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The map label for this gene is cutM [H]

Identifier: 15920272

GI number: 15920272

Start: 118302

End: 119618

Strand: Direct

Name: cutM [H]

Synonym: ST0094

Alternate gene names: 15920272

Gene position: 118302-119618 (Clockwise)

Preceding gene: 15920271

Following gene: 15920275

Centisome position: 4.39

GC content: 32.5

Gene sequence:

>1317_bases
ATGAGCTTTGTGTTAGGTATTCCTAAAAAGTTTAAGTACATTAAGGTTAACTCTCTTGATGAAGCCTTAGAGTTACTTAG
AGATGGATCAAAAGTATTAGCTGGTGGTCAAAGCTTATTACCGCTATTAAAATTAAGAATACTTAACGTTGATACTCTTA
TAGATATAAAGAATTTAGATTTAAGGGGCGTAAAGGAAAATGAAAAAGAAATTGAGATTTACTCATTAACCACTCATAAT
GAAGTTGCTTCGAAAGTTAAATTACTCTCTAAAGTTGCATTCACAATTGCTGATTTTCAAGTTAGGAATAAAGGAACTAT
AGGAGGCTCATTAGCACACGCTGATCCTTCAAGTAATTACTATCCGGCGTTACTAACACTAGATGCTAAAGTTAAGGTAA
AGTCTAAAAAAGGCGAAAGAGAGATAAAAATTTCAGATTTATACTTATCACCTTACACTACTTCAATGAGAGAAGATGAA
ATAATAACTAGTATTATTATCCCTAAGAAGAAAGAGTTAAACTTCACTTACGAAGTTTATAAGAGAGGTGGCTCTGCATA
TCCTACAGCTATAGTTGCAGTTGCTATTGAGGGAAATAAATATAAGGTTAGCTTTGGTGGAATAACCGAGAAACCTACTT
TATTTGAAGGTGAAGTTGAAGGTGAAAGTACTATCAAAAATGTTATTGAAAGGTTAAGAAAGGAAAAAATTATTTCAGAT
ATTCACGCTGATAGTAGTACTAGATTAAAAATAGCCGAAAGGCTGTTTGTGAACGCTTTTTTAAAGGCTTTAAAAGGAGT
CATAGATAAACTCGATATTCCAAATATTGAGAATAAATGGAAAAGTGATATGATAAGAGGCGAGGAAATGGTTAAAGTTA
GAATGAAAGTTAATGATTTCGAAATAGAAGATGAGGTTGAACCTAGGACTCTTCTTTTGGATTTCCTAAGAAGGAATGGA
TATAAGGAAGTTAAAAGAGGTTGCGATGAGGGAAAATGTGGTGCTTGTACGGTAATCATAAACGGTAAGTCGATTAAATC
ATGTTTGACTCTGGCTGTTGAAGTTGCAGGATCAGATATAAGGACTGTTAAAGGACTTTCAGATATTAAACCGATAAAGG
ACTCTTTCTTAGAAAACTTTGCAATGCAATGTGGATATTGTACACATGGGTTTTTAATGGTTACTTATGATTATCTAAAG
AGAGTAGGTAAAAGGGATAATGACGAGTTACTTAGACATAGCATAAAAAATATTTGTCGATGTACTGGTTACTTTAATAT
TATAAAAGCAATTAAGTCTTCTTCCTTGAGTCAATAA

Upstream 100 bases:

>100_bases
GTGGAGAAGGACCAATAATGGCTGCTCCAGCTGCATTGGCTAATGCAATCTCAAGGCTTATAGGAAAAAGAATAAGTGAA
GTGCCTATTAGGGTGATTGA

Downstream 100 bases:

>100_bases
ATTCTTTCATCCTCTTTTTTGCTGACTCTGTTTGAGATAATAATGCTAATTCCATTATAGCCTTTTCAACTATTTTCTTA
TCTTTTCTAAGCCATCTTTT

Product: xanthine dehydrogenase

Products: NA

Alternate protein names: CO dehydrogenase subunit M; CO-DH M [H]

Number of amino acids: Translated: 438; Mature: 437

Protein sequence:

>438_residues
MSFVLGIPKKFKYIKVNSLDEALELLRDGSKVLAGGQSLLPLLKLRILNVDTLIDIKNLDLRGVKENEKEIEIYSLTTHN
EVASKVKLLSKVAFTIADFQVRNKGTIGGSLAHADPSSNYYPALLTLDAKVKVKSKKGEREIKISDLYLSPYTTSMREDE
IITSIIIPKKKELNFTYEVYKRGGSAYPTAIVAVAIEGNKYKVSFGGITEKPTLFEGEVEGESTIKNVIERLRKEKIISD
IHADSSTRLKIAERLFVNAFLKALKGVIDKLDIPNIENKWKSDMIRGEEMVKVRMKVNDFEIEDEVEPRTLLLDFLRRNG
YKEVKRGCDEGKCGACTVIINGKSIKSCLTLAVEVAGSDIRTVKGLSDIKPIKDSFLENFAMQCGYCTHGFLMVTYDYLK
RVGKRDNDELLRHSIKNICRCTGYFNIIKAIKSSSLSQ

Sequences:

>Translated_438_residues
MSFVLGIPKKFKYIKVNSLDEALELLRDGSKVLAGGQSLLPLLKLRILNVDTLIDIKNLDLRGVKENEKEIEIYSLTTHN
EVASKVKLLSKVAFTIADFQVRNKGTIGGSLAHADPSSNYYPALLTLDAKVKVKSKKGEREIKISDLYLSPYTTSMREDE
IITSIIIPKKKELNFTYEVYKRGGSAYPTAIVAVAIEGNKYKVSFGGITEKPTLFEGEVEGESTIKNVIERLRKEKIISD
IHADSSTRLKIAERLFVNAFLKALKGVIDKLDIPNIENKWKSDMIRGEEMVKVRMKVNDFEIEDEVEPRTLLLDFLRRNG
YKEVKRGCDEGKCGACTVIINGKSIKSCLTLAVEVAGSDIRTVKGLSDIKPIKDSFLENFAMQCGYCTHGFLMVTYDYLK
RVGKRDNDELLRHSIKNICRCTGYFNIIKAIKSSSLSQ
>Mature_437_residues
SFVLGIPKKFKYIKVNSLDEALELLRDGSKVLAGGQSLLPLLKLRILNVDTLIDIKNLDLRGVKENEKEIEIYSLTTHNE
VASKVKLLSKVAFTIADFQVRNKGTIGGSLAHADPSSNYYPALLTLDAKVKVKSKKGEREIKISDLYLSPYTTSMREDEI
ITSIIIPKKKELNFTYEVYKRGGSAYPTAIVAVAIEGNKYKVSFGGITEKPTLFEGEVEGESTIKNVIERLRKEKIISDI
HADSSTRLKIAERLFVNAFLKALKGVIDKLDIPNIENKWKSDMIRGEEMVKVRMKVNDFEIEDEVEPRTLLLDFLRRNGY
KEVKRGCDEGKCGACTVIINGKSIKSCLTLAVEVAGSDIRTVKGLSDIKPIKDSFLENFAMQCGYCTHGFLMVTYDYLKR
VGKRDNDELLRHSIKNICRCTGYFNIIKAIKSSSLSQ

Specific function: Catalyzes the oxidation of carbon monoxide to carbon dioxide [H]

COG id: COG2080

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Escherichia coli, GI1786480, Length=166, Percent_Identity=36.7469879518072, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1789232, Length=148, Percent_Identity=34.4594594594595, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1789231, Length=171, Percent_Identity=29.2397660818713, Blast_Score=69, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17539860, Length=145, Percent_Identity=32.4137931034483, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI32566215, Length=147, Percent_Identity=31.9727891156463, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17540638, Length=150, Percent_Identity=32.6666666666667, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24647201, Length=139, Percent_Identity=35.9712230215827, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17737937, Length=142, Percent_Identity=32.3943661971831, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24647199, Length=138, Percent_Identity=35.5072463768116, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24647195, Length=162, Percent_Identity=32.0987654320988, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24647197, Length=162, Percent_Identity=32.0987654320988, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24647193, Length=135, Percent_Identity=34.0740740740741, Blast_Score=72, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005107
- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR002346 [H]

Pfam domain/function: PF03450 CO_deh_flav_C; PF00941 FAD_binding_5 [H]

EC number: =1.2.99.2 [H]

Molecular weight: Translated: 49199; Mature: 49068

Theoretical pI: Translated: 9.45; Mature: 9.45

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFVLGIPKKFKYIKVNSLDEALELLRDGSKVLAGGQSLLPLLKLRILNVDTLIDIKNLD
CCCEECCCCCEEEEEECCHHHHHHHHHCCCHHHCCCHHHHHHHHHHHCCHHHEEEEECCC
LRGVKENEKEIEIYSLTTHNEVASKVKLLSKVAFTIADFQVRNKGTIGGSLAHADPSSNY
CCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCEECCCCCCCC
YPALLTLDAKVKVKSKKGEREIKISDLYLSPYTTSMREDEIITSIIIPKKKELNFTYEVY
CCEEEEEECEEEEECCCCCCEEEEEEEEECCCCCCCCHHHHHHHHCCCCCCCCCEEEEHH
KRGGSAYPTAIVAVAIEGNKYKVSFGGITEKPTLFEGEVEGESTIKNVIERLRKEKIISD
HCCCCCCCEEEEEEEEECCEEEEEECCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHH
IHADSSTRLKIAERLFVNAFLKALKGVIDKLDIPNIENKWKSDMIRGEEMVKVRMKVNDF
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCEEEEEEEECCE
EIEDEVEPRTLLLDFLRRNGYKEVKRGCDEGKCGACTVIINGKSIKSCLTLAVEVAGSDI
ECCCCCCHHHHHHHHHHHCCHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCH
RTVKGLSDIKPIKDSFLENFAMQCGYCTHGFLMVTYDYLKRVGKRDNDELLRHSIKNICR
HHHCCCHHCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
CTGYFNIIKAIKSSSLSQ
HHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SFVLGIPKKFKYIKVNSLDEALELLRDGSKVLAGGQSLLPLLKLRILNVDTLIDIKNLD
CCEECCCCCEEEEEECCHHHHHHHHHCCCHHHCCCHHHHHHHHHHHCCHHHEEEEECCC
LRGVKENEKEIEIYSLTTHNEVASKVKLLSKVAFTIADFQVRNKGTIGGSLAHADPSSNY
CCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCEECCCCCCCC
YPALLTLDAKVKVKSKKGEREIKISDLYLSPYTTSMREDEIITSIIIPKKKELNFTYEVY
CCEEEEEECEEEEECCCCCCEEEEEEEEECCCCCCCCHHHHHHHHCCCCCCCCCEEEEHH
KRGGSAYPTAIVAVAIEGNKYKVSFGGITEKPTLFEGEVEGESTIKNVIERLRKEKIISD
HCCCCCCCEEEEEEEEECCEEEEEECCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHH
IHADSSTRLKIAERLFVNAFLKALKGVIDKLDIPNIENKWKSDMIRGEEMVKVRMKVNDF
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCEEEEEEEECCE
EIEDEVEPRTLLLDFLRRNGYKEVKRGCDEGKCGACTVIINGKSIKSCLTLAVEVAGSDI
ECCCCCCHHHHHHHHHHHCCHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCH
RTVKGLSDIKPIKDSFLENFAMQCGYCTHGFLMVTYDYLKRVGKRDNDELLRHSIKNICR
HHHCCCHHCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
CTGYFNIIKAIKSSSLSQ
HHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10482497; 2818128; 10966817; 11076018 [H]