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The map label for this gene is 159040980

Identifier: 159040980

GI number: 159040980

Start: 432705

End: 433817

Strand: Reverse

Name: 159040980

Synonym: Cmaq_0396

Alternate gene names: NA

Gene position: 433817-432705 (Counterclockwise)

Preceding gene: 159040981

Following gene: 159040979

Centisome position: 20.88

GC content: 45.73

Gene sequence:

>1113_bases
ATGAGGATTAGTATTGATGAGGTTAAGAGGATTTATAAACCTAAGGTTAAACCCATTGAGTGGAGGGATAATAGGTTAAT
CATCCTTGATCAATCCAAGGTACCCTTTGAGACAATTTACGTTGAACTACATACACCGCAGGATGTGGCTGATGCGATAA
GGTCAATGAAGGTTAGGGGCGCGCCTGCAATAGGCATAACGGCGGCGTACGGTATGTTACTCAGCCTATTAAGCAGCATG
AGTAAGGTAAGTGACCTTAATGACGCCTTAAGGGTTCTTGAGAATGCCAAGAGGATTATGGATGCTGCCAGGCCAACTGC
AGTTAACTTACCCTGGGCTACAGGTAGGATGCTTAATAAGGCTAAGTCAAGTATAAGTAATGGTAGCGTTAGGAGTGTTA
AGGAATTGGTGGATGCACTTAAGGCCGAGGCTGACGCCGTCTTTAATGAGGAGTACGATGCCGAGATAGCCATGGGTATC
TACGGCATGGAGAAGCTTAACAATGGTGACTCAATTATGACTCAGTGTAATGCAGGTGGTTTAGCAACAGGTACTGGCTT
AGGGACTGCCTTGGCTCCTGTTAAGTTGGCTAAGTTAATGGGTATGGAGGTTTCAATGTTCGTACCTGAAACCAGACCGT
GGCTGCAGGGAGCTAGGTTAACTGTTTACGAATTAGTGATGGAGGGTATCGACACCACGTTAATCACGGATACAGCGGTT
GGGTTAGTTATGTATAAGGGCATGGTTAACCACGTCATGGTTGGGGCAGATAGGATTTTAAAGGACGGACACGTGTTTAA
TAAGGTGGGTACGTTTAAGGAGGCTGTGATAGCCCATGAATTGGGAATACCCTTCTACGCCCTTGCCCCATCCTCAACCT
TCGACTTAACCAGTGATGTGAATGATGTTAAGATTGAGGAGAGGGACCCTAATGAAGTTAGGTTAATTAGGGGGGTTCCA
ATAACTCTAAGTGACGTTAAGGTGTATAACCCAGTCTTCGACGTAACACCCCCCAGGTACGTTACGGCGATAATAACGGA
GAAGGGTATAATATACCCACCCTTCGATAAGAATGTGAATAGGGTTATAAACGGGGGTGGTGGCTACGGATAG

Upstream 100 bases:

>100_bases
GGAGGTTGCAGACCTGCTTAGGCAATTCCTCCAGCATTAACAATTTGTGAGTAAATTTTAAAACCCAGTTGAATTCGAAG
GTGACGGTTAGTGATTATTA

Downstream 100 bases:

>100_bases
TGTGAATATTGAGGAGAAGCTGGCTAAGGCCCTTGTTAAGCTCATCAGTGGCTCAAGGGGTAGGAGGGTTACTATTAAGA
CAGCCACATTAGTGAGGTTA

Product: translation initiation factor IF-2B subunit alpha

Products: NA

Alternate protein names: M1Pi; MTR-1-P isomerase; MTNA-like protein; aMTNA; S-methyl-5-thioribose-1-phosphate isomerase [H]

Number of amino acids: Translated: 370; Mature: 370

Protein sequence:

>370_residues
MRISIDEVKRIYKPKVKPIEWRDNRLIILDQSKVPFETIYVELHTPQDVADAIRSMKVRGAPAIGITAAYGMLLSLLSSM
SKVSDLNDALRVLENAKRIMDAARPTAVNLPWATGRMLNKAKSSISNGSVRSVKELVDALKAEADAVFNEEYDAEIAMGI
YGMEKLNNGDSIMTQCNAGGLATGTGLGTALAPVKLAKLMGMEVSMFVPETRPWLQGARLTVYELVMEGIDTTLITDTAV
GLVMYKGMVNHVMVGADRILKDGHVFNKVGTFKEAVIAHELGIPFYALAPSSTFDLTSDVNDVKIEERDPNEVRLIRGVP
ITLSDVKVYNPVFDVTPPRYVTAIITEKGIIYPPFDKNVNRVINGGGGYG

Sequences:

>Translated_370_residues
MRISIDEVKRIYKPKVKPIEWRDNRLIILDQSKVPFETIYVELHTPQDVADAIRSMKVRGAPAIGITAAYGMLLSLLSSM
SKVSDLNDALRVLENAKRIMDAARPTAVNLPWATGRMLNKAKSSISNGSVRSVKELVDALKAEADAVFNEEYDAEIAMGI
YGMEKLNNGDSIMTQCNAGGLATGTGLGTALAPVKLAKLMGMEVSMFVPETRPWLQGARLTVYELVMEGIDTTLITDTAV
GLVMYKGMVNHVMVGADRILKDGHVFNKVGTFKEAVIAHELGIPFYALAPSSTFDLTSDVNDVKIEERDPNEVRLIRGVP
ITLSDVKVYNPVFDVTPPRYVTAIITEKGIIYPPFDKNVNRVINGGGGYG
>Mature_370_residues
MRISIDEVKRIYKPKVKPIEWRDNRLIILDQSKVPFETIYVELHTPQDVADAIRSMKVRGAPAIGITAAYGMLLSLLSSM
SKVSDLNDALRVLENAKRIMDAARPTAVNLPWATGRMLNKAKSSISNGSVRSVKELVDALKAEADAVFNEEYDAEIAMGI
YGMEKLNNGDSIMTQCNAGGLATGTGLGTALAPVKLAKLMGMEVSMFVPETRPWLQGARLTVYELVMEGIDTTLITDTAV
GLVMYKGMVNHVMVGADRILKDGHVFNKVGTFKEAVIAHELGIPFYALAPSSTFDLTSDVNDVKIEERDPNEVRLIRGVP
ITLSDVKVYNPVFDVTPPRYVTAIITEKGIIYPPFDKNVNRVINGGGGYG

Specific function: Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) [H]

COG id: COG0182

COG function: function code J; Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily [H]

Homologues:

Organism=Homo sapiens, GI72534748, Length=349, Percent_Identity=35.5300859598854, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI23943880, Length=340, Percent_Identity=33.8235294117647, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI78000158, Length=264, Percent_Identity=27.6515151515151, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI78000156, Length=264, Percent_Identity=27.6515151515151, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI187607323, Length=264, Percent_Identity=27.6515151515151, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI4503503, Length=149, Percent_Identity=30.2013422818792, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17557462, Length=361, Percent_Identity=32.1329639889197, Blast_Score=147, Evalue=9e-36,
Organism=Caenorhabditis elegans, GI17557123, Length=282, Percent_Identity=24.822695035461, Blast_Score=76, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6325375, Length=388, Percent_Identity=32.9896907216495, Blast_Score=166, Evalue=7e-42,
Organism=Saccharomyces cerevisiae, GI6322878, Length=152, Percent_Identity=32.8947368421053, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI21357667, Length=353, Percent_Identity=31.728045325779, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24651647, Length=353, Percent_Identity=31.728045325779, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI21358605, Length=133, Percent_Identity=38.3458646616541, Blast_Score=82, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000649
- InterPro:   IPR005251
- InterPro:   IPR011559 [H]

Pfam domain/function: PF01008 IF-2B [H]

EC number: =5.3.1.23 [H]

Molecular weight: Translated: 40448; Mature: 40448

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRISIDEVKRIYKPKVKPIEWRDNRLIILDQSKVPFETIYVELHTPQDVADAIRSMKVRG
CCCCHHHHHHHHCCCCCCEEECCCEEEEEECCCCCEEEEEEEEECCHHHHHHHHHHCCCC
APAIGITAAYGMLLSLLSSMSKVSDLNDALRVLENAKRIMDAARPTAVNLPWATGRMLNK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHH
AKSSISNGSVRSVKELVDALKAEADAVFNEEYDAEIAMGIYGMEKLNNGDSIMTQCNAGG
HHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHCCCCCCEEEECCCCC
LATGTGLGTALAPVKLAKLMGMEVSMFVPETRPWLQGARLTVYELVMEGIDTTLITDTAV
CCCCCCCHHHHHHHHHHHHHCCEEEEECCCCCHHHCCCHHHHHHHHHHCCCCEEHHHHHH
GLVMYKGMVNHVMVGADRILKDGHVFNKVGTFKEAVIAHELGIPFYALAPSSTFDLTSDV
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCC
NDVKIEERDPNEVRLIRGVPITLSDVKVYNPVFDVTPPRYVTAIITEKGIIYPPFDKNVN
CCCEEECCCCCCEEEEECCCEEEECEEEECCCCCCCCCHHEEEEEECCCCEECCCCCCCH
RVINGGGGYG
HHCCCCCCCC
>Mature Secondary Structure
MRISIDEVKRIYKPKVKPIEWRDNRLIILDQSKVPFETIYVELHTPQDVADAIRSMKVRG
CCCCHHHHHHHHCCCCCCEEECCCEEEEEECCCCCEEEEEEEEECCHHHHHHHHHHCCCC
APAIGITAAYGMLLSLLSSMSKVSDLNDALRVLENAKRIMDAARPTAVNLPWATGRMLNK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHH
AKSSISNGSVRSVKELVDALKAEADAVFNEEYDAEIAMGIYGMEKLNNGDSIMTQCNAGG
HHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHCCCCCCEEEECCCCC
LATGTGLGTALAPVKLAKLMGMEVSMFVPETRPWLQGARLTVYELVMEGIDTTLITDTAV
CCCCCCCHHHHHHHHHHHHHCCEEEEECCCCCHHHCCCHHHHHHHHHHCCCCEEHHHHHH
GLVMYKGMVNHVMVGADRILKDGHVFNKVGTFKEAVIAHELGIPFYALAPSSTFDLTSDV
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCC
NDVKIEERDPNEVRLIRGVPITLSDVKVYNPVFDVTPPRYVTAIITEKGIIYPPFDKNVN
CCCEEECCCCCCEEEEECCCEEEECEEEECCCCCCCCCHHEEEEEECCCCEECCCCCCCH
RVINGGGGYG
HHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA