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The map label for this gene is cobD [H]

Identifier: 15920344

GI number: 15920344

Start: 192269

End: 193240

Strand: Direct

Name: cobD [H]

Synonym: ST0165

Alternate gene names: 15920344

Gene position: 192269-193240 (Clockwise)

Preceding gene: 15920343

Following gene: 15920345

Centisome position: 7.13

GC content: 30.76

Gene sequence:

>972_bases
ATGAAGCATGGAGGAGTAAAGTGGGGTAAGGATGGACCAGAACATATTAATGATTTTAGTGTGAATTTGAATCCTTTAGG
AACTTTGCCCAGAGTACATGAACTTATAGATGAAGCGGTGAAGAAGAGGGTTTACTCATTTTATCCACCAGAAGATTATA
AGGAAATAAAGGAGTTTATAGCTGAACTTTATAATGTTGATATTGATTTAATTGGTGTTTTTAATGGTTCCTCAGAAGTA
ATAAAACTACTAGATGCTTGTGATGTTCCAGAACCAAATTTTTCTGAGTATAAGAGGAAACGTAGTTATTTTGCAATAGA
GAGAGAAAATTACTTTGAATATTATCTCTCTGGGGATTGTGTCATAACTAGTAATCCAGTTAATCCTACTGGGAGTATGA
TTAAAGAGAAGGATATTATCAATTTTCTATCCTTTGGAAGAAAATTAATACTAGATGAATCTTTTGCAGATATAAGTCTA
ATAAAGAGTTCTATTAAATATACTGAAGAGTTTAATAATCTTCTTATAATTTCATCTTTTACAAAATCCTTATCTATTCC
AGGGTTAAGAATAGGTTTTTCTATTGGAAAGAATTCAAGAAAATTAGAGGAGAAAGCACCGCCTTGGAGGATAAATAGTA
TTGTGTATTATGTTTTTGTTAATCTAGATCCTAAGGAGGTTAGGGATTTTTTTGAAAGATCTAAGAGAGAGATTGAAAGG
CTTATTAGCGTTTTAAAAAGCACTAAAGCTAAATTTAAAATATATGATACAGTAGCCCCGTATTTTTTGGCTGAATTTCC
TATCCCTACTAAAGAGTTAAATATGAAGCTAAGGAAATATGGGTATCAGATTAGAGAGCCAGAGGGTTTTTTAGGTTTAA
GACCAACCCACGGCAGAATTTCTTTAAAAAATAACTTTAAAGAGCTAATATTTTTAATAAATAAGATTCTTGATTGCGAA
AAACTTTATTAA

Upstream 100 bases:

>100_bases
AGTTAGCTGAAAAATTAAACATAAGTTCTTCTACGTTAGCTGAGATATTAAGAAGAGCTGAAAAGAATATTATTGAGGCT
TACTTTAAGGAGAGAGGCTT

Downstream 100 bases:

>100_bases
TCATTATCTTTTATTATCTACTTGTGTTAGAAAAAGTTATTAAATATGCTATTGTTGGTGGATTAGGTACTATTGTTAAT
GAGGGAATTCTTTTATCTAC

Product: aminotransferase

Products: NA

Alternate protein names: L-threonine-O-3-phosphate decarboxylase [H]

Number of amino acids: Translated: 323; Mature: 323

Protein sequence:

>323_residues
MKHGGVKWGKDGPEHINDFSVNLNPLGTLPRVHELIDEAVKKRVYSFYPPEDYKEIKEFIAELYNVDIDLIGVFNGSSEV
IKLLDACDVPEPNFSEYKRKRSYFAIERENYFEYYLSGDCVITSNPVNPTGSMIKEKDIINFLSFGRKLILDESFADISL
IKSSIKYTEEFNNLLIISSFTKSLSIPGLRIGFSIGKNSRKLEEKAPPWRINSIVYYVFVNLDPKEVRDFFERSKREIER
LISVLKSTKAKFKIYDTVAPYFLAEFPIPTKELNMKLRKYGYQIREPEGFLGLRPTHGRISLKNNFKELIFLINKILDCE
KLY

Sequences:

>Translated_323_residues
MKHGGVKWGKDGPEHINDFSVNLNPLGTLPRVHELIDEAVKKRVYSFYPPEDYKEIKEFIAELYNVDIDLIGVFNGSSEV
IKLLDACDVPEPNFSEYKRKRSYFAIERENYFEYYLSGDCVITSNPVNPTGSMIKEKDIINFLSFGRKLILDESFADISL
IKSSIKYTEEFNNLLIISSFTKSLSIPGLRIGFSIGKNSRKLEEKAPPWRINSIVYYVFVNLDPKEVRDFFERSKREIER
LISVLKSTKAKFKIYDTVAPYFLAEFPIPTKELNMKLRKYGYQIREPEGFLGLRPTHGRISLKNNFKELIFLINKILDCE
KLY
>Mature_323_residues
MKHGGVKWGKDGPEHINDFSVNLNPLGTLPRVHELIDEAVKKRVYSFYPPEDYKEIKEFIAELYNVDIDLIGVFNGSSEV
IKLLDACDVPEPNFSEYKRKRSYFAIERENYFEYYLSGDCVITSNPVNPTGSMIKEKDIINFLSFGRKLILDESFADISL
IKSSIKYTEEFNNLLIISSFTKSLSIPGLRIGFSIGKNSRKLEEKAPPWRINSIVYYVFVNLDPKEVRDFFERSKREIER
LISVLKSTKAKFKIYDTVAPYFLAEFPIPTKELNMKLRKYGYQIREPEGFLGLRPTHGRISLKNNFKELIFLINKILDCE
KLY

Specific function: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1- amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin [H]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005860
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.1.1.81 [H]

Molecular weight: Translated: 37552; Mature: 37552

Theoretical pI: Translated: 8.86; Mature: 8.86

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHGGVKWGKDGPEHINDFSVNLNPLGTLPRVHELIDEAVKKRVYSFYPPEDYKEIKEFI
CCCCCCCCCCCCHHHCCCCEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
AELYNVDIDLIGVFNGSSEVIKLLDACDVPEPNFSEYKRKRSYFAIERENYFEYYLSGDC
HHHHCCCEEEEEEECCHHHHHHHHHHCCCCCCCHHHHHHHHHEEEEECCCEEEEEEECCE
VITSNPVNPTGSMIKEKDIINFLSFGRKLILDESFADISLIKSSIKYTEEFNNLLIISSF
EEECCCCCCCHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHCCEEEEEEH
TKSLSIPGLRIGFSIGKNSRKLEEKAPPWRINSIVYYVFVNLDPKEVRDFFERSKREIER
HHHCCCCCEEEEEEECCCCHHHHHCCCCEEECEEEEEEEEECCHHHHHHHHHHHHHHHHH
LISVLKSTKAKFKIYDTVAPYFLAEFPIPTKELNMKLRKYGYQIREPEGFLGLRPTHGRI
HHHHHHCCCCCEEEEHHHHHHHHHCCCCCHHHHHHHHHHCCCEEECCCCCCCCCCCCCEE
SLKNNFKELIFLINKILDCEKLY
EEHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKHGGVKWGKDGPEHINDFSVNLNPLGTLPRVHELIDEAVKKRVYSFYPPEDYKEIKEFI
CCCCCCCCCCCCHHHCCCCEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
AELYNVDIDLIGVFNGSSEVIKLLDACDVPEPNFSEYKRKRSYFAIERENYFEYYLSGDC
HHHHCCCEEEEEEECCHHHHHHHHHHCCCCCCCHHHHHHHHHEEEEECCCEEEEEEECCE
VITSNPVNPTGSMIKEKDIINFLSFGRKLILDESFADISLIKSSIKYTEEFNNLLIISSF
EEECCCCCCCHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHCCEEEEEEH
TKSLSIPGLRIGFSIGKNSRKLEEKAPPWRINSIVYYVFVNLDPKEVRDFFERSKREIER
HHHCCCCCEEEEEEECCCCHHHHHCCCCEEECEEEEEEEEECCHHHHHHHHHHHHHHHHH
LISVLKSTKAKFKIYDTVAPYFLAEFPIPTKELNMKLRKYGYQIREPEGFLGLRPTHGRI
HHHHHHCCCCCEEEEHHHHHHHHHCCCCCHHHHHHHHHHCCCEEECCCCCCCCCCCCCEE
SLKNNFKELIFLINKILDCEKLY
EEHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]