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Identifier: 159041690

GI number: 159041690

Start: 1180673

End: 1182484

Strand: Reverse

Name: lig

Synonym: Cmaq_1124

Alternate gene names: 159041690

Gene position: 1182484-1180673 (Counterclockwise)

Preceding gene: 159041691

Following gene: 159041688

Centisome position: 56.92

GC content: 46.74

Gene sequence:

>1812_bases
GTGGAATCTGACTTAGAATTCTCCAATATTGTATCCGTACTTAAGTTAGTGGAGGCTACAACGCAGAGGACTGTTATGGC
TAAGGCACTCTCAAGCCTACTTGCTAAAACGCCACCACAGGTCATTGATAAGGTCATATACTTCCTACTGGGTAGCCTTA
GGCCTGACTGGGAGGGTGTGGAGCTTGGTTTAGCTGAAAGGCTAACACTTAGGGCAATATCCATGGCCACTGGCTTACCT
ATCAGGCAGGTTGAGGAATTGTATAAGAAGCTTGGTGATGCAGGTGAGGTGGCTAAGAGGGCTGCGGAGATTAAGAGGAG
TAAGGGGGGTGGTGGCACTATATTCGACTTCATTGACACTGGACCTAAGAGGAGGCTAACGATCAGTAAGGTCTACGACA
CTTTAATGGCCATAGCAAAGGCATCTGGGGAAGGAGCCCAGGACACTAAGGTTAAGTTACTGTCAAGTCTATTAACTGAT
GCCGAACCCGATGAGGCTAAGTACATTACTAGATTCGTCATAGGGAGGTTAAGATTGGGGGTGGCTGACATGACTATTCT
AGATGCCTTATCAGACGCCTTTGATGTTAATAGGGATTTACTGGAGAAGGCTTACCACGTTTACCCGGACCTCGGTAAGA
TAGCTAAGACACTGGCTGAGGGGGGTGAGGAGGCTGTTAAGGCGATTAAGGTTACGCCTGGTGTACCTATACAGCCTATG
CTTGCTGAGAGGTTAAGTAGCCCTAAGGAGATTTTGAATAAGCTTGGTGGGGTTGCCATATGTGAGTTTAAGTATGATGG
TGAGAGGATGCAGATACATAAGCTTAAGGATGGTACTGTTAAAATATTCAGTAGGAGGATGGAGGATATAACTAACCAGT
ACCCTGATGTAGCCGAGTACGCCCGTGAGGCAATTGATGCTGAGGAATTCATAGTTGAGGGTGAGGGTGTTGCAATTGAC
CCGGATACAGGGGAGTTTAAGCCGTTTCAGGAATTAATGCATAGGAAGAGGAAGCATAATATTAAGGAGGCTATTGAGGA
GTACCCCATTAACCTATACTTATTCGACGTAATGTACGTTAATGGACAGGACTTAACAGACCTACCTCTACCCGATAGGA
AGAAGGTACTGTTCTCAATAATTAAGCCACATGAGCATGTTCACCACGCCGACTGGATAATAACCGATGATGCGGATTCA
CTGGAGAAGTTCTTCCTGGACGCAATATCGTCAGGTTGTGAAGGCGTCATGTGTAAGTCAGTTAAGTTAGGCTCAGTCTA
TGAAATGGGGGCTAGGGGTTGGTTGTGGATTAAGTATAAGAGGGATTATAAGAGCGAGTTATCAGACACAATGGATCTAG
TGGTGGTTGGGGCATTCTGGGGACGCGGTAAGAGAGCCGGAACCTATGGTGCACTCCTCCTAGCCGCATACGACCCTGAC
TCTGATCAATTCTACACAGTATGCAAGGTTGGGAGCGGCTTCACTGATGAGGATCTAAAGAAGCTGCCTCAAATGCTTGA
ACCATATAAAATACCGCATAGACACCCCAGGGTTGTTTCGAAAATGGAGCCGGACATATGGTTCACACCAGGCCTAGTGC
TGGAGATAACCGGCGCGGAGATAACCATGTCCCCACTCCACACTTGTTGCTCCGTCATGCTTAAGGGTGACGTGGGGTTG
GCTATAAGGTTCCCAAGGTTCACAGGTAGGTATAGGACTGATAAGAGGCCGGAGGATGCAACAACGGTTAAGGAGATATT
TGAAATGTACAGTAATCAGAAGAAGGTTAAGTTAACTGATCAAGTGCCTTGA

Upstream 100 bases:

>100_bases
CATAATTAGCATCACGCATAAGCTTTACTTATAAGGCTATTCACATGATGATGCAGAACCTAACGTAAGGTTAATTAATA
TCTAGGCCGCTTAGAGTGAT

Downstream 100 bases:

>100_bases
ATTGAGTTAGCTATTAAAACCCAATGCACTGGATTTAAATTCGGGGCGTGTGATGGTGGGTCACTTAAGGCGGCTACCCA
CCTGACACCCCCTTGATCAT

Product: ATP-dependent DNA ligase

Products: NA

Alternate protein names: Polydeoxyribonucleotide synthase [ATP]

Number of amino acids: Translated: 603; Mature: 603

Protein sequence:

>603_residues
MESDLEFSNIVSVLKLVEATTQRTVMAKALSSLLAKTPPQVIDKVIYFLLGSLRPDWEGVELGLAERLTLRAISMATGLP
IRQVEELYKKLGDAGEVAKRAAEIKRSKGGGGTIFDFIDTGPKRRLTISKVYDTLMAIAKASGEGAQDTKVKLLSSLLTD
AEPDEAKYITRFVIGRLRLGVADMTILDALSDAFDVNRDLLEKAYHVYPDLGKIAKTLAEGGEEAVKAIKVTPGVPIQPM
LAERLSSPKEILNKLGGVAICEFKYDGERMQIHKLKDGTVKIFSRRMEDITNQYPDVAEYAREAIDAEEFIVEGEGVAID
PDTGEFKPFQELMHRKRKHNIKEAIEEYPINLYLFDVMYVNGQDLTDLPLPDRKKVLFSIIKPHEHVHHADWIITDDADS
LEKFFLDAISSGCEGVMCKSVKLGSVYEMGARGWLWIKYKRDYKSELSDTMDLVVVGAFWGRGKRAGTYGALLLAAYDPD
SDQFYTVCKVGSGFTDEDLKKLPQMLEPYKIPHRHPRVVSKMEPDIWFTPGLVLEITGAEITMSPLHTCCSVMLKGDVGL
AIRFPRFTGRYRTDKRPEDATTVKEIFEMYSNQKKVKLTDQVP

Sequences:

>Translated_603_residues
MESDLEFSNIVSVLKLVEATTQRTVMAKALSSLLAKTPPQVIDKVIYFLLGSLRPDWEGVELGLAERLTLRAISMATGLP
IRQVEELYKKLGDAGEVAKRAAEIKRSKGGGGTIFDFIDTGPKRRLTISKVYDTLMAIAKASGEGAQDTKVKLLSSLLTD
AEPDEAKYITRFVIGRLRLGVADMTILDALSDAFDVNRDLLEKAYHVYPDLGKIAKTLAEGGEEAVKAIKVTPGVPIQPM
LAERLSSPKEILNKLGGVAICEFKYDGERMQIHKLKDGTVKIFSRRMEDITNQYPDVAEYAREAIDAEEFIVEGEGVAID
PDTGEFKPFQELMHRKRKHNIKEAIEEYPINLYLFDVMYVNGQDLTDLPLPDRKKVLFSIIKPHEHVHHADWIITDDADS
LEKFFLDAISSGCEGVMCKSVKLGSVYEMGARGWLWIKYKRDYKSELSDTMDLVVVGAFWGRGKRAGTYGALLLAAYDPD
SDQFYTVCKVGSGFTDEDLKKLPQMLEPYKIPHRHPRVVSKMEPDIWFTPGLVLEITGAEITMSPLHTCCSVMLKGDVGL
AIRFPRFTGRYRTDKRPEDATTVKEIFEMYSNQKKVKLTDQVP
>Mature_603_residues
MESDLEFSNIVSVLKLVEATTQRTVMAKALSSLLAKTPPQVIDKVIYFLLGSLRPDWEGVELGLAERLTLRAISMATGLP
IRQVEELYKKLGDAGEVAKRAAEIKRSKGGGGTIFDFIDTGPKRRLTISKVYDTLMAIAKASGEGAQDTKVKLLSSLLTD
AEPDEAKYITRFVIGRLRLGVADMTILDALSDAFDVNRDLLEKAYHVYPDLGKIAKTLAEGGEEAVKAIKVTPGVPIQPM
LAERLSSPKEILNKLGGVAICEFKYDGERMQIHKLKDGTVKIFSRRMEDITNQYPDVAEYAREAIDAEEFIVEGEGVAID
PDTGEFKPFQELMHRKRKHNIKEAIEEYPINLYLFDVMYVNGQDLTDLPLPDRKKVLFSIIKPHEHVHHADWIITDDADS
LEKFFLDAISSGCEGVMCKSVKLGSVYEMGARGWLWIKYKRDYKSELSDTMDLVVVGAFWGRGKRAGTYGALLLAAYDPD
SDQFYTVCKVGSGFTDEDLKKLPQMLEPYKIPHRHPRVVSKMEPDIWFTPGLVLEITGAEITMSPLHTCCSVMLKGDVGL
AIRFPRFTGRYRTDKRPEDATTVKEIFEMYSNQKKVKLTDQVP

