32.4427480916031, Blast_Score=147, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6325378, Length=272, Percent_Identity=27.5735294117647, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6324997, Length=337, Percent_Identity=25.5192878338279, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6324517, Length=273, Percent_Identity=27.1062271062271, Blast_Score=81, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 50945; Mature: 50945

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKVVALSVAGIDTGNGAGAETDIKVYEILGVHGTLVVSAITAQNTRGIKDILVIERDFF
CCCEEEEEEECCCCCCCCCCCCCEEEEEEECCCHHEEEEEEHHCCCCCCHHHEEHHHHHH
QKQLETVLEDFDINNVKIGMIYNKEQYEVVKEYLEGKTIVTDPVIFAKDGTQLIKDLEDY
HHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHCCCEEEECCEEEECCCHHHHHHHHHH
KKYILPITTVLTPNAVEASYFSGINIKTLEDMKKSSKIISNTYNIPYVIVKGGHISTKYS
HHHHHHHHEEECCCCCCHHHHCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCEEEEEEE
FDILYDAKKDFFYLVGYERINQKNTHGTGSVFSTVISAELAKGEKIYNAIRIARDILQTS
EEEEEECCCCEEEEEEHHHHCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
IEYGLEIGKGIGPVDPLVYIEKNAYKYKVIEDMYKFANFVESTPSFYKLIPEVQSNLAHS
HHHHHHHCCCCCCCCCEEEEECCCEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
IPSSYVKDLNDIATFKNRIIRNWDNKVSIGFPVVFGKPTHTARLLLATIRKGERATVLIN
CCHHHHHHHHHHHHHHHHHHHCCCCEEEECEEEEECCCCHHHHHHHHHHCCCCCEEEEEE
LRYDENTIKLLRLYGYDVIEIDREKEPEHEIEGKSMQWIIDFIYENYGKIPNVIFDKGMK
EEECCCHHEEHHHHCCCEEEECCCCCCCHHCCCCHHHHHHHHHHHHHCCCCCHHHCCCCC
GKEAMIRIWTEDIDTIIDTLNYICKNLS
CCHHEEEEHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKKVVALSVAGIDTGNGAGAETDIKVYEILGVHGTLVVSAITAQNTRGIKDILVIERDFF
CCCEEEEEEECCCCCCCCCCCCCEEEEEEECCCHHEEEEEEHHCCCCCCHHHEEHHHHHH
QKQLETVLEDFDINNVKIGMIYNKEQYEVVKEYLEGKTIVTDPVIFAKDGTQLIKDLEDY
HHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHCCCEEEECCEEEECCCHHHHHHHHHH
KKYILPITTVLTPNAVEASYFSGINIKTLEDMKKSSKIISNTYNIPYVIVKGGHISTKYS
HHHHHHHHEEECCCCCCHHHHCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCEEEEEEE
FDILYDAKKDFFYLVGYERINQKNTHGTGSVFSTVISAELAKGEKIYNAIRIARDILQTS
EEEEEECCCCEEEEEEHHHHCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
IEYGLEIGKGIGPVDPLVYIEKNAYKYKVIEDMYKFANFVESTPSFYKLIPEVQSNLAHS
HHHHHHHCCCCCCCCCEEEEECCCEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
IPSSYVKDLNDIATFKNRIIRNWDNKVSIGFPVVFGKPTHTARLLLATIRKGERATVLIN
CCHHHHHHHHHHHHHHHHHHHCCCCEEEECEEEEECCCCHHHHHHHHHHCCCCCEEEEEE
LRYDENTIKLLRLYGYDVIEIDREKEPEHEIEGKSMQWIIDFIYENYGKIPNVIFDKGMK
EEECCCHHEEHHHHCCCEEEECCCCCCCHHCCCCHHHHHHHHHHHHHCCCCCHHHCCCCC
GKEAMIRIWTEDIDTIIDTLNYICKNLS
CCHHEEEEHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11418146 [H]