Click here to switch to the map view.

The map label for this gene is pip

Identifier: 15899824

GI number: 15899824

Start: 2866355

End: 2867287

Strand: Reverse

Name: pip

Synonym: SSO3115

Alternate gene names: 15899824

Gene position: 2867287-2866355 (Counterclockwise)

Preceding gene: 15899825

Following gene: 15899823

Centisome position: 95.82

GC content: 35.37

Gene sequence:

>933_bases
TTGTCATACTATTTTATCACTATGAAAGGTTATTCTATAAATGTGGAGGAAGGTTATAAGAGAATCTTTGGAATAAACAT
ATACTATAAGTTGTATAGAGTAAAGGGTAGTAATAGGAATTTGGTCACTTTGCATGGCGGTCCTGGAGGTTCTCATGATT
ACCTAATACCTTTAGCTGACTTGTCAAATTACGGAATTAACGTCTTATTTTATGACCAATTTGGTTGCGGTAGGTCCGAC
GACCCTAAAGATACTTCTGATTATACCATAGATCACGGCTTAGAGGAATTAGAGGAACTTAGAAAGCAAGTTTTCGGCAA
TGATAAGATTGTATTATTGGGACACTCCTACGGTGGAGCGTTGGCAATAGCTTATGCACTTAAGTATCAACAGTTTTTAA
GAGGTCTTATTGTAAGTAGTGGACTATCAAGTGTTCCCTATACCGTTAAAGAGATGAGGAGATTAATTGAGGAATTACCA
GATAAGTACAAGACAATTATAAAGAGATATGAAAGTTTAGGTGATTTCAAAAACCCAGAATATTTAGATGCCGTAAACTT
CTTCTATAGTCAACATCTATTGAGACTTAAGGAAATGCCGGAACCAGTTAAAAGGACTTTCGAGTACATAGGAAAAAGGA
GGACGTATGAAATAATGAATGGTCCGAACGAGTTTACTATCATTGGAACAATAAAGGATTGGGACGTTACTGAGCAATTG
TATAAAATAACTGTTCCTACTCTAATAACCGTGGGAAAATACGATGAAGTAACTGTTAATGTAGCTCAGCTTATTCATAA
AAATATTAAGGGATCTAGACTTGTCATTTTCGAGAATAGCTCCCATATGGCCATGTGGGAGGAAAAGGATAAGTATCTTG
AAGTTATAAAGGAGTTTATCGATCAAGTGTATTCACTTAATATGGTTAAGTGA

Upstream 100 bases:

>100_bases
GTTCTACCTTAAGGAGAAGACAGTATACGAAGGCTGGTAATTAATTCTTTTTTCTCATATCATCTTAATTCAAAGTTGCA
AGTCAAGGTTTTTTATCATC

Downstream 100 bases:

>100_bases
TTCCTTTTTATAATACTAATGAAGTTTTTCGTTAAAATCCAATAGCGAGTTAGTAATTGATACTATCACAATAATAATAT
AAGTATATTTACGTCAGTAG

Product: Tricorn protease interacting factor F1

Products: NA

Alternate protein names: PIP; Prolyl aminopeptidase; PAP; Tricorn protease-interacting factor F1

Number of amino acids: Translated: 310; Mature: 309

Protein sequence:

>310_residues
MSYYFITMKGYSINVEEGYKRIFGINIYYKLYRVKGSNRNLVTLHGGPGGSHDYLIPLADLSNYGINVLFYDQFGCGRSD
DPKDTSDYTIDHGLEELEELRKQVFGNDKIVLLGHSYGGALAIAYALKYQQFLRGLIVSSGLSSVPYTVKEMRRLIEELP
DKYKTIIKRYESLGDFKNPEYLDAVNFFYSQHLLRLKEMPEPVKRTFEYIGKRRTYEIMNGPNEFTIIGTIKDWDVTEQL
YKITVPTLITVGKYDEVTVNVAQLIHKNIKGSRLVIFENSSHMAMWEEKDKYLEVIKEFIDQVYSLNMVK

Sequences:

>Translated_310_residues
MSYYFITMKGYSINVEEGYKRIFGINIYYKLYRVKGSNRNLVTLHGGPGGSHDYLIPLADLSNYGINVLFYDQFGCGRSD
DPKDTSDYTIDHGLEELEELRKQVFGNDKIVLLGHSYGGALAIAYALKYQQFLRGLIVSSGLSSVPYTVKEMRRLIEELP
DKYKTIIKRYESLGDFKNPEYLDAVNFFYSQHLLRLKEMPEPVKRTFEYIGKRRTYEIMNGPNEFTIIGTIKDWDVTEQL
YKITVPTLITVGKYDEVTVNVAQLIHKNIKGSRLVIFENSSHMAMWEEKDKYLEVIKEFIDQVYSLNMVK
>Mature_309_residues
SYYFITMKGYSINVEEGYKRIFGINIYYKLYRVKGSNRNLVTLHGGPGGSHDYLIPLADLSNYGINVLFYDQFGCGRSDD
PKDTSDYTIDHGLEELEELRKQVFGNDKIVLLGHSYGGALAIAYALKYQQFLRGLIVSSGLSSVPYTVKEMRRLIEELPD
KYKTIIKRYESLGDFKNPEYLDAVNFFYSQHLLRLKEMPEPVKRTFEYIGKRRTYEIMNGPNEFTIIGTIKDWDVTEQLY
KITVPTLITVGKYDEVTVNVAQLIHKNIKGSRLVIFENSSHMAMWEEKDKYLEVIKEFIDQVYSLNMVK

Specific function: Cleaves H-Pro-AMC as well as a wide spectrum of amino acid substrates and several peptide substrates without a proline at the N-terminus. In conjunction with the three factors F1, F2 and F3, Tricorn degrades oligopeptides in a sequential manner, yielding

COG id: COG0596

COG function: function code R; Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S33 family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PIP_SULSO (Q97UA2)

Other databases:

- EMBL:   AE006641
- PIR:   D90495
- RefSeq:   NP_344429.1
- ProteinModelPortal:   Q97UA2
- SMR:   Q97UA2
- MEROPS:   S33.005
- GeneID:   1453138
- GenomeReviews:   AE006641_GR
- KEGG:   sso:SSO3115
- NMPDR:   fig|273057.1.peg.2852
- HOGENOM:   HBG515521
- OMA:   YIGKRRT
- ProtClustDB:   CLSK374918
- BioCyc:   SSOL273057:SSO3115-MONOMER
- BRENDA:   3.4.11.5
- GO:   GO:0005737
- GO:   GO:0006508
- InterPro:   IPR000073
- InterPro:   IPR005945
- InterPro:   IPR002410
- PIRSF:   PIRSF005539
- PRINTS:   PR00793
- TIGRFAMs:   TIGR01250

Pfam domain/function: PF00561 Abhydrolase_1

EC number: =3.4.11.5

Molecular weight: Translated: 35962; Mature: 35831

Theoretical pI: Translated: 7.23; Mature: 7.23

Prosite motif: NA

Important sites: ACT_SITE 116-116 ACT_SITE 255-255 ACT_SITE 282-282

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYYFITMKGYSINVEEGYKRIFGINIYYKLYRVKGSNRNLVTLHGGPGGSHDYLIPLAD
CEEEEEEEECCEEEHHHHHHHHEEEEEEEEEEEEECCCCCEEEEECCCCCCCCEEEEECC
LSNYGINVLFYDQFGCGRSDDPKDTSDYTIDHGLEELEELRKQVFGNDKIVLLGHSYGGA
CCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCH
LAIAYALKYQQFLRGLIVSSGLSSVPYTVKEMRRLIEELPDKYKTIIKRYESLGDFKNPE
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCH
YLDAVNFFYSQHLLRLKEMPEPVKRTFEYIGKRRTYEIMNGPNEFTIIGTIKDWDVTEQL
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEECCCCCCEEEEEEECCCCHHHHH
YKITVPTLITVGKYDEVTVNVAQLIHKNIKGSRLVIFENSSHMAMWEEKDKYLEVIKEFI
HHEEHHHEEEECCCCHHHHHHHHHHHHCCCCCEEEEEECCCCEEEHHHHHHHHHHHHHHH
DQVYSLNMVK
HHHHHCCCCC
>Mature Secondary Structure 
SYYFITMKGYSINVEEGYKRIFGINIYYKLYRVKGSNRNLVTLHGGPGGSHDYLIPLAD
EEEEEEEECCEEEHHHHHHHHEEEEEEEEEEEEECCCCCEEEEECCCCCCCCEEEEECC
LSNYGINVLFYDQFGCGRSDDPKDTSDYTIDHGLEELEELRKQVFGNDKIVLLGHSYGGA
CCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCH
LAIAYALKYQQFLRGLIVSSGLSSVPYTVKEMRRLIEELPDKYKTIIKRYESLGDFKNPE
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCH
YLDAVNFFYSQHLLRLKEMPEPVKRTFEYIGKRRTYEIMNGPNEFTIIGTIKDWDVTEQL
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEECCCCCCEEEEEEECCCCHHHHH
YKITVPTLITVGKYDEVTVNVAQLIHKNIKGSRLVIFENSSHMAMWEEKDKYLEVIKEFI
HHEEHHHEEEECCCCHHHHHHHHHHHHCCCCCEEEEEECCCCEEEHHHHHHHHHHHHHHH
DQVYSLNMVK
HHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11427726