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The map label for this gene is fdhA [H]

Identifier: 15920549

GI number: 15920549

Start: 368669

End: 370633

Strand: Reverse

Name: fdhA [H]

Synonym: ST0348

Alternate gene names: 15920549

Gene position: 370633-368669 (Counterclockwise)

Preceding gene: 15920550

Following gene: 15920545

Centisome position: 13.75

GC content: 33.54

Gene sequence:

>1965_bases
ATGGAAACAGTAAAGAGCATTTGTCCATTTTGTGGAGTAGGATGTGGTGTTGAATTATATGTAGAGAGTTCGACTATTAT
AAGATTATCTCCAGTTAAAGAACATGTTGTAAGTAGGGGACACTTATGTGGAAAGGGAACTCTGGCATATGAACCTATTT
TTGCTTGGGATAGATTGACTTACCCTTTGAAGAAAGTTAAGGGAGAGCATATAAGAATAAGCTGGGAAATAGCGATAAAA
GAAATAGCTTCTAAACTTAAGGAAATAATTCAGCAATATGGTAGTGACGCAATAGCATTTTATGGTGGGTGTCAAAACAC
TTTAGAAGAAGACTATTTAATGCAGAAATTAGCAAGAGCTATGGGTACTAATAACATAGATTCTTGCGCTAGAGTATGCC
ATGATCCTTCAGCAACTGCATTAAAGGAAATGGTTGGAATAGGGGCTTCATCAGTTTCCGTAGAAATGATCCCTAGAATG
AAAGTAGTAGTAATCACGGGAGAATCTATTACTGAAAGCCACCCCGTATTATCTCAGTATTTGACCGAGGCAAAAAAGAA
CGGTACTAAACTCATTGTAATAGATCCTAGAGTAACTGGGACAGCAAAATTCTCTGATCTTCATTTAAGATTAAGACCAG
GAACAGATATAGCATTGTTTAATGCGGTAGGAAATTATTTAATTGAAAATTCGTTAATCGATGAAAAGTTCATTAAAGAA
AGGGTGATTGGTTTTGAAGAATATGCTAAAGGAGTGTCAAAATACACGTTAGAGTACGCTGAAAAGGTAACAGGAGTAAG
AAAAGAGAATATAAAAAAGTTTGCTGAGTTAATTGCCCAAAAAGGAGTAATATTTTCATGGGGACTTGGTTTAACTCAGT
CTTCAGGGGTTAATGGTGTTAGAGCTTATATAAACTTAGCATTACTTACTGGAAATATAGGAAAGAACGGAGGACTTTTA
GTATTTAGAGGACAAACTAATGTTCAAGGTTCAGGGGATCTTCTAAAGCCAGATAAATTTCCTAACGGTACAATGGATGA
AGAAAACGCTAAAAAATTAGCAGAAATATGGAATTTTCTACCACCAACTAAACCTGGATTATCAGTAACTGAAGCATTAT
TAAGAGATAATAATATTAGGGCTATCATATTCATGGGATTTAATCCCTTAATCAGTTTACCAAATAGAGAAAAAGTTGAA
AGAAAATTAAAGAGCCTAGATCTATTGGTAGTAATTGACGCATTTATGACAGAGACAGCTAGTTTAGCACATTATGTTTT
GCCAGCCGCAGTATGGGCTGAGAAAGAGGGTTCAGTTACTAATTTGGATAGGTTAGCCAAGTGGAGATTTAAAGCTATAG
ATCCTCCAGGGGAGGCTAAGCCAGATTATGAAATATTAAAGAAACTTGCAGAGGAATTAGGCTATAATTTTAGCTCAGAT
CCAAAGGAAATTTTCGAAGAGATGAAAAAAGTTGTTCCTTTGTACTCCAATTTAACTTTAGATGAAATCATGGATTATTC
TTCGAGCTCAAGATATCCTAACCATGAGATTTATTTATATGATGAAAAGTTTTACACAGAGACAAATAAGGCGAAATTAA
TTTTAGTAGAACAGCCAGAAGTTAAGAATGGAATAATATTAATTACTGTTAGAAATGTGACCAGATATAATACCGATGTA
ATCACTGGAAGAATACCAGGATATGGAAAATATGAAAGTTTAATCTATGTAAGTCAAGAAGATGCACTAGAATTAAAAAT
AAGAGATAATGAGGAAGTTTTAGTAACTTCTGAATGTGGAAAAATGAATTTCAGGGTAATGATTTCCAAAGATGTTCAGA
AAGGAACTGCAATAATGTATATGCATGATCCTAAAGTTAATTATATCATATGTGATGAACTTGATGAAATTACAAAAACT
CCAAAGTATAAGTATACAGAAATAAAGATAATGAAATTGAATTAA

Upstream 100 bases:

>100_bases
TTATTTTTTATTCTATTATTATTAATTATAATATATCAAATATTTACTCTAAAGAACTATTTAACGCAAATTTTTATTTA
TAAGAACGCATAGTAACATA

Downstream 100 bases:

>100_bases
CAAAAAATTCTTTTTTATATCTATATATAACTATATTTGATTTTGGTGTAATTCTAAACAATACTCATTGCCCTCGAGCT
AATAGTCTATCTTGAGACAA

Product: formate dehydrogenase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 654; Mature: 654

Protein sequence:

>654_residues
METVKSICPFCGVGCGVELYVESSTIIRLSPVKEHVVSRGHLCGKGTLAYEPIFAWDRLTYPLKKVKGEHIRISWEIAIK
EIASKLKEIIQQYGSDAIAFYGGCQNTLEEDYLMQKLARAMGTNNIDSCARVCHDPSATALKEMVGIGASSVSVEMIPRM
KVVVITGESITESHPVLSQYLTEAKKNGTKLIVIDPRVTGTAKFSDLHLRLRPGTDIALFNAVGNYLIENSLIDEKFIKE
RVIGFEEYAKGVSKYTLEYAEKVTGVRKENIKKFAELIAQKGVIFSWGLGLTQSSGVNGVRAYINLALLTGNIGKNGGLL
VFRGQTNVQGSGDLLKPDKFPNGTMDEENAKKLAEIWNFLPPTKPGLSVTEALLRDNNIRAIIFMGFNPLISLPNREKVE
RKLKSLDLLVVIDAFMTETASLAHYVLPAAVWAEKEGSVTNLDRLAKWRFKAIDPPGEAKPDYEILKKLAEELGYNFSSD
PKEIFEEMKKVVPLYSNLTLDEIMDYSSSSRYPNHEIYLYDEKFYTETNKAKLILVEQPEVKNGIILITVRNVTRYNTDV
ITGRIPGYGKYESLIYVSQEDALELKIRDNEEVLVTSECGKMNFRVMISKDVQKGTAIMYMHDPKVNYIICDELDEITKT
PKYKYTEIKIMKLN

Sequences:

>Translated_654_residues
METVKSICPFCGVGCGVELYVESSTIIRLSPVKEHVVSRGHLCGKGTLAYEPIFAWDRLTYPLKKVKGEHIRISWEIAIK
EIASKLKEIIQQYGSDAIAFYGGCQNTLEEDYLMQKLARAMGTNNIDSCARVCHDPSATALKEMVGIGASSVSVEMIPRM
KVVVITGESITESHPVLSQYLTEAKKNGTKLIVIDPRVTGTAKFSDLHLRLRPGTDIALFNAVGNYLIENSLIDEKFIKE
RVIGFEEYAKGVSKYTLEYAEKVTGVRKENIKKFAELIAQKGVIFSWGLGLTQSSGVNGVRAYINLALLTGNIGKNGGLL
VFRGQTNVQGSGDLLKPDKFPNGTMDEENAKKLAEIWNFLPPTKPGLSVTEALLRDNNIRAIIFMGFNPLISLPNREKVE
RKLKSLDLLVVIDAFMTETASLAHYVLPAAVWAEKEGSVTNLDRLAKWRFKAIDPPGEAKPDYEILKKLAEELGYNFSSD
PKEIFEEMKKVVPLYSNLTLDEIMDYSSSSRYPNHEIYLYDEKFYTETNKAKLILVEQPEVKNGIILITVRNVTRYNTDV
ITGRIPGYGKYESLIYVSQEDALELKIRDNEEVLVTSECGKMNFRVMISKDVQKGTAIMYMHDPKVNYIICDELDEITKT
PKYKYTEIKIMKLN
>Mature_654_residues
METVKSICPFCGVGCGVELYVESSTIIRLSPVKEHVVSRGHLCGKGTLAYEPIFAWDRLTYPLKKVKGEHIRISWEIAIK
EIASKLKEIIQQYGSDAIAFYGGCQNTLEEDYLMQKLARAMGTNNIDSCARVCHDPSATALKEMVGIGASSVSVEMIPRM
KVVVITGESITESHPVLSQYLTEAKKNGTKLIVIDPRVTGTAKFSDLHLRLRPGTDIALFNAVGNYLIENSLIDEKFIKE
RVIGFEEYAKGVSKYTLEYAEKVTGVRKENIKKFAELIAQKGVIFSWGLGLTQSSGVNGVRAYINLALLTGNIGKNGGLL
VFRGQTNVQGSGDLLKPDKFPNGTMDEENAKKLAEIWNFLPPTKPGLSVTEALLRDNNIRAIIFMGFNPLISLPNREKVE
RKLKSLDLLVVIDAFMTETASLAHYVLPAAVWAEKEGSVTNLDRLAKWRFKAIDPPGEAKPDYEILKKLAEELGYNFSSD
PKEIFEEMKKVVPLYSNLTLDEIMDYSSSSRYPNHEIYLYDEKFYTETNKAKLILVEQPEVKNGIILITVRNVTRYNTDV
ITGRIPGYGKYESLIYVSQEDALELKIRDNEEVLVTSECGKMNFRVMISKDVQKGTAIMYMHDPKVNYIICDELDEITKT
PKYKYTEIKIMKLN

Specific function: Catalyzes the oxidation of formate [H]

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI3868721, Length=698, Percent_Identity=34.2406876790831, Blast_Score=374, Evalue=1e-105,
Organism=Escherichia coli, GI3868719, Length=635, Percent_Identity=26.9291338582677, Blast_Score=200, Evalue=2e-52,
Organism=Escherichia coli, GI3868720, Length=628, Percent_Identity=28.343949044586, Blast_Score=196, Evalue=4e-51,
Organism=Escherichia coli, GI1788534, Length=528, Percent_Identity=26.5151515151515, Blast_Score=177, Evalue=1e-45,
Organism=Escherichia coli, GI1787778, Length=676, Percent_Identity=26.6272189349112, Blast_Score=175, Evalue=8e-45,
Organism=Escherichia coli, GI87081797, Length=486, Percent_Identity=28.1893004115226, Blast_Score=115, Evalue=1e-26,
Organism=Escherichia coli, GI171474008, Length=524, Percent_Identity=26.7175572519084, Blast_Score=114, Evalue=3e-26,
Organism=Escherichia coli, GI1787870, Length=544, Percent_Identity=25.3676470588235, Blast_Score=110, Evalue=4e-25,
Organism=Escherichia coli, GI1787231, Length=482, Percent_Identity=22.8215767634855, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI87081994, Length=485, Percent_Identity=25.360824742268, Blast_Score=70, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009010
- InterPro:   IPR006478
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006963
- InterPro:   IPR006655 [H]

Pfam domain/function: PF04879 Molybdop_Fe4S4; PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: =1.2.1.2 [H]

Molecular weight: Translated: 73422; Mature: 73422

Theoretical pI: Translated: 7.21; Mature: 7.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METVKSICPFCGVGCGVELYVESSTIIRLSPVKEHVVSRGHLCGKGTLAYEPIFAWDRLT
CCCHHHHHHHCCCCCCEEEEEECCEEEEECCHHHHHHHCCCCCCCCCEEECCEEHHHHHH
YPLKKVKGEHIRISWEIAIKEIASKLKEIIQQYGSDAIAFYGGCQNTLEEDYLMQKLARA
CCHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHH
MGTNNIDSCARVCHDPSATALKEMVGIGASSVSVEMIPRMKVVVITGESITESHPVLSQY
HCCCCHHHHHHHHCCCCHHHHHHHHCCCCCCEEEEEECCEEEEEEECCCCCCCCHHHHHH
LTEAKKNGTKLIVIDPRVTGTAKFSDLHLRLRPGTDIALFNAVGNYLIENSLIDEKFIKE
HHHHHCCCCEEEEECCCCCCCEEEEEEEEEECCCCCEEHHHHHHHHHHHHCHHHHHHHHH
RVIGFEEYAKGVSKYTLEYAEKVTGVRKENIKKFAELIAQKGVIFSWGLGLTQSSGVNGV
HHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCE
RAYINLALLTGNIGKNGGLLVFRGQTNVQGSGDLLKPDKFPNGTMDEENAKKLAEIWNFL
EEEEEEEEEECCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCC
PPTKPGLSVTEALLRDNNIRAIIFMGFNPLISLPNREKVERKLKSLDLLVVIDAFMTETA
CCCCCCHHHHHHHHCCCCCEEEEEECCCCEECCCCHHHHHHHHHHCCCEEEHHHHHHHHH
SLAHYVLPAAVWAEKEGSVTNLDRLAKWRFKAIDPPGEAKPDYEILKKLAEELGYNFSSD
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHEECCCCCCCCCCHHHHHHHHHHHCCCCCCC
PKEIFEEMKKVVPLYSNLTLDEIMDYSSSSRYPNHEIYLYDEKFYTETNKAKLILVEQPE
HHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCEEEEEECCEECCCCCEEEEEEECCC
VKNGIILITVRNVTRYNTDVITGRIPGYGKYESLIYVSQEDALELKIRDNEEVLVTSECG
CCCCEEEEEEECCEEECCEEEEECCCCCCCCCEEEEEECCCCEEEEEECCCCEEEEECCC
KMNFRVMISKDVQKGTAIMYMHDPKVNYIICDELDEITKTPKYKYTEIKIMKLN
CEEEEEEEECCCCCCEEEEEEECCCCCEEECCCHHHHHCCCCEEEEEEEEEEEC
>Mature Secondary Structure
METVKSICPFCGVGCGVELYVESSTIIRLSPVKEHVVSRGHLCGKGTLAYEPIFAWDRLT
CCCHHHHHHHCCCCCCEEEEEECCEEEEECCHHHHHHHCCCCCCCCCEEECCEEHHHHHH
YPLKKVKGEHIRISWEIAIKEIASKLKEIIQQYGSDAIAFYGGCQNTLEEDYLMQKLARA
CCHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHH
MGTNNIDSCARVCHDPSATALKEMVGIGASSVSVEMIPRMKVVVITGESITESHPVLSQY
HCCCCHHHHHHHHCCCCHHHHHHHHCCCCCCEEEEEECCEEEEEEECCCCCCCCHHHHHH
LTEAKKNGTKLIVIDPRVTGTAKFSDLHLRLRPGTDIALFNAVGNYLIENSLIDEKFIKE
HHHHHCCCCEEEEECCCCCCCEEEEEEEEEECCCCCEEHHHHHHHHHHHHCHHHHHHHHH
RVIGFEEYAKGVSKYTLEYAEKVTGVRKENIKKFAELIAQKGVIFSWGLGLTQSSGVNGV
HHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCE
RAYINLALLTGNIGKNGGLLVFRGQTNVQGSGDLLKPDKFPNGTMDEENAKKLAEIWNFL
EEEEEEEEEECCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCC
PPTKPGLSVTEALLRDNNIRAIIFMGFNPLISLPNREKVERKLKSLDLLVVIDAFMTETA
CCCCCCHHHHHHHHCCCCCEEEEEECCCCEECCCCHHHHHHHHHHCCCEEEHHHHHHHHH
SLAHYVLPAAVWAEKEGSVTNLDRLAKWRFKAIDPPGEAKPDYEILKKLAEELGYNFSSD
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHEECCCCCCCCCCHHHHHHHHHHHCCCCCCC
PKEIFEEMKKVVPLYSNLTLDEIMDYSSSSRYPNHEIYLYDEKFYTETNKAKLILVEQPE
HHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCEEEEEECCEECCCCCEEEEEEECCC
VKNGIILITVRNVTRYNTDVITGRIPGYGKYESLIYVSQEDALELKIRDNEEVLVTSECG
CCCCEEEEEEECCEEECCEEEEECCCCCCCCCEEEEEECCCCEEEEEECCCCEEEEECCC
KMNFRVMISKDVQKGTAIMYMHDPKVNYIICDELDEITKTPKYKYTEIKIMKLN
CEEEEEEEECCCCCCEEEEEEECCCCCEEECCCHHHHHCCCCEEEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]