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The map label for this gene is eif2b [H]

Identifier: 15920733

GI number: 15920733

Start: 513222

End: 513719

Strand: Direct

Name: eif2b [H]

Synonym: ST0516

Alternate gene names: 15920733

Gene position: 513222-513719 (Clockwise)

Preceding gene: 15920727

Following gene: 15920734

Centisome position: 19.05

GC content: 30.72

Gene sequence:

>498_bases
GTGCACAACCATATGTTTCAATATAAACCTTCACAACTAATCATAAGTAATTTATACTTCAACCTCTTAAGATTACTTGT
GTCTACAGAAGAAGAGTATATTAAACTATTGGACAGATTGTATTCAAAACTACCTGAAAGAGTTCAAAAGGTCAGTGGAC
AGTCATTACCAAATCTGATTATATTATCAATAGGAAATAACACAATAATAAAGAATTTTAGTGAATATTGTGATAGAATA
AGAAGAGAAGATAAGCTGTGTGCAAAATTCATCTTAAAGGAATTAGCAGCTCCAGGAAATGTTGATGAAAACGGACAATT
AGTCATTCAAGGAAAATTCTCTTCAGCTTCTATAAATAAAATCATGGAAAGATTTATAAAAACTTACGTTCAATGCAGTA
CATGTAAAAGTCTTGATACCGTTCTAATAAAAGAGAAAAAAGCGTGGTATATTTCATGTTTAGCTTGTGGTGCTAAAACA
CCAGTTAAACCGTTGTGA

Upstream 100 bases:

>100_bases
GTATTCAGAACTATTACATCAGCCTGATTATAACTGTCAACTATATCATGCCCTCTATCTTTTAATAAAGTCATCATTAT
GTATGAATCTCCTTTATTAA

Downstream 100 bases:

>100_bases
GCAAAATGAAAGTTAGCTTAAATATTATAAGGAGAGAAGGTTATGTTTTTGTTAATATTTGTGAGCCTGAACTTATAGGT
AAGACATTTAAAGAAGGCGA

Product: translation initiation factor IF-2 subunit beta

Products: NA

Alternate protein names: aIF2-beta; eIF-2-beta [H]

Number of amino acids: Translated: 165; Mature: 165

Protein sequence:

>165_residues
MHNHMFQYKPSQLIISNLYFNLLRLLVSTEEEYIKLLDRLYSKLPERVQKVSGQSLPNLIILSIGNNTIIKNFSEYCDRI
RREDKLCAKFILKELAAPGNVDENGQLVIQGKFSSASINKIMERFIKTYVQCSTCKSLDTVLIKEKKAWYISCLACGAKT
PVKPL

Sequences:

>Translated_165_residues
MHNHMFQYKPSQLIISNLYFNLLRLLVSTEEEYIKLLDRLYSKLPERVQKVSGQSLPNLIILSIGNNTIIKNFSEYCDRI
RREDKLCAKFILKELAAPGNVDENGQLVIQGKFSSASINKIMERFIKTYVQCSTCKSLDTVLIKEKKAWYISCLACGAKT
PVKPL
>Mature_165_residues
MHNHMFQYKPSQLIISNLYFNLLRLLVSTEEEYIKLLDRLYSKLPERVQKVSGQSLPNLIILSIGNNTIIKNFSEYCDRI
RREDKLCAKFILKELAAPGNVDENGQLVIQGKFSSASINKIMERFIKTYVQCSTCKSLDTVLIKEKKAWYISCLACGAKT
PVKPL

Specific function: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA [H]

COG id: COG1601

COG function: function code J; Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-2-beta/eIF-5 family [H]

Homologues:

Organism=Homo sapiens, GI29826335, Length=136, Percent_Identity=32.3529411764706, Blast_Score=84, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17508049, Length=98, Percent_Identity=32.6530612244898, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6325018, Length=138, Percent_Identity=31.8840579710145, Blast_Score=76, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17647377, Length=136, Percent_Identity=30.1470588235294, Blast_Score=80, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004458
- InterPro:   IPR002735
- InterPro:   IPR016189
- InterPro:   IPR016190 [H]

Pfam domain/function: PF01873 eIF-5_eIF-2B [H]

EC number: NA

Molecular weight: Translated: 18922; Mature: 18922

Theoretical pI: Translated: 9.57; Mature: 9.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
3.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHNHMFQYKPSQLIISNLYFNLLRLLVSTEEEYIKLLDRLYSKLPERVQKVSGQSLPNLI
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEE
ILSIGNNTIIKNFSEYCDRIRREDKLCAKFILKELAAPGNVDENGQLVIQGKFSSASINK
EEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCHHHHHH
IMERFIKTYVQCSTCKSLDTVLIKEKKAWYISCLACGAKTPVKPL
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MHNHMFQYKPSQLIISNLYFNLLRLLVSTEEEYIKLLDRLYSKLPERVQKVSGQSLPNLI
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEE
ILSIGNNTIIKNFSEYCDRIRREDKLCAKFILKELAAPGNVDENGQLVIQGKFSSASINK
EEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCHHHHHH
IMERFIKTYVQCSTCKSLDTVLIKEKKAWYISCLACGAKTPVKPL
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479 [H]