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The map label for this gene is ilvD [H]

Identifier: 15899814

GI number: 15899814

Start: 2858222

End: 2859898

Strand: Reverse

Name: ilvD [H]

Synonym: SSO3107

Alternate gene names: 15899814

Gene position: 2859898-2858222 (Counterclockwise)

Preceding gene: 15899820

Following gene: 15899813

Centisome position: 95.58

GC content: 42.99

Gene sequence:

>1677_bases
ATGCCAGCAAAATTAAATAGTCCCTCGAGATATCATGGCATATATAATGCTCCACACAGAGCGTTTCTAAGATCTGTAGG
TTTAACGGATGAAGAGATAGGTAAACCATTGGTTGCCATAGCCACAGCATGGAGTGAGGCAGGCCCTTGTAACTTCCACA
CATTAGCTTTAGCAAGAGTAGCTAAGGAGGGGACAAAGGAAGCCGGTTTATCCCCATTAGCATTCCCAACCATGGTAGTT
AACGATAACATTGGAATGGGATCTGAAGGAATGAGGTATAGTTTAGTTAGCAGGGATTTAATAGCAGATATGGTAGAGGC
GCAATTTAATGCTCACGCGTTTGATGGACTAGTGGGCATAGGAGGGTGTGATAAGACAACGCCTGGTATACTAATGGCAA
TGGCTAGGTTAAACGTTCCCTCAATTTACATTTATGGCGGATCAGCAGAGCCAGGGTACTTTATGGGTAAAAGACTAACA
ATAGAGGATGTACATGAGGCAATAGGCGCATATTTAGCGAAGAGAATAACAGAAAATGAGCTATACGAAATAGAGAAAAG
GGCACATCCGACATTGGGAACTTGCTCTGGATTATTTACAGCCAATACTATGGGCTCAATGTCGGAGGCATTAGGAATGG
CATTGCCAGGTAGTGCATCACCAACCGCTACCTCATCTAGGAGAGTAATGTATGTGAAGGAAACTGGAAAAGCTTTAGGT
AGTTTAATTGAAAACGGAATAAAGTCAAGGGAAATATTAACTTTTGAGGCCTTTGAGAACGCAATAACAACGCTAATGGC
TATGGGTGGTTCAACAAACGCGGTATTACACCTATTGGCAATAGCCTATGAAGCAGGAGTGAAATTAACCTTAGATGATT
TCAATAGGATATCTAAAAGAACACCATATATTGCAAGTATGAAACCTGGTGGAGATTACGTGATGGCTGATTTGGACGAA
GTTGGAGGTGTCCCAGTAGTCTTAAAGAAGCTACTAGACGCTGGTCTACTTCATGGTGACGTTTTAACAGTTACTGGAAA
GACTATGAAGCAAAACCTTGAGCAATACAAGTATCCTAATGTACCTCACAGTCATATAGTTAGGGATGTTAAGAATCCGA
TTAAGCCTAGAGGAGGAATAGTTATATTGAAGGGATCGTTAGCCCCAGAAGGTGCCGTAATTAAGGTAGCCGCAACTAAC
GTTGTTAAATTTGAAGGAAAGGCTAAGGTGTATAATTCCGAGGACGACGCTTTTAAGGGAGTTCAAAGTGGCGAAGTTAG
TGAGGGTGAAGTTGTAATTATAAGATATGAAGGACCTAAGGGAGCTCCAGGTATGCCAGAAATGCTGAGAGTTACAGCGG
CAATCATGGGTGCGGGTTTGAATAACGTTGCCTTAGTTACTGATGGTAGATTTTCCGGAGCCACTAGGGGACCTATGGTA
GGCCATGTAGCTCCAGAGGCAATGGTAGGTGGTCCTATCGCAATAGTTGAAGATGGAGATACTATAGTGATTGATGTTGA
GAGCGAAAGACTTGACTTGAAGCTATCCGAGGAGGAGATAAAGAATAGACTGAAAAGATGGTCTCCTCCATCTCCAAGAT
ACAAGTCTGGTCTATTGGCTAAATACGCCTCCTTGGTCTCCCAGGCGTCAATGGGGGCTGTGACTAGACCAGCTTAA

Upstream 100 bases:

>100_bases
TGAAATGGTTCTACTGGGTGGGAAGACATACTAAAATCATCCTTGTTAAACCTAACTTGTAAACATGATCACTTATTAGT
TTCAGTTTAGATTTCTCTAT

Downstream 100 bases:

>100_bases
TTTTTTATTTAATTCTCCTAATTCTCCTTTATGTATGAAGACATTTGGGCAATTGAACACGCAATAAGCTTACTGGATTG
GGATATCCAAACTTACATGC

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 558; Mature: 557

Protein sequence:

>558_residues
MPAKLNSPSRYHGIYNAPHRAFLRSVGLTDEEIGKPLVAIATAWSEAGPCNFHTLALARVAKEGTKEAGLSPLAFPTMVV
NDNIGMGSEGMRYSLVSRDLIADMVEAQFNAHAFDGLVGIGGCDKTTPGILMAMARLNVPSIYIYGGSAEPGYFMGKRLT
IEDVHEAIGAYLAKRITENELYEIEKRAHPTLGTCSGLFTANTMGSMSEALGMALPGSASPTATSSRRVMYVKETGKALG
SLIENGIKSREILTFEAFENAITTLMAMGGSTNAVLHLLAIAYEAGVKLTLDDFNRISKRTPYIASMKPGGDYVMADLDE
VGGVPVVLKKLLDAGLLHGDVLTVTGKTMKQNLEQYKYPNVPHSHIVRDVKNPIKPRGGIVILKGSLAPEGAVIKVAATN
VVKFEGKAKVYNSEDDAFKGVQSGEVSEGEVVIIRYEGPKGAPGMPEMLRVTAAIMGAGLNNVALVTDGRFSGATRGPMV
GHVAPEAMVGGPIAIVEDGDTIVIDVESERLDLKLSEEEIKNRLKRWSPPSPRYKSGLLAKYASLVSQASMGAVTRPA

Sequences:

>Translated_558_residues
MPAKLNSPSRYHGIYNAPHRAFLRSVGLTDEEIGKPLVAIATAWSEAGPCNFHTLALARVAKEGTKEAGLSPLAFPTMVV
NDNIGMGSEGMRYSLVSRDLIADMVEAQFNAHAFDGLVGIGGCDKTTPGILMAMARLNVPSIYIYGGSAEPGYFMGKRLT
IEDVHEAIGAYLAKRITENELYEIEKRAHPTLGTCSGLFTANTMGSMSEALGMALPGSASPTATSSRRVMYVKETGKALG
SLIENGIKSREILTFEAFENAITTLMAMGGSTNAVLHLLAIAYEAGVKLTLDDFNRISKRTPYIASMKPGGDYVMADLDE
VGGVPVVLKKLLDAGLLHGDVLTVTGKTMKQNLEQYKYPNVPHSHIVRDVKNPIKPRGGIVILKGSLAPEGAVIKVAATN
VVKFEGKAKVYNSEDDAFKGVQSGEVSEGEVVIIRYEGPKGAPGMPEMLRVTAAIMGAGLNNVALVTDGRFSGATRGPMV
GHVAPEAMVGGPIAIVEDGDTIVIDVESERLDLKLSEEEIKNRLKRWSPPSPRYKSGLLAKYASLVSQASMGAVTRPA
>Mature_557_residues
PAKLNSPSRYHGIYNAPHRAFLRSVGLTDEEIGKPLVAIATAWSEAGPCNFHTLALARVAKEGTKEAGLSPLAFPTMVVN
DNIGMGSEGMRYSLVSRDLIADMVEAQFNAHAFDGLVGIGGCDKTTPGILMAMARLNVPSIYIYGGSAEPGYFMGKRLTI
EDVHEAIGAYLAKRITENELYEIEKRAHPTLGTCSGLFTANTMGSMSEALGMALPGSASPTATSSRRVMYVKETGKALGS
LIENGIKSREILTFEAFENAITTLMAMGGSTNAVLHLLAIAYEAGVKLTLDDFNRISKRTPYIASMKPGGDYVMADLDEV
GGVPVVLKKLLDAGLLHGDVLTVTGKTMKQNLEQYKYPNVPHSHIVRDVKNPIKPRGGIVILKGSLAPEGAVIKVAATNV
VKFEGKAKVYNSEDDAFKGVQSGEVSEGEVVIIRYEGPKGAPGMPEMLRVTAAIMGAGLNNVALVTDGRFSGATRGPMVG
HVAPEAMVGGPIAIVEDGDTIVIDVESERLDLKLSEEEIKNRLKRWSPPSPRYKSGLLAKYASLVSQASMGAVTRPA

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=609, Percent_Identity=38.2594417077176, Blast_Score=389, Evalue=1e-109,
Organism=Escherichia coli, GI2367371, Length=457, Percent_Identity=34.7921225382932, Blast_Score=209, Evalue=4e-55,
Organism=Escherichia coli, GI1788157, Length=463, Percent_Identity=32.3974082073434, Blast_Score=206, Evalue=3e-54,
Organism=Escherichia coli, GI1786464, Length=496, Percent_Identity=33.4677419354839, Blast_Score=204, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6322476, Length=545, Percent_Identity=45.6880733944954, Blast_Score=484, Evalue=1e-137,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 59422; Mature: 59291

Theoretical pI: Translated: 7.38; Mature: 7.38

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAKLNSPSRYHGIYNAPHRAFLRSVGLTDEEIGKPLVAIATAWSEAGPCNFHTLALARV
CCCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHCCCEEEEEECCCCCCCCCHHHHHHHHH
AKEGTKEAGLSPLAFPTMVVNDNIGMGSEGMRYSLVSRDLIADMVEAQFNAHAFDGLVGI
HHHCCHHCCCCCCCCCEEEEECCCCCCCCCCEEHHHHHHHHHHHHHHHCCCHHHCCEEEC
GGCDKTTPGILMAMARLNVPSIYIYGGSAEPGYFMGKRLTIEDVHEAIGAYLAKRITENE
CCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCHHH
LYEIEKRAHPTLGTCSGLFTANTMGSMSEALGMALPGSASPTATSSRRVMYVKETGKALG
HHHHHHHCCCCCCCCCCCEECCCHHHHHHHHCCCCCCCCCCCCCCCCEEEEEHHHHHHHH
SLIENGIKSREILTFEAFENAITTLMAMGGSTNAVLHLLAIAYEAGVKLTLDDFNRISKR
HHHHCCCCCCEEEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEHHHHHHHHHC
TPYIASMKPGGDYVMADLDEVGGVPVVLKKLLDAGLLHGDVLTVTGKTMKQNLEQYKYPN
CCEEEEECCCCCEEEEEHHHHCCHHHHHHHHHHCCCCCCCEEEEECHHHHHHHHHHCCCC
VPHSHIVRDVKNPIKPRGGIVILKGSLAPEGAVIKVAATNVVKFEGKAKVYNSEDDAFKG
CCHHHHHHHHHHCCCCCCCEEEEECCCCCCCCEEEEEECEEEEECCCEEEECCCCHHHCC
VQSGEVSEGEVVIIRYEGPKGAPGMPEMLRVTAAIMGAGLNNVALVTDGRFSGATRGPMV
CCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCEE
GHVAPEAMVGGPIAIVEDGDTIVIDVESERLDLKLSEEEIKNRLKRWSPPSPRYKSGLLA
ECCCCHHHCCCCEEEEECCCEEEEEECCCCEEEEECHHHHHHHHHCCCCCCCCHHHHHHH
KYASLVSQASMGAVTRPA
HHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
PAKLNSPSRYHGIYNAPHRAFLRSVGLTDEEIGKPLVAIATAWSEAGPCNFHTLALARV
CCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHCCCEEEEEECCCCCCCCCHHHHHHHHH
AKEGTKEAGLSPLAFPTMVVNDNIGMGSEGMRYSLVSRDLIADMVEAQFNAHAFDGLVGI
HHHCCHHCCCCCCCCCEEEEECCCCCCCCCCEEHHHHHHHHHHHHHHHCCCHHHCCEEEC
GGCDKTTPGILMAMARLNVPSIYIYGGSAEPGYFMGKRLTIEDVHEAIGAYLAKRITENE
CCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCHHH
LYEIEKRAHPTLGTCSGLFTANTMGSMSEALGMALPGSASPTATSSRRVMYVKETGKALG
HHHHHHHCCCCCCCCCCCEECCCHHHHHHHHCCCCCCCCCCCCCCCCEEEEEHHHHHHHH
SLIENGIKSREILTFEAFENAITTLMAMGGSTNAVLHLLAIAYEAGVKLTLDDFNRISKR
HHHHCCCCCCEEEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEHHHHHHHHHC
TPYIASMKPGGDYVMADLDEVGGVPVVLKKLLDAGLLHGDVLTVTGKTMKQNLEQYKYPN
CCEEEEECCCCCEEEEEHHHHCCHHHHHHHHHHCCCCCCCEEEEECHHHHHHHHHHCCCC
VPHSHIVRDVKNPIKPRGGIVILKGSLAPEGAVIKVAATNVVKFEGKAKVYNSEDDAFKG
CCHHHHHHHHHHCCCCCCCEEEEECCCCCCCCEEEEEECEEEEECCCEEEECCCCHHHCC
VQSGEVSEGEVVIIRYEGPKGAPGMPEMLRVTAAIMGAGLNNVALVTDGRFSGATRGPMV
CCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCEE
GHVAPEAMVGGPIAIVEDGDTIVIDVESERLDLKLSEEEIKNRLKRWSPPSPRYKSGLLA
ECCCCHHHCCCCEEEEECCCEEEEEECCCCEEEEECHHHHHHHHHCCCCCCCCHHHHHHH
KYASLVSQASMGAVTRPA
HHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA