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The map label for this gene is rph [C]

Identifier: 15920654

GI number: 15920654

Start: 449277

End: 450104

Strand: Reverse

Name: rph [C]

Synonym: ST0442

Alternate gene names: 15920654

Gene position: 450104-449277 (Counterclockwise)

Preceding gene: 15920655

Following gene: 15920653

Centisome position: 16.7

GC content: 33.82

Gene sequence:

>828_bases
ATGTCAATCACGCCTTCTAATCAAAACATAACTTCCTTGCTTAAAAAAGAAAGTATATTAAACGCATTAGAAAGAGGTAT
TAGATTAGATGGAAGAAAGAATAGTGATTATAGACCAATTTCTGTTACACTCAATTATGCTAAAAAAGCCGAAGGTTCAG
CTTTGGTAAAACTAGGAGATACAATGGTTTTAGCCGGTGTAAAATTAGAGGAGGAAGAACCGTTTCCAGATACTCCAAAC
CAGGGAAACTTAGTAGTTAACGTAGAACTCCTTCCTTTAGCTTACGAGACATTTGAGCCAGGACCACCAGATGAAAATGC
TATAGAATTAGCTAGAGTTGTGGATAGAAGCCTTAGAGATTCAAAAGCAGTTGATCTATCTAAATTAGTTATTATACCAG
GTAAAAAAGTATGGACTGCATGGGTCGATGTATATGTTCTTGATTATGGAGGAAATGTATTAGATGCTTGTACTTTAGCA
GCAGTTGCGGCTCTATATAATACTAAACTTCCTAAAGTTGAAATAGAAGGAGATAATGTAAAAATAATAAAAGAGGAAAA
AACTGATGTAACTCCAATTGCTTATCCAGTAGTCACTGTTACTGTTGCTAAAATAGGTAAGTATCTTGTTGTAGATCCAA
GTTTAGATGAAGAAAGTATTGCAGATGTAAAAATCTCATTCTCTTACGTACAAGATGGTAGAATAGTAGGAATGCAAAAG
AGTAATTTTGGAAGCTTAAGCTTACAAGAAGTAGATGTTGCAGAAAGTTTAGCAAGATCAGCTTCACAGAAATTATTCGA
AGAGCTTAAAAAGCAAATTAATATGTAA

Upstream 100 bases:

>100_bases
GACAAGCATTAGAGATGGCTCAAAAAGGAATTGAAACAATATATAATTTAGAAAAAGAAGCCATTAGGAGCAAATATGCA
GAATTAAAGGAGGAATAAAA

Downstream 100 bases:

>100_bases
TTATGGTGATTAGAAATGGGAAAAGTTACAGGAATTGCTGGTAGATTTGGTGCACGATACGGCTCTTCAGTCAGGAAGAA
ATGGAAAGAGATAATGGAAA

Product: exosome complex RNA-binding protein Rrp42

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 275; Mature: 274

Protein sequence:

>275_residues
MSITPSNQNITSLLKKESILNALERGIRLDGRKNSDYRPISVTLNYAKKAEGSALVKLGDTMVLAGVKLEEEEPFPDTPN
QGNLVVNVELLPLAYETFEPGPPDENAIELARVVDRSLRDSKAVDLSKLVIIPGKKVWTAWVDVYVLDYGGNVLDACTLA
AVAALYNTKLPKVEIEGDNVKIIKEEKTDVTPIAYPVVTVTVAKIGKYLVVDPSLDEESIADVKISFSYVQDGRIVGMQK
SNFGSLSLQEVDVAESLARSASQKLFEELKKQINM

Sequences:

>Translated_275_residues
MSITPSNQNITSLLKKESILNALERGIRLDGRKNSDYRPISVTLNYAKKAEGSALVKLGDTMVLAGVKLEEEEPFPDTPN
QGNLVVNVELLPLAYETFEPGPPDENAIELARVVDRSLRDSKAVDLSKLVIIPGKKVWTAWVDVYVLDYGGNVLDACTLA
AVAALYNTKLPKVEIEGDNVKIIKEEKTDVTPIAYPVVTVTVAKIGKYLVVDPSLDEESIADVKISFSYVQDGRIVGMQK
SNFGSLSLQEVDVAESLARSASQKLFEELKKQINM
>Mature_274_residues
SITPSNQNITSLLKKESILNALERGIRLDGRKNSDYRPISVTLNYAKKAEGSALVKLGDTMVLAGVKLEEEEPFPDTPNQ
GNLVVNVELLPLAYETFEPGPPDENAIELARVVDRSLRDSKAVDLSKLVIIPGKKVWTAWVDVYVLDYGGNVLDACTLAA
VAALYNTKLPKVEIEGDNVKIIKEEKTDVTPIAYPVVTVTVAKIGKYLVVDPSLDEESIADVKISFSYVQDGRIVGMQKS
NFGSLSLQEVDVAESLARSASQKLFEELKKQINM

Specific function: Probably involved in the 3'->5' degradation of a variety of RNA species (Potential)

COG id: COG2123

COG function: function code J; RNase PH-related exoribonuclease

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNase PH family

Homologues:

Organism=Homo sapiens, GI31415882, Length=254, Percent_Identity=33.4645669291339, Blast_Score=146, Evalue=2e-35,
Organism=Homo sapiens, GI189083688, Length=234, Percent_Identity=34.6153846153846, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI77812672, Length=235, Percent_Identity=33.1914893617021, Blast_Score=124, Evalue=9e-29,
Organism=Homo sapiens, GI77812670, Length=234, Percent_Identity=33.3333333333333, Blast_Score=124, Evalue=1e-28,
Organism=Escherichia coli, GI157672248, Length=224, Percent_Identity=29.9107142857143, Blast_Score=82, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI25144570, Length=257, Percent_Identity=29.1828793774319, Blast_Score=110, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI32566065, Length=230, Percent_Identity=30, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6320486, Length=203, Percent_Identity=29.5566502463054, Blast_Score=109, Evalue=5e-25,
Organism=Drosophila melanogaster, GI28573444, Length=210, Percent_Identity=38.5714285714286, Blast_Score=130, Evalue=9e-31,
Organism=Drosophila melanogaster, GI24642649, Length=217, Percent_Identity=34.1013824884793, Blast_Score=118, Evalue=5e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ECX2_SULTO (Q975G9)

Other databases:

- EMBL:   BA000023
- RefSeq:   NP_376323.1
- ProteinModelPortal:   Q975G9
- SMR:   Q975G9
- GeneID:   1458379
- GenomeReviews:   BA000023_GR
- KEGG:   sto:ST0442
- NMPDR:   fig|273063.1.peg.491
- HOGENOM:   HBG737187
- OMA:   VEYNEET
- ProtClustDB:   PRK04282
- BioCyc:   STOK273063:ST0442-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00622
- InterPro:   IPR001247
- InterPro:   IPR015847
- InterPro:   IPR020869
- InterPro:   IPR020568

Pfam domain/function: PF01138 RNase_PH; PF03725 RNase_PH_C; SSF55666 3_ExoRNase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: 3.1.13.-

Molecular weight: Translated: 30139; Mature: 30008

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSITPSNQNITSLLKKESILNALERGIRLDGRKNSDYRPISVTLNYAKKAEGSALVKLGD
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEECCCCCCCEEEEECC
TMVLAGVKLEEEEPFPDTPNQGNLVVNVELLPLAYETFEPGPPDENAIELARVVDRSLRD
EEEEEEEEECCCCCCCCCCCCCCEEEEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHCC
SKAVDLSKLVIIPGKKVWTAWVDVYVLDYGGNVLDACTLAAVAALYNTKLPKVEIEGDNV
CCCCCEEEEEEECCCCEEEEEEEEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEECCCCE
KIIKEEKTDVTPIAYPVVTVTVAKIGKYLVVDPSLDEESIADVKISFSYVQDGRIVGMQK
EEEECCCCCCCCEEHHHHHHHHHHCCCEEEECCCCCCCCCCEEEEEEEEEECCEEEEEEC
SNFGSLSLQEVDVAESLARSASQKLFEELKKQINM
CCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SITPSNQNITSLLKKESILNALERGIRLDGRKNSDYRPISVTLNYAKKAEGSALVKLGD
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEECCCCCCCEEEEECC
TMVLAGVKLEEEEPFPDTPNQGNLVVNVELLPLAYETFEPGPPDENAIELARVVDRSLRD
EEEEEEEEECCCCCCCCCCCCCCEEEEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHCC
SKAVDLSKLVIIPGKKVWTAWVDVYVLDYGGNVLDACTLAAVAALYNTKLPKVEIEGDNV
CCCCCEEEEEEECCCCEEEEEEEEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEECCCCE
KIIKEEKTDVTPIAYPVVTVTVAKIGKYLVVDPSLDEESIADVKISFSYVQDGRIVGMQK
EEEECCCCCCCCEEHHHHHHHHHHCCCEEEECCCCCCCCCCEEEEEEEEEECCEEEEEEC
SNFGSLSLQEVDVAESLARSASQKLFEELKKQINM
CCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479