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The map label for this gene is strD [H]

Identifier: 15899922

GI number: 15899922

Start: 2967851

End: 2968612

Strand: Reverse

Name: strD [H]

Synonym: SSO3219

Alternate gene names: 15899922

Gene position: 2968612-2967851 (Counterclockwise)

Preceding gene: 15899924

Following gene: 15899921

Centisome position: 99.21

GC content: 35.3

Gene sequence:

>762_bases
ATGCTTGAAAAGGCCGTAATTACATCAGCTGGAAAAGGAAGTCGAATGAAACATATAACAAATGTATTACCAAAGGCATT
ATTACCCTTATTCGTAACGGAAAATGGAGGGAAGGTAACTAGACCAGTTATAGATTTAATAATGGATTCATTAAATAAGA
TTGGTGTAGAAAAGTTCTGTATCGTGGTAGGAAGAAATGGAATGTTACTAATGCAATACTTATTCGATAGAACACCAACT
TTTGTATTTCAAGATATGCCTAAGGGATTTGGCGATGCAGTCTTGAGGGCAGAGGACTTCTCAACAAATGAACCTTTCTT
CGTTCATGCTGATGATGGTGTTCTAACTAAAGGATATGACTCTCTCAAATTGCTATTTAATGAAATAAGTCCAGATGGCG
TACTTTTAGTCAGAAGAGTGGAAAATCCTAGTAGATATGGTGTGGTAACTGTTCAAGATAAGGGTATGTACAATGGTCAC
AAATTATATAGGGTAATTGACGCGGAGGAGAAACCATTACATCCAAAATCTAACTTAGCCATAGCTGCAGTTTACATTTT
TAAGCCTAGTATATTCAGTGCCTTAAGGCAAATTAAGGTTGAGGAAGGTAAAGAGTTGGAGTTAACTTATGGGATACATA
ATTTGTTGCTAGATGGTAAAGAAGTTTACGCGTTAGAAATGAATGAAGATGAGAAATGGTTAAACGTAGGAGACCCTAAA
AGCTATCTAGACGCATTAAACTATTCATTTAAATTTCTTTAA

Upstream 100 bases:

>100_bases
TTCCCATAGGTAATACTTAAACGAATAATTTATAAACTTTTTGTACAATTCTGAAGCAATCCACAAAGCATATATAATAT
GAATACTTTAATATGAATTA

Downstream 100 bases:

>100_bases
CAACATAATATATTTCATGATACTTGTCGGAGTGGATGGGGGAGGAAGTAAAACAAGTGCTATAGCTTATACTTGTAGCG
GATCCTTCTTAGGCAAGGGT

Product: sugar phosphate nucleotydyl transferase

Products: NA

Alternate protein names: Sugar-nucleotidylation enzyme; dTDP-glucose pyrophosphorylase; dTDP-glucose synthase [H]

Number of amino acids: Translated: 253; Mature: 253

Protein sequence:

>253_residues
MLEKAVITSAGKGSRMKHITNVLPKALLPLFVTENGGKVTRPVIDLIMDSLNKIGVEKFCIVVGRNGMLLMQYLFDRTPT
FVFQDMPKGFGDAVLRAEDFSTNEPFFVHADDGVLTKGYDSLKLLFNEISPDGVLLVRRVENPSRYGVVTVQDKGMYNGH
KLYRVIDAEEKPLHPKSNLAIAAVYIFKPSIFSALRQIKVEEGKELELTYGIHNLLLDGKEVYALEMNEDEKWLNVGDPK
SYLDALNYSFKFL

Sequences:

>Translated_253_residues
MLEKAVITSAGKGSRMKHITNVLPKALLPLFVTENGGKVTRPVIDLIMDSLNKIGVEKFCIVVGRNGMLLMQYLFDRTPT
FVFQDMPKGFGDAVLRAEDFSTNEPFFVHADDGVLTKGYDSLKLLFNEISPDGVLLVRRVENPSRYGVVTVQDKGMYNGH
KLYRVIDAEEKPLHPKSNLAIAAVYIFKPSIFSALRQIKVEEGKELELTYGIHNLLLDGKEVYALEMNEDEKWLNVGDPK
SYLDALNYSFKFL
>Mature_253_residues
MLEKAVITSAGKGSRMKHITNVLPKALLPLFVTENGGKVTRPVIDLIMDSLNKIGVEKFCIVVGRNGMLLMQYLFDRTPT
FVFQDMPKGFGDAVLRAEDFSTNEPFFVHADDGVLTKGYDSLKLLFNEISPDGVLLVRRVENPSRYGVVTVQDKGMYNGH
KLYRVIDAEEKPLHPKSNLAIAAVYIFKPSIFSALRQIKVEEGKELELTYGIHNLLLDGKEVYALEMNEDEKWLNVGDPK
SYLDALNYSFKFL

Specific function: Involved in the biosynthesis of the streptose moiety of streptomycin. Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761619, Length=260, Percent_Identity=24.6153846153846, Blast_Score=65, Evalue=8e-11,
Organism=Homo sapiens, GI11761621, Length=259, Percent_Identity=23.5521235521236, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI1790224, Length=253, Percent_Identity=26.4822134387352, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1788351, Length=255, Percent_Identity=24.7058823529412, Blast_Score=77, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005908
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 28509; Mature: 28509

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEKAVITSAGKGSRMKHITNVLPKALLPLFVTENGGKVTRPVIDLIMDSLNKIGVEKFC
CCCCCEEECCCCCCHHHHHHHHHHHHHHEEEEECCCCEEHHHHHHHHHHHHHHCCCEEEE
IVVGRNGMLLMQYLFDRTPTFVFQDMPKGFGDAVLRAEDFSTNEPFFVHADDGVLTKGYD
EEECCCCHHHHHHHHCCCCCEEEHHCCCCCCCCEEEECCCCCCCCEEEECCCCCEECCCH
SLKLLFNEISPDGVLLVRRVENPSRYGVVTVQDKGMYNGHKLYRVIDAEEKPLHPKSNLA
HHHHHHHHCCCCCEEEEEEECCCCCEEEEEEECCCCCCCCEEEEEECCCCCCCCCCCCEE
IAAVYIFKPSIFSALRQIKVEEGKELELTYGIHNLLLDGKEVYALEMNEDEKWLNVGDPK
EEEEEEECCHHHHHHHHHHHCCCCEEEEEECHHHHHCCCCEEEEEEECCCCCEEECCCHH
SYLDALNYSFKFL
HHHHHHCCCEECC
>Mature Secondary Structure
MLEKAVITSAGKGSRMKHITNVLPKALLPLFVTENGGKVTRPVIDLIMDSLNKIGVEKFC
CCCCCEEECCCCCCHHHHHHHHHHHHHHEEEEECCCCEEHHHHHHHHHHHHHHCCCEEEE
IVVGRNGMLLMQYLFDRTPTFVFQDMPKGFGDAVLRAEDFSTNEPFFVHADDGVLTKGYD
EEECCCCHHHHHHHHCCCCCEEEHHCCCCCCCCEEEECCCCCCCCEEEECCCCCEECCCH
SLKLLFNEISPDGVLLVRRVENPSRYGVVTVQDKGMYNGHKLYRVIDAEEKPLHPKSNLA
HHHHHHHHCCCCCEEEEEEECCCCCEEEEEEECCCCCCCCEEEEEECCCCCCCCCCCCEE
IAAVYIFKPSIFSALRQIKVEEGKELELTYGIHNLLLDGKEVYALEMNEDEKWLNVGDPK
EEEEEEECCHHHHHHHHHHHCCCCEEEEEECHHHHHCCCCEEEEEEECCCCCEEECCCHH
SYLDALNYSFKFL
HHHHHHCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3118332 [H]