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The map label for this gene is gltA [H]

Identifier: 159040892

GI number: 159040892

Start: 344625

End: 345818

Strand: Reverse

Name: gltA [H]

Synonym: Cmaq_0306

Alternate gene names: 159040892

Gene position: 345818-344625 (Counterclockwise)

Preceding gene: 159040893

Following gene: 159040888

Centisome position: 16.65

GC content: 45.39

Gene sequence:

>1194_bases
ATGGAGTCTGTTAGGAAAGTTGAAATAAGTACAAGCGGAAAGGTGATAGAGTCCCCATGTGGACCAATAATACATGGTCT
TGAGGATGTTTTAATAAAGGTAACGTCAATAAGCGATATAGATGGTAGGAAGGGAATACTGTGGTATAGGGGGTATAGGA
TTGATGACCTAGCCAAGTACTCCAACTTCGAGGAGACAGCGTACCTGGTGCTCTACGGTAAGTTACCCACTAGGAGTGAG
CTCTCGGAGTTCAGTGAGAAGCTTGCCTCTAATAGGGATTTACCTGAGGAGATTTACTCAATAATAAGGGTTCTTGCTGA
GAATAAGGTTCACCCAATGCTTGTACTAGAGTCAGCTGTATCAGCCTTAGCCGGCTTCGACCCTAAGGCCGGGGATTTAA
GTAAGGAAGCCCTCTACGATCAGGCGATAAGATTAACAGCAGTGCTACCAACAATAATAGCCGCCCACTATAGATTCAGT
AGAGGGTTAGGGGTTATTAAGCCTAAGAAGGACCTCAGCCATGCTGCCAACTTCCTCTACATGATGTTCGGTTCAACACC
TGATGAAGTATCCACTAGGGCAATAGACCTATACCTAGTGCTTCACATTGATCATGAAGTCCCTGCATCAACATTCGCAA
CACACGTAGCCATATCCACTTGGACCGACTTATACTCAGCCATTGTAGCTGGCATAGCGGCATTAAAGGGGCCTCTTCAC
GGTGGTGCTAATGAGGCGGCAATGAAGCAGTACCTTGAGATTGGGAGCCCGAGTAACGCTAGACCTTATGTTGAGAAGCT
TCTTGCTGAGGGTAAGAGATTAATGGGTGTTGGTCATAGGGTTTACAAGACCTATGACCCAAGGGCCAGGATCTATAAGG
ATCTTGTAAGGGAGTTAAGTGAGAAGAAGGGTAACATGACTTACTACCAGATAGCCGAGGAGGTTGAGAAGGTTGTTTTA
GAGAAGCTTGCACCAAAGAATCTTTACCCCAATATTGACTTCTGGAGTGGTATAGCAATGTACCTGCTTGGTATACCCTA
CGAGTACTACACTCCTATATTTGCCATGTCCAGGGTTGTGGGTTGGTCAGCCCACGCAATAGAGTACTTGAATGAACATA
GGTTATTTAGGCCAAGGGCATGCTACATTGGGCCACATGATGTTCAATACGTTCCAATTGATCAAAGGAAGTAA

Upstream 100 bases:

>100_bases
TCACAAGCCATGGGTAACGTGGTTGTCGAATTCTCTACACTTAAGGTGTTATATTTATAGGTAAATTAGCTTTTTAAGCA
TAAATTCAACTAGGTGAACT

Downstream 100 bases:

>100_bases
GCCGTAATTATTTAGAAATATTAAAATGAGGCCTTTCTCTGCTTTAGGAACTCCCTGAATATGTCTGTTTCAGTGAACAT
ATCCTCATACCCATCGTTAA

Product: 2-methylcitrate synthase/citrate synthase II

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MESVRKVEISTSGKVIESPCGPIIHGLEDVLIKVTSISDIDGRKGILWYRGYRIDDLAKYSNFEETAYLVLYGKLPTRSE
LSEFSEKLASNRDLPEEIYSIIRVLAENKVHPMLVLESAVSALAGFDPKAGDLSKEALYDQAIRLTAVLPTIIAAHYRFS
RGLGVIKPKKDLSHAANFLYMMFGSTPDEVSTRAIDLYLVLHIDHEVPASTFATHVAISTWTDLYSAIVAGIAALKGPLH
GGANEAAMKQYLEIGSPSNARPYVEKLLAEGKRLMGVGHRVYKTYDPRARIYKDLVRELSEKKGNMTYYQIAEEVEKVVL
EKLAPKNLYPNIDFWSGIAMYLLGIPYEYYTPIFAMSRVVGWSAHAIEYLNEHRLFRPRACYIGPHDVQYVPIDQRK

Sequences:

>Translated_397_residues
MESVRKVEISTSGKVIESPCGPIIHGLEDVLIKVTSISDIDGRKGILWYRGYRIDDLAKYSNFEETAYLVLYGKLPTRSE
LSEFSEKLASNRDLPEEIYSIIRVLAENKVHPMLVLESAVSALAGFDPKAGDLSKEALYDQAIRLTAVLPTIIAAHYRFS
RGLGVIKPKKDLSHAANFLYMMFGSTPDEVSTRAIDLYLVLHIDHEVPASTFATHVAISTWTDLYSAIVAGIAALKGPLH
GGANEAAMKQYLEIGSPSNARPYVEKLLAEGKRLMGVGHRVYKTYDPRARIYKDLVRELSEKKGNMTYYQIAEEVEKVVL
EKLAPKNLYPNIDFWSGIAMYLLGIPYEYYTPIFAMSRVVGWSAHAIEYLNEHRLFRPRACYIGPHDVQYVPIDQRK
>Mature_397_residues
MESVRKVEISTSGKVIESPCGPIIHGLEDVLIKVTSISDIDGRKGILWYRGYRIDDLAKYSNFEETAYLVLYGKLPTRSE
LSEFSEKLASNRDLPEEIYSIIRVLAENKVHPMLVLESAVSALAGFDPKAGDLSKEALYDQAIRLTAVLPTIIAAHYRFS
RGLGVIKPKKDLSHAANFLYMMFGSTPDEVSTRAIDLYLVLHIDHEVPASTFATHVAISTWTDLYSAIVAGIAALKGPLH
GGANEAAMKQYLEIGSPSNARPYVEKLLAEGKRLMGVGHRVYKTYDPRARIYKDLVRELSEKKGNMTYYQIAEEVEKVVL
EKLAPKNLYPNIDFWSGIAMYLLGIPYEYYTPIFAMSRVVGWSAHAIEYLNEHRLFRPRACYIGPHDVQYVPIDQRK

Specific function: Catalyzes The Synthesis Of 2-Methylcitrate From Propionyl-CoA And Oxaloacetate. Also Catalyzes The Condensation Of Oxaloacetate With Acetyl-CoA But With A Lower Specificity. [C]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=368, Percent_Identity=30.7065217391304, Blast_Score=120, Evalue=3e-27,
Organism=Escherichia coli, GI1786527, Length=364, Percent_Identity=36.5384615384615, Blast_Score=249, Evalue=3e-67,
Organism=Escherichia coli, GI1786939, Length=363, Percent_Identity=39.6694214876033, Blast_Score=240, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI17555174, Length=373, Percent_Identity=30.0268096514745, Blast_Score=121, Evalue=8e-28,
Organism=Saccharomyces cerevisiae, GI6319850, Length=334, Percent_Identity=27.5449101796407, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6325257, Length=340, Percent_Identity=27.3529411764706, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6324328, Length=315, Percent_Identity=26.031746031746, Blast_Score=92, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24640124, Length=380, Percent_Identity=28.6842105263158, Blast_Score=118, Evalue=7e-27,
Organism=Drosophila melanogaster, GI24640126, Length=378, Percent_Identity=28.042328042328, Blast_Score=118, Evalue=8e-27,
Organism=Drosophila melanogaster, GI21356863, Length=370, Percent_Identity=27.027027027027, Blast_Score=107, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011278
- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.1 [H]

Molecular weight: Translated: 44653; Mature: 44653

Theoretical pI: Translated: 7.43; Mature: 7.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESVRKVEISTSGKVIESPCGPIIHGLEDVLIKVTSISDIDGRKGILWYRGYRIDDLAKY
CCCCEEEEECCCCCEECCCCCHHHHHHHHHHEEHHCCCCCCCCCCEEEEECCCHHHHHHH
SNFEETAYLVLYGKLPTRSELSEFSEKLASNRDLPEEIYSIIRVLAENKVHPMLVLESAV
CCCCCEEEEEEEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHH
SALAGFDPKAGDLSKEALYDQAIRLTAVLPTIIAAHYRFSRGLGVIKPKKDLSHAANFLY
HHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
MMFGSTPDEVSTRAIDLYLVLHIDHEVPASTFATHVAISTWTDLYSAIVAGIAALKGPLH
HEECCCCHHHHHEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GGANEAAMKQYLEIGSPSNARPYVEKLLAEGKRLMGVGHRVYKTYDPRARIYKDLVRELS
CCCCHHHHHHHHHCCCCCCCCHHHHHHHHCCHHHHHCCHHHHHCCCCHHHHHHHHHHHHH
EKKGNMTYYQIAEEVEKVVLEKLAPKNLYPNIDFWSGIAMYLLGIPYEYYTPIFAMSRVV
HHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHH
GWSAHAIEYLNEHRLFRPRACYIGPHDVQYVPIDQRK
CCHHHHHHHHHHCCCCCCCEEEECCCCCEEECCCCCC
>Mature Secondary Structure
MESVRKVEISTSGKVIESPCGPIIHGLEDVLIKVTSISDIDGRKGILWYRGYRIDDLAKY
CCCCEEEEECCCCCEECCCCCHHHHHHHHHHEEHHCCCCCCCCCCEEEEECCCHHHHHHH
SNFEETAYLVLYGKLPTRSELSEFSEKLASNRDLPEEIYSIIRVLAENKVHPMLVLESAV
CCCCCEEEEEEEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHH
SALAGFDPKAGDLSKEALYDQAIRLTAVLPTIIAAHYRFSRGLGVIKPKKDLSHAANFLY
HHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
MMFGSTPDEVSTRAIDLYLVLHIDHEVPASTFATHVAISTWTDLYSAIVAGIAALKGPLH
HEECCCCHHHHHEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GGANEAAMKQYLEIGSPSNARPYVEKLLAEGKRLMGVGHRVYKTYDPRARIYKDLVRELS
CCCCHHHHHHHHHCCCCCCCCHHHHHHHHCCHHHHHCCHHHHHCCCCHHHHHHHHHHHHH
EKKGNMTYYQIAEEVEKVVLEKLAPKNLYPNIDFWSGIAMYLLGIPYEYYTPIFAMSRVV
HHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHH
GWSAHAIEYLNEHRLFRPRACYIGPHDVQYVPIDQRK
CCHHHHHHHHHHCCCCCCCEEEECCCCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8532683; 9254593 [H]