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The map label for this gene is sulD [H]

Identifier: 159041100

GI number: 159041100

Start: 550517

End: 551392

Strand: Reverse

Name: sulD [H]

Synonym: Cmaq_0517

Alternate gene names: 159041100

Gene position: 551392-550517 (Counterclockwise)

Preceding gene: 159041101

Following gene: 159041097

Centisome position: 26.54

GC content: 45.09

Gene sequence:

>876_bases
ATGAGCATGGGTTTATTCAAGATAGAGATTAGGGGGCTTAAGGTTAATACAATCATTGGGGTGAAGCCCAGTGAGAGGGC
AAGGCCCCAGCCTGTGGTTATTAATGTTGAGGCTTGGGCTGACTTAAGTGAGGGGGCTGCTAAGGATTCCATTGAATGCA
CGGTTGATTATAAGGTTCTTAAGGATGAGTTAATCTCATACGTTAGTAGTAGTGATTTTAAATTAATTGAAACCCTTGCT
GATAGGTTGGCTAAGGTTTGCCTGCAGGATCATAGGGTTAGGATGGTTAAGGTTAGGGTTGAGAAACCGGGTGCATTAAC
CGGTGCCGAGGCGGCTGCAGTGGAGGTTTTTAGGAGGAGGATGAGTAAATTGGCTAAGGTATTCATAGCCGTTGGCTCAA
ACATTAATCCCGAGTACAATGTTAGGGAAGCTGTTATTAGGGTTAGGAGGATTCTCGGTCCATTAAGGGTATCCACGGTT
TACTTAACTAAACCAATACCAGATAACCAACCCCCCTATTACAATTGCGTATTAGAGGCTGAAACAGCCCTAAGCCCAGT
ATCGGTTAAGAGCGCGTTAAGGGGGATTGAGAGTGAGATGGGTAGGGTTAGGGTGAGTGATAAGTATGCCCCAAGGGTCA
TTGACCTAGACCTAATACTTTACGGTAATTTAATAATTAAGAGTAATGAATTAACCTTACCTGACCCGGAGATAGGTAGT
AGGCCCTTCCTAACCCTACCTTTACTTGAGCTTGAACCAGACTTAGTCATACCTGGGTTAAATAAGGCAATTAGGGAGTT
GGCTAAGGGGGTTAGCGGCGAGGGTATGAAGCCTCTACCTGATTACACCGAGGAGTTGAGGAGATTAGCCGGTTGA

Upstream 100 bases:

>100_bases
TCGCCCACGCCGTAGTGTTTCTGCTTAAGAGTAGTTACGTAACTGGTCAAGTAATATATGTTGACGGTGGGGAGCATCTT
AAGCCCAGGGTGGTTTATGA

Downstream 100 bases:

>100_bases
ATTAAGGTTTAACATTACTGCTGCTGGATCTCCTTAACCTCTGGGTTAACTGAGGTTACGTCATCAGGTCTCTTACCAAG
TACAACGAAGGATATGAACT

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: Dihydroneopterin aldolase; DHNA; 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 291; Mature: 290

Protein sequence:

>291_residues
MSMGLFKIEIRGLKVNTIIGVKPSERARPQPVVINVEAWADLSEGAAKDSIECTVDYKVLKDELISYVSSSDFKLIETLA
DRLAKVCLQDHRVRMVKVRVEKPGALTGAEAAAVEVFRRRMSKLAKVFIAVGSNINPEYNVREAVIRVRRILGPLRVSTV
YLTKPIPDNQPPYYNCVLEAETALSPVSVKSALRGIESEMGRVRVSDKYAPRVIDLDLILYGNLIIKSNELTLPDPEIGS
RPFLTLPLLELEPDLVIPGLNKAIRELAKGVSGEGMKPLPDYTEELRRLAG

Sequences:

>Translated_291_residues
MSMGLFKIEIRGLKVNTIIGVKPSERARPQPVVINVEAWADLSEGAAKDSIECTVDYKVLKDELISYVSSSDFKLIETLA
DRLAKVCLQDHRVRMVKVRVEKPGALTGAEAAAVEVFRRRMSKLAKVFIAVGSNINPEYNVREAVIRVRRILGPLRVSTV
YLTKPIPDNQPPYYNCVLEAETALSPVSVKSALRGIESEMGRVRVSDKYAPRVIDLDLILYGNLIIKSNELTLPDPEIGS
RPFLTLPLLELEPDLVIPGLNKAIRELAKGVSGEGMKPLPDYTEELRRLAG
>Mature_290_residues
SMGLFKIEIRGLKVNTIIGVKPSERARPQPVVINVEAWADLSEGAAKDSIECTVDYKVLKDELISYVSSSDFKLIETLAD
RLAKVCLQDHRVRMVKVRVEKPGALTGAEAAAVEVFRRRMSKLAKVFIAVGSNINPEYNVREAVIRVRRILGPLRVSTVY
LTKPIPDNQPPYYNCVLEAETALSPVSVKSALRGIESEMGRVRVSDKYAPRVIDLDLILYGNLIIKSNELTLPDPEIGSR
PFLTLPLLELEPDLVIPGLNKAIRELAKGVSGEGMKPLPDYTEELRRLAG

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=139, Percent_Identity=37.410071942446, Blast_Score=93, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006156
- InterPro:   IPR006157
- InterPro:   IPR000550 [H]

Pfam domain/function: PF02152 FolB; PF01288 HPPK [H]

EC number: =4.1.2.25; =2.7.6.3 [H]

Molecular weight: Translated: 32245; Mature: 32114

Theoretical pI: Translated: 9.01; Mature: 9.01

Prosite motif: PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMGLFKIEIRGLKVNTIIGVKPSERARPQPVVINVEAWADLSEGAAKDSIECTVDYKVL
CCCCEEEEEEEEEEEEEEEECCCCCCCCCCCEEEEEHHCCCCCCCCCCCCEEEEEHHHHH
KDELISYVSSSDFKLIETLADRLAKVCLQDHRVRMVKVRVEKPGALTGAEAAAVEVFRRR
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEEEEEECCCCCCCHHHHHHHHHHHH
MSKLAKVFIAVGSNINPEYNVREAVIRVRRILGPLRVSTVYLTKPIPDNQPPYYNCVLEA
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCEEEEEEC
ETALSPVSVKSALRGIESEMGRVRVSDKYAPRVIDLDLILYGNLIIKSNELTLPDPEIGS
CCCCCCHHHHHHHHHHHHHHCEEEECCCCCCEEEEEEEEEECCEEEECCCCCCCCCCCCC
RPFLTLPLLELEPDLVIPGLNKAIRELAKGVSGEGMKPLPDYTEELRRLAG
CCEEEEEHEECCCCEECCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
SMGLFKIEIRGLKVNTIIGVKPSERARPQPVVINVEAWADLSEGAAKDSIECTVDYKVL
CCCEEEEEEEEEEEEEEEECCCCCCCCCCCEEEEEHHCCCCCCCCCCCCEEEEEHHHHH
KDELISYVSSSDFKLIETLADRLAKVCLQDHRVRMVKVRVEKPGALTGAEAAAVEVFRRR
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEEEEEECCCCCCCHHHHHHHHHHHH
MSKLAKVFIAVGSNINPEYNVREAVIRVRRILGPLRVSTVYLTKPIPDNQPPYYNCVLEA
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCEEEEEEC
ETALSPVSVKSALRGIESEMGRVRVSDKYAPRVIDLDLILYGNLIIKSNELTLPDPEIGS
CCCCCCHHHHHHHHHHHHHHCEEEECCCCCCEEEEEEEEEECCEEEECCCCCCCCCCCCC
RPFLTLPLLELEPDLVIPGLNKAIRELAKGVSGEGMKPLPDYTEELRRLAG
CCEEEEEHEECCCCEECCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2168367; 7798151; 11463916; 8385663 [H]