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The map label for this gene is acd-7 [H]

Identifier: 15899848

GI number: 15899848

Start: 2895037

End: 2896206

Strand: Reverse

Name: acd-7 [H]

Synonym: SSO3145

Alternate gene names: 15899848

Gene position: 2896206-2895037 (Counterclockwise)

Preceding gene: 15899849

Following gene: 15899846

Centisome position: 96.79

GC content: 37.18

Gene sequence:

>1170_bases
ATGTTATTGCAACCAAAAGATGAAGAAGAGAAATTGATCCTCTCAACAGTTGACCAATTAATGGACAAATACAACGAAAG
GTATTGGTTGGATAAGGATCAAAAGAGGGAATTCCCTATAGACTTCCTCAATGACTTTATGAAGTTAGGATTGGGATCAA
TTCTGATACCAGTAGAATATGGTGGAGTGGGGAAAGGAGTCAGACTAGCTTCCTTAATCCTCTATAATATAAATCTAAGA
GGTGGTAATTCATATTTCGTACACGGACATTATTATAACACTGCCTTACTATCAAAACATAGCGGTAAGAGGATAATAGA
AAAGTACTTCAAGGATCTTGCAAATGGTGCTAAAGTACTATCATTAGCTTTAACTGAGCCACAAGTTGGGTCGGATACGA
CGAAAATTAAGACAGTTGCTGAAAAAGTTGGGAATAGTTTCTTCATAAAGGGTCACAAGATATTCATTTCTAGGTTAAAG
TACACTGACTTTATGATATTAGTAGCAAGAACGACACCCTATGAAAAAGTTGAAAAGAAGACAGATGGGATAACCTTGTT
TTTAGTTGATCTAAGAGAGGGAAGGGATGGAATTGAGATGAGGGAAATAAAGACCATGTCAAATACTAATGCTTATGAAG
TGTTTATAGATGGTCTCAAAGTGCCAGAGGATAACGTTATAGGAGAGGTCGGAAAGGGTTTCTACTATTTACTTGACCTA
TTAAATGCGGAAAGGTTTATGATAGCAGCTGAAATGATCGGCAATGCGGAGTGGTTCATAAACAAAGCAGTTGAATACGC
AAAGAACAGAGTCGTCTTCGACAAACAAATAGGTAGTTTTCAAGGTGTTCAGTTTCCAATAGCTGAGGTATATGCTAAGT
TGGTATCCCTCTCATCTTATTTTAATGAAGGTTTAAGAGTAATAGAAAAGGGGAAAGATACAAAAACTGTTGGAAGTTAC
GCGAATATATCCAAATACTTAGCTACTGAGATAGCTTGGGAAGCTGGAAATGTCGCAATGGACGTTTACGGAGGTTATGG
GTATGCTGTGGAAACTGGAATAGAGAGAAAACTTAGAGAGACCAGATTATATAAGGTAGCCCCAATATCGCAAAACTTAA
TCCTAGCTTACATTGCTCATCATATACTGGGCCTTCCTAAATCATATTAG

Upstream 100 bases:

>100_bases
GTCTTACAGAGTTTTATAGGAGGTTATGTTGGGAGATTACCAATTCCGGTTGAAATTTGACGGAAAATCTATATAAACAA
GTTAATTACCTTTTATTTGT

Downstream 100 bases:

>100_bases
CATTATTATCCCCTTTTCAGCAAGTCTATTTATCTCCCCTTCCGAATACCCTAACTCAAGTAAAACCTCTTTAGTATTCT
CGCCAAGTCTAGGTGCTTTA

Product: Acyl-CoA dehydrogenase (acd-7)

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MLLQPKDEEEKLILSTVDQLMDKYNERYWLDKDQKREFPIDFLNDFMKLGLGSILIPVEYGGVGKGVRLASLILYNINLR
GGNSYFVHGHYYNTALLSKHSGKRIIEKYFKDLANGAKVLSLALTEPQVGSDTTKIKTVAEKVGNSFFIKGHKIFISRLK
YTDFMILVARTTPYEKVEKKTDGITLFLVDLREGRDGIEMREIKTMSNTNAYEVFIDGLKVPEDNVIGEVGKGFYYLLDL
LNAERFMIAAEMIGNAEWFINKAVEYAKNRVVFDKQIGSFQGVQFPIAEVYAKLVSLSSYFNEGLRVIEKGKDTKTVGSY
ANISKYLATEIAWEAGNVAMDVYGGYGYAVETGIERKLRETRLYKVAPISQNLILAYIAHHILGLPKSY

Sequences:

>Translated_389_residues
MLLQPKDEEEKLILSTVDQLMDKYNERYWLDKDQKREFPIDFLNDFMKLGLGSILIPVEYGGVGKGVRLASLILYNINLR
GGNSYFVHGHYYNTALLSKHSGKRIIEKYFKDLANGAKVLSLALTEPQVGSDTTKIKTVAEKVGNSFFIKGHKIFISRLK
YTDFMILVARTTPYEKVEKKTDGITLFLVDLREGRDGIEMREIKTMSNTNAYEVFIDGLKVPEDNVIGEVGKGFYYLLDL
LNAERFMIAAEMIGNAEWFINKAVEYAKNRVVFDKQIGSFQGVQFPIAEVYAKLVSLSSYFNEGLRVIEKGKDTKTVGSY
ANISKYLATEIAWEAGNVAMDVYGGYGYAVETGIERKLRETRLYKVAPISQNLILAYIAHHILGLPKSY
>Mature_389_residues
MLLQPKDEEEKLILSTVDQLMDKYNERYWLDKDQKREFPIDFLNDFMKLGLGSILIPVEYGGVGKGVRLASLILYNINLR
GGNSYFVHGHYYNTALLSKHSGKRIIEKYFKDLANGAKVLSLALTEPQVGSDTTKIKTVAEKVGNSFFIKGHKIFISRLK
YTDFMILVARTTPYEKVEKKTDGITLFLVDLREGRDGIEMREIKTMSNTNAYEVFIDGLKVPEDNVIGEVGKGFYYLLDL
LNAERFMIAAEMIGNAEWFINKAVEYAKNRVVFDKQIGSFQGVQFPIAEVYAKLVSLSSYFNEGLRVIEKGKDTKTVGSY
ANISKYLATEIAWEAGNVAMDVYGGYGYAVETGIERKLRETRLYKVAPISQNLILAYIAHHILGLPKSY

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958412, Length=368, Percent_Identity=26.9021739130435, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI4557235, Length=347, Percent_Identity=29.971181556196, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI76496475, Length=347, Percent_Identity=29.971181556196, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI4501859, Length=384, Percent_Identity=28.125, Blast_Score=135, Evalue=4e-32,
Organism=Homo sapiens, GI226958414, Length=344, Percent_Identity=28.1976744186047, Blast_Score=135, Evalue=6e-32,
Organism=Homo sapiens, GI4501857, Length=342, Percent_Identity=27.1929824561404, Blast_Score=125, Evalue=5e-29,
Organism=Homo sapiens, GI7656849, Length=358, Percent_Identity=27.0949720670391, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI21361497, Length=361, Percent_Identity=26.3157894736842, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI4557231, Length=355, Percent_Identity=28.169014084507, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI187960098, Length=355, Percent_Identity=28.169014084507, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI4557233, Length=380, Percent_Identity=25.5263157894737, Blast_Score=112, Evalue=8e-25,
Organism=Escherichia coli, GI1786223, Length=384, Percent_Identity=26.8229166666667, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI87081958, Length=379, Percent_Identity=25.8575197889182, Blast_Score=132, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI71985184, Length=399, Percent_Identity=29.3233082706767, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17538396, Length=370, Percent_Identity=27.5675675675676, Blast_Score=128, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17533517, Length=357, Percent_Identity=26.0504201680672, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17534899, Length=347, Percent_Identity=28.8184438040346, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17570075, Length=362, Percent_Identity=27.0718232044199, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI71985192, Length=326, Percent_Identity=28.8343558282209, Blast_Score=117, Evalue=7e-27,
Organism=Caenorhabditis elegans, GI17508101, Length=380, Percent_Identity=26.8421052631579, Blast_Score=117, Evalue=9e-27,
Organism=Caenorhabditis elegans, GI17551932, Length=351, Percent_Identity=25.3561253561254, Blast_Score=117, Evalue=9e-27,
Organism=Caenorhabditis elegans, GI17569725, Length=361, Percent_Identity=26.8698060941828, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17505929, Length=329, Percent_Identity=25.2279635258359, Blast_Score=108, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI17506239, Length=344, Percent_Identity=25.5813953488372, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71990804, Length=268, Percent_Identity=28.7313432835821, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71982178, Length=288, Percent_Identity=29.5138888888889, Blast_Score=98, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI32563615, Length=239, Percent_Identity=26.7782426778243, Blast_Score=88, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17534353, Length=257, Percent_Identity=26.4591439688716, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17531909, Length=254, Percent_Identity=25.9842519685039, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI281363737, Length=382, Percent_Identity=28.7958115183246, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI21355753, Length=330, Percent_Identity=28.4848484848485, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI24666513, Length=386, Percent_Identity=27.979274611399, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24660351, Length=348, Percent_Identity=26.4367816091954, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI21356377, Length=341, Percent_Identity=26.6862170087977, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24646207, Length=352, Percent_Identity=26.4204545454545, Blast_Score=96, Evalue=5e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 44074; Mature: 44074

Theoretical pI: Translated: 9.00; Mature: 9.00

Prosite motif: PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLQPKDEEEKLILSTVDQLMDKYNERYWLDKDQKREFPIDFLNDFMKLGLGSILIPVEY
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEC
GGVGKGVRLASLILYNINLRGGNSYFVHGHYYNTALLSKHSGKRIIEKYFKDLANGAKVL
CCCCCCHHEEEEEEEEEEEECCCEEEEEEEEECHHHHCCCCCHHHHHHHHHHHCCCCEEE
SLALTEPQVGSDTTKIKTVAEKVGNSFFIKGHKIFISRLKYTDFMILVARTTPYEKVEKK
EEEECCCCCCCCHHHHHHHHHHCCCEEEEECHHHHHHHHCCCEEEEEEEECCCHHHHHHC
TDGITLFLVDLREGRDGIEMREIKTMSNTNAYEVFIDGLKVPEDNVIGEVGKGFYYLLDL
CCCEEEEEEEECCCCCCCHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHCCHHHHHHHH
LNAERFMIAAEMIGNAEWFINKAVEYAKNRVVFDKQIGSFQGVQFPIAEVYAKLVSLSSY
HCCHHHHHHHHHHCCHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHH
FNEGLRVIEKGKDTKTVGSYANISKYLATEIAWEAGNVAMDVYGGYGYAVETGIERKLRE
HHHHHHHHHCCCCCCHHCCHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEHHHHHHHHHH
TRLYKVAPISQNLILAYIAHHILGLPKSY
HHCEEECCCCCHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MLLQPKDEEEKLILSTVDQLMDKYNERYWLDKDQKREFPIDFLNDFMKLGLGSILIPVEY
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEC
GGVGKGVRLASLILYNINLRGGNSYFVHGHYYNTALLSKHSGKRIIEKYFKDLANGAKVL
CCCCCCHHEEEEEEEEEEEECCCEEEEEEEEECHHHHCCCCCHHHHHHHHHHHCCCCEEE
SLALTEPQVGSDTTKIKTVAEKVGNSFFIKGHKIFISRLKYTDFMILVARTTPYEKVEKK
EEEECCCCCCCCHHHHHHHHHHCCCEEEEECHHHHHHHHCCCEEEEEEEECCCHHHHHHC
TDGITLFLVDLREGRDGIEMREIKTMSNTNAYEVFIDGLKVPEDNVIGEVGKGFYYLLDL
CCCEEEEEEEECCCCCCCHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHCCHHHHHHHH
LNAERFMIAAEMIGNAEWFINKAVEYAKNRVVFDKQIGSFQGVQFPIAEVYAKLVSLSSY
HCCHHHHHHHHHHCCHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHH
FNEGLRVIEKGKDTKTVGSYANISKYLATEIAWEAGNVAMDVYGGYGYAVETGIERKLRE
HHHHHHHHHCCCCCCHHCCHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEHHHHHHHHHH
TRLYKVAPISQNLILAYIAHHILGLPKSY
HHCEEECCCCCHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]