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The map label for this gene is MCM [H]

Identifier: 15920683

GI number: 15920683

Start: 469878

End: 471524

Strand: Reverse

Name: MCM [H]

Synonym: ST0467

Alternate gene names: 15920683

Gene position: 471524-469878 (Counterclockwise)

Preceding gene: 15920685

Following gene: 15920679

Centisome position: 17.5

GC content: 34.43

Gene sequence:

>1647_bases
GTGTTTAAACACATTAATCCAGATTGTATGCAAGATTTTGTATGGCCACCAGAAGGAGAATTTGATGAAATTATTGAACT
ACCTACAACATGTCCGGTGTGTGGAAAAGCTGGACAATTTAAACTTATTGAGGACAGATCAGAATTCATAGATTGGCAAA
AAGCAGTCATTCAAGAGAGGCCAGAAGAAATTCCACCTGGACAGTTACCTAGACAACTTGAAGTAGTCTTTGAAGACGAT
TTAGTTGATTCTGCCCGTCCTGGAGATAGAGTGAAGATAGTTGGAATTTTAGAGATAAAGAAAGATTCTCAAATAAAAAG
AGGGAGCAAAGCTATCTTTGATTTTTATTTGAAAGTTAATAGTATAGAAATTTCACAAAAAGTATTGGATGAAGTAAAGA
TCTCAGAAGAAGATGAGAAAAAAATTAGAGAATTATCTAGAGATCCTTGGATAAGAGAGAAGATAATTAGTTCAATAGCG
CCATCAATATACGGACATTGGGAGATAAAGGAAGCAATAGCATTAGCCCTATTTGGGGGAGTACCAAAGATAATGGAAGA
TGGTACCAGAGTAAGAGGAGATATACATGTACTAATTATTGGTGATCCAGGTACAGCGAAATCTCAAATTTTACAGTTTG
CTGCAAGAGTTGCTCCTAGAGCTGTATATACAACTGGAAAAGGTTCTACTGCTGCTGGATTAACAGCTACGGTAACTAGA
GATAAAAATACTGGAGATTATTATTTAGAAGCTGGTGCATTAGTATTAGCAGATGGAGGAGTCGCAGTAATAGATGAAAT
TGATAAAATGAGAGAAGAAGATAGAGTAGCAATACATGAAGCAATGGAACAGCAAACAGTCTCTATAGCAAAAGCTGGAA
TTGTTGCTAAGCTAAATGCAAGAGCTACAGTAGTAGCTGCAGGAAATCCTAAGTTAGGAAGATATATAGCTGAAAGAGGA
ATAGCTGAAAATATTAATTTACCACCTACTATACTTTCAAGATTTGATTTGATATTTATACTAATAGATAAACCTGGTGT
AGAAGATCAATTATTAGCTTCACATATATTAAATGTTCATGCTGGTAAAACAAAGAGTACAGAAATTATAGATGTAGATT
TACTTAAGAAGTACATAGCATATGCAAGGAAGAATGTATTTCCAAAACTGAGTGATGAAGCAAAGAGTTTATTGCAAGAT
TTCTTCGTAGAGATGAGAAAGAAGAGTTCTGAATCACCAGATTCTCCAATAATTATAACCCCAAGACAACTTGAAGCCTT
AATAAGAATATCTGAAGCTTATGCAAGAATGGCACTAAAAAATGAAGTTACGAGAGAAGATGCTGAAAGAGCAATAAATA
TAATGAGAATATTCCTCGAGAATGTAGGATTAGATGTAGAATCTGGCAAAATAGATATTGATACGATTATGACTGGAAAG
CCAAAGAGTGCAAGAGAAAAAATGGCCAGAATACTAGAAATCATCGATACCTTAGCTGGCACAAACGAGTGTGCAAAAGT
AAAAGAGATTGTAAAAGAAGCTGAGGGAATAGGAATTGATAAAGCAAGTGTAGAAAAATTATTAACCGATATGAGAAAAC
AAGGCTTAATTTACGAATCTAGACCAGATTGTTATAGAAAAGTCTAA

Upstream 100 bases:

>100_bases
AGAATTAAGAAAAATAAGAAGTAGTGATGCAGGAAAACTAATTACAATAGAAGGTATATTAGTTAAATCTACTCCAGTAA
AAGAAAGATTGAGCAGATCA

Downstream 100 bases:

>100_bases
ACTTTTAGCTTTTTATAAATAGGAAGAGGAGTCCACATTACCCATGCTGGTACTTGCTTAACTAATTCATAGGCTTCTTC
CCATCCACTTAATCCTAACC

Product: DNA replication licensing factor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 548; Mature: 548

Protein sequence:

>548_residues
MFKHINPDCMQDFVWPPEGEFDEIIELPTTCPVCGKAGQFKLIEDRSEFIDWQKAVIQERPEEIPPGQLPRQLEVVFEDD
LVDSARPGDRVKIVGILEIKKDSQIKRGSKAIFDFYLKVNSIEISQKVLDEVKISEEDEKKIRELSRDPWIREKIISSIA
PSIYGHWEIKEAIALALFGGVPKIMEDGTRVRGDIHVLIIGDPGTAKSQILQFAARVAPRAVYTTGKGSTAAGLTATVTR
DKNTGDYYLEAGALVLADGGVAVIDEIDKMREEDRVAIHEAMEQQTVSIAKAGIVAKLNARATVVAAGNPKLGRYIAERG
IAENINLPPTILSRFDLIFILIDKPGVEDQLLASHILNVHAGKTKSTEIIDVDLLKKYIAYARKNVFPKLSDEAKSLLQD
FFVEMRKKSSESPDSPIIITPRQLEALIRISEAYARMALKNEVTREDAERAINIMRIFLENVGLDVESGKIDIDTIMTGK
PKSAREKMARILEIIDTLAGTNECAKVKEIVKEAEGIGIDKASVEKLLTDMRKQGLIYESRPDCYRKV

Sequences:

>Translated_548_residues
MFKHINPDCMQDFVWPPEGEFDEIIELPTTCPVCGKAGQFKLIEDRSEFIDWQKAVIQERPEEIPPGQLPRQLEVVFEDD
LVDSARPGDRVKIVGILEIKKDSQIKRGSKAIFDFYLKVNSIEISQKVLDEVKISEEDEKKIRELSRDPWIREKIISSIA
PSIYGHWEIKEAIALALFGGVPKIMEDGTRVRGDIHVLIIGDPGTAKSQILQFAARVAPRAVYTTGKGSTAAGLTATVTR
DKNTGDYYLEAGALVLADGGVAVIDEIDKMREEDRVAIHEAMEQQTVSIAKAGIVAKLNARATVVAAGNPKLGRYIAERG
IAENINLPPTILSRFDLIFILIDKPGVEDQLLASHILNVHAGKTKSTEIIDVDLLKKYIAYARKNVFPKLSDEAKSLLQD
FFVEMRKKSSESPDSPIIITPRQLEALIRISEAYARMALKNEVTREDAERAINIMRIFLENVGLDVESGKIDIDTIMTGK
PKSAREKMARILEIIDTLAGTNECAKVKEIVKEAEGIGIDKASVEKLLTDMRKQGLIYESRPDCYRKV
>Mature_548_residues
MFKHINPDCMQDFVWPPEGEFDEIIELPTTCPVCGKAGQFKLIEDRSEFIDWQKAVIQERPEEIPPGQLPRQLEVVFEDD
LVDSARPGDRVKIVGILEIKKDSQIKRGSKAIFDFYLKVNSIEISQKVLDEVKISEEDEKKIRELSRDPWIREKIISSIA
PSIYGHWEIKEAIALALFGGVPKIMEDGTRVRGDIHVLIIGDPGTAKSQILQFAARVAPRAVYTTGKGSTAAGLTATVTR
DKNTGDYYLEAGALVLADGGVAVIDEIDKMREEDRVAIHEAMEQQTVSIAKAGIVAKLNARATVVAAGNPKLGRYIAERG
IAENINLPPTILSRFDLIFILIDKPGVEDQLLASHILNVHAGKTKSTEIIDVDLLKKYIAYARKNVFPKLSDEAKSLLQD
FFVEMRKKSSESPDSPIIITPRQLEALIRISEAYARMALKNEVTREDAERAINIMRIFLENVGLDVESGKIDIDTIMTGK
PKSAREKMARILEIIDTLAGTNECAKVKEIVKEAEGIGIDKASVEKLLTDMRKQGLIYESRPDCYRKV

Specific function: Has ATPase and DNA helicase activities. The latter preferentially melts 5'-tailed oligonucleotides and is stimulated by the SSB protein (single-stranded DNA binding protein) [H]

COG id: COG1241

COG function: function code L; Predicted ATPase involved in replication control, Cdc46/Mcm family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 MCM domain [H]

Homologues:

Organism=Homo sapiens, GI33469919, Length=527, Percent_Identity=39.4686907020873, Blast_Score=348, Evalue=8e-96,
Organism=Homo sapiens, GI33469917, Length=527, Percent_Identity=39.4686907020873, Blast_Score=348, Evalue=8e-96,
Organism=Homo sapiens, GI19923727, Length=592, Percent_Identity=36.6554054054054, Blast_Score=343, Evalue=2e-94,
Organism=Homo sapiens, GI23510448, Length=456, Percent_Identity=43.2017543859649, Blast_Score=342, Evalue=5e-94,
Organism=Homo sapiens, GI33356547, Length=518, Percent_Identity=38.6100386100386, Blast_Score=339, Evalue=4e-93,
Organism=Homo sapiens, GI33469924, Length=579, Percent_Identity=36.6148531951641, Blast_Score=334, Evalue=1e-91,
Organism=Homo sapiens, GI7427519, Length=494, Percent_Identity=38.4615384615385, Blast_Score=316, Evalue=3e-86,
Organism=Homo sapiens, GI33469922, Length=450, Percent_Identity=40.2222222222222, Blast_Score=298, Evalue=1e-80,
Organism=Homo sapiens, GI33469968, Length=450, Percent_Identity=40.2222222222222, Blast_Score=298, Evalue=1e-80,
Organism=Homo sapiens, GI6631095, Length=464, Percent_Identity=39.4396551724138, Blast_Score=288, Evalue=9e-78,
Organism=Homo sapiens, GI310128402, Length=265, Percent_Identity=38.4905660377359, Blast_Score=176, Evalue=8e-44,
Organism=Homo sapiens, GI310119838, Length=265, Percent_Identity=38.4905660377359, Blast_Score=176, Evalue=8e-44,
Organism=Homo sapiens, GI310115110, Length=265, Percent_Identity=38.4905660377359, Blast_Score=175, Evalue=8e-44,
Organism=Homo sapiens, GI23397546, Length=239, Percent_Identity=33.4728033472803, Blast_Score=144, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17508417, Length=484, Percent_Identity=41.1157024793388, Blast_Score=374, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI71997752, Length=451, Percent_Identity=43.0155210643016, Blast_Score=363, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17554306, Length=484, Percent_Identity=42.5619834710744, Blast_Score=355, Evalue=3e-98,
Organism=Caenorhabditis elegans, GI17562700, Length=464, Percent_Identity=41.1637931034483, Blast_Score=326, Evalue=2e-89,
Organism=Caenorhabditis elegans, GI71997563, Length=482, Percent_Identity=40.0414937759336, Blast_Score=300, Evalue=2e-81,
Organism=Caenorhabditis elegans, GI17562702, Length=456, Percent_Identity=37.280701754386, Blast_Score=298, Evalue=5e-81,
Organism=Caenorhabditis elegans, GI71997571, Length=330, Percent_Identity=46.969696969697, Blast_Score=266, Evalue=3e-71,
Organism=Saccharomyces cerevisiae, GI6325276, Length=529, Percent_Identity=38.9413988657845, Blast_Score=360, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6323304, Length=436, Percent_Identity=45.6422018348624, Blast_Score=343, Evalue=4e-95,
Organism=Saccharomyces cerevisiae, GI6319448, Length=480, Percent_Identity=39.1666666666667, Blast_Score=334, Evalue=2e-92,
Organism=Saccharomyces cerevisiae, GI6321237, Length=335, Percent_Identity=45.0746268656716, Blast_Score=283, Evalue=4e-77,
Organism=Saccharomyces cerevisiae, GI6320803, Length=505, Percent_Identity=37.4257425742574, Blast_Score=274, Evalue=3e-74,
Organism=Saccharomyces cerevisiae, GI6319679, Length=454, Percent_Identity=37.4449339207048, Blast_Score=273, Evalue=4e-74,
Organism=Drosophila melanogaster, GI17137242, Length=537, Percent_Identity=39.1061452513966, Blast_Score=353, Evalue=2e-97,
Organism=Drosophila melanogaster, GI17137132, Length=446, Percent_Identity=42.152466367713, Blast_Score=351, Evalue=8e-97,
Organism=Drosophila melanogaster, GI24645774, Length=449, Percent_Identity=43.4298440979955, Blast_Score=337, Evalue=1e-92,
Organism=Drosophila melanogaster, GI24639835, Length=463, Percent_Identity=40.8207343412527, Blast_Score=313, Evalue=3e-85,
Organism=Drosophila melanogaster, GI17530827, Length=475, Percent_Identity=38.3157894736842, Blast_Score=310, Evalue=2e-84,
Organism=Drosophila melanogaster, GI17647617, Length=519, Percent_Identity=36.0308285163777, Blast_Score=289, Evalue=4e-78,
Organism=Drosophila melanogaster, GI24647251, Length=455, Percent_Identity=28.3516483516484, Blast_Score=169, Evalue=5e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR001208
- InterPro:   IPR012340
- InterPro:   IPR016027 [H]

Pfam domain/function: PF00493 MCM [H]

EC number: NA

Molecular weight: Translated: 61089; Mature: 61089

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS50051 MCM_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKHINPDCMQDFVWPPEGEFDEIIELPTTCPVCGKAGQFKLIEDRSEFIDWQKAVIQER
CCCCCCHHHHHHCCCCCCCCHHHHHCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHC
PEEIPPGQLPRQLEVVFEDDLVDSARPGDRVKIVGILEIKKDSQIKRGSKAIFDFYLKVN
CCCCCCCCCCHHHHEEECCCCCCCCCCCCCEEEEEEEEECCCCHHHCCCHHHEEEEEEEC
SIEISQKVLDEVKISEEDEKKIRELSRDPWIREKIISSIAPSIYGHWEIKEAIALALFGG
CHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCC
VPKIMEDGTRVRGDIHVLIIGDPGTAKSQILQFAARVAPRAVYTTGKGSTAAGLTATVTR
CHHHHCCCCEEECEEEEEEEECCCCHHHHHHHHHHHHCCCEEEECCCCCCCCCEEEEEEC
DKNTGDYYLEAGALVLADGGVAVIDEIDKMREEDRVAIHEAMEQQTVSIAKAGIVAKLNA
CCCCCCEEEECCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECC
RATVVAAGNPKLGRYIAERGIAENINLPPTILSRFDLIFILIDKPGVEDQLLASHILNVH
CEEEEECCCCHHHHHHHHCCCCCCCCCCHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHC
AGKTKSTEIIDVDLLKKYIAYARKNVFPKLSDEAKSLLQDFFVEMRKKSSESPDSPIIIT
CCCCCCCEEEEHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEC
PRQLEALIRISEAYARMALKNEVTREDAERAINIMRIFLENVGLDVESGKIDIDTIMTGK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCC
PKSAREKMARILEIIDTLAGTNECAKVKEIVKEAEGIGIDKASVEKLLTDMRKQGLIYES
CHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEECC
RPDCYRKV
CCHHHHCC
>Mature Secondary Structure
MFKHINPDCMQDFVWPPEGEFDEIIELPTTCPVCGKAGQFKLIEDRSEFIDWQKAVIQER
CCCCCCHHHHHHCCCCCCCCHHHHHCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHC
PEEIPPGQLPRQLEVVFEDDLVDSARPGDRVKIVGILEIKKDSQIKRGSKAIFDFYLKVN
CCCCCCCCCCHHHHEEECCCCCCCCCCCCCEEEEEEEEECCCCHHHCCCHHHEEEEEEEC
SIEISQKVLDEVKISEEDEKKIRELSRDPWIREKIISSIAPSIYGHWEIKEAIALALFGG
CHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCC
VPKIMEDGTRVRGDIHVLIIGDPGTAKSQILQFAARVAPRAVYTTGKGSTAAGLTATVTR
CHHHHCCCCEEECEEEEEEEECCCCHHHHHHHHHHHHCCCEEEECCCCCCCCCEEEEEEC
DKNTGDYYLEAGALVLADGGVAVIDEIDKMREEDRVAIHEAMEQQTVSIAKAGIVAKLNA
CCCCCCEEEECCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECC
RATVVAAGNPKLGRYIAERGIAENINLPPTILSRFDLIFILIDKPGVEDQLLASHILNVH
CEEEEECCCCHHHHHHHHCCCCCCCCCCHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHC
AGKTKSTEIIDVDLLKKYIAYARKNVFPKLSDEAKSLLQDFFVEMRKKSSESPDSPIIIT
CCCCCCCEEEEHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEC
PRQLEALIRISEAYARMALKNEVTREDAERAINIMRIFLENVGLDVESGKIDIDTIMTGK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCC
PKSAREKMARILEIIDTLAGTNECAKVKEIVKEAEGIGIDKASVEKLLTDMRKQGLIYES
CHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEECC
RPDCYRKV
CCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10701121; 11427726 [H]