Specific function: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair

COG id: COG1793

COG function: function code L; ATP-dependent DNA ligase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent DNA ligase family

Homologues:

Organism=Homo sapiens, GI4557719, Length=628, Percent_Identity=33.2802547770701, Blast_Score=347, Evalue=2e-95,
Organism=Homo sapiens, GI73747829, Length=492, Percent_Identity=30.4878048780488, Blast_Score=188, Evalue=1e-47,
Organism=Homo sapiens, GI73747844, Length=487, Percent_Identity=30.5954825462012, Blast_Score=188, Evalue=1e-47,
Organism=Homo sapiens, GI46255052, Length=500, Percent_Identity=29.2, Blast_Score=147, Evalue=3e-35,
Organism=Homo sapiens, GI23199993, Length=500, Percent_Identity=29.2, Blast_Score=147, Evalue=3e-35,
Organism=Homo sapiens, GI148539894, Length=500, Percent_Identity=29.2, Blast_Score=147, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI71985269, Length=582, Percent_Identity=35.9106529209622, Blast_Score=356, Evalue=2e-98,
Organism=Caenorhabditis elegans, GI71985278, Length=160, Percent_Identity=30.625, Blast_Score=85, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6320038, Length=628, Percent_Identity=33.7579617834395, Blast_Score=333, Evalue=4e-92,
Organism=Saccharomyces cerevisiae, GI6324578, Length=574, Percent_Identity=26.1324041811847, Blast_Score=104, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24762424, Length=620, Percent_Identity=32.741935483871, Blast_Score=337, Evalue=1e-92,
Organism=Drosophila melanogaster, GI85815841, Length=490, Percent_Identity=29.3877551020408, Blast_Score=168, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24641829, Length=539, Percent_Identity=25.2319109461967, Blast_Score=89, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DNLI_CALMQ (A8MDU6)

Other databases:

- EMBL:   CP000852
- RefSeq:   YP_001540942.1
- ProteinModelPortal:   A8MDU6
- SMR:   A8MDU6
- GeneID:   5710004
- GenomeReviews:   CP000852_GR
- KEGG:   cma:Cmaq_1124
- HOGENOM:   HBG570821
- OMA:   ETICNIG
- ProtClustDB:   PRK01109
- BioCyc:   CMAQ397948:CMAQ_1124-MONOMER
- HAMAP:   MF_00407
- InterPro:   IPR022865
- InterPro:   IPR000977
- InterPro:   IPR012309
- InterPro:   IPR012310
- InterPro:   IPR016059
- InterPro:   IPR012308
- InterPro:   IPR012340
- InterPro:   IPR016027
- Gene3D:   G3DSA:2.40.50.140
- TIGRFAMs:   TIGR00574

Pfam domain/function: PF04679 DNA_ligase_A_C; PF01068 DNA_ligase_A_M; PF04675 DNA_ligase_A_N; SSF50249 Nucleic_acid_OB

EC number: =6.5.1.1

Molecular weight: Translated: 67562; Mature: 67562

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS00697 DNA_LIGASE_A1; PS00333 DNA_LIGASE_A2; PS50160 DNA_LIGASE_A3

Important sites: ACT_SITE 264-264 BINDING 262-262 BINDING 269-269 BINDING 285-285 BINDING 315-315 BINDING 355-355 BINDING 432-432 BINDING 438-438

