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The map label for this gene is ywrD [H]

Identifier: 159041836

GI number: 159041836

Start: 1339056

End: 1340561

Strand: Reverse

Name: ywrD [H]

Synonym: Cmaq_1271

Alternate gene names: 159041836

Gene position: 1340561-1339056 (Counterclockwise)

Preceding gene: 159041837

Following gene: 159041835

Centisome position: 64.53

GC content: 44.69

Gene sequence:

>1506_bases
ATGTCTTCCTTCAGTAAAACACCATGGGTTAGTAAACTTGGTGGCGTCGCCTCAGAACACCCAGTATCCAGTGGTGTTGG
TGTTAATGTGCTTAAACTTGGTGGTAACGCCGTTGATGCAGCCGTGGCTGTATCACTGGCATTAGCTGTAACTCAACCAC
ACCTGGGTGGCTTAGGTTCAGACCTAGTTGCCTTAATATACAATGGTGATGAGGTTAAGGTCCTTAACGCCACTGGATGG
GCTCCAGCCAAGTTAACTAGGGGGTTACTTGAATCAAGGGGTTTAAGTAAAGTCCCATTGAGAGGACCCTTATCTCCAGT
GGTTCCGGGGATGCTGGCTGGGTTATACACCATGTGGAGGGAAATGGGTACGTTGGAGTGGCGTAGCATAGTTAACACTG
TGATTGAGGCTGTTAAGGATGGTTTCCCAGCAGGGTTAAGCCTAGTGAGGGCTATTAGAAGCGTTATCAGTAATGAATTA
ATCGACGACGCCTTTAAATCAACCTACCCGATTAATGCTGAACCATGGAGCGTGGTTAAGATTAGTAAGCTTACCAAGGC
CCTTGAGTTGATAGCTGAACATGGGGCTGATTCAATGTATAATGGTGAATTAGGTGAATCCCTGGTTAAGAGGGTTAATG
AACTGGGTGGTGTATTGGATTTAAGTGATTTAAGGGATTATAGACCTGAGTGGGTTAATCCAGTAAGCATAGAGTACAGG
GGATTCATTATTAATGAGGCTCCACCCAATACTCAAGGCTTAACCACACTCATGATACTTAAGCTACTTGAGGATGAGGA
TATGCCTAAGGATCCATTTTCAAGTGAGAGAATTAGGCAATTCCTTAACGCCTATAGGATAGCGTATAAGGCGCGGGATG
AATTCATAGGTGACCCAAGGTTCACTAATATCCCCATTAATACACTGCTTGACGTAGGCTTCCTAAGGAGCCTAGGCCAA
GGCAAGTCACCTAGTGGTGTTGGTGACACAACATACTTCATCACTGCTGATAATCATGGTAATGTTGTAAGCTGCATACA
AAGCCTATACCACCACTTTGGTTCCCTTGTCACAGATCCCGAATACGGTGTAACATTGAATAATAGGGCCTCGGACTTCG
CGTTAAGTGGCCCTAATGCGCTTGAGCCTAGGAAGAGGCCGTTGCATACATTATCCTCGGTGATGATTCTTAAAAACGGT
GAATTAAAATACACCCTAGGTACCTCTGGTGCTCACTTTAGGCCGCAGCAGCATGCCTTAATGATAACTAACATTATTGA
TTACGGGATGAATCCAGTGGATGCTGTTAATGCTCCGAGATTCCTATGGAACAGTGATGAACTCATAATTGAGGATGATT
ACGAAACCTCTGGGGTTAATGAGAAGTTCAGGTTAATTAAGTACCCCGGTAGTACTGGTGTTGCCAGTGTACTGGCTATG
CTTGATAATGGCTTTAAACTACTTTACTCAGATATAAGGGGTGATGGGTTAGCCCTAGGTCTTTGA

Upstream 100 bases:

>100_bases
TAGCATTAGCCGTAATAGGTCCTGGTGCATTATCAATAGATCACCTAATACTGGCCTACGCGTAGTATTATTTAAACCCC
CTTAACTGGTATTAAAAATA

Downstream 100 bases:

>100_bases
ACAGGGAGGCTAGTTTTTATAAAAGGTGGATTACTGAGGCTTCTTCATGTCGCTGAGGGTTATTGAGGTTAATGGTTACC
CAATAATGGTGTTTGAATGG

Product: gamma-glutamyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 501; Mature: 500

Protein sequence:

>501_residues
MSSFSKTPWVSKLGGVASEHPVSSGVGVNVLKLGGNAVDAAVAVSLALAVTQPHLGGLGSDLVALIYNGDEVKVLNATGW
APAKLTRGLLESRGLSKVPLRGPLSPVVPGMLAGLYTMWREMGTLEWRSIVNTVIEAVKDGFPAGLSLVRAIRSVISNEL
IDDAFKSTYPINAEPWSVVKISKLTKALELIAEHGADSMYNGELGESLVKRVNELGGVLDLSDLRDYRPEWVNPVSIEYR
GFIINEAPPNTQGLTTLMILKLLEDEDMPKDPFSSERIRQFLNAYRIAYKARDEFIGDPRFTNIPINTLLDVGFLRSLGQ
GKSPSGVGDTTYFITADNHGNVVSCIQSLYHHFGSLVTDPEYGVTLNNRASDFALSGPNALEPRKRPLHTLSSVMILKNG
ELKYTLGTSGAHFRPQQHALMITNIIDYGMNPVDAVNAPRFLWNSDELIIEDDYETSGVNEKFRLIKYPGSTGVASVLAM
LDNGFKLLYSDIRGDGLALGL

Sequences:

>Translated_501_residues
MSSFSKTPWVSKLGGVASEHPVSSGVGVNVLKLGGNAVDAAVAVSLALAVTQPHLGGLGSDLVALIYNGDEVKVLNATGW
APAKLTRGLLESRGLSKVPLRGPLSPVVPGMLAGLYTMWREMGTLEWRSIVNTVIEAVKDGFPAGLSLVRAIRSVISNEL
IDDAFKSTYPINAEPWSVVKISKLTKALELIAEHGADSMYNGELGESLVKRVNELGGVLDLSDLRDYRPEWVNPVSIEYR
GFIINEAPPNTQGLTTLMILKLLEDEDMPKDPFSSERIRQFLNAYRIAYKARDEFIGDPRFTNIPINTLLDVGFLRSLGQ
GKSPSGVGDTTYFITADNHGNVVSCIQSLYHHFGSLVTDPEYGVTLNNRASDFALSGPNALEPRKRPLHTLSSVMILKNG
ELKYTLGTSGAHFRPQQHALMITNIIDYGMNPVDAVNAPRFLWNSDELIIEDDYETSGVNEKFRLIKYPGSTGVASVLAM
LDNGFKLLYSDIRGDGLALGL
>Mature_500_residues
SSFSKTPWVSKLGGVASEHPVSSGVGVNVLKLGGNAVDAAVAVSLALAVTQPHLGGLGSDLVALIYNGDEVKVLNATGWA
PAKLTRGLLESRGLSKVPLRGPLSPVVPGMLAGLYTMWREMGTLEWRSIVNTVIEAVKDGFPAGLSLVRAIRSVISNELI
DDAFKSTYPINAEPWSVVKISKLTKALELIAEHGADSMYNGELGESLVKRVNELGGVLDLSDLRDYRPEWVNPVSIEYRG
FIINEAPPNTQGLTTLMILKLLEDEDMPKDPFSSERIRQFLNAYRIAYKARDEFIGDPRFTNIPINTLLDVGFLRSLGQG
KSPSGVGDTTYFITADNHGNVVSCIQSLYHHFGSLVTDPEYGVTLNNRASDFALSGPNALEPRKRPLHTLSSVMILKNGE
LKYTLGTSGAHFRPQQHALMITNIIDYGMNPVDAVNAPRFLWNSDELIIEDDYETSGVNEKFRLIKYPGSTGVASVLAML
DNGFKLLYSDIRGDGLALGL

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=484, Percent_Identity=26.2396694214876, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI73915090, Length=484, Percent_Identity=26.2396694214876, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI73915096, Length=484, Percent_Identity=26.2396694214876, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI73915094, Length=484, Percent_Identity=26.2396694214876, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI113429326, Length=489, Percent_Identity=25.3578732106339, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI113429324, Length=484, Percent_Identity=25.4132231404959, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI153266901, Length=546, Percent_Identity=24.3589743589744, Blast_Score=96, Evalue=8e-20,
Organism=Homo sapiens, GI153266885, Length=545, Percent_Identity=23.6697247706422, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI109148539, Length=449, Percent_Identity=24.7216035634744, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI153266907, Length=542, Percent_Identity=22.140221402214, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI1789856, Length=488, Percent_Identity=32.5819672131148, Blast_Score=219, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI17506189, Length=460, Percent_Identity=25.8695652173913, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI193208247, Length=486, Percent_Identity=24.0740740740741, Blast_Score=115, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI193208245, Length=486, Percent_Identity=24.0740740740741, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI212646519, Length=529, Percent_Identity=23.2514177693762, Blast_Score=112, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI72000294, Length=529, Percent_Identity=23.2514177693762, Blast_Score=111, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI17542894, Length=460, Percent_Identity=23.4782608695652, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17564448, Length=395, Percent_Identity=25.0632911392405, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6323330, Length=500, Percent_Identity=24.6, Blast_Score=81, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24642670, Length=496, Percent_Identity=24.7983870967742, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24642666, Length=496, Percent_Identity=24.7983870967742, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI161077878, Length=496, Percent_Identity=24.7983870967742, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI161077880, Length=496, Percent_Identity=24.7983870967742, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI45551474, Length=496, Percent_Identity=24.7983870967742, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI18859893, Length=442, Percent_Identity=27.6018099547511, Blast_Score=129, Evalue=4e-30,
Organism=Drosophila melanogaster, GI161077496, Length=446, Percent_Identity=25.3363228699552, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI18859741, Length=440, Percent_Identity=22.5, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 54459; Mature: 54328

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSFSKTPWVSKLGGVASEHPVSSGVGVNVLKLGGNAVDAAVAVSLALAVTQPHLGGLGS
CCCCCCCCCHHHHCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCC
DLVALIYNGDEVKVLNATGWAPAKLTRGLLESRGLSKVPLRGPLSPVVPGMLAGLYTMWR
CEEEEEECCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHH
EMGTLEWRSIVNTVIEAVKDGFPAGLSLVRAIRSVISNELIDDAFKSTYPINAEPWSVVK
HHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHH
ISKLTKALELIAEHGADSMYNGELGESLVKRVNELGGVLDLSDLRDYRPEWVNPVSIEYR
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCEEHHHHHHCCCCCCCCEEEEEE
GFIINEAPPNTQGLTTLMILKLLEDEDMPKDPFSSERIRQFLNAYRIAYKARDEFIGDPR
EEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
FTNIPINTLLDVGFLRSLGQGKSPSGVGDTTYFITADNHGNVVSCIQSLYHHFGSLVTDP
CCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCCC
EYGVTLNNRASDFALSGPNALEPRKRPLHTLSSVMILKNGELKYTLGTSGAHFRPQQHAL
CCCEEECCCCCCCEECCCCCCCCCHHHHHHHHHEEEEECCCEEEEECCCCCCCCCCCCHH
MITNIIDYGMNPVDAVNAPRFLWNSDELIIEDDYETSGVNEKFRLIKYPGSTGVASVLAM
HHHHHHHHCCCCHHHCCCCCEEECCCCEEEECCCCCCCCCCCEEEEECCCCHHHHHHHHH
LDNGFKLLYSDIRGDGLALGL
HHCCHHHHHHHHCCCCEEECC
>Mature Secondary Structure 
SSFSKTPWVSKLGGVASEHPVSSGVGVNVLKLGGNAVDAAVAVSLALAVTQPHLGGLGS
CCCCCCCCHHHHCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCC
DLVALIYNGDEVKVLNATGWAPAKLTRGLLESRGLSKVPLRGPLSPVVPGMLAGLYTMWR
CEEEEEECCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHH
EMGTLEWRSIVNTVIEAVKDGFPAGLSLVRAIRSVISNELIDDAFKSTYPINAEPWSVVK
HHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHH
ISKLTKALELIAEHGADSMYNGELGESLVKRVNELGGVLDLSDLRDYRPEWVNPVSIEYR
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCEEHHHHHHCCCCCCCCEEEEEE
GFIINEAPPNTQGLTTLMILKLLEDEDMPKDPFSSERIRQFLNAYRIAYKARDEFIGDPR
EEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
FTNIPINTLLDVGFLRSLGQGKSPSGVGDTTYFITADNHGNVVSCIQSLYHHFGSLVTDP
CCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCCC
EYGVTLNNRASDFALSGPNALEPRKRPLHTLSSVMILKNGELKYTLGTSGAHFRPQQHAL
CCCEEECCCCCCCEECCCCCCCCCHHHHHHHHHEEEEECCCEEEEECCCCCCCCCCCCHH
MITNIIDYGMNPVDAVNAPRFLWNSDELIIEDDYETSGVNEKFRLIKYPGSTGVASVLAM
HHHHHHHHCCCCHHHCCCCCEEECCCCEEEECCCCCCCCCCCEEEEECCCCHHHHHHHHH
LDNGFKLLYSDIRGDGLALGL
HHCCHHHHHHHHCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]