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The map label for this gene is purM [H]

Identifier: 159041243

GI number: 159041243

Start: 700348

End: 701346

Strand: Reverse

Name: purM [H]

Synonym: Cmaq_0665

Alternate gene names: 159041243

Gene position: 701346-700348 (Counterclockwise)

Preceding gene: 159041244

Following gene: 159041241

Centisome position: 33.76

GC content: 41.54

Gene sequence:

>999_bases
ATGAAGTGGACTTACAGTAAAGCTGGGGTGGATTTAAGTAAACACCACAGCATGCACTCAATAGCCCAGGACGCGATTAG
GCGTATTGAGGAATCCCTTGGAGTAAAGTTAATTGAGGGGAACTTCACTAGGTTAATTACACTAAACGGCGTTGAATTAA
CAATGCACACTGATGGGGTTGGCACTAAGTCAATTATAGCTTGGGAAGCAAGGAAACTGAGGGTTCTTGGGTGGGATTGC
GTAGTGAGTAATATTAATGATGTTGCATGCGACGGCGTAACCCCAATGGCTGTGGTGGATTACATAGCCATCTCAAGTAA
TGATACTGAAGCCGTCGGTGAAGTGATTAAGGGTGTTACCGATGCCTCACTGGAATCAAACATAGTATTACTTGGTGGGG
AAACGGCAATAATGCCTGACTTAATTAATGGAATAGACGTATCCTGCACCGTACTGGGTATTAAGAGTGGGGGTAGATTA
ATGAGGGTTAATGCAGGTGACTTAATTATTGGAGTTGAATCCAATGGATTACACATGAATGGCTACACCCTAGCCCGTAG
GGTTCTCCTAAGTAGGTTTAAGCTCAGTGATGAGGTGTGTAGTGTTCAATTGGCTAATGAACTCCTTAAGCCAACATTAA
ATTACAGTAAACTACTGTTGAGGCTGTATAATGATAATTTAATTAAGGCGGCTGTTAATGTTACAGGAGGAGGCTTCACT
AAGGTTAGGAGGGTGATTGGTGAAATGGGTGTTGAATTCAATGCGCCTGAACCTCCATGCATATTTAGGGTAATTAAGGA
GACTGGTAACGTTGAGTGGAGTGAAATGTACAGGGTCTTCAACATGGGTGTTGGATTAATGCTAATTGTGAATGAAGAGA
AAGCTAGTAGGGTTGAGAATACTATTGATGAATTCGGTTTAAGGCATTGGGTAATGGGTAGTGTTAATAATAGTGGTAGA
TTAACGGTTAATCTAGGTAACGTGAATTTCAACCTTTAA

Upstream 100 bases:

>100_bases
TCAATATCCTGGCTTCAACTAAGTGACTTAATCAAGGCTGCGGAGGATGTAGGGATAGGGAAGGGGAACCTATGCCTAGA
ATGCTTCCTGAGGAGGGACC

Downstream 100 bases:

>100_bases
GCCCTAAGCCCAGTATACTGTTTAACCGTGAGTATGCCTCAATCAGCTCCTTAACTGACCCACCCATTCTGAAGAGTTCC
TTATCAAGGTGTTTACCATT

Product: phosphoribosylformylglycinamidine cyclo-ligase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MKWTYSKAGVDLSKHHSMHSIAQDAIRRIEESLGVKLIEGNFTRLITLNGVELTMHTDGVGTKSIIAWEARKLRVLGWDC
VVSNINDVACDGVTPMAVVDYIAISSNDTEAVGEVIKGVTDASLESNIVLLGGETAIMPDLINGIDVSCTVLGIKSGGRL
MRVNAGDLIIGVESNGLHMNGYTLARRVLLSRFKLSDEVCSVQLANELLKPTLNYSKLLLRLYNDNLIKAAVNVTGGGFT
KVRRVIGEMGVEFNAPEPPCIFRVIKETGNVEWSEMYRVFNMGVGLMLIVNEEKASRVENTIDEFGLRHWVMGSVNNSGR
LTVNLGNVNFNL

Sequences:

>Translated_332_residues
MKWTYSKAGVDLSKHHSMHSIAQDAIRRIEESLGVKLIEGNFTRLITLNGVELTMHTDGVGTKSIIAWEARKLRVLGWDC
VVSNINDVACDGVTPMAVVDYIAISSNDTEAVGEVIKGVTDASLESNIVLLGGETAIMPDLINGIDVSCTVLGIKSGGRL
MRVNAGDLIIGVESNGLHMNGYTLARRVLLSRFKLSDEVCSVQLANELLKPTLNYSKLLLRLYNDNLIKAAVNVTGGGFT
KVRRVIGEMGVEFNAPEPPCIFRVIKETGNVEWSEMYRVFNMGVGLMLIVNEEKASRVENTIDEFGLRHWVMGSVNNSGR
LTVNLGNVNFNL
>Mature_332_residues
MKWTYSKAGVDLSKHHSMHSIAQDAIRRIEESLGVKLIEGNFTRLITLNGVELTMHTDGVGTKSIIAWEARKLRVLGWDC
VVSNINDVACDGVTPMAVVDYIAISSNDTEAVGEVIKGVTDASLESNIVLLGGETAIMPDLINGIDVSCTVLGIKSGGRL
MRVNAGDLIIGVESNGLHMNGYTLARRVLLSRFKLSDEVCSVQLANELLKPTLNYSKLLLRLYNDNLIKAAVNVTGGGFT
KVRRVIGEMGVEFNAPEPPCIFRVIKETGNVEWSEMYRVFNMGVGLMLIVNEEKASRVENTIDEFGLRHWVMGSVNNSGR
LTVNLGNVNFNL

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=332, Percent_Identity=31.6265060240964, Blast_Score=147, Evalue=9e-36,
Organism=Homo sapiens, GI209869995, Length=332, Percent_Identity=31.6265060240964, Blast_Score=147, Evalue=9e-36,
Organism=Homo sapiens, GI209869993, Length=332, Percent_Identity=31.6265060240964, Blast_Score=147, Evalue=9e-36,
Organism=Escherichia coli, GI1788845, Length=333, Percent_Identity=30.3303303303303, Blast_Score=134, Evalue=9e-33,
Organism=Caenorhabditis elegans, GI17567511, Length=292, Percent_Identity=29.7945205479452, Blast_Score=125, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6321203, Length=278, Percent_Identity=32.7338129496403, Blast_Score=137, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24582400, Length=285, Percent_Identity=30.1754385964912, Blast_Score=108, Evalue=7e-24,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 36311; Mature: 36311

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKWTYSKAGVDLSKHHSMHSIAQDAIRRIEESLGVKLIEGNFTRLITLNGVELTMHTDGV
CCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCEEEEECCEEEEEEECCEEEEEEECCC
GTKSIIAWEARKLRVLGWDCVVSNINDVACDGVTPMAVVDYIAISSNDTEAVGEVIKGVT
CCCEEEEECCCEEEEEEEEHHCCCCCCEECCCCCHHHHHEEEEECCCCHHHHHHHHCCCC
DASLESNIVLLGGETAIMPDLINGIDVSCTVLGIKSGGRLMRVNAGDLIIGVESNGLHMN
CCCCCCCEEEECCCCEECHHHHCCCCEEEEEEEEECCCEEEEEECCCEEEEEECCCEEEC
GYTLARRVLLSRFKLSDEVCSVQLANELLKPTLNYSKLLLRLYNDNLIKAAVNVTGGGFT
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEEEEECCCCHH
KVRRVIGEMGVEFNAPEPPCIFRVIKETGNVEWSEMYRVFNMGVGLMLIVNEEKASRVEN
HHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEEECCHHHHHHHH
TIDEFGLRHWVMGSVNNSGRLTVNLGNVNFNL
HHHHHCCCEEEEECCCCCCEEEEEECCEEECC
>Mature Secondary Structure
MKWTYSKAGVDLSKHHSMHSIAQDAIRRIEESLGVKLIEGNFTRLITLNGVELTMHTDGV
CCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCEEEEECCEEEEEEECCEEEEEEECCC
GTKSIIAWEARKLRVLGWDCVVSNINDVACDGVTPMAVVDYIAISSNDTEAVGEVIKGVT
CCCEEEEECCCEEEEEEEEHHCCCCCCEECCCCCHHHHHEEEEECCCCHHHHHHHHCCCC
DASLESNIVLLGGETAIMPDLINGIDVSCTVLGIKSGGRLMRVNAGDLIIGVESNGLHMN
CCCCCCCEEEECCCCEECHHHHCCCCEEEEEEEEECCCEEEEEECCCEEEEEECCCEEEC
GYTLARRVLLSRFKLSDEVCSVQLANELLKPTLNYSKLLLRLYNDNLIKAAVNVTGGGFT
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEEEEECCCCHH
KVRRVIGEMGVEFNAPEPPCIFRVIKETGNVEWSEMYRVFNMGVGLMLIVNEEKASRVEN
HHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEEECCHHHHHHHH
TIDEFGLRHWVMGSVNNSGRLTVNLGNVNFNL
HHHHHCCCEEEEECCCCCCEEEEEECCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10701121; 11427726 [H]