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESDLEFSNIVSVLKLVEATTQRTVMAKALSSLLAKTPPQVIDKVIYFLLGSLRPDWEGV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCC
ELGLAERLTLRAISMATGLPIRQVEELYKKLGDAGEVAKRAAEIKRSKGGGGTIFDFIDT
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCEEEHHHCC
GPKRRLTISKVYDTLMAIAKASGEGAQDTKVKLLSSLLTDAEPDEAKYITRFVIGRLRLG
CCCCEEEHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHC
VADMTILDALSDAFDVNRDLLEKAYHVYPDLGKIAKTLAEGGEEAVKAIKVTPGVPIQPM
HHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHEEECCCCCCCCHH
LAERLSSPKEILNKLGGVAICEFKYDGERMQIHKLKDGTVKIFSRRMEDITNQYPDVAEY
HHHHCCCHHHHHHHCCCEEEEEEEECCCEEEEEECCCCHHHHHHHHHHHHHHCCCCHHHH
AREAIDAEEFIVEGEGVAIDPDTGEFKPFQELMHRKRKHNIKEAIEEYPINLYLFDVMYV
HHHHCCHHHHEECCCCEEECCCCCCCCHHHHHHHHHHHCCHHHHHHHCCCEEEEEEEEEE
NGQDLTDLPLPDRKKVLFSIIKPHEHVHHADWIITDDADSLEKFFLDAISSGCEGVMCKS
CCCCCCCCCCCCHHHHHHHHHCCHHHCCCCCEEEECCHHHHHHHHHHHHHCCCCCEEECC
VKLGSVYEMGARGWLWIKYKRDYKSELSDTMDLVVVGAFWGRGKRAGTYGALLLAAYDPD
EECCCHHHCCCCCEEEEEECCCHHHHHHHHHHHHEEEHHHCCCCCCCCCEEEEEEEECCC
SDQFYTVCKVGSGFTDEDLKKLPQMLEPYKIPHRHPRVVSKMEPDIWFTPGLVLEITGAE
CCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCEECCCEEEEECCCE
ITMSPLHTCCSVMLKGDVGLAIRFPRFTGRYRTDKRPEDATTVKEIFEMYSNQKKVKLTD
EEHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEECC
QVP
CCC
>Mature Secondary Structure
MESDLEFSNIVSVLKLVEATTQRTVMAKALSSLLAKTPPQVIDKVIYFLLGSLRPDWEGV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCC
ELGLAERLTLRAISMATGLPIRQVEELYKKLGDAGEVAKRAAEIKRSKGGGGTIFDFIDT
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCEEEHHHCC
GPKRRLTISKVYDTLMAIAKASGEGAQDTKVKLLSSLLTDAEPDEAKYITRFVIGRLRLG
CCCCEEEHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHC
VADMTILDALSDAFDVNRDLLEKAYHVYPDLGKIAKTLAEGGEEAVKAIKVTPGVPIQPM
HHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHEEECCCCCCCCHH
LAERLSSPKEILNKLGGVAICEFKYDGERMQIHKLKDGTVKIFSRRMEDITNQYPDVAEY
HHHHCCCHHHHHHHCCCEEEEEEEECCCEEEEEECCCCHHHHHHHHHHHHHHCCCCHHHH
AREAIDAEEFIVEGEGVAIDPDTGEFKPFQELMHRKRKHNIKEAIEEYPINLYLFDVMYV
HHHHCCHHHHEECCCCEEECCCCCCCCHHHHHHHHHHHCCHHHHHHHCCCEEEEEEEEEE
NGQDLTDLPLPDRKKVLFSIIKPHEHVHHADWIITDDADSLEKFFLDAISSGCEGVMCKS
CCCCCCCCCCCCHHHHHHHHHCCHHHCCCCCEEEECCHHHHHHHHHHHHHCCCCCEEECC
VKLGSVYEMGARGWLWIKYKRDYKSELSDTMDLVVVGAFWGRGKRAGTYGALLLAAYDPD
EECCCHHHCCCCCEEEEEECCCHHHHHHHHHHHHEEEHHHCCCCCCCCCEEEEEEEECCC
SDQFYTVCKVGSGFTDEDLKKLPQMLEPYKIPHRHPRVVSKMEPDIWFTPGLVLEITGAE
CCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCEECCCEEEEECCCE
ITMSPLHTCCSVMLKGDVGLAIRFPRFTGRYRTDKRPEDATTVKEIFEMYSNQKKVKLTD
EEHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEECC
QVP
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA