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The map label for this gene is thrB [H]

Identifier: 159040847

GI number: 159040847

Start: 298235

End: 299161

Strand: Reverse

Name: thrB [H]

Synonym: Cmaq_0261

Alternate gene names: 159040847

Gene position: 299161-298235 (Counterclockwise)

Preceding gene: 159040848

Following gene: 159040845

Centisome position: 14.4

GC content: 44.77

Gene sequence:

>927_bases
TTGGGTACTGAGGAGTTGATTATTGAGGCTCCCGCATCAATAGCCAACCTTGGTCCTGCCTTTGATGTTGCTGCGCTTGC
CATTAATCCACCAAGTGATATTGTTAAGGTTAAGGTAACTGATGGTGATGGTGTATTCATAAGGAATAGCGGTGAATACG
CCTCCAGCCTACCCAGTGAGGGTAATGGGAACTCAGCCTACTTGGTGGCTACTAGGGCTATTGAGTTAGCTGGGTTAAGG
AGGAGGATTGAGATTGAGGTTATTAAGCGTATTAAACCCGCCAGTGGATTAGGGAGTAGTGGTGCAACATCTGCTGCTGT
GGCTTACGCATTGAATAAGTTACTTAACCTAAGCCTGAGTGAATGGGACTTAGTTGAATTAGCCTCCTACGGTGAATTAG
CCTCAGCTGGGGTGAGGCATATGGATAATGTAGCCGCATCACTACTGGGTGGTTTAGTTCTTGTCAACCCAGTGATTAGG
AGGGTTATTAGGGTTAACTTCCCTGAGTTAAGCATAGTGGTGGTTATTGAGGGTTCTAAACCAAACACCGGTTTCATGAG
GAGTATCCTACCTAAGGCCTATGAGTTAAGCGACGTGGTTGCGAATATGGCTAATGTCGCCCAATTAGTTGCGTCAGTTT
TAATGAATGACCTAGACTTATTCTCAAGGGTTATCACAAATGATAGGGTTGCAATGCCCTACAGGGTTAAGGCTTATGAG
CATTGGGGTGTTGTTAAGAGTGTGCTTGAGAATCATGGCGCCTTAGGCGTAATATTAAGTGGAGCTGGGCCATCCATAGC
GGCTTTCTTTAAGGAGAAGCCTCAGGTTAATGAGATTAAAACCGAGTTAATGAGTGCTGGGTTAAGTCCAGTGGTTATTT
TAACTAAGCCATCCAATGAGGGGGCTAGGGAAATTAATCATTATTAA

Upstream 100 bases:

>100_bases
GGGGTAAGATTGAGGAGCTTTGGTCATACATTAAGGCTCATTTCGATGAATTAATGAGTAGGGTCGCCTCAGAGCAGGAG
GAGCTTAGGGGTGATTCGGA

Downstream 100 bases:

>100_bases
GTATACTTAATTTAACCAAGGTCTCAGTCTTCGGTACACCTCTCTCATCGTAGCCCCTTAACCTATAGTACTCCTTAATC
ATGCTCATCCACTCCTCCTC

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK [H]

Number of amino acids: Translated: 308; Mature: 307

Protein sequence:

>308_residues
MGTEELIIEAPASIANLGPAFDVAALAINPPSDIVKVKVTDGDGVFIRNSGEYASSLPSEGNGNSAYLVATRAIELAGLR
RRIEIEVIKRIKPASGLGSSGATSAAVAYALNKLLNLSLSEWDLVELASYGELASAGVRHMDNVAASLLGGLVLVNPVIR
RVIRVNFPELSIVVVIEGSKPNTGFMRSILPKAYELSDVVANMANVAQLVASVLMNDLDLFSRVITNDRVAMPYRVKAYE
HWGVVKSVLENHGALGVILSGAGPSIAAFFKEKPQVNEIKTELMSAGLSPVVILTKPSNEGAREINHY

Sequences:

>Translated_308_residues
MGTEELIIEAPASIANLGPAFDVAALAINPPSDIVKVKVTDGDGVFIRNSGEYASSLPSEGNGNSAYLVATRAIELAGLR
RRIEIEVIKRIKPASGLGSSGATSAAVAYALNKLLNLSLSEWDLVELASYGELASAGVRHMDNVAASLLGGLVLVNPVIR
RVIRVNFPELSIVVVIEGSKPNTGFMRSILPKAYELSDVVANMANVAQLVASVLMNDLDLFSRVITNDRVAMPYRVKAYE
HWGVVKSVLENHGALGVILSGAGPSIAAFFKEKPQVNEIKTELMSAGLSPVVILTKPSNEGAREINHY
>Mature_307_residues
GTEELIIEAPASIANLGPAFDVAALAINPPSDIVKVKVTDGDGVFIRNSGEYASSLPSEGNGNSAYLVATRAIELAGLRR
RIEIEVIKRIKPASGLGSSGATSAAVAYALNKLLNLSLSEWDLVELASYGELASAGVRHMDNVAASLLGGLVLVNPVIRR
VIRVNFPELSIVVVIEGSKPNTGFMRSILPKAYELSDVVANMANVAQLVASVLMNDLDLFSRVITNDRVAMPYRVKAYEH
WGVVKSVLENHGALGVILSGAGPSIAAFFKEKPQVNEIKTELMSAGLSPVVILTKPSNEGAREINHY

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate [H]

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786184, Length=279, Percent_Identity=28.673835125448, Blast_Score=98, Evalue=6e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.39 [H]

Molecular weight: Translated: 32715; Mature: 32584

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTEELIIEAPASIANLGPAFDVAALAINPPSDIVKVKVTDGDGVFIRNSGEYASSLPSE
CCCCCEEEECCCHHHHCCCCCCEEEEEECCCCCEEEEEEECCCEEEEECCCCHHHCCCCC
GNGNSAYLVATRAIELAGLRRRIEIEVIKRIKPASGLGSSGATSAAVAYALNKLLNLSLS
CCCCEEEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCC
EWDLVELASYGELASAGVRHMDNVAASLLGGLVLVNPVIRRVIRVNFPELSIVVVIEGSK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCC
PNTGFMRSILPKAYELSDVVANMANVAQLVASVLMNDLDLFSRVITNDRVAMPYRVKAYE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEHHH
HWGVVKSVLENHGALGVILSGAGPSIAAFFKEKPQVNEIKTELMSAGLSPVVILTKPSNE
HHHHHHHHHHCCCCEEEEEECCCCHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEECCCCC
GAREINHY
CCHHCCCC
>Mature Secondary Structure 
GTEELIIEAPASIANLGPAFDVAALAINPPSDIVKVKVTDGDGVFIRNSGEYASSLPSE
CCCCEEEECCCHHHHCCCCCCEEEEEECCCCCEEEEEEECCCEEEEECCCCHHHCCCCC
GNGNSAYLVATRAIELAGLRRRIEIEVIKRIKPASGLGSSGATSAAVAYALNKLLNLSLS
CCCCEEEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCC
EWDLVELASYGELASAGVRHMDNVAASLLGGLVLVNPVIRRVIRVNFPELSIVVVIEGSK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCC
PNTGFMRSILPKAYELSDVVANMANVAQLVASVLMNDLDLFSRVITNDRVAMPYRVKAYE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEHHH
HWGVVKSVLENHGALGVILSGAGPSIAAFFKEKPQVNEIKTELMSAGLSPVVILTKPSNE
HHHHHHHHHHCCCCEEEEEECCCCHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEECCCCC
GAREINHY
CCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA