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The map label for this gene is flpA [H]

Identifier: 159041875

GI number: 159041875

Start: 1383408

End: 1384118

Strand: Reverse

Name: flpA [H]

Synonym: Cmaq_1310

Alternate gene names: 159041875

Gene position: 1384118-1383408 (Counterclockwise)

Preceding gene: 159041877

Following gene: 159041871

Centisome position: 66.62

GC content: 43.46

Gene sequence:

>711_bases
ATGTCTAGTGTAAGGGCAGTGGATGTTAAGGAGCATGAGAGGTTTAAGGGTGTTTACTGGATTGAGTTTGAGGATGGCTC
AACCAGGTTAGCCACAAGGAATTTGACGCCGGGGAAGAGGGTGTATGGTGAGCAGTTAATTAACCTAGGTGGTGTTGAGT
ATAGGGTTTGGAACCCCTATAGGTCTAAGCTTGGTGCCGCAATAATGAATAAGCTTGAAGCCATGCCTATTAGTGAAGGC
TCTAAGGTGCTTTACCTTGGTGCAGCAAGCGGTACAACTGTTAGCCATGTTAGTGATATAGTTGGGTTAAATGGCTTAAT
TTACGGTGTTGAGTTTAGTCCAAGGGTTTTCAGGGAGTTTATGCAGAATATCATAGATCAAGGTAGGTTAAACGTAATAC
CAATACTCGCCGACGCCAGGTATCCTGAGCAGTATATTTCACTGGTTAAGGGTGTTGATGTAGCCTACATTGATGTTGCC
CAGCCGTTTCAAGCTAAGATACTTGCGGATAATGCAGACGTATACTTAGTTAAGGGTGGTTACATAATCTTAGTCATAAA
GGCAATGTCCATTGACGTCACTAAGGAACCCTCTGAAACCTTTAAGAGGGAGATAGATACCATTAAGGAGAGGGGATTCG
ATATAATAAACATGGTTCACCTAGAGCCCTATGATGTGGCCCATGCCTTAGTTGTTGGTAAGAGGGATTGA

Upstream 100 bases:

>100_bases
ACCAACGTTAAGCCGCATGGAGTCAAGTAATGTTAAGGCACGTACGTATTCATGAGGAAGTGACGCTAAGGCTTAAATAC
CTTAATTAATAAGGTTAAGT

Downstream 100 bases:

>100_bases
GTGAATAATCCTAATTAACCTCCATGGCTCAGCATTAGTCTTAACCCCATCAGTAGTGAAATGCGTACCGTAGGCCTCAA
TACCATTCTCCATTAAATAT

Product: fibrillarin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 236; Mature: 235

Protein sequence:

>236_residues
MSSVRAVDVKEHERFKGVYWIEFEDGSTRLATRNLTPGKRVYGEQLINLGGVEYRVWNPYRSKLGAAIMNKLEAMPISEG
SKVLYLGAASGTTVSHVSDIVGLNGLIYGVEFSPRVFREFMQNIIDQGRLNVIPILADARYPEQYISLVKGVDVAYIDVA
QPFQAKILADNADVYLVKGGYIILVIKAMSIDVTKEPSETFKREIDTIKERGFDIINMVHLEPYDVAHALVVGKRD

Sequences:

>Translated_236_residues
MSSVRAVDVKEHERFKGVYWIEFEDGSTRLATRNLTPGKRVYGEQLINLGGVEYRVWNPYRSKLGAAIMNKLEAMPISEG
SKVLYLGAASGTTVSHVSDIVGLNGLIYGVEFSPRVFREFMQNIIDQGRLNVIPILADARYPEQYISLVKGVDVAYIDVA
QPFQAKILADNADVYLVKGGYIILVIKAMSIDVTKEPSETFKREIDTIKERGFDIINMVHLEPYDVAHALVVGKRD
>Mature_235_residues
SSVRAVDVKEHERFKGVYWIEFEDGSTRLATRNLTPGKRVYGEQLINLGGVEYRVWNPYRSKLGAAIMNKLEAMPISEGS
KVLYLGAASGTTVSHVSDIVGLNGLIYGVEFSPRVFREFMQNIIDQGRLNVIPILADARYPEQYISLVKGVDVAYIDVAQ
PFQAKILADNADVYLVKGGYIILVIKAMSIDVTKEPSETFKREIDTIKERGFDIINMVHLEPYDVAHALVVGKRD

Specific function: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the sub

COG id: COG1889

COG function: function code J; Fibrillarin-like rRNA methylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. Fibrillarin family [H]

Homologues:

Organism=Homo sapiens, GI12056465, Length=227, Percent_Identity=44.9339207048458, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17563672, Length=228, Percent_Identity=48.2456140350877, Blast_Score=206, Evalue=9e-54,
Organism=Saccharomyces cerevisiae, GI6320190, Length=237, Percent_Identity=44.3037974683544, Blast_Score=192, Evalue=6e-50,
Organism=Drosophila melanogaster, GI17647425, Length=233, Percent_Identity=45.9227467811159, Blast_Score=197, Evalue=6e-51,
Organism=Drosophila melanogaster, GI24646406, Length=231, Percent_Identity=34.1991341991342, Blast_Score=122, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000692
- InterPro:   IPR020813 [H]

Pfam domain/function: PF01269 Fibrillarin [H]

EC number: NA

Molecular weight: Translated: 26414; Mature: 26283

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS00566 FIBRILLARIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSVRAVDVKEHERFKGVYWIEFEDGSTRLATRNLTPGKRVYGEQLINLGGVEYRVWNPY
CCCCEEECCHHHHHHCCEEEEEECCCCCEEEECCCCCCHHHHHHHHHHCCCEEEEEECHH
RSKLGAAIMNKLEAMPISEGSKVLYLGAASGTTVSHVSDIVGLNGLIYGVEFSPRVFREF
HHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCEEEEEEECCHHHHHHH
MQNIIDQGRLNVIPILADARYPEQYISLVKGVDVAYIDVAQPFQAKILADNADVYLVKGG
HHHHHCCCCCEEEEEEECCCCCHHHHHHHCCCCEEEEECCCCCEEEEEECCCCEEEEECC
YIILVIKAMSIDVTKEPSETFKREIDTIKERGFDIINMVHLEPYDVAHALVVGKRD
EEEEEEEEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEEEECCHHHEEEEEEECCC
>Mature Secondary Structure 
SSVRAVDVKEHERFKGVYWIEFEDGSTRLATRNLTPGKRVYGEQLINLGGVEYRVWNPY
CCCEEECCHHHHHHCCEEEEEECCCCCEEEECCCCCCHHHHHHHHHHCCCEEEEEECHH
RSKLGAAIMNKLEAMPISEGSKVLYLGAASGTTVSHVSDIVGLNGLIYGVEFSPRVFREF
HHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCEEEEEEECCHHHHHHH
MQNIIDQGRLNVIPILADARYPEQYISLVKGVDVAYIDVAQPFQAKILADNADVYLVKGG
HHHHHCCCCCEEEEEEECCCCCHHHHHHHCCCCEEEEECCCCCEEEEEECCCCEEEEECC
YIILVIKAMSIDVTKEPSETFKREIDTIKERGFDIINMVHLEPYDVAHALVVGKRD
EEEEEEEEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEEEECCHHHEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11792869 [H]